Toxicological assessment of a prototype e-cigaret device and three flavor formulations: A 90-day inhalation study in rats

Inhalation Toxicology

Volumn 28, Issue 1, 2016, Pages 22-38

  Werley, Michael S ^a   Kirkpatrick, Dan J ^b   Oldham, Michael J ^a   Jerome, Ann M ^a   Langston, Timothy B ^a   Lilly, Patrick D ^a   Smith, Donna C ^a   Mckinney, Willie J ^a  

^a Altria Client Services Inc   (United States)

^b WIL RESEARCH LABORATORIES   (United States)

Author keywords

E cigaret; rodent; subchronic inhalation

Indexed keywords

CARBOXYHEMOGLOBIN; COTININE; GLYCEROL; LACTATE DEHYDROGENASE; NICOTINE; PROPYLENE GLYCOL; PROTEIN; AEROSOL; FLAVORING AGENT;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BACTERIOLOGY; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CELL VACUOLE; CLINICAL OBSERVATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ELECTRONIC CIGARETTE; EPITHELIUM HYPERPLASIA; EXPOSURE; FEMALE; FLAVOR; FOOD INTAKE; HISTOPATHOLOGY; LUNG ALVEOLUS MACROPHAGE; LUNG FUNCTION TEST; LUNG WEIGHT; MALE; NEUTROPHIL; NONHUMAN; OPHTHALMOSCOPY; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; SPLEEN WEIGHT; THYMUS; TOXICOLOGY; URINALYSIS; VIROLOGY; ANIMAL; BLOOD; CELL COUNT; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NOSE; PATHOLOGY; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL COUNT; COTININE; ELECTRONIC CIGARETTES; FEMALE; FLAVORING AGENTS; L-LACTATE DEHYDROGENASE; MALE; NICOTINE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; NOSE; RATS, SPRAGUE-DAWLEY; TOXICITY TESTS, SUBCHRONIC;

EID: 84956737173     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2015.1130758     Document Type: Article

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