Type I interferon response impairs differentiation potential of pluripotent stem cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 116, Issue 4, 2019, Pages 1384-1393

  Eggenberger, Julie ^a   Blanco Melo, Daniel ^a   Panis, Maryline ^a   Brennand, Kristen J ^a   Ten Oever, Benjamin R ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Interferon; IRF7; KLF4; Pluripotency; Virus

Indexed keywords

INTERFERON; INTERFERON REGULATORY FACTOR 7; KRUPPEL LIKE FACTOR 4; MESSENGER RNA; OCTAMER TRANSCRIPTION FACTOR 4; STAT1 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IFIT1; TRANSCRIPTION FACTOR MX1; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; VIRUS RNA; ANTIVIRUS AGENT; BIOLOGICAL MARKER;

ANIMAL CELL; ARTICLE; CARDIAC MUSCLE CELL; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; FIBROBLAST; GENE EXPRESSION PROFILING; GENE PRODUCT; HUMAN; HUMAN CELL; IMMUNE RECONSTITUTION; INDUCED PLURIPOTENT STEM CELL; MESODERM; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SEQUENCE; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; UPREGULATION; VIRUS INFECTION; CELL CULTURE; DRUG EFFECT; GENETICS; GERM LAYER; METABOLISM; PHYSIOLOGY; VIROLOGY;

ANTIVIRAL AGENTS; BIOMARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; CELLULAR REPROGRAMMING; ECTODERM; ENDODERM; FIBROBLASTS; GERM LAYERS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTERFERON TYPE I; RNA, VIRAL; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 85060303296     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1812449116     Document Type: Article

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