What’s new with stress ulcer prophylaxis in the ICU?

Intensive Care Medicine

Volumn 43, Issue 8, 2017, Pages 1132-1134

  Marker, Søren ^a   Krag, Mette ^a   Møller, Morten Hylander ^a  

^a University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HUMAN; INTENSIVE CARE UNIT; PHASE 3 CLINICAL TRIAL (TOPIC); PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); STRESS ULCER; COMPLICATION; CRITICAL ILLNESS; OBSERVATIONAL STUDY; PEPTIC ULCER BLEEDING; PHYSIOLOGICAL STRESS; PRACTICE GUIDELINE; RISK FACTOR; STOMACH ULCER;

ANTIULCER AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; PROTON PUMP INHIBITOR;

ANTI-ULCER AGENTS; CRITICAL ILLNESS; HISTAMINE H2 ANTAGONISTS; HUMANS; INTENSIVE CARE UNITS; OBSERVATIONAL STUDIES AS TOPIC; PEPTIC ULCER HEMORRHAGE; PRACTICE GUIDELINES AS TOPIC; PROTON PUMP INHIBITORS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; STOMACH ULCER; STRESS, PHYSIOLOGICAL;

EID: 85013855007     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-017-4733-0     Document Type: Article

References (18)

1. Marik PE, Vasu T, Hirani A, Pachinburavan M (2010) Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis. Crit Care Med 38:2222–2228
2. Cook DJ, Fuller HD, Guyatt GH, Marshall JC, Leasa D, Hall R et al (1994) Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 330:377–381
3. Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S et al (2015) Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med 41:833–845
4. MacLaren R, Reynolds PM, Allen RR (2014) Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit. JAMA Intern Med 174:564–574
5. Cook D, Heyland D, Griffith L, Cook R, Marshall J, Pagliarello J (1999) Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27:2812–2817
6. Krag M, Perner A, Wetterslev J, Wise MP, Hylander Møller M (2014) Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 40:11–22
7. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al (2017) Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. doi:10.1007/s00134-017-4683-6. (Epub ahead of print)
8. Alshamsi F, Belley-Cote E, Cook D, Almenawer SA, Alqahtani Z, Perri D et al (2016) Efficacy and safety of proton pump inhibitors for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care 20:120
9. Charlot M, Ahlehoff O, Norgaard ML, et al. (2010) Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study. Ann Intern Med 153:378–386
10. Faleck DM, Salmasian H, Furuya EY, Larson EL, Abrams JA, Freedberg DE (2016) Proton pump inhibitors do not increase risk for Clostridium difficile infection in the intensive care unit. Am J Gastroenterol 111:1–8
11. Karanika S, Paudel S, Zervou FN, Grigoras C, Zacharioudakis IM, Mylonakis E (2015) Prevalence and clinical outcomes of Clostridium difficile infection in the intensive care unit: a systematic review and meta-analysis. Open Forum Infect Dis 3:ovf86
12. Sehested TS, Fosbøl EL, Hansen PW, Charlot MG, Torp-Pedersen C, Gislason GH (2016) Abstract 18462: proton pump inhibitor use increases the associated risk of first-time ischemic stroke. A Nationwide Cohort Study. Circulation 134:A18462
13. Farley KJ, Barned KL, Crozier TM (2013) Inappropriate continuation of stress ulcer prophylaxis beyond the intensive care setting. Crit Care Resusc 15:147–151
14. Selvanderan SP, Summers MJ, Finnis ME, Plummer MP, Ali Abdelhamid Y, Anderson MB et al (2016) Pantoprazole or Placebo for Stress Ulcer Prophylaxis (POP-UP). Crit Care Med 44:1842–1850
15. Lin C-C, Hsu Y-L, Chung C-S, Lee T-H (2016) Stress ulcer prophylaxis in patients being weaned from the ventilator in a respiratory care center: a randomized control trial. J Formos Med Assoc 115:19–24
16. Andrews J, Guyatt G, Oxman AD, Alderson P, Dahm P, Falck-Ytter Y et al (2013) GRADE guidelines: 14. Going from evidence to recommendations: the significance and presentation of recommendations. J Clin Epidemiol 66:719–725
17. Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S et al (2016) Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial. Trials 17:205
18. Alhazzani W, Guyatt G, Marshall JC, Hall R, Muscedere J, Lauzier F et al (2016) Re-evaluating the Inhibition of Stress Erosions (REVISE): a protocol for pilot randomized controlled trial. Ann Saudi Med 36:427–433