Stress ulcer prophylaxis in critically ill patients: A randomized controlled trial

Hepato-Gastroenterology

Volumn 51, Issue 57, 2004, Pages 757-761

  Kantorova, Ilona ^a   Svoboda, Petr ^a,c   Scheer, Peter ^b   Doubek, Jaroslav ^b   Rehorkova, Dagmar ^a   Bosakova, Hana ^a   Ochmann, Jiri ^a  

^a Traumatological Hospital of Brno   (Czech Republic)

^b UNIVERSITY OF VETERINARY AND PHARMACEUTICAL SCIENCES   (Czech Republic)

^c NONE   (Czech Republic)

Author keywords

Famotidine; Nosocomial pneumonia; Omeprazole; Stress related bleeding; Sucralfate

Indexed keywords

FAMOTIDINE; OMEPRAZOLE; SUCRALFATE;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; BLOOD CLOTTING DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICAL ILLNESS; FEMALE; GASTROINTESTINAL HEMORRHAGE; HIGH RISK PATIENT; HOSPITAL INFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; STATISTICAL SIGNIFICANCE; STOMACH PH; STRESS ULCER; TREATMENT OUTCOME;

AGED; ANTI-ULCER AGENTS; BACTERIA; CRITICAL ILLNESS; CROSS INFECTION; FAMOTIDINE; FEMALE; GASTRIC ACIDITY DETERMINATION; GASTROINTESTINAL HEMORRHAGE; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; PEPTIC ULCER; PNEUMONIA; PROTON PUMPS; STOMACH; STRESS; SUCRALFATE;

EID: 2342485034     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Scheer P, Kantorova I, Doubek J, et al: Mechanism of stress ulcer prophylaxis in experimental rats. Hepatogastroenterology 2001; 48(Suppl1):p. CCLXXVI.
2. Gonzales ER: Pathophysiologic changes in the critically ill patient: Risk factors for ulceration and altered drug metabolism. DICP Ann Pharmacother 1990; 24(Suppl):S5-S7.
3. Cook DJ, Witt LG, Cook RJ, Guyatt GH: Stress ulcer prophylaxis in the critically ill: a meta-analysis. Am J Med 1991; 91:519-527.
4. Karlstadt RG, Iberti TJ, Silverstein J, et al: Comparison of cimetidine and placebo for the prophylaxis of upper gastrointestinal bleeding due to stress-related gastric mucosal damage in the intensive care unit. J Intensive Care Med 1990; 5:26-32.
5. Ruiz-Santana S, Ortiz E, Gonzales B, et al: Stress-induced gastroduodenal lesions and total parenteral nutrition in critically ill patients: Frequency, complications, and the value of prophylactic treatment. A prospective randomized study. Crit Care Med 1991; 19:887-891.
6. Cook DJ, Fuller HD, Guyatt GH, et al: Risk factors for gastrointestinal bleeding in critically ill patients. N Engl J Med 1994; 330:377-381.
7. Ben-Menachem T, McCarthy BD, Fogel R, et al: Prophylaxis for stress-related gastrointestinal hemorrhage: A cost effectiveness analysis. Crit Care Med 1996; 24:338-345.
8. Schuster DP: Stress ulcer prophylaxis: In whom? With what? Crit Care Med 1993; 21:4-6.
9. Peterson WL: Prevention of upper gastrointestinal bleeding. N Engl J Med 1994; 330:428-429.
10. Perez J, Dellinger RP: Other supportive therapies in sepsis. Intensive Care Med 2001; 27:S116-S127.
11. Saint S, Matthay M: Risk reduction in the intensive care unit. Am J Med 1998; 105:515-523.
12. Cook DJ, Reeve BK, Guyatt GH, et al: Stress ulcer prophylaxis in critically ill patients: resolving discordant meta-analysis. JAMA 1996; 275:308-314.
13. Inglis TJ, Sherrat MJ, Sproat LJ, et al: Gastroduodenal dysfunction and bacterial colonisation of the ventilated lung. Lancet 1993; 341:911-913.
14. Garvey BM, McCambley JA, Tuxen DV: Effects of gastric alkalization on bacterial colonization in critically ill patients. Crit Care Med 1989; 160:211-216.
15. Simms HH, DeMaria E, McDonald L, et al: Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial. J Trauma 1991; 31:531-537.
16. Tryba M: The gastropulmonary route of infection - fact or fiction? Am J Med 1991; 91:135-146.
17. Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med 1985; 13:818-829.
18. Messori A, Trippoli S, Vaiani M, et al: Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer: meta-analysis of randomized controlled trials. BMJ 2000; 321:1103-1106.
19. Ben-Menachem T, Fogel R, Patel RV, et al: Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit: a randomized controlled, single-blind study. Ann Int Med 1994; 121:568-575.
20. Devlin JW, Ben-Menachem T, Ulep SK, et al: Stress ulcer prophylaxis in medical ICU patients: annual utilization in relation to the incidence of endoscopically proven stress ulceration. Ann Pharmacother 1998; 32:869-874.
21. Heyland D, Mandell LA: Gastric colonization by gram-negative bacilli and nosocomial pneumonia in the intensive care patient: evidence for causation. Chest 1992; 101:187-193.
22. Inglis TJJ, Sheratt MJ, Sproat LJ, et al: Gastroduodenal dysfunction and bacterial colonization of the ventilated lung. Lancet 1993; 341:911-913.
23. Bonten MJJ, Gailard CA, van der Giest S, et al: The role of intragastric acidity and stress ulcer prophylaxis on colonization and infection in mechanically ventilated ICU patients. Am J Respir Crit Care Med 1995; 152:1825-1834.
24. Hanisch EW, Encke A, Naujocks F, Windolf J: A randomized double blind trial for stress ulcer prophylaxis shows no evidence of increased pneumonia. Am J Surg 1998; 176:453-457.
25. Eddleston JM, Vohra A, Scott P, et al: A comparison of the frequency of stress ulceration and secondary pneumonia in sucralfate- or ranitidine-treated intensive care unit patients. Crit Care Med 1991; 19:1491-1496.
26. Kappstein I, Schulgen G, Friedrich T, et al: Incidence of pneumonia in mechanically ventilated patients treated with sucralfate or cimetidine as prophylaxis for stress bleeding: bacterial colonization of the stomach. Am J Med 1991; 91:125-131.
27. Proud'hom G, Leuenberger P, Koerfer J, et al: Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis of stress ulcer: a randomized controlled trial. Ann Intern Med 1994; 120:653-662.