Unfractionated Heparin Alleviates Sepsis-Induced Acute Lung Injury by Protecting Tight Junctions

Journal of Surgical Research

Volumn 238, Issue , 2019, Pages 175-185

  Liu, Yina ^a   Mu, Shengtian ^b   Li, Xu ^a   Liang, Yingjian ^a   Wang, Liang ^a   Ma, Xiaochun ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b LIAONING CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Acute lung injury; Lung microvascular endothelial cells; Sepsis; Tight junctions; Unfractionated heparin; Vascular permeability

Indexed keywords

CLAUDIN 5; HEPARIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCCLUDIN; PROTEIN ZO1; TIGHT JUNCTION PROTEIN;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CAPILLARY ENDOTHELIAL CELL; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRY WEIGHT; ELECTRIC RESISTANCE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG BLOOD VESSEL; LUNG EDEMA; LUNG ENDOTHELIUM; LUNG WEIGHT; MALE; MAPK SIGNALING; MICROVASCULATURE; NONHUMAN; PERMEABILITY; PERMEABILITY BARRIER; PNEUMONIA; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; RAT; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL; CELL LINE; COMPLICATION; CYTOLOGY; DISEASE MODEL; ENDOTHELIUM CELL; LUNG; METABOLISM; PATHOLOGY; SEPSIS; SUBCUTANEOUS DRUG ADMINISTRATION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ACUTE LUNG INJURY; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HEPARIN; HUMANS; INJECTIONS, SUBCUTANEOUS; LIPOPOLYSACCHARIDES; LUNG; MALE; MICROVESSELS; RATS; RESPIRATORY DISTRESS SYNDROME, ADULT; SEPSIS; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS;

EID: 85061394404     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2019.01.020     Document Type: Article

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