A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice

Journal of Virology

Volumn 93, Issue 4, 2019, Pages

  Bennion, Brock G ^a   Ingle, Harshad ^a   Ai, Teresa L ^a   Miner, Cathrine A ^a   Platt, Derek J ^a   Smith, Amber M ^a   Baldridge, Megan T ^a   Miner, Jonathan J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptive immunity; Autoimmunity; Gammaherpesvirus; Innate immunity; MHV68; Pulmonary fibrosis; STING; Vasculopathy

Indexed keywords

INTERFERON; MEMBRANE PROTEIN; MPYS PROTEIN, MOUSE; TMEM173 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; GAIN OF FUNCTION MUTATION; GAMMAHERPESVIRINAE; GENE; HETEROZYGOTE; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; INNATE IMMUNITY; INTERFERON STIMULATED GENE; KNOCKOUT MOUSE; LUNG FIBROSIS; MACROPHAGE; MOUSE; MOUSE STRAIN; MURINE GAMMAHERPESVIRUS 68; NONHUMAN; PRIORITY JOURNAL; STING GENE; STRAIN DIFFERENCE; UPREGULATION; VIRUS REPLICATION; ANIMAL; C57BL MOUSE; GENETICS; INFLAMMATION; LUNG; METABOLISM; MUTATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIROLOGY;

ADAPTIVE IMMUNITY; ANIMALS; GAIN OF FUNCTION MUTATION; GAMMAHERPESVIRINAE; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFLAMMATION; LUNG; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MUTATION; PULMONARY FIBROSIS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 85061730931     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01806-18     Document Type: Article

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