메뉴 건너뛰기




Volumn 45, Issue 2, 2019, Pages 143-158

Stress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis

Author keywords

Critical care; Gastrointestinal haemorrhage; Histamine 2 receptor antagonists; Meta analysis; Peptic ulcer; Proton pump inhibitors; Stress ulcer prophylaxis

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR;

EID: 85060699062     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-019-05526-z     Document Type: Review
Times cited : (50)

References (84)
  • 1
    • 78049448951 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis
    • Marik PE, Vasu T, Hirani A, Pachinburavan M (2010) Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis. Crit Care Med 38(11):2222–2228
    • (2010) Crit Care Med , vol.38 , Issue.11 , pp. 2222-2228
    • Marik, P.E.1    Vasu, T.2    Hirani, A.3    Pachinburavan, M.4
  • 2
    • 84928801013 scopus 로고    scopus 로고
    • Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients
    • Krag M, Perner A, Wetterslev J, Wise M, Borthwick M, Bendel S et al (2015) Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med 41(5):833–845
    • (2015) Intensive Care Med , vol.41 , Issue.5 , pp. 833-845
    • Krag, M.1    Perner, A.2    Wetterslev, J.3    Wise, M.4    Borthwick, M.5    Bendel, S.6
  • 4
    • 85020492571 scopus 로고    scopus 로고
    • Withholding pantoprazole for stress ulcer prophylaxis in critically ill patients: a pilot randomized clinical trial and meta-analysis
    • Alhazzani W, Guyatt G, Alshahrani M, Deane AM, Marshall JC, Hall R et al (2017) Withholding pantoprazole for stress ulcer prophylaxis in critically ill patients: a pilot randomized clinical trial and meta-analysis. Crit Care Med 45(7):1121–1129
    • (2017) Crit Care Med , vol.45 , Issue.7 , pp. 1121-1129
    • Alhazzani, W.1    Guyatt, G.2    Alshahrani, M.3    Deane, A.M.4    Marshall, J.C.5    Hall, R.6
  • 5
  • 6
    • 85009740698 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016
    • Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43(3):304–377
    • (2017) Intensive Care Med , vol.43 , Issue.3 , pp. 304-377
    • Rhodes, A.1    Evans, L.E.2    Alhazzani, W.3    Levy, M.M.4    Antonelli, M.5    Ferrer, R.6
  • 8
    • 84879846201 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis in the intensive care unit: is it indicated? A topical systematic review
    • Krag M, Perner A, Wetterslev J, Moller MH (2013) Stress ulcer prophylaxis in the intensive care unit: is it indicated? A topical systematic review. Acta Anaesthesiol Scand 57(7):835–847
    • (2013) Acta Anaesthesiol Scand , vol.57 , Issue.7 , pp. 835-847
    • Krag, M.1    Perner, A.2    Wetterslev, J.3    Moller, M.H.4
  • 9
    • 85013855007 scopus 로고    scopus 로고
    • What’s new with stress ulcer prophylaxis in the ICU?
    • Marker S, Krag M, Moller MH (2017) What’s new with stress ulcer prophylaxis in the ICU? Intensive Care Med 43(8):1132–1134
    • (2017) Intensive Care Med , vol.43 , Issue.8 , pp. 1132-1134
    • Marker, S.1    Krag, M.2    Moller, M.H.3
  • 10
    • 84874940674 scopus 로고    scopus 로고
    • Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis
    • Alhazzani W, Alenezi F, Jaeschke RZ, Moayyedi P, Cook DJ (2013) Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 41(3):693–705
    • (2013) Crit Care Med , vol.41 , Issue.3 , pp. 693-705
    • Alhazzani, W.1    Alenezi, F.2    Jaeschke, R.Z.3    Moayyedi, P.4    Cook, D.J.5
  • 11
    • 77950294683 scopus 로고    scopus 로고
    • The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis
    • Lin PC, Chang CH, Hsu PI, Tseng PL, Huang YB (2010) The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis. Crit Care Med 38(4):1197–1205
    • (2010) Crit Care Med , vol.38 , Issue.4 , pp. 1197-1205
    • Lin, P.C.1    Chang, C.H.2    Hsu, P.I.3    Tseng, P.L.4    Huang, Y.B.5
  • 13
    • 66649092882 scopus 로고    scopus 로고
    • Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis
    • Pongprasobchai S, Kridkratoke S, Nopmaneejumruslers C (2009) Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis. J Med Assoc Thai 92(5):632–637
    • (2009) J Med Assoc Thai , vol.92 , Issue.5 , pp. 632-637
    • Pongprasobchai, S.1    Kridkratoke, S.2    Nopmaneejumruslers, C.3
  • 14
    • 84859577697 scopus 로고    scopus 로고
    • Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta analysis
    • Barkun AN, Bardou M, Pham CQ, Martel M (2012) Proton pump inhibitors vs. histamine 2 receptor antagonists for stress-related mucosal bleeding prophylaxis in critically ill patients: a meta analysis. Am J Gastroenterol 107(4):507–520
    • (2012) Am J Gastroenterol , vol.107 , Issue.4 , pp. 507-520
    • Barkun, A.N.1    Bardou, M.2    Pham, C.Q.3    Martel, M.4
  • 15
    • 85008656029 scopus 로고    scopus 로고
    • Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials
    • Alshamsi F, Belley-Cote E, Cook D, Almenawer SA, Alqahtani Z, Perri D et al (2016) Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care 20(1):120
    • (2016) Crit Care , vol.20 , Issue.1 , pp. 120
    • Alshamsi, F.1    Belley-Cote, E.2    Cook, D.3    Almenawer, S.A.4    Alqahtani, Z.5    Perri, D.6
  • 16
    • 84872172491 scopus 로고    scopus 로고
    • A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage
    • Liu BL, Li B, Zhang X, Fei Z, Hu SJ, Lin W et al (2013) A randomized controlled study comparing omeprazole and cimetidine for the prophylaxis of stress-related upper gastrointestinal bleeding in patients with intracerebral hemorrhage. J Neurosurg 118(1):115–120
    • (2013) J Neurosurg , vol.118 , Issue.1 , pp. 115-120
    • Liu, B.L.1    Li, B.2    Zhang, X.3    Fei, Z.4    Hu, S.J.5    Lin, W.6
  • 17
    • 84958740463 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: a randomized control trial
    • Lin CC, Hsu YL, Chung CS, Lee TH (2016) Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: a randomized control trial. J Formos Med Assoc 115(1):19–24
    • (2016) J Formos Med Assoc , vol.115 , Issue.1 , pp. 19-24
    • Lin, C.C.1    Hsu, Y.L.2    Chung, C.S.3    Lee, T.H.4
  • 18
    • 85035806098 scopus 로고    scopus 로고
    • Enteral nutrition as stress ulcer prophylaxis in critically ill patients: a randomized controlled exploratory study
    • El-Kersh K, Jalil B, Mcclave SA, Cavallazzi R, Guardiola J, Guilkey K et al (2018) Enteral nutrition as stress ulcer prophylaxis in critically ill patients: a randomized controlled exploratory study. J Crit Care 43:108–113
    • (2018) J Crit Care , vol.43 , pp. 108-113
    • El-Kersh, K.1    Jalil, B.2    Mcclave, S.A.3    Cavallazzi, R.4    Guardiola, J.5    Guilkey, K.6
  • 19
    • 85044413113 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis in adult intensive care unit patients—a protocol for a systematic review
    • Barbateskovic M, Marker S, Jakobsen JC, Krag M (2018) Stress ulcer prophylaxis in adult intensive care unit patients—a protocol for a systematic review. Acta Anaesthesiol Scand 62(6):744–755
    • (2018) Acta Anaesthesiol Scand , vol.62 , Issue.6 , pp. 744-755
    • Barbateskovic, M.1    Marker, S.2    Jakobsen, J.C.3    Krag, M.4
  • 20
    • 85100415918 scopus 로고    scopus 로고
    • Cochrane handbook for systematic reviews of interventions version 5.1.0
    • (eds), Updated March 2011, Available from
    • Higgins JPT, Green S (eds) (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0. Updated March 2011. The cochrane collaboration, 2011. Available from www.handbook.cochrane.org
    • (2011) The Cochrane Collaboration , pp. 2011
    • Higgins, J.P.T.1    Green, S.2
  • 21
    • 68549101842 scopus 로고    scopus 로고
    • The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
    • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700
    • (2009) BMJ , vol.339 , pp. b2700
    • Liberati, A.1    Altman, D.G.2    Tetzlaff, J.3    Mulrow, C.4    Gotzsche, P.C.5    Ioannidis, J.P.6
  • 22
  • 23
    • 84988602803 scopus 로고    scopus 로고
    • Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods
    • Jakobsen JC, Wetterslev J, Winkel P, Lange T, Gluud C (2014) Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods. BMC Med Res Methodol 14:120
    • (2014) BMC Med Res Methodol , vol.14 , pp. 120
    • Jakobsen, J.C.1    Wetterslev, J.2    Winkel, P.3    Lange, T.4    Gluud, C.5
  • 24
  • 26
    • 85047158504 scopus 로고    scopus 로고
    • Association between risk-of-bias assessments and results of randomized trials in cochrane reviews: the ROBES meta-epidemiologic study
    • Savovic J, Turner RM, Mawdsley D, Jones HE, Beynon R, Higgins JPT et al (2018) Association between risk-of-bias assessments and results of randomized trials in cochrane reviews: the ROBES meta-epidemiologic study. Am J Epidemiol 187(5):1113–1122
    • (2018) Am J Epidemiol , vol.187 , Issue.5 , pp. 1113-1122
    • Savovic, J.1    Turner, R.M.2    Mawdsley, D.3    Jones, H.E.4    Beynon, R.5    Higgins, J.P.T.6
  • 27
    • 33748090675 scopus 로고    scopus 로고
    • A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints
    • Harbord RM, Egger M, Sterne JA (2006) A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 25(20):3443–3457
    • (2006) Stat Med , vol.25 , Issue.20 , pp. 3443-3457
    • Harbord, R.M.1    Egger, M.2    Sterne, J.A.3
  • 29
    • 85014688174 scopus 로고    scopus 로고
    • Trial sequential analysis in systematic reviews with meta-analysis
    • Wetterslev J, Jakobsen JC, Gluud C (2017) Trial sequential analysis in systematic reviews with meta-analysis. BMC Med Res Methodol 17(1):39
    • (2017) BMC Med Res Methodol , vol.17 , Issue.1 , pp. 39
    • Wetterslev, J.1    Jakobsen, J.C.2    Gluud, C.3
  • 30
    • 84964921069 scopus 로고    scopus 로고
    • version 5.3. The Nordic Cochrane Center, the Cochrane Collaboration, Copenhagen, Accessed 15 Oct 2018
    • Revman (2014) Review manager (Revman) (computer program), version 5.3. The Nordic Cochrane Center, the Cochrane Collaboration, Copenhagen. https://Community.Cochrane.Org/Help/Tools-and-Software/Revman-5/Revman-5-Download. Accessed 15 Oct 2018
    • (2014) Review Manager (Revman) (Computer Program)
  • 31
    • 75649084582 scopus 로고    scopus 로고
    • Estimating required information size by quantifying diversity in random-effects model meta-analyses
    • Wetterslev J, Thorlund K, Brok J, Gluud C (2009) Estimating required information size by quantifying diversity in random-effects model meta-analyses. BMC Med Res Methodol 9:86
    • (2009) BMC Med Res Methodol , vol.9 , pp. 86
    • Wetterslev, J.1    Thorlund, K.2    Brok, J.3    Gluud, C.4
  • 32
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719–748
    • (1959) J Natl Cancer Inst , vol.22 , Issue.4 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 33
    • 0023280282 scopus 로고
    • Methods for combining randomized clinical trials: strengths and limitations
    • Demets DL (1987) Methods for combining randomized clinical trials: strengths and limitations. Stat Med 6(3):341–350
    • (1987) Stat Med , vol.6 , Issue.3 , pp. 341-350
    • Demets, D.L.1
  • 34
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • Dersimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188
    • (1986) Control Clin Trials , vol.7 , Issue.3 , pp. 177-188
    • Dersimonian, R.1    Laird, N.2
  • 36
    • 45949100256 scopus 로고    scopus 로고
    • Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses
    • Brok J, Thorlund K, Gluud C, Wetterslev J (2008) Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses. J Clin Epidemiol 61(8):763–769
    • (2008) J Clin Epidemiol , vol.61 , Issue.8 , pp. 763-769
    • Brok, J.1    Thorlund, K.2    Gluud, C.3    Wetterslev, J.4
  • 37
    • 60149098740 scopus 로고    scopus 로고
    • Apparently conclusive meta-analyses may be inconclusive—trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses
    • Brok J, Thorlund K, Wetterslev J, Gluud C (2009) Apparently conclusive meta-analyses may be inconclusive—trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses. Int J Epidemiol 38(1):287–298
    • (2009) Int J Epidemiol , vol.38 , Issue.1 , pp. 287-298
    • Brok, J.1    Thorlund, K.2    Wetterslev, J.3    Gluud, C.4
  • 38
    • 79953740257 scopus 로고    scopus 로고
    • Sequential methods for random-effects meta-analysis
    • Higgins JP, Whitehead A, Simmonds M (2011) Sequential methods for random-effects meta-analysis. Stat Med 30(9):903–921
    • (2011) Stat Med , vol.30 , Issue.9 , pp. 903-921
    • Higgins, J.P.1    Whitehead, A.2    Simmonds, M.3
  • 39
    • 84948692253 scopus 로고    scopus 로고
    • Systematic reviews of anesthesiologic interventions reported as statistically significant: problems with power, precision, and type 1 error protection
    • Imberger G, Gluud C, Boylan J, Wetterslev J (2015) Systematic reviews of anesthesiologic interventions reported as statistically significant: problems with power, precision, and type 1 error protection. Anesth Analg 121(6):1611–1622
    • (2015) Anesth Analg , vol.121 , Issue.6 , pp. 1611-1622
    • Imberger, G.1    Gluud, C.2    Boylan, J.3    Wetterslev, J.4
  • 40
    • 84948653129 scopus 로고    scopus 로고
    • Alpha, beta, meta: guidelines for assessing power and type i error in meta-analyses
    • Mascha EJ (2015) Alpha, beta, meta: guidelines for assessing power and type i error in meta-analyses. Anesth Analg 121(6):1430–1433
    • (2015) Anesth Analg , vol.121 , Issue.6 , pp. 1430-1433
    • Mascha, E.J.1
  • 41
    • 0030703712 scopus 로고    scopus 로고
    • Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis
    • Pogue JM, Yusuf S (1997) Cumulating evidence from randomized trials: utilizing sequential monitoring boundaries for cumulative meta-analysis. Control Clin Trials 18(6):580–593
    • (1997) Control Clin Trials , vol.18 , Issue.6 , pp. 580-593
    • Pogue, J.M.1    Yusuf, S.2
  • 42
    • 84979828286 scopus 로고    scopus 로고
    • Does ondansetron modify sympathectomy due to subarachnoid anesthesia?: Meta-analysis, meta-regression, and trial sequential analysis
    • Terkawi AS, Mavridis D, Flood P, Wetterslev J, Terkawi RS, Bin Abdulhak AA et al (2016) Does ondansetron modify sympathectomy due to subarachnoid anesthesia?: Meta-analysis, meta-regression, and trial sequential analysis. Anesthesiology 124(4):846–869
    • (2016) Anesthesiology , vol.124 , Issue.4 , pp. 846-869
    • Terkawi, A.S.1    Mavridis, D.2    Flood, P.3    Wetterslev, J.4    Terkawi, R.S.5    Bin Abdulhak, A.A.6
  • 44
    • 37049035730 scopus 로고    scopus 로고
    • Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
    • Wetterslev J, Thorlund K, Brok J, Gluud C (2008) Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. J Clin Epidemiol 61(1):64–75
    • (2008) J Clin Epidemiol , vol.61 , Issue.1 , pp. 64-75
    • Wetterslev, J.1    Thorlund, K.2    Brok, J.3    Gluud, C.4
  • 45
    • 84864371513 scopus 로고    scopus 로고
    • Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses
    • Thorlund K, Imberger G, Johnston BC, Walsh M, Awad T, Thabane L et al (2012) Evolution of heterogeneity (I2) estimates and their 95% confidence intervals in large meta-analyses. PLoS ONE 7(7):e39471
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Thorlund, K.1    Imberger, G.2    Johnston, B.C.3    Walsh, M.4    Awad, T.5    Thabane, L.6
  • 46
    • 0026637190 scopus 로고
    • Gastric colonization and pneumonia in intubated critically ill patients receiving stress ulcer prophylaxis: a randomized controlled trial
    • Apte NM, Karnad DR, Medhekar TP, Tilve GH, Morye S, Bhave GG (1992) Gastric colonization and pneumonia in intubated critically ill patients receiving stress ulcer prophylaxis: a randomized controlled trial. Crit Care Med 20(5):590–593
    • (1992) Crit Care Med , vol.20 , Issue.5 , pp. 590-593
    • Apte, N.M.1    Karnad, D.R.2    Medhekar, T.P.3    Tilve, G.H.4    Morye, S.5    Bhave, G.G.6
  • 47
    • 0019429427 scopus 로고
    • Cimetidine and antacid prophylaxis of acute upper gastrointestinal bleeding in high risk patients: controlled, randomized trial
    • Basso N, Bagarani M, Materia A, Fiorani S, Lunardi P, Speranza V (1981) Cimetidine and antacid prophylaxis of acute upper gastrointestinal bleeding in high risk patients: controlled, randomized trial. Am J Surg 141(3):339–341
    • (1981) Am J Surg , vol.141 , Issue.3 , pp. 339-341
    • Basso, N.1    Bagarani, M.2    Materia, A.3    Fiorani, S.4    Lunardi, P.5    Speranza, V.6
  • 48
    • 0028567869 scopus 로고
    • Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit: a randomized, controlled, single-blind study
    • Ben-Menachem T, Fogel R, Patel RV, Touchette M, Zarowitz BJ, Hadzijahic N et al (1994) Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit: a randomized, controlled, single-blind study. Ann Intern Med 121(8):568–575
    • (1994) Ann Intern Med , vol.121 , Issue.8 , pp. 568-575
    • Ben-Menachem, T.1    Fogel, R.2    Patel, R.V.3    Touchette, M.4    Zarowitz, B.J.5    Hadzijahic, N.6
  • 49
    • 0021994712 scopus 로고
    • Prevention of stress-induced upper gastrointestinal bleeding by cimetidine in patients on assisted ventilation
    • Van Den Berg B, Van Blankenstein M (1985) Prevention of stress-induced upper gastrointestinal bleeding by cimetidine in patients on assisted ventilation. Digestion 31(1):1–8
    • (1985) Digestion , vol.31 , Issue.1 , pp. 1-8
    • Van Den Berg, B.1    Van Blankenstein, M.2
  • 50
    • 0028930993 scopus 로고
    • Effect of ranitidine on intragastric ph and stress-related upper gastrointestinal bleeding in patients with severe head injury
    • Burgess P, Larson GM, Davidson P, Brown J, Metz CA (1995) Effect of ranitidine on intragastric ph and stress-related upper gastrointestinal bleeding in patients with severe head injury. Dig Dis Sci 40(3):645–650
    • (1995) Dig Dis Sci , vol.40 , Issue.3 , pp. 645-650
    • Burgess, P.1    Larson, G.M.2    Davidson, P.3    Brown, J.4    Metz, C.A.5
  • 52
    • 0028936654 scopus 로고
    • Prospective double-blind placebo-controlled randomized trial on the use of ranitidine in preventing postoperative gastroduodenal complications in high-risk neurosurgical patients
    • Chan KH, Lai EC, Tuen H, Ngan JH, Mok F, Fan YW et al (1995) Prospective double-blind placebo-controlled randomized trial on the use of ranitidine in preventing postoperative gastroduodenal complications in high-risk neurosurgical patients. J Neurosurg 82(3):413–417
    • (1995) J Neurosurg , vol.82 , Issue.3 , pp. 413-417
    • Chan, K.H.1    Lai, E.C.2    Tuen, H.3    Ngan, J.H.4    Mok, F.5    Fan, Y.W.6
  • 54
    • 0022354961 scopus 로고
    • Ranitidina Injetável Em Pacientes De Alto Risco
    • Domingues SHS, Stoeber GH, Stoeber AC (1985) Ranitidina Injetável Em Pacientes De Alto Risco. Folha Med 91(3):225–228
    • (1985) Folha Med , vol.91 , Issue.3 , pp. 225-228
    • Domingues, S.H.S.1    Stoeber, G.H.2    Stoeber, A.C.3
  • 56
    • 0022636315 scopus 로고
    • Cimetidine prophylaxis for gastrointestinal bleeding in an intensive care unit
    • Groll A, Simon JB, Wigle RD, Taguchi K, Todd RJ, Depew WT (1986) Cimetidine prophylaxis for gastrointestinal bleeding in an intensive care unit. Gut 27(2):135–140
    • (1986) Gut , vol.27 , Issue.2 , pp. 135-140
    • Groll, A.1    Simon, J.B.2    Wigle, R.D.3    Taguchi, K.4    Todd, R.J.5    Depew, W.T.6
  • 57
    • 85060683061 scopus 로고    scopus 로고
    • Effects of enteral nutrition on stress ulcer hemorrhage in critically ill patients: multicenter randomized controlled trial
    • Gundogan K, Karakoc E, Teke T, Zerman A, Coruh A, Sungur M (2017) Effects of enteral nutrition on stress ulcer hemorrhage in critically ill patients: multicenter randomized controlled trial. Intensive Care Med Exp 5(2):44
    • (2017) Intensive Care Med Exp , vol.5 , Issue.2 , pp. 44
    • Gundogan, K.1    Karakoc, E.2    Teke, T.3    Zerman, A.4    Coruh, A.5    Sungur, M.6
  • 58
    • 55849087629 scopus 로고    scopus 로고
    • Effect of proton pump inhibitors on gastric juice volume, gastric ph and gastric intramucosal pH in critically ill patients: a randomized, double-blind placebo-controlled study
    • Gursoy O, Memis D, Sut N (2008) Effect of proton pump inhibitors on gastric juice volume, gastric ph and gastric intramucosal pH in critically ill patients: a randomized, double-blind placebo-controlled study. Clin Drug Investig 28(12):777–782
    • (2008) Clin Drug Investig , vol.28 , Issue.12 , pp. 777-782
    • Gursoy, O.1    Memis, D.2    Sut, N.3
  • 59
    • 0018921305 scopus 로고
    • Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis
    • Halloran LG, Zfass AM, Gayle WE, Wheeler CB, Miller JD (1980) Prevention of acute gastrointestinal complications after severe head injury: a controlled trial of cimetidine prophylaxis. Am J Surg 139(1):44–48
    • (1980) Am J Surg , vol.139 , Issue.1 , pp. 44-48
    • Halloran, L.G.1    Zfass, A.M.2    Gayle, W.E.3    Wheeler, C.B.4    Miller, J.D.5
  • 60
    • 0032214866 scopus 로고    scopus 로고
    • A randomized, double-blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia
    • Hanisch EW, Encke A, Naujoks F, Windolf J (1998) A randomized, double-blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia. Am J Surg 176(5):453–457
    • (1998) Am J Surg , vol.176 , Issue.5 , pp. 453-457
    • Hanisch, E.W.1    Encke, A.2    Naujoks, F.3    Windolf, J.4
  • 62
    • 15944400015 scopus 로고    scopus 로고
    • Lack of effect of ranitidine on gastric luminal Ph and mucosal PCO2 during the first day in the ICU
    • Jakob SM, Parviainen I, Ruokonen E, Uusaro A, Takala J (2005) Lack of effect of ranitidine on gastric luminal Ph and mucosal PCO2 during the first day in the ICU. Acta Anaesthesiol Scand 49(3):390–396
    • (2005) Acta Anaesthesiol Scand , vol.49 , Issue.3 , pp. 390-396
    • Jakob, S.M.1    Parviainen, I.2    Ruokonen, E.3    Uusaro, A.4    Takala, J.5
  • 64
    • 0025266138 scopus 로고
    • Comparison of cimetidine and placebo for the prophylaxis of upper gastrointestinal bleeding due to stress-related gastric mucosal damage in the intensive care unit
    • Karlstadt RG, Iberti TJ, Silverstein J, Lindenberg L, Bright-Asare P, Rockhold F et al (1990) Comparison of cimetidine and placebo for the prophylaxis of upper gastrointestinal bleeding due to stress-related gastric mucosal damage in the intensive care unit. J Intensive Care Med 5:26–32
    • (1990) J Intensive Care Med , vol.5 , pp. 26-32
    • Karlstadt, R.G.1    Iberti, T.J.2    Silverstein, J.3    Lindenberg, L.4    Bright-Asare, P.5    Rockhold, F.6
  • 65
    • 0023628765 scopus 로고
    • Prophylactic treatment of acute gastroduodenal stress ulceration: low-dose antacid treatment without and with additional ranitidine
    • Koelz HR, Aeberhard P, Hassler H, Kunz H, Wagner HE, Roth F et al (1987) Prophylactic treatment of acute gastroduodenal stress ulceration: low-dose antacid treatment without and with additional ranitidine. Scand J Gastroenterol 22(9):1147–1152
    • (1987) Scand J Gastroenterol , vol.22 , Issue.9 , pp. 1147-1152
    • Koelz, H.R.1    Aeberhard, P.2    Hassler, H.3    Kunz, H.4    Wagner, H.E.5    Roth, F.6
  • 66
    • 0011885827 scopus 로고
    • Comparison of ranitidine versus placebo on 24-hour gastric Ph and upper gastrointestinal (UGI) bleeding in head injury patients
    • Larson GM, Davidson P, Brown J, Wilson T, Bishop A (1989) Comparison of ranitidine versus placebo on 24-hour gastric Ph and upper gastrointestinal (UGI) bleeding in head injury patients. Abstr Am J Gastroenterol 84:1165
    • (1989) Abstr Am J Gastroenterol , vol.84 , pp. 1165
    • Larson, G.M.1    Davidson, P.2    Brown, J.3    Wilson, T.4    Bishop, A.5
  • 67
    • 0020074645 scopus 로고
    • Cimetidine and antacid in prophylaxis of acute gastrointestinal bleeding: a randomized, double-blind, controlled study
    • Luk GD, Summer WR, Messersmith JF (1982) Cimetidine and antacid in prophylaxis of acute gastrointestinal bleeding: a randomized, double-blind, controlled study. Gastroenterology 82:1121
    • (1982) Gastroenterology , vol.82 , pp. 1121
    • Luk, G.D.1    Summer, W.R.2    Messersmith, J.F.3
  • 68
    • 0017366538 scopus 로고
    • H2-receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure: two controlled trials
    • Macdougall BR, Bailey RJ, Williams R (1977) H2-receptor antagonists and antacids in the prevention of acute gastrointestinal haemorrhage in fulminant hepatic failure: two controlled trials. Lancet 1(8012):617–619
    • (1977) Lancet , vol.1 , Issue.8012 , pp. 617-619
    • Macdougall, B.R.1    Bailey, R.J.2    Williams, R.3
  • 69
    • 0027531495 scopus 로고
    • Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia
    • Martin LF, Booth FV, Karlstadt RG, Silverstein JH, Jacobs DM, Hampsey J et al (1993) Continuous intravenous cimetidine decreases stress-related upper gastrointestinal hemorrhage without promoting pneumonia. Crit Care Med 21(1):19–30
    • (1993) Crit Care Med , vol.21 , Issue.1 , pp. 19-30
    • Martin, L.F.1    Booth, F.V.2    Karlstadt, R.G.3    Silverstein, J.H.4    Jacobs, D.M.5    Hampsey, J.6
  • 70
    • 0027527150 scopus 로고
    • Impact of multiple risk factors and ranitidine prophylaxis on the development of stress-related upper gastrointestinal bleeding: a prospective, multicenter, double-blind, randomized trial. The Ranitidine Head Injury Study Group
    • Metz CA, Livingston DH, Smith JS, Larson GM, Wilson TH (1993) Impact of multiple risk factors and ranitidine prophylaxis on the development of stress-related upper gastrointestinal bleeding: a prospective, multicenter, double-blind, randomized trial. The Ranitidine Head Injury Study Group. Crit Care Med 21(12):1844–1849
    • (1993) Crit Care Med , vol.21 , Issue.12 , pp. 1844-1849
    • Metz, C.A.1    Livingston, D.H.2    Smith, J.S.3    Larson, G.M.4    Wilson, T.H.5
  • 71
    • 0024821390 scopus 로고
    • Ranitidine for improvement of delayed hypersensitivity response in patients with sepsis
    • Nielsen HJ, Witt K, Moesgaard F, Kehlet H (1989) Ranitidine for improvement of delayed hypersensitivity response in patients with sepsis. Acta Chir Scand 155(9):445–449
    • (1989) Acta Chir Scand , vol.155 , Issue.9 , pp. 445-449
    • Nielsen, H.J.1    Witt, K.2    Moesgaard, F.3    Kehlet, H.4
  • 72
    • 0021804965 scopus 로고
    • Cimetidine for prevention and treatment of gastroduodenal mucosal lesions in patients in an intensive care unit
    • Peura DA, Johnson LF (1985) Cimetidine for prevention and treatment of gastroduodenal mucosal lesions in patients in an intensive care unit. Ann Intern Med 103(2):173–177
    • (1985) Ann Intern Med , vol.103 , Issue.2 , pp. 173-177
    • Peura, D.A.1    Johnson, L.F.2
  • 73
    • 0027197666 scopus 로고
    • Inhibition of gastric acid secretion in the intensive care unit after coronary artery bypass graft
    • Powell H, Morgan M, Li SK, Baron JH (1993) Inhibition of gastric acid secretion in the intensive care unit after coronary artery bypass graft. Theor Surg 8:125–130
    • (1993) Theor Surg , vol.8 , pp. 125-130
    • Powell, H.1    Morgan, M.2    Li, S.K.3    Baron, J.H.4
  • 74
    • 0023858971 scopus 로고
    • Persistence of circadian rhythms in gastric acid, gastrin, and pancreatic polypeptide secretions despite loss of cortisol and body temperature rhythms in man under stress
    • Rigaud D, Accary JP, Chastre J, Mignon M, Laigneau JP, Reinberg A et al (1988) Persistence of circadian rhythms in gastric acid, gastrin, and pancreatic polypeptide secretions despite loss of cortisol and body temperature rhythms in man under stress. Gastroenterol Clin Biol 12(1):12–18
    • (1988) Gastroenterol Clin Biol , vol.12 , Issue.1 , pp. 12-18
    • Rigaud, D.1    Accary, J.P.2    Chastre, J.3    Mignon, M.4    Laigneau, J.P.5    Reinberg, A.6
  • 75
    • 0018859892 scopus 로고
    • Eine Randomisierte Klinische Studie Zur Stressulkusprophylaxe Mit Cimetidin Beim Schweren Polytrauma
    • Rohde H, Lorenz W, Fischer M (1980) Eine Randomisierte Klinische Studie Zur Stressulkusprophylaxe Mit Cimetidin Beim Schweren Polytrauma. Z Gastroenterol 18(6):328–329
    • (1980) Z Gastroenterol , vol.18 , Issue.6 , pp. 328-329
    • Rohde, H.1    Lorenz, W.2    Fischer, M.3
  • 76
    • 0025824439 scopus 로고
    • Stress-induced gastroduodenal lesions and total parenteral nutrition in critically ill patients: frequency, complications, and the value of prophylactic treatment: a prospective, randomized study
    • Ruiz-Santana S, Ortiz E, Gonzalez B, Bolanos J, Ruiz-Santana AJ, Manzano JL (1991) Stress-induced gastroduodenal lesions and total parenteral nutrition in critically ill patients: frequency, complications, and the value of prophylactic treatment: a prospective, randomized study. Crit Care Med 19(7):887–891
    • (1991) Crit Care Med , vol.19 , Issue.7 , pp. 887-891
    • Ruiz-Santana, S.1    Ortiz, E.2    Gonzalez, B.3    Bolanos, J.4    Ruiz-Santana, A.J.5    Manzano, J.L.6
  • 77
    • 0029556625 scopus 로고
    • One week treatment with cimetidine does not attenuate the cortisol response to a short corticotropin test in stable intensive care patients: a prospective, randomized, and controlled study
    • Spapen H, Diltoer M, Nguyen DN, Ingels G, Ramet J, Huyghens L (1995) One week treatment with cimetidine does not attenuate the cortisol response to a short corticotropin test in stable intensive care patients: a prospective, randomized, and controlled study. Acta Anaesthesiol Belg 46(3–4):133–140
    • (1995) Acta Anaesthesiol Belg , vol.46 , Issue.3-4 , pp. 133-140
    • Spapen, H.1    Diltoer, M.2    Nguyen, D.N.3    Ingels, G.4    Ramet, J.5    Huyghens, L.6
  • 78
    • 85061221298 scopus 로고    scopus 로고
    • Stressulkus-Prophylaxe Bei Hoch-Risiko-Intensivpatienten. Vergleich Von Omeprazol, Pirenzepin Und Plazebo
    • Vlatten A, Wiedeck H, Reinelt H, Stanescu A, Georgieff M (1998) Stressulkus-Prophylaxe Bei Hoch-Risiko-Intensivpatienten. Vergleich Von Omeprazol, Pirenzepin Und Plazebo. Wien Klin Wochenschr Suppl 110(suppl. 1):38
    • (1998) Wien Klin Wochenschr Suppl , vol.110 , pp. 38
    • Vlatten, A.1    Wiedeck, H.2    Reinelt, H.3    Stanescu, A.4    Georgieff, M.5
  • 79
    • 0019413689 scopus 로고
    • The prevention of upper gastrointestinal tract bleeding in patients in an intensive care unit
    • Zinner MJ, Zuidema GD, Smith P, Mignosa M (1981) The prevention of upper gastrointestinal tract bleeding in patients in an intensive care unit. Surg Gynecol Obstet 153(2):214–220
    • (1981) Surg Gynecol Obstet , vol.153 , Issue.2 , pp. 214-220
    • Zinner, M.J.1    Zuidema, G.D.2    Smith, P.3    Mignosa, M.4
  • 80
    • 84890920368 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis
    • Krag M, Perner A, Wetterslev J, Wise MP, Hylander Moller M (2014) Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 40(1):11–22
    • (2014) Intensive Care Med , vol.40 , Issue.1 , pp. 11-22
    • Krag, M.1    Perner, A.2    Wetterslev, J.3    Wise, M.P.4    Hylander Moller, M.5
  • 82
    • 85040996789 scopus 로고    scopus 로고
    • Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis
    • Huang HB, Jiang W, Wang CY, Qin HY, Du B (2018) Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis. Crit Care 22(1):20
    • (2018) Crit Care , vol.22 , Issue.1 , pp. 20
    • Huang, H.B.1    Jiang, W.2    Wang, C.Y.3    Qin, H.Y.4    Du, B.5
  • 84
    • 31744445032 scopus 로고    scopus 로고
    • Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis
    • Macias WL, Nelson DR, Williams M, Garg R, Janes J, Sashegyi A (2005) Lack of evidence for qualitative treatment by disease severity interactions in clinical studies of severe sepsis. Crit Care 9(6):R607–R622
    • (2005) Crit Care , vol.9 , Issue.6 , pp. R607-R622
    • Macias, W.L.1    Nelson, D.R.2    Williams, M.3    Garg, R.4    Janes, J.5    Sashegyi, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.