-
2
-
-
77958559483
-
Potentiating role of gas6 and tyro3, axl and mer (TAM) receptors in human and murine platelet activation and thrombus stabilization
-
Cosemans, J.M.E.M. et al. Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J. Thromb. Haemost. 8, 1797-1808 (2010).
-
(2010)
J. Thromb. Haemost.
, vol.8
, pp. 1797-1808
-
-
Cosemans, J.M.E.M.1
-
3
-
-
0034684039
-
Expression of the receptor protein-tyrosine kinases tyro3, axl and mer in the developing rat central nervous system
-
Prieto, A.L., Weber, J.L. & Lai, C. Expression of the receptor protein-tyrosine kinases Tyro3, Axl and Mer in the developing rat central nervous system. J. Comp. Neurol. 425, 295-314 (2000).
-
(2000)
J. Comp. Neurol.
, vol.425
, pp. 295-314
-
-
Prieto, A.L.1
Weber, J.L.2
Lai, C.3
-
4
-
-
84992570470
-
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities
-
Lew, E.D. et al. Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. eLife 3, e03385 (2014).
-
(2014)
ELife
, vol.3
, pp. e03385
-
-
Lew, E.D.1
-
5
-
-
33745208276
-
Natural killer cell differentiation driven by tyro3 receptor tyrosine kinases
-
Caraux, A. et al. Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat. Immunol. 7, 747-754 (2006).
-
(2006)
Nat. Immunol.
, vol.7
, pp. 747-754
-
-
Caraux, A.1
-
6
-
-
84897954522
-
The E3 ligase cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
-
Paolino, M. et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature 507, 508-512 (2014).
-
(2014)
Nature
, vol.507
, pp. 508-512
-
-
Paolino, M.1
-
7
-
-
76749123429
-
R428, a selective small molecule inhibitor of axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer
-
Holland, S.J. et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 70, 1544-1554 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 1544-1554
-
-
Holland, S.J.1
-
8
-
-
27144492628
-
Multiple roles for the receptor tyrosine kinase axl in tumor formation
-
Holland, S.J. et al. Multiple roles for the receptor tyrosine kinase Axl in tumor formation. Cancer Res. 65, 9294-9303 (2005).
-
(2005)
Cancer Res.
, vol.65
, pp. 9294-9303
-
-
Holland, S.J.1
-
9
-
-
84871056650
-
The Vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a mer- and SHP2-dependent manner
-
Fraineau, S. et al. The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner. Blood 120, 5073-5083 (2012).
-
(2012)
Blood
, vol.120
, pp. 5073-5083
-
-
Fraineau, S.1
-
10
-
-
85047694191
-
Role of gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy
-
Angelillo-Scherrer, A. et al. Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J. Clin. Invest. 115, 237-246 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 237-246
-
-
Angelillo-Scherrer, A.1
-
11
-
-
36849033963
-
TAM receptors are pleiotropic inhibitors of the innate immune response
-
Rothlin, C.V., Ghosh, S., Zuniga, E.I., Oldstone, M.B.A. & Lemke, G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136 (2007).
-
(2007)
Cell
, vol.131
, pp. 1124-1136
-
-
Rothlin, C.V.1
Ghosh, S.2
Zuniga, E.I.3
Oldstone, M.B.A.4
Lemke, G.5
-
12
-
-
33747889597
-
TAM receptor function in the retinal pigment epithelium
-
Prasad, D. et al. TAM receptor function in the retinal pigment epithelium. Mol. Cell. Neurosci. 33, 96-108 (2006).
-
(2006)
Mol. Cell. Neurosci.
, vol.33
, pp. 96-108
-
-
Prasad, D.1
-
13
-
-
0035837323
-
Phagocytosis and clearance of apoptotic cells is mediated by MER
-
Scott, R.S. et al. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411, 207-211 (2001).
-
(2001)
Nature
, vol.411
, pp. 207-211
-
-
Scott, R.S.1
-
14
-
-
84908322844
-
Diversification of TAM receptor tyrosine kinase function
-
Zagórska, A., Traves, P.G., Lew, E.D., Dransfield, I. & Lemke, G. Diversification of TAM receptor tyrosine kinase function. Nat. Immunol. 15, 920-928 (2014).
-
(2014)
Nat. Immunol.
, vol.15
, pp. 920-928
-
-
Zagórska, A.1
Traves, P.G.2
Lew, E.D.3
Dransfield, I.4
Lemke, G.5
-
15
-
-
84892438921
-
First axl inhibitor enters clinical trials
-
Sheridan, C. First Axl inhibitor enters clinical trials. Nat. Biotechnol. 31, 775-776 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 775-776
-
-
Sheridan, C.1
-
16
-
-
84922481128
-
The TAM family: Phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
-
Graham, D.K., DeRyckere, D., Davies, K.D. & Earp, H.S. The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer. Nat. Rev. Cancer 14, 769-785 (2014).
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 769-785
-
-
Graham, D.K.1
DeRyckere, D.2
Davies, K.D.3
Earp, H.S.4
-
17
-
-
84874427303
-
Therapeutic efficacy of tyro3, axl and mer tyrosine kinase agonists in collagen-induced arthritis
-
van den Brand, B.T. et al. Therapeutic efficacy of Tyro3, Axl and Mer tyrosine kinase agonists in collagen-induced arthritis. Arthritis Rheum. 65, 671-680 (2013).
-
(2013)
Arthritis Rheum.
, vol.65
, pp. 671-680
-
-
Van Den-Brand, B.T.1
-
18
-
-
84867647748
-
The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry
-
Meertens, L. et al. The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe 12, 544-557 (2012).
-
(2012)
Cell Host Microbe
, vol.12
, pp. 544-557
-
-
Meertens, L.1
-
19
-
-
84882338751
-
Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors
-
Bhattacharyya, S. et al. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell Host Microbe 14, 136-147 (2013).
-
(2013)
Cell Host Microbe
, vol.14
, pp. 136-147
-
-
Bhattacharyya, S.1
-
20
-
-
84898632757
-
Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma
-
Shibata, T. et al. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma. J. Immunol. 192, 3569-3581 (2014).
-
(2014)
J. Immunol.
, vol.192
, pp. 3569-3581
-
-
Shibata, T.1
-
21
-
-
84896786643
-
An AXL-LRP-1-RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo
-
Subramanian, M. et al. An AXL-LRP-1-RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J. Clin. Invest. 124, 1296-1308 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 1296-1308
-
-
Subramanian, M.1
-
22
-
-
84908428514
-
Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals
-
Daniels, B.P. et al. Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals. MBio 5, e01476-14 (2014).
-
(2014)
MBio
, vol.5
, pp. e01476-e01514
-
-
Daniels, B.P.1
-
23
-
-
0035869275
-
La crosse encephalitis in children
-
McJunkin, J.E. et al. La Crosse encephalitis in children. N. Engl. J. Med. 344, 801-807 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 801-807
-
-
McJunkin, J.E.1
-
24
-
-
11144273976
-
Toll-like receptor 3 mediates west nile virus entry into the brain causing lethal encephalitis
-
Wang, T. et al. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat. Med. 10, 1366-1373 (2004).
-
(2004)
Nat. Med.
, vol.10
, pp. 1366-1373
-
-
Wang, T.1
-
25
-
-
77954747250
-
Protein S controls hypoxic-ischemic blood-brain barrier disruption through the TAM receptor tyro3 and sphingosine-1-phosphate receptor
-
Zhu, D. et al. Protein S controls hypoxic-ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine-1-phosphate receptor. Blood 115, 4963-4972 (2010).
-
(2010)
Blood
, vol.115
, pp. 4963-4972
-
-
Zhu, D.1
-
26
-
-
84890547494
-
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
-
Chung, W.-S. et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504, 394-400 (2013).
-
(2013)
Nature
, vol.504
, pp. 394-400
-
-
Chung, W.-S.1
-
27
-
-
84891441339
-
Replication cycle and molecular biology of the west nile virus
-
Brinton, M.A. Replication cycle and molecular biology of the West Nile virus. Viruses 6, 13-53 (2013).
-
(2013)
Viruses
, vol.6
, pp. 13-53
-
-
Brinton, M.A.1
-
28
-
-
84928659307
-
Interferon-λ restricts west nile virus neuroinvasion by tightening the blood-brain barrier
-
Lazear, H.M. et al. Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Sci. Transl. Med. 7, 284ra59 (2015).
-
(2015)
Sci. Transl. Med.
, vol.7
, pp. 284ra59
-
-
Lazear, H.M.1
-
29
-
-
33750364634
-
Blocking monoclonal antibodies specific for mouse IFN-α/β receptor subunit 1 (Ifnar-1) from mice immunized by in vivo hydrodynamic transfection
-
Sheehan, K.C. et al. Blocking monoclonal antibodies specific for mouse IFN-α/β receptor subunit 1 (Ifnar-1) from mice immunized by in vivo hydrodynamic transfection. J. Interferon Cytokine Res. 26, 804-819 (2006).
-
(2006)
J. Interferon Cytokine Res.
, vol.26
, pp. 804-819
-
-
Sheehan, K.C.1
-
30
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S. & Hall, A. Rho GTPases in cell biology. Nature 420, 629-635 (2002).
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
31
-
-
0142211201
-
An SH2 domain-dependent, phosphotyrosine-independent interaction between vav1 and the mer receptor tyrosine kinase: A mechanism for localizaing guanine nucleotide-exchange factor action
-
Mahajan, N.P. & Earp, H.S. An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizaing guanine nucleotide-exchange factor action. J. Biol. Chem. 278, 42596-42603 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 42596-42603
-
-
Mahajan, N.P.1
Earp, H.S.2
-
32
-
-
84867740805
-
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
-
Gautier, E.L. et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 13, 1118-1128 (2012).
-
(2012)
Nat. Immunol.
, vol.13
, pp. 1118-1128
-
-
Gautier, E.L.1
-
33
-
-
84890388574
-
TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation
-
Ji, R. et al. TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J. Immunol. 191, 6165-6177 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 6165-6177
-
-
Ji, R.1
-
34
-
-
41249092199
-
Autophosphorylation docking site tyr867 in mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation
-
Tibrewal, N. et al. Autophosphorylation docking site Tyr867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-κB transcriptional activation. J. Biol. Chem. 283, 3618-3627 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3618-3627
-
-
Tibrewal, N.1
-
36
-
-
3242677841
-
+ T cells in control of west nile virus infection
-
+ T cells in control of West Nile virus infection. J. Virol. 78, 8312-8321 (2004).
-
(2004)
J. Virol.
, vol.78
, pp. 8312-8321
-
-
Shrestha, B.1
Diamond, M.S.2
-
37
-
-
34447580875
-
Antigen-specific cytotoxic tlymphocytes protect against lethal west nile virus encephalitis
-
Purtha, W.E. et al. Antigen-specific cytotoxic Tlymphocytes protect against lethal West Nile virus encephalitis. Eur. J. Immunol. 37, 1845-1854 (2007).
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 1845-1854
-
-
Purtha, W.E.1
-
38
-
-
84879273566
-
Systemic autoimmunity in TAM triple-knockout mice causes inflammatory brain damage and cell death
-
Li, Q., Lu, Q., Lu, H., Tian, S. & Lu, Q. Systemic autoimmunity in TAM triple-knockout mice causes inflammatory brain damage and cell death. PLoS ONE 8, e64812 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e64812
-
-
Li, Q.1
Lu, Q.2
Lu, H.3
Tian, S.4
Lu, Q.5
-
39
-
-
70349656483
-
Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
-
Burstyn-Cohen, T., Heeb, M.J. & Lemke, G. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J. Clin. Invest. 119, 2942-2953 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2942-2953
-
-
Burstyn-Cohen, T.1
Heeb, M.J.2
Lemke, G.3
-
40
-
-
80053944035
-
Targeting axl and mer kinases in cancer
-
Verma, A., Warner, S.L., Vankayalapati, H., Bearss, D.J. & Sharma, S. Targeting Axl and Mer kinases in cancer. Mol. Cancer Ther. 10, 1763-1773 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1763-1773
-
-
Verma, A.1
Warner, S.L.2
Vankayalapati, H.3
Bearss, D.J.4
Sharma, S.5
-
41
-
-
84874937924
-
Inhibitors of the TAM subfamily of tyrosine kinases: Synthesis and biological evaluation
-
Suárez, R.M. et al. Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluation. Eur. J. Med. Chem. 61, 2-25 (2013).
-
(2013)
Eur. J. Med. Chem.
, vol.61
, pp. 2-25
-
-
Suárez, R.M.1
-
42
-
-
0035854442
-
Homeostatic regulation of the immune system by receptor tyrosine kinases of the tyro3 family
-
Lu, Q. & Lemke, G. Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro3 family. Science 293, 306-311 (2001).
-
(2001)
Science
, vol.293
, pp. 306-311
-
-
Lu, Q.1
Lemke, G.2
-
43
-
-
0037319970
-
B cells and antibody play critical roles in the immediate defense of disseminated infection by west nile encephalitis virus
-
Diamond, M.S., Shrestha, B., Marri, A., Mahan, D. & Engle, M. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. J. Virol. 77, 2578-2586 (2003).
-
(2003)
J. Virol.
, vol.77
, pp. 2578-2586
-
-
Diamond, M.S.1
Shrestha, B.2
Marri, A.3
Mahan, D.4
Engle, M.5
-
44
-
-
33745789833
-
PKR and RNase L contribute to protection against lethal west nile virus infection by controlling early viral spread in the periphery and replication in neurons
-
Samuel, M.A. et al. PKR and RNase L contribute to protection against lethal West Nile virus infection by controlling early viral spread in the periphery and replication in neurons. J. Virol. 80, 7009-7019 (2006).
-
(2006)
J. Virol.
, vol.80
, pp. 7009-7019
-
-
Samuel, M.A.1
-
45
-
-
84870665996
-
Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type I interferon-mediated control of murine norovirus replication
-
Thackray, L.B. et al. Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type I interferon-mediated control of murine norovirus replication. J. Virol. 86, 13515-13523 (2012).
-
(2012)
J. Virol.
, vol.86
, pp. 13515-13523
-
-
Thackray, L.B.1
-
46
-
-
33646707490
-
Protective immune responses against west nile virus are primed by distinct complement activation pathways
-
Mehlhop, E. & Diamond, M.S. Protective immune responses against West Nile virus are primed by distinct complement activation pathways. J. Exp. Med. 203, 1371-1381 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1371-1381
-
-
Mehlhop, E.1
Diamond, M.S.2
-
47
-
-
0347593991
-
A critical role for induced IgM in the protection against west nile virus infection
-
Diamond, M.S. et al. A critical role for induced IgM in the protection against West Nile virus infection. J. Exp. Med. 198, 1853-1862 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1853-1862
-
-
Diamond, M.S.1
-
48
-
-
84886048507
-
+ T cell-dependent clearance of west nile virus from the central nervous system
-
+ T cell-dependent clearance of West Nile virus from the central nervous system. J. Virol. 87, 11401-11415 (2013).
-
(2013)
J. Virol.
, vol.87
, pp. 11401-11415
-
-
Lazear, H.M.1
-
49
-
-
84906982919
-
Interferon regulatory factor 5 (IRF5)-dependent immune responses in the draining lymph node protect against west nile virus infection
-
Thackray, L.B. et al. Interferon regulatory factor 5 (IRF5)-dependent immune responses in the draining lymph node protect against West Nile virus infection. J. Virol. 88, 11007-11021 (2014).
-
(2014)
J. Virol.
, vol.88
, pp. 11007-11021
-
-
Thackray, L.B.1
-
50
-
-
84859726329
-
Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma
-
Howell, G.R. et al. Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma. J. Clin. Invest. 122, 1246-1261 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1246-1261
-
-
Howell, G.R.1
|