Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

Gut

Volumn 68, Issue 10, 2019, Pages 1791-1800

  Mullish, Benjamin H ^a   McDonald, Julie A K ^a   Pechlivanis, Alexandros ^a   Allegretti, Jessica R ^b,c   Kao, Dina ^d   Barker, Grace F ^a   Kapila, Diya ^a   Petrof, Elaine O ^e   Joyce, Susan A ^f,g   Gahan, Cormac G M ^f,g   Glegola Madejska, Izabela ^a   Williams, Horace R T ^a   Holmes, Elaine ^a   Clarke, Thomas B ^a   Thursz, Mark R ^a   Marchesi, Julian R ^a,h  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

^e QUEEN S UNIVERSITY   (Canada)

^f UNIVERSITY COLLEGE CORK   (Ireland)

^g UNIVERSITY COLLEGE CORK   (Ireland)

^h CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

bile acids; bile salt hydrolase; clostridioides difficile; gut microbiota; metabonome

Indexed keywords

BACTERIAL ENZYME; BILE ACID; HYDROLASE; MICROBIAL BILE SALT HYDROLASE; RIBOSOME RNA; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; AMIDASE; BACTERIAL DNA; CHOLOYLGLYCINE HYDROLASE; GLYCOCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIAL GENE; BACTERIAL VIABILITY; BACTERIUM CULTURE; BACTEROIDES OVATUS; BACTEROIDES VULGATUS; BAI GENE; BILE; BLAUTIA OBEUM; BSH GENE; C57BL 6 MOUSE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CLOSTRIDIUM DIFFICILE INFECTION; COLLINSELLA AEROFACIENS; DONOR; ENZYME ACTIVITY; ESCHERICHIA COLI; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GENE DOSAGE; GENE SEQUENCE; GENETIC ENGINEERING; GUT BILE METABOLISM; HUMAN; INFECTION SENSITIVITY; INTERMETHOD COMPARISON; MASS SPECTROMETRY; METABOLISM; MOUSE; MOUSE MODEL; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT INFECTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; C57BL MOUSE; CLOSTRIDIOIDES DIFFICILE; CLOSTRIDIUM INFECTION; DISEASE MODEL; GENETICS; INTESTINE FLORA; MICROBIOLOGY; PHYSIOLOGY; PROCEDURES; RECURRENT DISEASE; TANDEM MASS SPECTROMETRY;

AMIDOHYDROLASES; ANIMALS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; DISEASE MODELS, ANIMAL; DNA, BACTERIAL; FECAL MICROBIOTA TRANSPLANTATION; FEMALE; GASTROINTESTINAL MICROBIOME; GLYCOCHOLIC ACID; HUMANS; MICE; MICE, INBRED C57BL; RECURRENCE; TANDEM MASS SPECTROMETRY;

EID: 85061542690     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2018-317842     Document Type: Article

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