Clinical disease and viral load in children infected with respiratory syncytial virus or human metapneumovirus

Diagnostic Microbiology and Infectious Disease

Volumn 62, Issue 4, 2008, Pages 382-388

  Martin, Emily T ^a   Kuypers, Jane ^b   Heugel, Judson ^c   Englund, Janet A ^a,b,c  

^a SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Children; Human metapneumovirus; Respiratory disease; Respiratory syncytial virus; Viral load

Indexed keywords

ANTIBIOTIC AGENT; BRONCHODILATING AGENT;

ADOLESCENT; ARTICLE; BREATHING RATE; BRONCHIOLITIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FEVER; HOSPITAL ADMISSION; HUMAN; HUMAN METAPNEUMOVIRUS; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THORAX RADIOGRAPHY; VIRUS LOAD;

CHILD, PRESCHOOL; FEMALE; HOSPITALIZATION; HUMANS; INFANT; MALE; METAPNEUMOVIRUS; ODDS RATIO; PARAMYXOVIRIDAE INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; TIME FACTORS; VIRAL LOAD;

EID: 56049100212     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2008.08.002     Document Type: Article

References (28)

1. Allander T., Tammi M.T., Eriksson M., Bjerkner A., Tiveljung-Lindell A., and Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 12891-12896
2. Bennett B.L., Garofalo R.P., Cron S.G., Hosakote Y.M., Atmar R.L., Macias C.G., and Piedra P.A. Immunopathogenesis of respiratory syncytial virus bronchiolitis. J. Infect. Dis. 195 (2007) 1532-1540
3. Boeckh M., Englund J., Li Y., Miller C., Cross A., Fernandez H., Kuypers J., Kim H., Gnann J., Whitley R., and NIAID Collaborative Antiviral Study Group. Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. Clin. Infect. Dis. 44 (2007) 245-249
4. Buckingham S.C., Bush A.J., and Devincenzo J.P. Nasal quantity of respiratory syncytial virus correlates with disease severity in hospitalized infants. Pediatr. Infect. Dis. J. 19 (2000) 113-117
5. DeVincenzo J.P., El Saleeby C.M., and Bush A.J. Respiratory syncytial virus load predicts disease severity in previously healthy infants. J. Infect. Dis. 191 (2005) 1861-1868
6. Englund J.A., Piedra P.A., Jewell A., Patel K., Baxter B.B., and Whimbey E. Rapid diagnosis of respiratory syncytial virus infections in immunocompromised adults. J. Clin. Microbiol. 34 (1996) 1649-1653
7. Feudtner C., Christakis D.A., and Connell F.A. Pediatric deaths attributable to complex chronic conditions: a population-based study of Washington State, 1980-1997. Pediatrics 106 1 Pt 2 (2000) 205-209
8. Fouchier R.A., Hartwig N.G., Bestebroer T.M., Niemeyer B., de Jong J.C., Simon J.H., and Osterhaus A.D. A previously undescribed coronavirus associated with respiratory disease in humans. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 6212-6216
9. Gerna G., Campanini G., Rognoni V., Marchi A., Rovida F., Piralla A., and Percivalle E. Correlation of viral load as determined by real-time RT-PCR and clinical characteristics of respiratory syncytial virus lower respiratory tract infections in early infancy. J. Clin. Virol. 41 (2008) 45-48
10. Gerna G., Sarasini A., Percivalle E., Campanini G., Rovida F., Marchi A., and Baldanti F. Prospective study of human metapneumovirus infection: diagnosis, typing and virus quantification in nasopharyngeal secretions from pediatric patients. J. Clin. Virol. 40 (2007) 236-240
11. Hall C.B., Douglas Jr. R.G., and Geiman J.M. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J. Pediatr. 89 (1976) 11-15
12. Hayden F.G., Treanor J.J., Fritz R.S., Lobo M., Betts R.F., Miller M., Kinnersley N., Mills R.G., Ward P., and Straus S.E. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment. JAMA 282 (1999) 1240-1246
13. Kehl S.C., Henrickson K.J., Hua W., and Fan J. Evaluation of the Hexaplex assay for detection of respiratory viruses in children. J. Clin. Microbiol. 39 (2001) 1696-1701
14. Klein M.I., Coviello S., Bauer G., Benitez A., Serra M.E., Schiatti M.P., Delgado M.F., Melendi G.A., Novalli L., Pena H.G., Karron R.A., Kleeberger S.R., and Polack F.P. The impact of infection with human metapneumovirus and other respiratory viruses in young infants and children at high risk for severe pulmonary disease. J. Infect. Dis. 193 (2006) 1544-1551
15. Kuypers J., Wright N., and Morrow R. Evaluation of quantitative and type-specific real-time RT-PCR assays for detection of respiratory syncytial virus in respiratory specimens from children. J. Clin. Virol. 31 (2004) 123-129
16. Kuypers J., Wright N., Corey L., and Morrow R. Detection and quantification of human metapneumovirus in pediatric specimens by real-time RT-PCR. J. Clin. Virol. 33 (2005) 299-305
17. Monto A.S. The threat of an avian influenza pandemic. N. Engl. J. Med. 352 (2005) 323-325
18. Perkins S.M., Webb D.L., Torrance S.A., El Saleeby C., Harrison L.M., Aitken J.A., Patel A., and DeVincenzo J.P. Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus. J. Clin. Microbiol. 43 (2005) 2356-2362
19. Piedra P.A., Englund J.A., and Glezen W.P. Respiratory syncytial virus and parainfluenza viruses. In: Richman D.D., Whitley R.J., and Hayden F.G. (Eds). Clinical virology. 2nd ed. (2002), ASM Press, Washington, DC 763-790
20. Sarasini A., Percivalle E., Rovida F., Campanini G., Genini E., Torsellini M., Paolucci S., Baldanti F., Marchi A., Grazia Revello M., and Gerna G. Detection and pathogenicity of human metapneumovirus respiratory infection in pediatric Italian patients during a winter-spring season. J. Clin. Virol. 35 (2006) 59-68
21. van Burik J.A. Human metapneumovirus: important but not currently diagnosable. Ann. Intern. Med. 144 (2006) 374-375
22. van den Hoogen B.G., van Doornum G.J., Fockens J.C., Cornelissen J.J., Beyer W.E., de Groot R., Osterhaus A.D., and Fouchier R.A. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J. Infect. Dis. 188 (2003) 1571-1577
23. van der Hoek L., Pyrc K., Jebbink M.F., Vermeulen-Oost W., Berkhout R.J., Wolthers K.C., Wertheim-van Dillen P.M., Kaandorp J., Spaargaren J., and Berkhout B. Identification of a new human coronavirus. Nat. Med. 10 (2004) 368-373
24. Watzinger F., Suda M., Preuner S., Baumgartinger R., Ebner K., Baskova L., Niesters H.G., Lawitschka A., and Lion T. Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients. J. Clin. Microbiol. 42 (2004) 5189-5198
25. Wilkesmann A., Ammann R.A., Schildgen O., Eis-Hubinger A.M., Muller A., Seidenberg J., Stephan V., Rieger C., Herting E., Wygold T., Hornschuh F., Groothuis J.R., Simon A., and DSM RSV Ped Study Group. Hospitalized children with respiratory syncytial virus infection and neuromuscular impairment face an increased risk of a complicated course. Pediatr. Infect. Dis. J. 26 (2007) 485-491
26. Wolf D.G., Greenberg D., Kalkstein D., Shemer-Avni Y., Givon-Lavi N., Saleh N., Goldberg M.D., and Dagan R. Comparison of human metapneumovirus, respiratory syncytial virus and influenza A virus lower respiratory tract infections in hospitalized young children. Pediatr. Infect. Dis. J. 25 (2006) 320-324
27. Woo P.C., Lau S.K., Chu C.M., Chan K.H., Tsoi H.W., Huang Y., Wong B.H., Poon R.W., Cai J.J., Luk W.K., Poon L.L., Wong S.S., Guan Y., Peiris J.S., and Yuen K.Y. Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J. Virol. 79 (2005) 884-895
28. Wright P.F., Gruber W.C., Peters M., Reed G., Zhu Y., Robinson F., Coleman-Dockery S., and Graham B.S. Illness severity, viral shedding, and antibody responses in infants hospitalized with bronchiolitis caused by respiratory syncytial virus. J. Infect. Dis. 185 (2002) 1011-1018