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Volumn 30, Issue 13-14, 2018, Pages 553-567

Biological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols

Author keywords

3R4F; aerosols; e cigarette; e vapor; inhalation; MarkTen ; mice; proteomics; transcriptomics

Indexed keywords

ACETALDEHYDE; ACROLEIN; BIOLOGICAL MARKER; CARBOXYHEMOGLOBIN; CATHEPSIN S; CIGARETTE SMOKE; COTININE; CROTONALDEHYDE; FORMALDEHYDE; GELATINASE B; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 7; MACROPHAGE ELASTASE; NICOTINE; PROPIONALDEHYDE; PROTEOME;

EID: 85062791846     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958378.2019.1576807     Document Type: Article
Times cited : (23)

References (47)
  • 1
    • 63449107173 scopus 로고    scopus 로고
    • A general modular framework for gene set enrichment analysis
    • Ackermann M, Strimmer K. (2009). A general modular framework for gene set enrichment analysis. BMC Bioinformatics 10:47.
    • (2009) BMC Bioinformatics , vol.10 , pp. 47
    • Ackermann, M.1    Strimmer, K.2
  • 2
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57:289–300.
    • (1995) J R Stat Soc Series B Stat Methodol , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 84901019653 scopus 로고    scopus 로고
    • Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells
    • Cervellati F, Muresan XM, Sticozzi C, et al. (2014). Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol in Vitro 28:999–1005.
    • (2014) Toxicol in Vitro , vol.28 , pp. 999-1005
    • Cervellati, F.1    Muresan, X.M.2    Sticozzi, C.3
  • 5
    • 84899640337 scopus 로고    scopus 로고
    • Chemical evaluation of electronic cigarettes
    • Cheng T. (2014). Chemical evaluation of electronic cigarettes. Tob Control 23 Suppl 2:ii11–7.
    • (2014) Tob Control , vol.23 Suppl 2 , pp. ii11-ii17
    • Cheng, T.1
  • 6
    • 85062767189 scopus 로고    scopus 로고
    • CORESTA recommended method N° 81, routine analytical machine for e-cigarette aerosol generation and collectiondefinitions and standard conditions; [accessed 2018 July 4]. Available from
    • [CORESTA] Cooperation Centre for Scientific Research Relative to Tobacco. (2015). CORESTA recommended method N° 81, routine analytical machine for e-cigarette aerosol generation and collection–definitions and standard conditions; [accessed 2018 July 4]. Available from: https://www.coresta.org/sites/default/files/technical_documents/main/CRM_81.pdf.
    • (2015)
  • 7
    • 85048080312 scopus 로고    scopus 로고
    • Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice
    • Crotty Alexander LE, Drummond CA, Hepokoski M, et al. (2018). Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Integr Comp Physiol 314:R834–47.
    • (2018) Am J Physiol Integr Comp Physiol , vol.314 , pp. R834-R847
    • Crotty Alexander, L.E.1    Drummond, C.A.2    Hepokoski, M.3
  • 8
    • 85062788921 scopus 로고    scopus 로고
    • Draft guidance for industry: premarket tobacco product applications for electronic nicotine delivery systems; [accessed 2018 July 4]. Available from
    • [FDA] Food and Drug Administration. (2016). Draft guidance for industry: premarket tobacco product applications for electronic nicotine delivery systems; [accessed 2018 July 4]. Available from: https://www.fda.gov/downloads/tobaccoproducts/labeling/rulesregulationsguidance/ucm499352.pdf.
    • (2016)
  • 9
    • 85029668232 scopus 로고    scopus 로고
    • Method for the determination of carbonyl compounds in e-cigarette aerosols
    • Flora JW, Wilkinson CT, Wilkinson JW, et al. (2017). Method for the determination of carbonyl compounds in e-cigarette aerosols. J Chromatogr Sci 55:142–8.
    • (2017) J Chromatogr Sci , vol.55 , pp. 142-148
    • Flora, J.W.1    Wilkinson, C.T.2    Wilkinson, J.W.3
  • 10
    • 84931433719 scopus 로고    scopus 로고
    • Biological responses in rats exposed to mainstream smoke from a heated cigarette compared to a conventional reference cigarette
    • Fujimoto H, Tsuji H, Okubo C, et al. (2015). Biological responses in rats exposed to mainstream smoke from a heated cigarette compared to a conventional reference cigarette. Inhal Toxicol 27:224–36.
    • (2015) Inhal Toxicol , vol.27 , pp. 224-236
    • Fujimoto, H.1    Tsuji, H.2    Okubo, C.3
  • 11
    • 1342288026 scopus 로고    scopus 로고
    • affy--analysis of Affymetrix GeneChip data at the probe level
    • 307–315. Available from
    • Gautier L, Cope L, Bolstad BM, et al. (2004). affy--analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20:307–315. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14960456
    • (2004) Bioinformatics , vol.20
  • 12
    • 85055413627 scopus 로고    scopus 로고
    • Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice
    • Glynos C, Bibli SI, Katsaounou P, et al. (2018). Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice. Am J Physiol Lung Cell Mol Physiol 315:L662–72.
    • (2018) Am J Physiol Lung Cell Mol Physiol , vol.315 , pp. L662-L672
    • Glynos, C.1    Bibli, S.I.2    Katsaounou, P.3
  • 13
    • 84893908308 scopus 로고    scopus 로고
    • Levels of selected carcinogens and toxicants in vapour from electronic cigarettes
    • Goniewicz ML, Knysak J, Gawron M, et al. (2014). Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 23:133–9.
    • (2014) Tob Control , vol.23 , pp. 133-139
    • Goniewicz, M.L.1    Knysak, J.2    Gawron, M.3
  • 14
    • 84983050153 scopus 로고    scopus 로고
    • Comprehensive review of epidemiological and animal studies on the potential carcinogenic effects of nicotine per se
    • Haussmann HJ, Fariss MW. (2016). Comprehensive review of epidemiological and animal studies on the potential carcinogenic effects of nicotine per se. Crit Rev Toxicol 46:701–34.
    • (2016) Crit Rev Toxicol , vol.46 , pp. 701-734
    • Haussmann, H.J.1    Fariss, M.W.2
  • 15
    • 84873368065 scopus 로고    scopus 로고
    • Statistical inference from multiple iTRAQ experiments without using common reference standards
    • Herbrich SM, Cole RN, West KP, Jr, et al. (2013). Statistical inference from multiple iTRAQ experiments without using common reference standards. J Proteome Res 12:594–604.
    • (2013) J Proteome Res , vol.12 , pp. 594-604
    • Herbrich, S.M.1    Cole, R.N.2    West, K.P.3
  • 16
    • 84895918030 scopus 로고    scopus 로고
    • Case study: the role of mechanistic network models in systems toxicology
    • Hoeng J, Talikka M, Martin F, et al. (2014). Case study: the role of mechanistic network models in systems toxicology. Drug Discov Today 19:183–92.
    • (2014) Drug Discov Today , vol.19 , pp. 183-192
    • Hoeng, J.1    Talikka, M.2    Martin, F.3
  • 17
    • 11244346557 scopus 로고    scopus 로고
    • Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    • Huber W, Von Heydebreck A, Sültmann H, et al. (2002). Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18:S96–S104.
    • (2002) Bioinformatics , vol.18 , pp. S96-S104
    • Huber, W.1    Von Heydebreck, A.2    Sültmann, H.3
  • 18
    • 84880065240 scopus 로고    scopus 로고
    • Defining, comparing, and improving iTRAQ quantification in mass spectrometry proteomics data
    • Hultin-Rosenberg L, Forshed J, Branca RM, et al. (2013). Defining, comparing, and improving iTRAQ quantification in mass spectrometry proteomics data. Mol Cell Proteomics 12:2021–31.
    • (2013) Mol Cell Proteomics , vol.12 , pp. 2021-2031
    • Hultin-Rosenberg, L.1    Forshed, J.2    Branca, R.M.3
  • 19
    • 85016149190 scopus 로고    scopus 로고
    • KEGG: new perspectives on genomes, pathways, diseases and drugs
    • Kanehisa M, Furumichi M, Tanabe M, et al. (2017). KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 45:D353–61.
    • (2017) Nucleic Acids Res , vol.45 , pp. D353-D361
    • Kanehisa, M.1    Furumichi, M.2    Tanabe, M.3
  • 20
    • 84904074764 scopus 로고    scopus 로고
    • Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models
    • Martin F, Sewer A, Talikka M, et al. (2014). Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models. BMC Bioinformatics 15:238.
    • (2014) BMC Bioinformatics , vol.15 , pp. 238
    • Martin, F.1    Sewer, A.2    Talikka, M.3
  • 22
    • 84941772316 scopus 로고    scopus 로고
    • Effects of switching to electronic cigarettes with and without concurrent smoking on exposure to nicotine, carbon monoxide, and acrolein
    • McRobbie H, Phillips A, Goniewicz ML, et al. (2015). Effects of switching to electronic cigarettes with and without concurrent smoking on exposure to nicotine, carbon monoxide, and acrolein. Cancer Prev Res (Phila) 8:873–8.
    • (2015) Cancer Prev Res (Phila) , vol.8 , pp. 873-878
    • McRobbie, H.1    Phillips, A.2    Goniewicz, M.L.3
  • 23
    • 0029045189 scopus 로고
    • Particle inhalability curves for humans and small laboratory animals
    • Ménache MG, Miller FJ, Raabe OB. (1995). Particle inhalability curves for humans and small laboratory animals. Ann Occup Hyg 39:317–28.
    • (1995) Ann Occup Hyg , vol.39 , pp. 317-328
    • Ménache, M.G.1    Miller, F.J.2    Raabe, O.B.3
  • 24
    • 84908328821 scopus 로고    scopus 로고
    • Comparative in vitro toxicity profile of electronic and tobacco cigarettes, smokeless tobacco and nicotine replacement therapy products: e-liquids, extracts and collected aerosols
    • Misra M, Leverette RD, Cooper BT, et al. (2014). Comparative in vitro toxicity profile of electronic and tobacco cigarettes, smokeless tobacco and nicotine replacement therapy products: e-liquids, extracts and collected aerosols. Int J Environ Res Public Health 11:11325–47.
    • (2014) Int J Environ Res Public Health , vol.11 , pp. 11325-11347
    • Misra, M.1    Leverette, R.D.2    Cooper, B.T.3
  • 26
    • 0003633755 scopus 로고    scopus 로고
    • 8th ed,. Washington, DC: The National Academies Press
    • [NRC] National Research Council. (2011). Guide for the care and use of laboratory animals. 8th ed. Washington, DC: The National Academies Press.
    • (2011) Guide for the care and use of laboratory animals
  • 27
    • 84897360903 scopus 로고    scopus 로고
    • Estimating the harms of nicotine-containing products using the MCDA approach
    • Nutt DJ, Phillips LD, Balfour D, et al. (2014). Estimating the harms of nicotine-containing products using the MCDA approach. Eur Addict Res 20:218–25.
    • (2014) Eur Addict Res , vol.20 , pp. 218-225
    • Nutt, D.J.1    Phillips, L.D.2    Balfour, D.3
  • 28
    • 4344677172 scopus 로고    scopus 로고
    • Characterization of mainstream cigarette smoke (MS)-induced biomarker responses in ICR and C57Bl/6 mice
    • Obot CJ, Lee K, Fuciarelli AF, et al. (2004). Characterization of mainstream cigarette smoke (MS)-induced biomarker responses in ICR and C57Bl/6 mice. Inhal Toxicol 16:701–19.
    • (2004) Inhal Toxicol , vol.16 , pp. 701-719
    • Obot, C.J.1    Lee, K.2    Fuciarelli, A.F.3
  • 29
    • 85023193219 scopus 로고    scopus 로고
    • Aldehyde detection in electronic cigarette aerosols
    • Ogunwale MA, Li M, Ramakrishnam Raju MV, et al. (2017). Aldehyde detection in electronic cigarette aerosols. ACS Omega 2:1207–14.
    • (2017) ACS Omega , vol.2 , pp. 1207-1214
    • Ogunwale, M.A.1    Li, M.2    Ramakrishnam Raju, M.V.3
  • 30
    • 85062798137 scopus 로고    scopus 로고
    • Guidance document on acute inhalation toxicity testing, 39; [accessed 2018 Sept 16]. Available from
    • [OECD] Organisation for economic co-operation and development. (2009). Guidance document on acute inhalation toxicity testing, No. 39; [accessed 2018 Sept 16]. Available from: https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-gd39.pdf.
    • (2009)
  • 31
    • 85029499831 scopus 로고    scopus 로고
    • Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints
    • Phillips B, Titz B, Kogel U, et al. (2017). Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints. Food Chem Toxicol 109:315–32.
    • (2017) Food Chem Toxicol , vol.109 , pp. 315-332
    • Phillips, B.1    Titz, B.2    Kogel, U.3
  • 32
    • 84960118088 scopus 로고    scopus 로고
    • An 8-month systems toxicology inhalation/cessation study in Apoe-/- mice to investigate cardiovascular and respiatory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes
    • Phillips B, Veljkovic E, Boué S, et al. (2016). An 8-month systems toxicology inhalation/cessation study in Apoe-/- mice to investigate cardiovascular and respiatory exposure effects of a candidate modified risk tobacco product, THS 2.2, compared with conventional cigarettes. Toxicol Sci 149:411–32.
    • (2016) Toxicol Sci , vol.149 , pp. 411-432
    • Phillips, B.1    Veljkovic, E.2    Boué, S.3
  • 33
    • 84927607692 scopus 로고    scopus 로고
    • A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product
    • Phillips B, Veljkovic E, Peck MJ, et al. (2015). A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product. Food Chem Toxicol 80:328–45.
    • (2015) Food Chem Toxicol , vol.80 , pp. 328-345
    • Phillips, B.1    Veljkovic, E.2    Peck, M.J.3
  • 34
    • 84998044765 scopus 로고
    • Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals
    • Raabe OG, Al-Bayati MA, Teague SV, Rasolt A. (1988). Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann Occup Hyg 31:53–63.
    • (1988) Ann Occup Hyg , vol.31 , pp. 53-63
    • Raabe, O.G.1    Al-Bayati, M.A.2    Teague, S.V.3    Rasolt, A.4
  • 35
    • 85062773140 scopus 로고    scopus 로고
    • Nicotine without smoke: tobacco harm reduction; [accessed 2018 July 4]. Available from
    • [RCP UK] Royal College of Physicians. (2016). Nicotine without smoke: tobacco harm reduction; [accessed 2018 July 4]. Available from: https://www.rcplondon.ac.uk/projects/outputs/nicotine-without-smoke-tobacco-harm-reduction-0.
    • (2016)
  • 36
    • 4544341015 scopus 로고    scopus 로고
    • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    • Smyth GK. (2004). Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3:Article3.
    • (2004) Stat Appl Genet Mol Biol , vol.3 , pp. Article3
    • Smyth, G.K.1
  • 37
    • 84957429603 scopus 로고    scopus 로고
    • Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes
    • St Helen G, Havel C, Dempsey DA, et al. (2016). Nicotine delivery, retention and pharmacokinetics from various electronic cigarettes. Addiction 111:535–44.
    • (2016) Addiction , vol.111 , pp. 535-544
    • St Helen, G.1    Havel, C.2    Dempsey, D.A.3
  • 38
    • 84941350194 scopus 로고    scopus 로고
    • Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems
    • Hoeng J., Peitsch M.C., (eds),. In:, editors.,. New York, NY: Humana Press. p
    • Talikka M, Boue S, Schlage WK. (2015). Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems. In: Hoeng J, Peitsch MC, editors. Computational systems toxicology. New York, NY: Humana Press. p. 65–93.
    • (2015) Computational systems toxicology , pp. 65-93
    • Talikka, M.1    Boue, S.2    Schlage, W.K.3
  • 39
    • 85006826895 scopus 로고    scopus 로고
    • E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke
    • Taylor M, Carr T, Oke O, et al. (2016). E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke. Toxicol Mech Methods 26:465–76.
    • (2016) Toxicol Mech Methods , vol.26 , pp. 465-476
    • Taylor, M.1    Carr, T.2    Oke, O.3
  • 40
    • 84884695502 scopus 로고    scopus 로고
    • Quantitative assessment of biological impact using transcriptomic data and mechanistic network models
    • Thomson TM, Sewer A, Martin F, et al. (2013). Quantitative assessment of biological impact using transcriptomic data and mechanistic network models. Toxicol Appl Pharmacol 272:863–78.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 863-878
    • Thomson, T.M.1    Sewer, A.2    Martin, F.3
  • 41
    • 84938791821 scopus 로고    scopus 로고
    • Characterization of biochemical, functional and structural changes in mice respiratory organs chronically exposed to cigarette smoke
    • Tsuji H, Fujimoto H, Lee KM, et al. (2015). Characterization of biochemical, functional and structural changes in mice respiratory organs chronically exposed to cigarette smoke. Inhal Toxicol 27:342–53.
    • (2015) Inhal Toxicol , vol.27 , pp. 342-353
    • Tsuji, H.1    Fujimoto, H.2    Lee, K.M.3
  • 42
    • 80052121263 scopus 로고    scopus 로고
    • Comparison of mouse strains and exposure conditions in acute cigarette smoke inhalation studies
    • Tsuji H, Fujimoto H, Matsuura D, et al. (2011). Comparison of mouse strains and exposure conditions in acute cigarette smoke inhalation studies. Inhal Toxicol 23:602–15.
    • (2011) Inhal Toxicol , vol.23 , pp. 602-615
    • Tsuji, H.1    Fujimoto, H.2    Matsuura, D.3
  • 43
    • 85062784382 scopus 로고    scopus 로고
    • The Health Consequences of Smoking—50 Years of Progress. A Report of the Surgeon General. Available from
    • U.S. Department of Health and Human Services (US DHHS) (2014). The Health Consequences of Smoking—50 Years of Progress. A Report of the Surgeon General. Available from https://www.surgeongeneral.gov/library/reports/50-years-of-progress/exec-summary.pdf.
    • (2014)
  • 44
    • 85051646874 scopus 로고    scopus 로고
    • Characterization of puff topography of a prototype electronic cigarette in adult exclusive cigarette smokers and adult exclusive electronic cigarette users
    • Vansickel AR, Edmiston JS, Liang Q, et al. (2018). Characterization of puff topography of a prototype electronic cigarette in adult exclusive cigarette smokers and adult exclusive electronic cigarette users. Regul Toxicol Pharmacol 98:250–6.
    • (2018) Regul Toxicol Pharmacol , vol.98 , pp. 250-256
    • Vansickel, A.R.1    Edmiston, J.S.2    Liang, Q.3
  • 45
    • 85044441404 scopus 로고    scopus 로고
    • An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion
    • Wagner KA, Flora JW, Melvin MS, et al. (2018). An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion. Regul Toxicol Pharmacol 95:153–60.
    • (2018) Regul Toxicol Pharmacol , vol.95 , pp. 153-160
    • Wagner, K.A.1    Flora, J.W.2    Melvin, M.S.3
  • 46
    • 84956737173 scopus 로고    scopus 로고
    • Toxicological assessment of a prototype e-cigaret cartridge and three flavor formulations: a 90-day inhalation study in rats
    • Werley MS, Kirkpatrick DJ, Oldham MJ, et al. (2016). Toxicological assessment of a prototype e-cigaret cartridge and three flavor formulations: a 90-day inhalation study in rats. Inhal Toxicol 28:22–38.
    • (2016) Inhal Toxicol , vol.28 , pp. 22-38
    • Werley, M.S.1    Kirkpatrick, D.J.2    Oldham, M.J.3
  • 47
    • 80053312371 scopus 로고    scopus 로고
    • Non-clinical safety and pharmacokinetic evaluations of propylene glycol aerosol in Sprague-Dawley rats and Beagle dogs
    • Werley MS, McDonald P, Lilly P, et al. (2011). Non-clinical safety and pharmacokinetic evaluations of propylene glycol aerosol in Sprague-Dawley rats and Beagle dogs. Toxicology 287:76–90.
    • (2011) Toxicology , vol.287 , pp. 76-90
    • Werley, M.S.1    McDonald, P.2    Lilly, P.3


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