Influence of machine-based puffing parameters on aerosol and smoke emissions from next generation nicotine inhalation products

Regulatory Toxicology and Pharmacology

Volumn 101, Issue , 2019, Pages 156-165

  McAdam, K ^a   Davis, P ^a   Ashmore, L ^a   Eaton, D ^a   Jakaj, B ^a   Eldridge, A ^a   Liu, C ^a  

^a BRITISH AMERICAN TOBACCO   (United Kingdom)

Author keywords

Behaviour; e cigarettes; Nicotine; Parameters; Puffing; Standards; Tobacco; Topography

Indexed keywords

CARBON; NICOTINE;

AEROSOL; ARTICLE; CARBON FOOTPRINT; COMPARATIVE STUDY; LABORATORY TEST; PRIORITY JOURNAL; SMOKE; TOPOGRAPHY; ANALYSIS; ELECTRONIC CIGARETTE; EXPOSURE; TOBACCO;

AEROSOLS; ELECTRONIC NICOTINE DELIVERY SYSTEMS; INHALATION EXPOSURE; SMOKE; TOBACCO PRODUCTS;

EID: 85057448422     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2018.11.006     Document Type: Article

References (45)

1. Ayers, J.W., Ribisl, K.M., Brownstein, J.S., Tracking the rise in popularity of electronic nicotine delivery systems (electronic cigarettes) using search query surveillance. Am. J. Prev. Med. 40 (2011), 448–453.
2. Baker, R.R., Variation of the gas formation regions within a cigarette combustion coal during the smoking cycle. Beitrage zur Tabakforschung International 11 (1981), 1–17.
3. Baker, R.R., Davis, D.L., Nielsen, M.T., (eds.) World Agriculture Series: Tobacco, Production, Chemistry and Technology, 1999, Blackwell Science, 398–439 ISBN 0-632-04791-7.
4. Borgerding, M.F., Milhous, L.A. Jr., Hicks, R.D., Giles, J.A., Cigarette smoke composition. Part 2. Method for determining major components in smoke of cigarettes that heat instead of burn tobacco. J. Assoc. Off. Anal. Chem. 73 (1990), 610–615.
5. CORESTA No. 81, Routine Analytical Machine for E-cigarette Aerosol Generation and Collection - Definitions and Standard Conditions. June 2015 https://www.coresta.org/sites/default/files/technical_documents/main/CRM_81.pdf. (Accessed 18 April 2018)
6. deBethizy, J.D., Borgerding, M.F., Doolittle, D.J., Robinson, J.H., McManus, K.T., Rahn, C.A., Davis, R.A., Burger, G.T., Hayes, J.R., Reynolds, J.H., Hayes, W., Chemical and biological studies of a cigarette that heats rather than burns tobacco. J. Clin. Pharmacol. 30 (1990), 755–763.
7. Eclipse Expert Panel, A safer cigarette? A comparative study. A consensus report. Inhal. Toxicol. 12:Suppl. 5 (2000), 1–48 Addendum: reviewers’ comments and authors’ responses. 2000;12(suppl 5):49–58.
8. FDA, Draft Guidance: Premarket Tobacco Product Applications for Electronic Nicotine Delivery Systems (ENDS). 2016 https://www.fda.gov/downloads/TobaccoProducts/Labeling/RulesRegulationsGuidance/UCM499352.pdf. (Accessed 18 April 2018)
9. FDA TPSAC, page 15 https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/TobaccoProductsScientificAdvisoryCommittee/UCM593108.pdf, 2012. (Accessed 18 April 2018)
10. Fischer, S., Spiegelhalder, B., Preussmann, R., Influence of smoking parameters on the delivery of tobacco-specific nitrosamines in cigarette smoke — a contribution to relative risk evaluation. Carcinogenesis 10:6 (1989), 1059–1066.
11. Forster, M., Fiebelkorn, S., Yurteri, C., Mariner, D., Liu, C., Wright, C., McAdam, K., Murphy, J., Proctor, C., Assessment of novel tobacco heating product THP1.0. Part 3: comprehensive chemical characterisation of harmful and potentially harmful aerosol emissions. Regul. Toxicol. Pharmacol. 93 (2018), 14–33 https://doi.org/10.1016/j.yrtph.2017.10.006.
12. Gee, J., Prasad, K., Slayford, S., Gray, A., Nother, K., Cunningham, A., Mavropou, E., Proctor, C., Assessment of tobacco heating product THP1.0. Part 8: study to determine puffing topography, mouth level exposure and consumption among Japanese users. Regul. Toxicol. Pharmacol. 93 (2018), 84–91 https://doi.org/10.1016/j.yrtph.2017.08.005.
13. Goniewicz, M.L., Kuma, T., Gawron, M., Knysak, J., Kosider, L., Nicotine levels in electronic cigarettes. Nicotine. Tob. Res. 15:1 (2013), 158–166.
14. Goniewicz, M.L., Knysak, J., Gawron, M., Kosmider, L., Sobczak, A., Kurek, J., Prokopowicz, A., Jablonska-Czapla, M., Rosik-Dulewska, C., Havel, C., Jacob, P. III, Benowitz, N., Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tobac. Contr. 23:2 (2014), 133–139.
15. Guerin, M., Sensitivity of the federal trade commission test method to analytical parameters. Smok. Tobacco Control. Monograph. 7 (1996), 135–150.
16. Hammond, D., Collishaw, N.E., Callard, C., Secret science: tobacco industry research on smoking behaviour and cigarette toxicity. Lancet 367 (2006), 781–787.
17. Hammond, D., Wiebel, F., Kozlowski, L.T., Borland, R., Cummings, K.M., O'Connor, R.J., McNeill, A., Connolly, G.N., Arnott, D., Fong, G.T., Revising the machine smoking regime for cigarette emissions: implications for tobacco control policy. Tobac. Contr. 16:1 (2007), 8–14.
18. Haziza, C., de La Bourdonnaye, G., Skiada, D., Ancerewicz, J., Baker, G., Picavet, P., Lüdicke, F., Evaluation of the Tobacco Heating System 2.2. Part 8: 5-Day randomized reduced exposure clinical study in Poland. Regul. Toxicol. Pharmacol. 81 (2016), S139–S150 https://doi.org/10.1016/j.yrtph.2016.11.003.
19. Health Canada, Determination of “tar” Nicotine and Carbon Monoxide in Mainstream Tobacco Smoke‐official Method. 1999, Health Canada, Method T-115, Health Canada, Ottawa http://koreabizwire.com/ktg-challenges-philip-morris-bat-with-hnb-tobacco-product-lil/100430. (Accessed 18 April 2018)
20. International Organization for Standardization, ISO 3308:2012, Routine Analytical Cigarette-smoking Machine — Definitions and Standard Conditions. 2012, ISO, Geneva.
21. King, B.A., Patel, R., Nguyen, K., Dube, S.R., Trends in Awareness and Use of Electronic Cigarettes Among US Adults, 2010-2013. 2014, Nicotine Tob. Res https://doi.org/10.1093/ntr/ntu191.
22. Krasny, J.F., Cigarette Ignition of Soft Furnishings - a Literature Review with Commentary. Report of the Technical Study Group on Cigarette Safety., 1987, National Institute of Standards and Technology, Gaithersburg, MD, USA.
23. Liu, C., Feng, S., Van Heemst, J., McAdam, K., New insights into the formation of volatile compounds in mainstream cigarette smoke. Anal. Bioanal. Chem. 396:5 (2010), 1817–1830.
24. Margham, J., McAdam, K., Forster, M., Liu, C., Wright, C., Mariner, D., Proctor, C., Chemical composition of aerosol from an E-cigarette: a quantitative comparison with cigarette smoke. Chem. Res. Toxicol. 29:10 (2016), 1662–1678.
25. Marian, C., O'Connor, R.J., Djordjevic, M., Rees, V.W., Hatsukami, D.K., Shields, P.G., Reconciling human smoking behavior and machine smoking patterns: implications for understanding smoking behavior and the impact on laboratory studies. Cancer Epidemiol. Biomark. Prev. 18:12 (2009), 3305–3320.
26. McAuley, T.R., Hopke, P.K., Zhao, J., Babaian, S., Comparison of the effects of e-cigarette vapour and cigarette smoke on indoor air quality. Inhal. Toxicol. 24:12 (2012), 850–857.
27. McNeill, A., Brose, L.S., Calder, R., Bauld, L., Robson, D., Evidence review of e-cigarettes and heated tobacco products 2018. A report commissioned by Public Health England., 2018, Public Health England, London Available at: https://www.gov.uk/government/publications/e-cigarettes-and-heated-tobacco-products-evidence-review-of-e-cigarettes-and-heated-tobacco-products-2018-executive-summary. (Accessed 14 July 2018)
28. Pellegrino, R.M., Tinghino, B., Mangiaracina, G., Marani, A., Vitali, M., Protano, C., Osborn, J.F., Cattaruzza, M.S., Electronic cigarettes: an evaluation of exposure to chemicals and fine particulate matter (PM). Ann Ig 24:4 (2012), 279–288.
29. PMI, https://www.pmi.com/smoke-free-products/teeps-carbon-heated-tobacco-product, 2018. (Accessed 27 March 2018)
30. Poynton, S., Sutton, J., Goodall, S., Margham, J., Forster, M., Scott, K., Liu, C., McAdam, K., Murphy, J., Proctor, C., A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 1): product operation and preliminary aerosol chemistry assessment. Food Chem. Toxicol. 106:Pt A (2017), 522–532, 10.1016/j.fct.2017.05.022.
31. Purkis, S.W., Cahours, X., Rey, M., Teillet, B., Troude, V., Verron, T., Some consequences of using cigarette machine smoking regimes with different intensities on smoke yields and their variability. Regul Toxicol Pharmacol. Mar 59:2 (2011), 293–309.
32. Rickert, W.S., Collishaw, N.E., Bray, D.F., Robinson, J.C., Estimates of maximum or average cigarette tar, nicotine, and carbon monoxide yields can Be obtained from yields under standard conditions. Prev. Med. 15 (1986), 82–91.
33. RJ Reynolds Tobacco Co, Chemical and Biological Studies on New Cigarette Prototypes that Heat Instead of Burn Tobacco. 1988, RJ Reynolds Tobacco Co, Winston-Salem, North Carolina.
34. Schlotzhauer, W.S., Chortyk, O.T., Effects of varied smoking machine parameters on deliveries of total particulate matter and selected smoke constituents from an ultra low-tar cigarette. J. Anal. Toxicol. 7 (1983), 92–95.
35. Schorp, M.K., Tricker, A.R., Dempsey, R., Reduced exposure evaluation of an electrically heated cigarette smoking system. Part 1: clinical and non-clinical insights. Regul. Toxicol. Pharmacol. 64 (2012), S1–S10.
36. Slade, J., Innovative nicotine delivery devices from tobacco companies. Ferrence, R., Slade, J., Room, R., Pope, M., (eds.) Nicotine and Public Health, 2000, American Public Health Association, Washington DC, 209–228.
37. Slade, J., Connolly, G.N., Lymperis, D., Eclipse: does it live up to its health claims?. Tobac. Contr. 11:Suppl. II (2002), ii64–ii70 https://doi.org/10.1136/tc.11.suppl_2.ii64.
38. Stratton, K., Shetty, P., Wallace, R., Bondurant, S., (eds.) Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction, 2001, National Academy Press, Washington, 93–95.
39. Talih, S., Balhas, Z., Eissenberg, T., Salman, R., Karaoghlanian, N., El Hellani, A., Baalbaki, R., Saliba, N., Shihadeh, A., Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: measurements and model predictions. Nicotine Tob. Res., 2014, 1–8.
40. Trehy, M.L., Ye, W., Hadwiger, M., Moore, T.W., Allgire, J.F., Woodruff, J.T., Ahadi, S.S., Black, J.C., Westenberger, B.J., Analysis of electronic cigarette cartridges, refill solutions and smoke for nicotine and nicotine-related impurities. J. Liq. Chromatogr. Relat. Technol. 34:14 (2011), 1442–1458.
41. Trtchounian, A., Williams, M., Talbot, P., Conventional and electronic cigarettes (e-cigarettes) have different characteristics. Nicotine Tob. Res. 12:9 (2010), 905–912.
42. Werley, M.S., Freelin, S.A., Wrenn, S.E., Gerstenberg, B., Roemer, E., Schramke, H., Van Miert, E., Vanscheeuwijck, P., Weber, S., Coggins, C.R., Smoke chemistry, in vitro and in vivo toxicology evaluations of the electrically heated cigarette smoking system series K. Regul. Toxicol. Pharmacol. 52:2 (2008), 122–139.
43. WHO, Standard Operating Procedure for Intense Smoking of Cigarettes. WHO Tobacco Laboratory Network Official Method: Standard Operating Procedure 01. 2012, WHO, Geneva http://www.who.int/tobacco/publications/prod_regulation/sop_smoking_cigarettes_1/en/.
44. Zacny, J.P., Stitzer, M.L., Human Smoking Patterns, Chapter 11, in NCI Tobacco Control Monograph 7, the FTC Cigarette Test Method for Determining Nicotine, and Carbon Monoxide Yields for U.S. Cigarettes: Report of the NCI Expert Committee., 2012 https://cancercontrol.cancer.gov/Brp/TCRB/monographs/7/m7_11.pdf.
45. Zenzen, V., Diekmann, J., Gerstenberg, B., Weber, S., Wittke, S., Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 2: smoke chemistry and in vitro toxicological evaluation using smoking regimens reflecting human behaviour. Regul. Toxicol. Pharmacol. 64 (2012), S11–S34.