Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia

Food and Chemical Toxicology

Volumn 49, Issue 11, 2011, Pages 2899-2905

  Kim, Jae Yong ^a   Seo, Juyi ^a   Cho, Kyung Hyun ^a  

^a Yeungnam University   (South Korea)

Author keywords

Aspartame; Brain; Cholesteryl ester transfer protein; Lipid; Saccharin; Zebrafish

Indexed keywords

ASPARTAME; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; GLUCOSE; SACCHARIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DEATH; ENCEPHALITIS; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEPATITIS; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; INFLAMMATORY CELL; LIPID METABOLISM; NONHUMAN; PROTEIN FUNCTION; SURVIVAL RATE; SWIMMING; ZEBRA FISH;

ANIMALS; ASPARTAME; BLOOD GLUCOSE; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL, DIETARY; DIET; HYPERCHOLESTEROLEMIA; SACCHARIN; SWEETENING AGENTS; SWIMMING; ZEBRAFISH;

DANIO RERIO;

EID: 80052859721     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.08.001     Document Type: Article

References (39)

1. Alleva R., Borghi B., Santarelli L., Strafella E., Carbonari D., Bracci M., Tomasetti M. In vitro effect of aspartame in angiogenesis induction. Toxicol. In Vitro 2011, 25:286-293.
2. Anchelin M., Murcia L., Alcaraz-Pérez F., García-Navarro E.M., Cayuela M.L. Behaviour of telomere and telomerase during aging and regeneration in zebrafish. PLoS One. 2011, 6:e16955.
3. Babin P.J., Vernier J.M. Plasma lipoproteins in fish. J. Lipid Res. 1989, 30:467-489.
4. Bakkers J. Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovasc. Res. 2011, 91:279-288.
5. Bandyopadhyay A., Ghoshal S., Mukherjee A. Genotoxicity testing of low-calorie sweeteners: aspartame, acesulfame-K, and saccharin. Drug Chem. Toxicol. 2008, 31:447-457.
6. Bergstrom B.P., Cummings D.R., Skaggs T.A. Aspartame decreases evoked extracellular dopamine levels in the rat brain: an in vivo voltammetry study. Neuropharmacology 2007, 53:67-974.
7. Burgert S.L., Andersen D.W., Stegink L.D., Takeuchi H., Schedl H.P. Metabolism of aspartame and its l-phenylalanine methyl ester decomposition product by the porcine gut. Metabolism 1991, 40:612-618.
8. Burkhart C.G. 'Lone' atrial fibrillation precipitated by monosodium glutamate and aspartame. Int. J. Cardiol. 2009, 137:307-308.
9. Cho K.H., Park S.H., Park J.E., Kim Y.O., Choi I., Kim J.J., Kim J.R. The function, composition, and particle size of high-density lipoprotein were severely impaired in an oliguric phase of hemorrhagic fever with renal syndrome patients. Clin. Biochem. 2008, 41:56-64.
10. Cho K.H. Synthesis of reconstituted high density lipoprotein (rHDL) containing apoA-I and apoC-III: the functional role of apoC-III in rHDL. Mol. Cells 2009, 27:291-297.
11. Cho K.H., Shin D.G., Baek S.H., Kim J.R. Myocardial infarction patients show altered lipoprotein properties and functions when compared with stable angina pectoris patients. Exp. Mol. Med. 2009, 41:67-76.
12. Cho K.H. Biomedicinal implications of high-density lipoprotein: its composition, structure, functions, and clinical applications. BMB Rep. 2009, 42:393-400.
13. Davidson M.H. Update on CETP inhibition. J. Clin. Lipidol. 2010, 4:394-398.
14. Fang L., Harkewicz R., Hartvigsen K., Wiesner P., Choi S.H., Almazan F., Pattison J., Deer E., Sayaphupha T., Dennis E.A., Witztum J.L., Tsimikas S., Miller Y.I. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. J. Biol. Chem. 2010, 285:32343-32351.
15. Hölttä-Vuori M., Salo V.T., Nyberg L., Brackmann C., Enejder A., Panula P., Ikonen E. Zebrafish: gaining popularity in lipid research. Biochem. J. 2010, 429:235-242.
16. Humphries P., Pretorius E., Naudé H. Direct and indirect cellular effects of aspartame on the brain. Eur. J. Clin. Nutr. 2007, 62:451-462.
17. Jang W., Jeoung N.H., Cho K.H. Modified apolipoprotein (apo) A-I by artificial sweetener causes severe premature cellular senescence and atherosclerosis with impairment of functional and structural properties of apoA-I in lipid-free and lipid-bound state. Mol. Cells 2011, 31:461-470.
18. Jin S.R., Cho K.H. Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish. Food Chem. Toxicol. 2011, 49:1521-1529.
19. Leonards C., Ebinger M., Batluk J., Malzahn U., Heuschmann P., Endres M. The role of fasting versus non-fasting triglycerides in ischemic stroke: a systematic review. Front. Neurol. 2010, 1:133.
20. Libby P. Fat fuels the flame triglyceride-rich lipoproteins and arterial inflammation. Circ. Res. 2007, 100:299-301.
21. Mackey S.A., Berlin C.M.Jr. Effect of dietary aspartame on plasma concentrations of phenylalanine and tyrosine in normal and homozygous phenylketonuric patients. Clin. Pediatr. (Phila) 1992, 31:394-399.
22. McBride P.E. Triglycerides and risk for coronary heart disease. JAMA 2007, 298:336-338.
23. Miller Y.I., Choi S.H., Fang L., Harkewicz R. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Trends Cardiovasc. Med. 2009, 19:227-232.
24. Morton R.E. Cholesteryl ester transfer protein and its plasma regulator: lipid transfer inhibitor protein. Curr. Opin. Lipidol. 1999, 10:321-327.
25. Olney J.W. Excitotoxins in foods. Neurotoxicology 1994, 15:535-544.
26. Olney J.W., Farber N.B., Spitznagel E., Robins L.N. Increasing brain tumor rates: is there a link to aspartame?. J. Neuropathol. Exp. Neurol. 1996, 55:1115-1123.
27. Olsen A.S., Sarras M.P.Jr., Intine R.V. Limb regeneration is impaired in an adult zebrafish model of diabetes mellitus. Wound Repair Regen. 2010, 18:532-542.
28. Owusu-Ansah E., Yavari A., Mandal S., Banerjee U. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat. Genet. 2008, 40:356-361.
29. Park K.H., Shin D.G., Kim J.R., Hong J.H., Cho K.H. The functional and compositional properties of lipoproteins are altered in patients with metabolic syndrome with increased cholesteryl ester transfer protein activity. In. J. Mol. Med. 2010, 25:129-136.
30. Park K.H., Shin D.G., Kim J.R., Cho K.H. Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity. J. Gerontol. A. Biol. Sci. Med. Sci. 2010, 65:600-610.
31. Reuber M.D. Carcinogenicity of saccharin. Environ. Health Perspect. 1978, 25:173-200.
32. Rico, E.P., Rosemberg, D.B., Langoni, A.D., Souto, A.A., Dias, R.D., Bogo, M.R., Bonan, C.D., Souza, D.O., in press. Chronic ethanol treatment alters purine nucleotide hydrolysis and nucleotidase gene expression pattern in zebrafish brain. Neurotoxicology.
33. Sharma R.R., Coulombe R.A.Jr. Effects of repeated doses of aspartame on serotonin and its metabolite in various regions of the mouse brain. Food Chem. Toxicol. 1987, 25:565-568.
34. Soffritti M., Belpoggi F., Degli Esposti D., Lambertini L., Tibaldi E., Rigano A. First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats. Environ. Health Perspect. 2006, 114:379-385.
35. Soffritti M., Belpoggi F., Esposti D.D., Falcioni L., Bua L. Consequences of exposure to carcinogens beginning during developmental life. Basic. Clin. Pharmacol. Toxicol. 2008, 102:118-124.
36. Stoletov K., Fang L., Choi S.H., Hartvigsen K., Hansen L.F., Hall C., Pattison J., Juliano J., Miller E.R., Almazan F., Crosier P., Witztum J.L., Klemke R.L., Miller Y.I. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ. Res. 2009, 104:952-960.
37. Trede N.S., Zapata A., Zon L.I. Fishing for lymphoid genes. 2001. Trends Immunol. 2001, 22:302-307.
38. Van den Eeden S.K., Koepsell T.D., Longstreth W.T.Jr., van Belle G., Daling J.R., McKnight B. Aspartame ingestion and headaches: a randomized crossover trial. Neurology 1994, 44:1787-1793.
39. Weihrauch M.R., Diehl V. Artificial sweeteners - do they bear a carcinogenic risk?. Ann. Oncol. 2004, 15:1460-1465.