Robust cytokine and chemokine response in nasopharyngeal secretions: Association with decreased severity in children with physician diagnosed bronchiolitis

Journal of Infectious Diseases

Volumn 214, Issue 4, 2016, Pages 649-655

  Nicholson, Erin G ^a   Schlegel, Chelsea ^c   Garofalo, Roberto P ^d   Mehta, Reena ^e   Scheffler, Margaret ^f   Mei, Minghua ^b   Piedra, Pedro A ^a,b  

^a Departments of Pediatrics   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c Allergy and ENT Assoc   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

^e Allergy Asthma Specialists   (United States)

^f BROWN UNIVERSITY   (United States)

Author keywords

Bronchiolitis; Chemokine; Cytokine; Infants and children; Innate antiviral immune response

Indexed keywords

EOTAXIN; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; INTERLEUKIN 9; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR BB; RANTES; TUMOR NECROSIS FACTOR; VASCULOTROPIN; CYTOKINE;

ARTICLE; BRONCHIOLITIS; CHEMOKINE RESPONSE; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOKINE RESPONSE; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; HUMAN RHINOVIRUS; IMMUNE RESPONSE; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; UNIVARIATE ANALYSIS; BODILY SECRETIONS; CHEMISTRY; IMMUNOLOGY; INFANT; ISOLATION AND PURIFICATION; NASAL LAVAGE FLUID; NASOPHARYNX; NEWBORN; PATHOLOGY; VIROLOGY; VIRUS;

BODILY SECRETIONS; BRONCHIOLITIS; CROSS-SECTIONAL STUDIES; CYTOKINES; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; NASAL LAVAGE FLUID; NASOPHARYNX; PROSPECTIVE STUDIES; VIRUSES;

EID: 84988927923     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiw191     Document Type: Article

References (26)

1. American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics 2006; 118:1774-93.
2. Byington CL,Wilkes J, Korgenski K, Sheng X. Respiratory syncytial virus-associated mortality in hospitalized infants and young children. Pediatrics 2015; 135:e24-31.
3. Ralson SL, Lieberthal AS, Meissner HC, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics 2014; 134:e1474-502.
4. Fernandes RM, Baily LM, Vandermeer B, et al. Glucocorticoids for acute viral bronchiolitis in infants and young children (review). Cochrane Database Syst Rev 2013; 6:1-166.
5. Melendi GA, Laham FR, Monsalvo AC, et al. Cytokine profiles in the respiratory tract during primary infection with human metapneumovirus, respiratory syncytial virus, or influenza virus in infants. Pediatrics 2007; 120:e410-5.
6. McNamara PS, Flanagan F, Hart A, Smyth RL. Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis. J Infect Dis 2005; 191:1225-32.
7. Preeti J, Kakakios A, Jayasekera J, Isaacs D. A comparison of IL-2 levels in nasopharyngeal and endotracheal aspirates of babies with respiratory syncytial viral bronchiolitis. J Allergy Clin Immunology 1998; 102:618-20.
8. Pitrez PM, Brennan S, Sly PD. Inflammatory profile in nasal secretions of infants hospitalized with acute lower airways tract infections. Respirology 2005; 10:365-70.
9. Welliver TP, Garofalo RP, Hosakote Y, et al. Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. J Infect Dis 2007; 195:1126-36.
10. Bennett BL, Garofalo RP, Cron SG, et al. Immunopathogenesis of respiratory syncytial virus bronchiolitis. J Infect Dis 2007; 195:1532-40.
11. Mehta R, Scheffler M, Tapia L, et al. Lactate dehydrogenase and caspase activity in nasopharyngeal secretions are predictors of bronchiolitis severity. Influenza Other Respir Viruses 2014; 8:1-9.
12. Laham FR, Israele V, Casellas JM, et al. Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy. J Infect Dis 2004; 47:47-56.
13. Jin W, Dong C. IL-17 cytokines in immunity and inflammation. Emerg Microbes Infect 2013; 2:e60.
14. Tan HL, Rosenthal M. IL-17 in lung disease: friend or foe? Thorax 2013; 68:788-90.
15. Faber TE, Groen H,Welfing M, Jensen KJ, Bont LJ. Specific increase in local IL-17 production during recovery from primary RSV bronchiolitis. J Med Virol 2012; 84:1084-8.
16. Stoppelenbug AJ, Salimi V, Hennus M, et al. Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection. PLoS One 2013; 8:e78461.
17. Marguet C, Bocquel N, Benichou J, et al. Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants. Pediatr Allergy Immunol 2008; 19:157-65.
18. Dufour JH, Dziejman M, Lui MT, Leung JH, Lane TE, Luster AD. IFN-?-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 2002; 168:3195-204.
19. Graham BS, Bunton LA, Wright PF, Karzon DT. Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J Clin Invest 1991; 88:1026-33.
20. Kim HW, Canchola JG, Brandt CD, et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol 1969; 89:422-34.
21. Collins PL, Graham BS. Viral and host factors in human respiratory syncytial virus pathogenesis. J Virol 2008; 82:2040-55.
22. Mejias A, Ramilo O. New options in the treatment of respiratory syncytial virus disease. J Infect 2015; 71:S80-7.
23. Tulic MK, Hurrelbrink RJ, Prele CM, et al. TLR4 polymorphisms mediate impaired responses to respiratory syncytial virus and lipopolysaccharide. J Immunol 2007; 179:132-40.
24. Janssen R, Bont L, Siezen CL, et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 2007; 196:826-34.
25. Lambert L, Sagfors AM, Openshaw PJ, Culley FJ. Immunity to RSV in early-life. Front Immunol 2014; 5:1-15.
26. Mansbach JM, Piedra PA, Teach SJ, et al. Prospective, multicenter study of viral etiology and hospital length-of-stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med 2012; 166:700-6.