In utero exposure to commercial artificial sweeteners affects mice development and mammary gland structure

Environmental Science and Pollution Research

Volumn 26, Issue 5, 2019, Pages 5054-5064

  Al Qudsi, Fatma M ^a   Al Hasan, Manar M ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Artificial sweeteners; Congenital malformation; Growth retardation; Mammary gland; Mouse embryo; Terminal end buds

Indexed keywords

EMBRYO; EMBRYONIC DEVELOPMENT; GROWTH; PREGNANCY; RODENT;

MUS;

SWEETENING AGENT;

ANIMAL; BODY WEIGHT; CELL DIFFERENTIATION; CHEMICALLY INDUCED; DRUG EFFECT; EMBRYOLOGY; FEMALE; GESTATIONAL AGE; MATERNAL EXPOSURE; MOUSE; ORGANOGENESIS; PATHOLOGY; PREGNANCY; PRENATAL EXPOSURE; UDDER; ULTRASTRUCTURE;

ANIMALS; BODY WEIGHT; CELL DIFFERENTIATION; FEMALE; GESTATIONAL AGE; MAMMARY GLANDS, ANIMAL; MATERNAL EXPOSURE; MICE; ORGANOGENESIS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SWEETENING AGENTS;

EID: 85059577846     PISSN: 09441344     EISSN: 16147499     Source Type: Journal    
DOI: 10.1007/s11356-018-3935-5     Document Type: Article

References (43)

1. Byers SL, Wiles MV, Dunn SL, Taft RA (2012) Mouse estrous cycle identification tool and images. PLoS One 7(4):1–5
2. Cardoso FS et al. (2016). Exposure to sorbitol during lactation causes metabolic alterations and genotoxic effects in rat offspring. Toxicology Letters 260:36–45
3. Codex alimentarius C (2008) Codex General Standard for Food Additives (GSFA) online database. Rome, Italy, Food and Agriculture Organization of the United Nations (http://www.Codexalimentarius.net/gsfaonline/index.html)
4. Collison KS, Makhoul NJ, Zaidi MZ, Al-Rabiah R, Inglis A, Andres BL, Ubungen R, Shoukri M, Al-Mohanna FA (2012) Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis. Nutr Metab (Lond) 9(1):58
5. Drury AA, and Wallington EA (1980) Carleton’s histological technique, 5th edition, Oxford, UK: Oxford University press
6. Duong A, Steinmaus C, McHale CM, Vaughan CP, Zhang L (2011) Reproductive and developmental toxicity of formaldehyde: a systematic review. Mutat Res 728(3):118–138
7. Ginestra E, Saravo L, Ciuna I, Sciacca G, Finocchiaro A, Menzo GL (2004) Evaluation and comparison of deoxyribonucleic acid typing methods on human tissue fixed with different fixatives. Int Congr Ser 1261:574–576
8. Hassiotou F, Geddes D (2013) Anatomy of the human mammary gland: current status of knowledge. Clin Anat 26:29–48
9. Hedrich H (2004) The laboratory mouse, 1st edition. Academic Press. eBook ISBN 9780080542539
10. Hovey RC, Trott JF, Vonderhaar BK (2002) Establishing a framework for the functional mammary gland: from endocrinology to morphology. J Mammary Gland Biology and Neoplasia 7:17–38
11. Howlin J, Mcbryan J, Martin F (2006) Pubertal mammary gland development: insights from mouse models. J Mammary Gland Biology and Neoplasia 11:283–297
12. Islam MS, Sakaguchi E (2006) Sorbitol-based osmotic diarrhea: possible causes and mechanism of prevention investigated in rats. World J Gastroenterol: WJG 12(47):7635
13. Kim J-Y, Seo J, Coh K-H (2011) Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia. Food Chem Toxicol 49(11):2899–2905
14. Krause S (2008) Stromal-epithelial interactions in the mammary gland: development of a tissue morphogenesis model. (Doctoral dissertation, Sackler School of Graduate Biomedical Sciences (Tufts University))
15. Leme LFAG, Azoubel R (2006) Effects of aspartame on the exocrine pancreas of rat fetuses. Int J Morphol 24:679–684
16. Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, Spencer PS, Waddell WJ, Walker R, Williams GM (2007) Aspartame: a safety evaluation based on current use levels, regulations, and toxicological and epidemiological studies. CRC Crit Rev Toxicol 37(8):629–727
17. Martin J, Avery RA (1998) Effects of tail loss on the movement patterns of the lizard, Psammodromus algirus. Functional Ecology 12(5):794–802
18. Martins MRI, Azoubel R, Martins MRI, Azoubel R (2007) Effects of aspartame on fetal kidney: a morphometric and stereological study. Int J Morphol 25(4):689–694
19. Masso-Welch PA, Darcy KM, Stangle-Castor NC, Margot M (2000) A developmental atlas of rat mammary gland histology. J Mammary Gland Biol Neoplasia 5(2):165–185
20. Michno K, Boras-Granic K, Mill P, Hui CC, Hamel PA (2003) Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol 264(1):153–165
21. Modi SV, Borges VJ (2005) Artificial sweeteners: boon or bane? Int J Diabetes Dev Countries 25:1–6
22. Mourad IM, Noor NA (2011) Aspartame (a widely used artificial sweetener) and oxidative stress in the rat cerebral cortex. Int J Pharm Biomed Sci 2(1):4–10
23. Ozen IT, Karav S, Eksi A (2014) Variability of sorbitol/xylitol content in pomegranate (Punica Granatum) juice as affected by processing conditions. International journal of food and nutrition. science 3(1):4–7
24. Paine IS, Lewis MT (2017) The terminal end bud: the little engine that could. J Mammary Gland Biol Neoplasia 22(2):93–108
25. Plante I, Stewart MK, Laird DW (2011) Evaluation of mammary gland development and function in mouse models. J Visualized Exp: Jove (53):e2828. 10.3791/2828
26. Portela GS, Azoubel R, Batigălia F (2007) Effects of aspartame on maternal-fetal and placental weights, length of umbilical cord and fetal liver: a kariometric experimental study. Int J Morphol 25(3):549–554
27. Puică C, Crăcium C, Rusu M, Cristescu M, Borsa M & Roman I (2008) Ultrastructural aspects concerning the hypothalamus-pituitary complex reactivity following chronic administration of aspartame in juvenile rabbits. Bulletin UASVM, Veterinary Medicine 65(1)/ pISSN 1843–5270; eISSN 1843–5378
28. Puică C, Crăcium C, Rusu M, Cristescu M, Borsa M, & Roman I (2009). Ultrastructural aspects concerning the hypothalamus-pituitary complex reactivity following chronic administration of aspartame in juvenile rats. Studia Universitatis “Vasile Goldiş”, Seria Ştiinţele Vieţii 19:19–24
29. Richert MM, Schwertfeger KL, Ryder JW, Anderson SM (2000) An atlas of mouse mammary gland development. J Mammary Gland Biol Neoplasia 5(2):227–241
30. Silberstein GB (2001) Postnatal mammary gland morphogenesis. Microsc Res Tech 52(2):155–162
31. Siripurkpong P, Fungkrajai M, Kongkhum S, & Piumngam K (2014) Sorbitol has no significant effects on 3T3-L1 -adipogenesis and adiponectin synthesis and secretion. Thammasat Int J Sci Technol 19(2)
32. Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L (2005) Aspartame induces lymphomas and leukaemias in rats L’aspartame induce linfomi e leucemie nei ratti. Eur J Oncol 10(2):107–116
33. Soffritti M, Belpoggi F, Degli Esposti D, Lambertini L, Tibaldi E, Rigano A (2006) First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ Health Perspect 114(3):379–385
34. Soffritti M, Belpoggi F, Tibaldi E, Degli ED, Lauriola M (2007) Life-span exposure to low doses of aspartame beginning during prenatal life increases Cancer effects in rats. Environ Health Perspect 115(9):1293–1297
35. Soffritti M, Belpoggi F, Manservigi M, Tibaldi E, Lauriola M, Falcioni L, Bua L (2010) Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice. Am J Ind Med 53(12):1197–1206
36. Sordillo LM, Shafer-Weaver K, Derosa D (1997) Immunobiology of the mammary gland. Dairy Science 80(8):1851–1865
37. Stegink LD and Filer LG (1984) Aspartame: physiology and biochemistry. 1st edition (Vol. 12). Series food science and technology. CRC Press
38. Veltmaat JM, Mailleux AA, Thiery JP, Bellusci S (2003) Mouse embryonic mammogenesis as a model for the molecular regulation of pattern formation. Differentiation 71(1):1–17
39. Vorbach C, Capecchi MR, Penninger JM (2006) Evolution of the mammary gland from the innate immune system? Bioessays 28(6):606–616
40. Washburn C, & Christensen N (2012) Sugar substitutes: artificial sweeteners and sugar alcohols
41. Watson CJ (2006) Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ. Breast Cancer Res 8(2):203
42. Walker C, Vierck CJ, Ritz LA (1998) Balance in the cat: role of the tail and effects of sacrocaudal transection. Behav Brain Res 91(1):41–47
43. Zaidi Z & Lanigan SW (2010) Dermatology in clinical practice. Springer Verlag London. eBook ISBN 978-1-84882-862-9