Complement C4 Prevents Viral Infection through Capsid Inactivation

Cell Host and Microbe

Volumn 25, Issue 4, 2019, Pages 617-629.e7

  Bottermann, Maria ^a   Foss, Stian ^b,c,d   Caddy, Sarah L ^a   Clift, Dean ^a   van Tienen, Laurens M ^a   Vaysburd, Marina ^a   Cruickshank, James ^a   O'Connell, Kevin ^a   Clark, Jessica ^a   Mayes, Keith ^a   Higginson, Katie ^a   Lode, Heidrun E ^c,d   McAdam, Martin B ^c   Sandlie, Inger ^b,c   Andersen, Jan Terje ^c,d   James, Leo C ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF OSLO   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

adenovirus; complement; complement C4; complement mediated neutralization; gene therapy; host pathogen; humoral immunity; neutralizing antibodies; non enveloped virus; TRIM21

Indexed keywords

ANTIVIRUS AGENT; CELL SURFACE RECEPTOR; COAT PROTEIN; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; FC RECEPTOR; N (4 METHOXYPHENYLACETYL)DEHYDROALANINE; POLYCLONAL ANTIBODY; PROTEASOME; COMPLEMENT COMPONENT C1; IMMUNOLOGIC FACTOR; PROTEIN BINDING; VIRUS ANTIBODY;

ADENOVIRIDAE; ADENOVIRUS INFECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; COMPLEMENT SYSTEM; CONTROLLED STUDY; CYTOSOL; ENZYME DEGRADATION; ESCAPE BEHAVIOR; FLOW CYTOMETRY; GENE THERAPY; GENE VECTOR; INTERNALIZATION; MOUSE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PRY-SPRY DOMAIN; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CAPSID; VIRUS INACTIVATION; VIRUS LOAD; VIRUS PARTICLE; WESTERN BLOTTING; ANIMAL; CELL LINE; DISEASE MODEL; HUMAN ADENOVIRUS C; HUMAN ADENOVIRUS INFECTION; HUMORAL IMMUNITY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM;

ADENOVIRUS INFECTIONS, HUMAN; ADENOVIRUSES, HUMAN; ANIMALS; ANTIBODIES, VIRAL; CAPSID; CELL LINE; COMPLEMENT C1; COMPLEMENT C4; DISEASE MODELS, ANIMAL; IMMUNITY, HUMORAL; IMMUNOLOGIC FACTORS; MICE; MICE, KNOCKOUT; PROTEIN BINDING; VIRUS INACTIVATION;

EID: 85063714635     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2019.02.016     Document Type: Article

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