Enteral nutrition as stress ulcer prophylaxis in critically ill patients: A randomized controlled exploratory study

Journal of Critical Care

Volumn 43, Issue , 2018, Pages 108-113

  El Kersh, Karim ^a   Jalil, Bilal ^a   McClave, Stephen A ^a   Cavallazzi, Rodrigo ^a   Guardiola, Juan ^a   Guilkey, Karen ^a   Persaud, Annuradha K ^a   Furmanek, Stephen P ^a   Guinn, Brian E ^a   Wiemken, Timothy L ^a   Alhariri, Bashar Chihada ^a   Kellie, Scott P ^a   Saad, Mohamed ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Critical illness; Early enteral feeding; Gastrointestinal bleeding; Proton pump inhibitor; Stress ulcer prophylaxis

Indexed keywords

ANTACID AGENT; CORTICOSTEROID; HISTAMINE H2 RECEPTOR ANTAGONIST; NONSTEROID ANTIINFLAMMATORY AGENT; PANTOPRAZOLE; PLACEBO; PROTON PUMP INHIBITOR; 2 [[(2 PYRIDYL)METHYL]SULFINYL]BENZIMIDAZOLE DERIVATIVE; ANTIULCER AGENT;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DOUBLE BLIND PROCEDURE; EARLY INTERVENTION; ENTERIC FEEDING; EXPLORATORY RESEARCH; FEMALE; GASTROINTESTINAL HEMORRHAGE; HEMATOCRIT; HUMAN; HUMAN CELL; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MEDICAL INTENSIVE CARE UNIT; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STRESS ULCER; TEACHING HOSPITAL; TREATMENT RESPONSE; ACUTE DISEASE; CLINICAL TRIAL; COMPARATIVE STUDY; CRITICAL ILLNESS; INTRAVENOUS DRUG ADMINISTRATION; MIDDLE AGED; MULTICENTER STUDY; PEPTIC ULCER; PROCEDURES;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ACUTE DISEASE; AGED; ANTI-ULCER AGENTS; CRITICAL ILLNESS; DOUBLE-BLIND METHOD; ENTERAL NUTRITION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMANS; INCIDENCE; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; PEPTIC ULCER; PROSPECTIVE STUDIES; PROTON PUMP INHIBITORS; RESPIRATION, ARTIFICIAL;

EID: 85035806098     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2017.08.036     Document Type: Article

References (46)

1. Skillman, J.J., Bushnell, L.S., Goldman, H., Silen, W., Respiratory failure, hypotension, sepsis, and jaundice. A clinical syndrome associated with lethal hemorrhage from acute stress ulceration of the stomach. Am J Surg 117:4 (1969), 523–530.
2. Quenot, J.P., Thiery, N., Barbar, S., When should stress ulcer prophylaxis be used in the ICU?. Curr Opin Crit Care 15:2 (2009), 139–143.
3. Sesler, J.M., Stress-related mucosal disease in the intensive care unit: an update on prophylaxis. AACN Adv Crit Care 18:2 (2007), 119–126 [quiz 27-8].
4. Cook, D.J., Fuller, H.D., Guyatt, G.H., Marshall, J.C., Leasa, D., Hall, R., et al. Risk factors for gastrointestinal bleeding in critically ill patients. Canadian Critical Care Trials Group. N Engl J Med 330:6 (1994), 377–381.
5. Eddleston, J.M., Pearson, R.C., Holland, J., Tooth, J.A., Vohra, A., Doran, B.H., Prospective endoscopic study of stress erosions and ulcers in critically ill adult patients treated with either sucralfate or placebo. Crit Care Med 22:12 (1994), 1949–1954.
6. Martin, L.F., Stress ulcers are common after aortic surgery. Endoscopic evaluation of prophylactic therapy. Am Surg 60:3 (1994), 169–174.
7. Ben-Menachem, T., Fogel, R., Patel, R.V., Touchette, M., Zarowitz, B.J., Hadzijahic, N., et al. Prophylaxis for stress-related gastric hemorrhage in the medical intensive care unit. A randomized, controlled, single-blind study. Ann Intern Med 121:8 (1994), 568–575.
8. Cook, D., Heyland, D., Griffith, L., Cook, R., Marshall, J., Pagliarello, J., Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. Crit Care Med 27:12 (1999), 2812–2817.
9. Shuman, R.B., Schuster, D.P., Zuckerman, G.R., Prophylactic therapy for stress ulcer bleeding: a reappraisal. Ann Intern Med 106:4 (1987), 562–567.
10. Stollman, N., Metz, D.C., Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients. J Crit Care 20:1 (2005), 35–45.
11. Daley, R.J., Rebuck, J.A., Welage, L.S., Rogers, F.B., Prevention of stress ulceration: current trends in critical care. Crit Care Med 32:10 (2004), 2008–2013.
12. Krag, M., Perner, A., Wetterslev, J., Wise, M.P., Borthwick, M., Bendel, S., et al. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med 41:5 (2015), 833–845.
13. Herzig, S.J., Howell, M.D., Ngo, L.H., Marcantonio, E.R., Acid-suppressive medication use and the risk for hospital-acquired pneumonia. JAMA 301:20 (2009), 2120–2128.
14. Marik, P.E., Vasu, T., Hirani, A., Pachinburavan, M., Stress ulcer prophylaxis in the new millennium: a systematic review and meta-analysis. Crit Care Med 38:11 (2010), 2222–2228.
15. Miano, T.A., Reichert, M.G., Houle, T.T., MacGregor, D.A., Kincaid, E.H., Bowton, D.L., Nosocomial pneumonia risk and stress ulcer prophylaxis: a comparison of pantoprazole vs ranitidine in cardiothoracic surgery patients. Chest 136:2 (2009), 440–447.
16. Barletta, J.F., Sclar, D.A., Proton pump inhibitors increase the risk for hospital-acquired Clostridium difficile infection in critically ill patients. Crit Care, 18(6), 2014, 714.
17. Cunningham, R., Dale, B., Undy, B., Gaunt, N., Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. J Hosp Infect 54:3 (2003), 243–245.
18. Dial, S., Alrasadi, K., Manoukian, C., Huang, A., Menzies, D., Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case-control studies. CMAJ 171:1 (2004), 33–38.
19. Howell, M.D., Novack, V., Grgurich, P., Soulliard, D., Novack, L., Pencina, M., et al. Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. Arch Intern Med 170:9 (2010), 784–790.
20. Louie, T.J., Meddings, J., Clostridium difficile infection in hospitals: risk factors and responses. CMAJ 171:1 (2004), 45–46.
21. Bobo, L.D., Dubberke, E.R., Kollef, M., Clostridium difficile in the ICU: the struggle continues. Chest 140:6 (2011), 1643–1653.
22. Inoue, S., Lukes, S., Alexander, J.W., Trocki, O., Silberstein, E.B., Increased gut blood flow with early enteral feeding in burned guinea pigs. J Burn Care Rehabil 10:4 (1989), 300–308.
23. Kazamias, P., Kotzampassi, K., Koufogiannis, D., Eleftheriadis, E., Influence of enteral nutrition-induced splanchnic hyperemia on the septic origin of splanchnic ischemia. World J Surg 22:1 (1998), 6–11.
24. Purcell, P.N., Branson, R.D., Hurst, J.M., Davis, K. Jr., Johnson, D.J., Gut feeding and hepatic hemodynamics during PEEP ventilation for acute lung injury. J Surg Res 53:4 (1992), 335–341.
25. Hurt, R.T., Frazier, T.H., McClave, S.A., Crittenden, N.E., Kulisek, C., Saad, M., et al. Stress prophylaxis in intensive care unit patients and the role of enteral nutrition. JPEN 36:6 (2012), 721–731.
26. Lally, K.P., Andrassy, R.J., Foster, J.E., Wilz, W.R., Hosbein, D.P., Torma, M.J., Evaluation of various nutritional supplements in the prevention of stress-induced gastric ulcers in the rat. Surg Gynecol Obstet 158:2 (1984), 124–128.
27. Mabogunje, O.A., Andrassy, R.J., Isaacs, H. Jr., Mahour, G.H., The role of a defined formula diet in the prevention of stress-induced gastric mucosal injury in the rat. J Pediatr Surg 16:6 (1981), 1036–1039.
28. Pingleton, S.K., Hadzima, S.K., Enteral alimentation and gastrointestinal bleeding in mechanically ventilated patients. Crit Care Med 11:1 (1983), 13–16.
29. Raff, T., Germann, G., Hartmann, B., The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient. Burns 23:4 (1997), 313–318.
30. Palm, N.M., McKinzie, B., Ferguson, P.L., Chapman, E., Dorlon, M., Eriksson, E.A., et al. Pharmacologic stress gastropathy prophylaxis may not be necessary in at-risk surgical trauma ICU patients tolerating enteral nutrition. J Intensive Care Med, 2016 [Epub ahead of print].
31. Selvanderan, S.P., Summers, M.J., Finnis, M.E., Plummer, M.P., Ali Abdelhamid, Y., Anderson, M.B., et al. Pantoprazole or placebo for stress ulcer prophylaxis (POP-UP): randomized double-blind exploratory study. Crit Care Med 44:10 (2016), 1842–1850.
32. Kreymann, K.G., Berger, M.M., Deutz, N.E., Hiesmayr, M., Jolliet, P., Kazandjiev, G., et al. ESPEN guidelines on enteral nutrition: intensive care. Clin Nutr 25:2 (2006), 210–223.
33. McClave, S.A., Saad, M.A., Esterle, M., Anderson, M., Jotautas, A.E., Franklin, G.A., et al. Volume-based feeding in the critically ill patient. JPEN 39:6 (2015), 707–712.
34. Krag, M., Perner, A., Wetterslev, J., Wise, M.P., Hylander, Moller M., Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med 40:1 (2014), 11–22.
35. Alhazzani, W., Guyatt, G., Alshahrani, M., Deane, A.M., Marshall, J.C., Hall, R., et al. Withholding pantoprazole for stress ulcer prophylaxis in critically ill patients: a pilot randomized clinical trial and meta-analysis. Crit Care Med 45:7 (2017), 1121–1129.
36. Krag, M., Perner, A., Wetterslev, J., Wise, M.P., Borthwick, M., Bendel, S., et al. Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial. Trials, 17(1), 2016, 205.
37. Kantorova, I., Svoboda, P., Scheer, P., Doubek, J., Rehorkova, D., Bosakova, H., et al. Stress ulcer prophylaxis in critically ill patients: a randomized controlled trial. Hepato-Gastroenterology 51:57 (2004), 757–761.
38. Zandstra, D.F., Stoutenbeek, C.P., The virtual absence of stress-ulceration related bleeding in ICU patients receiving prolonged mechanical ventilation without any prophylaxis. A prospective cohort study. Intensive Care Med 20:5 (1994), 335–340.
39. Faisy, C., Guerot, E., Diehl, J.L., Iftimovici, E., Fagon, J.Y., Clinically significant gastrointestinal bleeding in critically ill patients with and without stress-ulcer prophylaxis. Intensive Care Med 29:8 (2003), 1306–1313.
40. Krag, M., Perner, A., Wetterslev, J., Wise, M.P., Borthwick, M., Bendel, S., et al. Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiol Scand 59:5 (2015), 576–585.
41. Devlin, J.W., Claire, K.S., Dulchavsky, S.A., Tyburski, J.G., Impact of trauma stress ulcer prophylaxis guidelines on drug cost and frequency of major gastrointestinal bleeding. Pharmacotherapy 19:4 (1999), 452–460.
42. Lam, N.P., Le, P.D., Crawford, S.Y., Patel, S., National survey of stress ulcer prophylaxis. Crit Care Med 27:1 (1999), 98–103.
43. Pitimana-aree, S., Forrest, D., Brown, G., Anis, A., Wang, X.H., Dodek, P., Implementation of a clinical practice guideline for stress ulcer prophylaxis increases appropriateness and decreases cost of care. Intensive Care Med 24:3 (1998), 217–223.
44. MacLaren, R., Reynolds, P.M., Allen, R.R., Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit. JAMA Intern Med 174:4 (2014), 564–574.
45. Lewis, S., Burmeister, S., Brazier, J., Effect of the prebiotic oligofructose on relapse of Clostridium difficile-associated diarrhea: a randomized, controlled study. Clin Gastroenterol Hepatol 3:5 (2005), 442–448.
46. Lawrence, S.J., Puzniak, L.A., Shadel, B.N., Gillespie, K.N., Kollef, M.H., Mundy, L.M., Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol 28:2 (2007), 123–130.