NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

Nature Biotechnology

Volumn 37, Issue 3, 2019, Pages 267-275

  Tchieu, Jason ^a,b   Calder, Elizabeth L ^a,b   Guttikonda, Sudha R ^a,b   Gutzwiller, Eveline M ^a,b   Aromolaran, Kelly A ^c   Steinbeck, Julius A ^a,b   Goldstein, Peter A ^c   Studer, Lorenz ^a,b  

^a The Center for Stem Cell Biology   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; MAMMALS;

CALCIUM TRANSIENTS; CHROMATIN REMODELING; GLIAL FIBRILLARY ACIDIC PROTEINS; MOLECULAR SWITCHES; PHARMACOLOGICAL MANIPULATION; PLURIPOTENT STEM CELLS; PROMOTING FACTORS; TRANSIENT EXPRESSION; 'CURRENT; HUMAN DEVELOPMENT; MECHANISTICS; NEURAL STEM CELL; NUCLEAR FACTORS; SYNAPTOGENESIS;

STEM CELLS;

CALCIUM; GLIAL FIBRILLARY ACIDIC PROTEIN; NUCLEAR FACTOR; NUCLEAR FACTOR IA; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; BRAIN DERIVED NEUROTROPHIC FACTOR; COMPLEMENT COMPONENT C1Q; DOXYCYCLINE; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 8; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; INTERLEUKIN 1ALPHA; NUCLEAR FACTOR I; PENTOBARBITAL; TRANSCRIPTION FACTOR SOX9; TUMOR NECROSIS FACTOR; NFIA PROTEIN, HUMAN;

ADULT; ASTROCYTE; BRAIN REGION; CALCIUM TRANSPORT; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DEMETHYLATION; GLIA; HUMAN; HUMAN CELL; LETTER; MOUSE; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; REGENERATIVE MEDICINE; SYNAPTOGENESIS; TRANSIENT EXPRESSION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME SEGREGATION; CORPUS CALLOSUM; DNA DEMETHYLATION; DNA REPAIR; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXCITOTOXICITY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE ASSAY; IMMUNOHISTOCHEMISTRY; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RNA ISOLATION; RNA SEQUENCE; UPREGULATION; ANIMAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT;

ANIMALS; ASTROCYTES; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; NEURAL STEM CELLS; NEUROGENESIS; NEUROGLIA; NEURONS; NFI TRANSCRIPTION FACTORS; PLURIPOTENT STEM CELLS; PROMOTER REGIONS, GENETIC;

EID: 85062088049     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/s41587-019-0035-0     Document Type: Article

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