A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncytial virus (RSV) infection: Effects on RSV quantity and clinical outcome

Journal of Infectious Diseases

Volumn 185, Issue 9, 2002, Pages 1222-1228

  Buckingham, Steven C ^a,c,d   Jafri, Hasan S ^e   Bush, Andrew J ^b   Carubelli, Cecilia M ^e,g   Sheeran, Paul ^e   Hardy, R Doug ^e   Ottolini, Martin G ^f   Ramilo, Octavio ^e   DeVincenzo, John P ^a,c  

^a Departments of Pediatrics   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c LE BONHEUR CHILDREN'S MEDICAL CENTER   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^g EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE SODIUM PHOSPHATE; PLACEBO;

ANTIBODY TITER; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INFANT; LEUKOCYTE COUNT; MALE; NOSE SECRETION; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; TREATMENT OUTCOME; VIRUS INFECTION;

ANTIBODIES, VIRAL; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LENGTH OF STAY; LEUKOCYTE COUNT; MALE; NOSE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; TRACHEA; VIRAL LOAD;

EID: 0036569233     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/340024     Document Type: Article

References (27)

1. Bronchiolitis-associated hospitalizations among U.S. children, 1980-1996
2. Steroid therapy in bronchiolitis: A double-blind study
3. Dexamethasone (16 alpha-methyl, 9 alpha-fluoroprednisolone) in obstructive respiratory tract infections in children: A controlled study
4. A double-blind study on the effects of corticosteroids in the treatment of bronchiolitis
5. A double blind trial of prednisolone in epidemic bronchiolitis due to respiratory syncytial virus
6. Corticosteroid treatment in bronchiolitis. A controlled, collaborative study in 297 infants and children
7. Dexamethasone and salbutamol in the treatment of acute wheezing in infants
8. Corticosteroids do not affect the clinical or physiological status of infants with bronchiolitis
9. Dexamethasone in bronchiolitis: A randomised controlled trial
10. Respiratory syncytial virus bronchiolitis: A double-blind dexamethasone efficacy study
11. Dexamethasone in salbutamol-treated inpatients with acute bronchiolitis: A randomized, controlled trial
12. Randomised double blind placebo controlled trial of prednisolone in children admitted to hospital with respiratory syncytial virus bronchiolitis
13. Prednisolone treatment of respiratory syncytial virus infection: A randomized controlled trial of 147 infants
14. Early nebulized budesonide in the treatment of bronchiolitis and the prevention of postbronchiolitic wheezing
15. Randomised placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis
16. Reduction of respiratory syncytial virus (RSV) in tracheal aspirates in intubated infants by use of humanized monoclonal antibody to RSV F protein
17. An antigenic analysis of respiratory syncytial virus isolates by a plaque reduction neutralization test
18. Respiratory syncytial virus infection in infants: Quantitation and duration of shedding
19. Nasal quantity of respiratory syncytial virus correlates with disease severity in hospitalized infants
20. Influence of host and viral factors in respiratory syncytial virus (RSV) duration of hospitalization
21. Elevated cytokine concentrations in the nasopharyngeal and tracheal secretions of children with respiratory syncytial virus disease
22. Virologic and inflammatory markers in children with respiratory syncytial virus (RSV) lower respiratory tract infection: Comparisons between outpatients and intubated infants
23. Cytokines and chemokines in respiratory secretion and severity of disease in infants with respiratory syncytial virus (RSV) infection
24. Systemic corticosteroids in infant bronchiolitis: A meta-analysis
25. Comparable efficacy of different glucocorticosteroids used in combination with palivizumab to treat RSV bronchiolitis and pneumonia in an animal model