메뉴 건너뛰기




Volumn 32, Issue 11, 2018, Pages 1223-1232

Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia

Author keywords

Cognition; development; kynurenine 3 monooxygenase; prenatal; tryptophan

Indexed keywords

3 HYDROXYKYNURENINE; KYNURENIC ACID; QUINOLINIC ACID; 3-HYDROXYKYNURENINE; KYNURENINE; KYNURENINE 3 MONOOXYGENASE;

EID: 85056277678     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881118805492     Document Type: Article
Times cited : (10)

References (70)
  • 1
    • 78649809112 scopus 로고    scopus 로고
    • Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology
    • Abazyan B, Nomura J, Kannan G. (2010) Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry 68: 1172–1181
    • (2010) Biol Psychiatry , vol.68 , pp. 1172-1181
    • Abazyan, B.1    Nomura, J.2    Kannan, G.3
  • 2
    • 84871863918 scopus 로고    scopus 로고
    • Exposure to kynurenic acid during adolescence produces memory deficits in adulthood
    • Akagbosu CO, Evans GC, Gulick D. (2012) Exposure to kynurenic acid during adolescence produces memory deficits in adulthood. Schizophr Bull 38: 769–778
    • (2012) Schizophr Bull , vol.38 , pp. 769-778
    • Akagbosu, C.O.1    Evans, G.C.2    Gulick, D.3
  • 3
    • 0030740556 scopus 로고    scopus 로고
    • Cloning and functional expression of human kynurenine 3-monooxygenase
    • Alberati-Giani D, Cesura AM, Broger C. (1997) Cloning and functional expression of human kynurenine 3-monooxygenase. FEBS Lett 410: 407–412
    • (1997) FEBS Lett , vol.410 , pp. 407-412
    • Alberati-Giani, D.1    Cesura, A.M.2    Broger, C.3
  • 4
    • 84858445314 scopus 로고    scopus 로고
    • Acute elevations of brain kynurenic acid impair cognitive flexibility: Normalization by the alpha7 positive modulator galantamine
    • Alexander KS, Wu HQ, Schwarcz R. (2012) Acute elevations of brain kynurenic acid impair cognitive flexibility: Normalization by the alpha7 positive modulator galantamine. Psychopharmacology (Berl) 220: 627–637
    • (2012) Psychopharmacology (Berl) , vol.220 , pp. 627-637
    • Alexander, K.S.1    Wu, H.Q.2    Schwarcz, R.3
  • 5
    • 33646925826 scopus 로고    scopus 로고
    • Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population
    • Aoyama N, Takahashi N, Saito S. (2006) Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population. Genes Brain Behav 5: 364–368
    • (2006) Genes Brain Behav , vol.5 , pp. 364-368
    • Aoyama, N.1    Takahashi, N.2    Saito, S.3
  • 6
    • 84922263888 scopus 로고    scopus 로고
    • Uncovering the hidden risk architecture of the schizophrenias: Confirmation in three independent genome-wide association studies
    • Arnedo J, Svrakic DM, Del Val C. (2015) Uncovering the hidden risk architecture of the schizophrenias: Confirmation in three independent genome-wide association studies. Am J Psychiatry 172: 139–153
    • (2015) Am J Psychiatry , vol.172 , pp. 139-153
    • Arnedo, J.1    Svrakic, D.M.2    Del Val, C.3
  • 7
    • 0026684818 scopus 로고
    • Developmental changes in brain kynurenic acid concentrations
    • Beal MF, Swartz KJ, Isacson O, (1992) Developmental changes in brain kynurenic acid concentrations. Brain Res Dev Brain Res 68: 136–139
    • (1992) Brain Res Dev Brain Res , vol.68 , pp. 136-139
    • Beal, M.F.1    Swartz, K.J.2    Isacson, O.3
  • 8
    • 0030613643 scopus 로고    scopus 로고
    • GABAA, NMDA and AMPA receptors: A developmentally regulated ‘menage a trois’
    • Ben-Ari Y, Khazipov R, Leinekugel X. (1997) GABAA, NMDA and AMPA receptors: A developmentally regulated ‘menage a trois’. Trends Neurosci 20: 523–529
    • (1997) Trends Neurosci , vol.20 , pp. 523-529
    • Ben-Ari, Y.1    Khazipov, R.2    Leinekugel, X.3
  • 9
    • 66949152499 scopus 로고    scopus 로고
    • Prenatal exposure to maternal infection and executive dysfunction in adult schizophrenia
    • Brown AS, Vinogradov S, Kremen WS. (2009) Prenatal exposure to maternal infection and executive dysfunction in adult schizophrenia. Am J Psychiatry 166: 683–690
    • (2009) Am J Psychiatry , vol.166 , pp. 683-690
    • Brown, A.S.1    Vinogradov, S.2    Kremen, W.S.3
  • 10
    • 0034884986 scopus 로고    scopus 로고
    • Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development
    • Cannazza G, Chiarugi A, Parenti C. (2001) Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development. Neurochem Res 26: 511–514
    • (2001) Neurochem Res , vol.26 , pp. 511-514
    • Cannazza, G.1    Chiarugi, A.2    Parenti, C.3
  • 11
    • 0028305047 scopus 로고
    • Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities
    • Carpenedo R, Chiarugi A, Russi P. (1994) Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities. Neuroscience 61: 237–243
    • (1994) Neuroscience , vol.61 , pp. 237-243
    • Carpenedo, R.1    Chiarugi, A.2    Russi, P.3
  • 13
    • 33748931998 scopus 로고    scopus 로고
    • Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain
    • Ceresoli-Borroni G, Rassoulpour A, Wu HQ. (2006) Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain. J Neural Transm (Vienna) 113: 1355–1365
    • (2006) J Neural Transm (Vienna) , vol.113 , pp. 1355-1365
    • Ceresoli-Borroni, G.1    Rassoulpour, A.2    Wu, H.Q.3
  • 14
    • 33747459300 scopus 로고    scopus 로고
    • Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding
    • Chess AC, Bucci DJ, (2006) Increased concentration of cerebral kynurenic acid alters stimulus processing and conditioned responding. Behav Brain Res 170: 326–332
    • (2006) Behav Brain Res , vol.170 , pp. 326-332
    • Chess, A.C.1    Bucci, D.J.2
  • 15
    • 34248335693 scopus 로고    scopus 로고
    • Elevations of endogenous kynurenic acid produce spatial working memory deficits
    • Chess AC, Simoni MK, Alling TE. (2007) Elevations of endogenous kynurenic acid produce spatial working memory deficits. Schizophr Bull 33: 797–804
    • (2007) Schizophr Bull , vol.33 , pp. 797-804
    • Chess, A.C.1    Simoni, M.K.2    Alling, T.E.3
  • 16
    • 0035290171 scopus 로고    scopus 로고
    • Standardization of the Whitten Effect to induce susceptibility to Neisseria gonorrhoeae in female mice
    • Dalal SJ, Estep JS, Valentin-Bon IE. (2001) Standardization of the Whitten Effect to induce susceptibility to Neisseria gonorrhoeae in female mice. Contemp Top Lab Anim Sci 40: 13–17
    • (2001) Contemp Top Lab Anim Sci , vol.40 , pp. 13-17
    • Dalal, S.J.1    Estep, J.S.2    Valentin-Bon, I.E.3
  • 17
    • 84920571212 scopus 로고    scopus 로고
    • Exposure to kynurenic acid during adolescence increases sign-tracking and impairs long-term potentiation in adulthood
    • DeAngeli NE, Todd TP, Chang SE. (2014) Exposure to kynurenic acid during adolescence increases sign-tracking and impairs long-term potentiation in adulthood. Front Behav Neurosci 8: 451
    • (2014) Front Behav Neurosci , vol.8 , pp. 451
    • DeAngeli, N.E.1    Todd, T.P.2    Chang, S.E.3
  • 19
    • 64549110661 scopus 로고    scopus 로고
    • The dynamic effects of nicotine on the developing brain
    • Dwyer JB, McQuown SC, Leslie FM, (2009) The dynamic effects of nicotine on the developing brain. Pharmacol Ther 122: 125–139
    • (2009) Pharmacol Ther , vol.122 , pp. 125-139
    • Dwyer, J.B.1    McQuown, S.C.2    Leslie, F.M.3
  • 20
    • 0026635895 scopus 로고
    • Uptake of 3-hydroxykynurenine measured in rat brain slices and in a neuronal cell line
    • Eastman CL, Guilarte TR, Lever JR, (1992) Uptake of 3-hydroxykynurenine measured in rat brain slices and in a neuronal cell line. Brain Res 584: 110–116
    • (1992) Brain Res , vol.584 , pp. 110-116
    • Eastman, C.L.1    Guilarte, T.R.2    Lever, J.R.3
  • 21
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
    • Erhardt S, Blennow K, Nordin C. (2001) Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 313: 96–98
    • (2001) Neurosci Lett , vol.313 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3
  • 22
    • 85011565078 scopus 로고    scopus 로고
    • Adaptive and behavioral changes in kynurenine 3-monooxygenase knockout mice: Relevance to psychotic disorders
    • Erhardt S, Pocivavsek A, Repici M. (2017) Adaptive and behavioral changes in kynurenine 3-monooxygenase knockout mice: Relevance to psychotic disorders. Biol Psychiatry 82: 756–765
    • (2017) Biol Psychiatry , vol.82 , pp. 756-765
    • Erhardt, S.1    Pocivavsek, A.2    Repici, M.3
  • 23
    • 4143096940 scopus 로고    scopus 로고
    • Endogenous kynurenic acid disrupts prepulse inhibition
    • Erhardt S, Schwieler L, Emanuelsson C. (2004) Endogenous kynurenic acid disrupts prepulse inhibition. Biol Psychiatry 56: 255–260
    • (2004) Biol Psychiatry , vol.56 , pp. 255-260
    • Erhardt, S.1    Schwieler, L.2    Emanuelsson, C.3
  • 24
    • 84983035812 scopus 로고    scopus 로고
    • Maternal immune activation: Implications for neuropsychiatric disorders
    • Estes ML, McAllister AK, (2016) Maternal immune activation: Implications for neuropsychiatric disorders. Science 353: 772–777
    • (2016) Science , vol.353 , pp. 772-777
    • Estes, M.L.1    McAllister, A.K.2
  • 25
    • 85028022053 scopus 로고    scopus 로고
    • Preferential disruption of prefrontal GABAergic function by nanomolar concentrations of the alpha7nACh negative modulator kynurenic acid
    • Flores-Barrera E, Thomases DR, Cass DK. (2017) Preferential disruption of prefrontal GABAergic function by nanomolar concentrations of the alpha7nACh negative modulator kynurenic acid. J Neurosci 37: 7921–7929
    • (2017) J Neurosci , vol.37 , pp. 7921-7929
    • Flores-Barrera, E.1    Thomases, D.R.2    Cass, D.K.3
  • 26
    • 84875231906 scopus 로고    scopus 로고
    • Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus
    • (, a
    • Forrest CM, Khalil OS, Pisar M. (2013a) Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus. Brain Res 1504: 1–15
    • (2013) Brain Res , vol.1504 , pp. 1-15
    • Forrest, C.M.1    Khalil, O.S.2    Pisar, M.3
  • 27
    • 84886943694 scopus 로고    scopus 로고
    • Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway
    • (, b
    • Forrest CM, Khalil OS, Pisar M. (2013b) Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway. Neuroscience 254: 241–259
    • (2013) Neuroscience , vol.254 , pp. 241-259
    • Forrest, C.M.1    Khalil, O.S.2    Pisar, M.3
  • 28
    • 0026076136 scopus 로고
    • Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism
    • Fukui S, Schwarcz R, Rapoport SI. (1991) Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 56: 2007–2017
    • (1991) J Neurochem , vol.56 , pp. 2007-2017
    • Fukui, S.1    Schwarcz, R.2    Rapoport, S.I.3
  • 29
    • 84890948960 scopus 로고    scopus 로고
    • Targeted deletion of kynurenine 3-monooxygenase in mice: A new tool for studying kynurenine pathway metabolism in periphery and brain
    • Giorgini F, Huang SY, Sathyasaikumar KV. (2013) Targeted deletion of kynurenine 3-monooxygenase in mice: A new tool for studying kynurenine pathway metabolism in periphery and brain. J Biol Chem 288: 36554–36566
    • (2013) J Biol Chem , vol.288 , pp. 36554-36566
    • Giorgini, F.1    Huang, S.Y.2    Sathyasaikumar, K.V.3
  • 30
    • 84866752013 scopus 로고    scopus 로고
    • Maternal genetic mutations as gestational and early life influences in producing psychiatric disease-like phenotypes in mice
    • Gleason G, Zupan B, Toth M, (2011) Maternal genetic mutations as gestational and early life influences in producing psychiatric disease-like phenotypes in mice. Front Psychiatry 2: 25
    • (2011) Front Psychiatry , vol.2 , pp. 25
    • Gleason, G.1    Zupan, B.2    Toth, M.3
  • 31
    • 84255168900 scopus 로고    scopus 로고
    • Kynurenine 3-monooxygenase polymorphisms: Relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls
    • Holtze M, Saetre P, Engberg G. (2012) Kynurenine 3-monooxygenase polymorphisms: Relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls. J Psychiatry Neurosci 37: 53–57
    • (2012) J Psychiatry Neurosci , vol.37 , pp. 53-57
    • Holtze, M.1    Saetre, P.2    Engberg, G.3
  • 32
    • 84900824439 scopus 로고    scopus 로고
    • Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring
    • Khalil OS, Pisar M, Forrest CM. (2014) Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring. Eur J Neurosci 39: 1558–1571
    • (2014) Eur J Neurosci , vol.39 , pp. 1558-1571
    • Khalil, O.S.1    Pisar, M.2    Forrest, C.M.3
  • 33
    • 84862258323 scopus 로고    scopus 로고
    • Prenatal nutrition, epigenetics and schizophrenia risk: Can we test causal effects?
    • Kirkbride JB, Susser E, Kundakovic M. (2012) Prenatal nutrition, epigenetics and schizophrenia risk: Can we test causal effects? Epigenomics 4: 303–315
    • (2012) Epigenomics , vol.4 , pp. 303-315
    • Kirkbride, J.B.1    Susser, E.2    Kundakovic, M.3
  • 34
    • 84966539133 scopus 로고    scopus 로고
    • Repeated LPS injection induces distinct changes in the kynurenine pathway in mice
    • Larsson MK, Faka A, Bhat M. (2016) Repeated LPS injection induces distinct changes in the kynurenine pathway in mice. Neurochem Res 41: 2243–2255
    • (2016) Neurochem Res , vol.41 , pp. 2243-2255
    • Larsson, M.K.1    Faka, A.2    Bhat, M.3
  • 35
    • 20444398841 scopus 로고    scopus 로고
    • Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: Implications for role of the kynurenine pathway in pregnancy
    • Ligam P, Manuelpillai U, Wallace EM. (2005) Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: Implications for role of the kynurenine pathway in pregnancy. Placenta 26: 498–504
    • (2005) Placenta , vol.26 , pp. 498-504
    • Ligam, P.1    Manuelpillai, U.2    Wallace, E.M.3
  • 36
    • 84860159640 scopus 로고    scopus 로고
    • Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia
    • Linderholm KR, Skogh E, Olsson SK. (2012) Increased levels of kynurenine and kynurenic acid in the CSF of patients with schizophrenia. Schizophr Bull 38: 426–432
    • (2012) Schizophr Bull , vol.38 , pp. 426-432
    • Linderholm, K.R.1    Skogh, E.2    Olsson, S.K.3
  • 37
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry OH, Rosebrough NJ, Farr AL. (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265–275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 38
    • 12844276776 scopus 로고    scopus 로고
    • Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection
    • Manuelpillai U, Ligam P, Smythe G. (2005) Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection. Am J Obstet Gynecol 192: 280–288
    • (2005) Am J Obstet Gynecol , vol.192 , pp. 280-288
    • Manuelpillai, U.1    Ligam, P.2    Smythe, G.3
  • 39
    • 84992144057 scopus 로고    scopus 로고
    • Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study
    • Martin J, Tilling K, Hubbard L. (2016) Association of genetic risk for schizophrenia with nonparticipation over time in a population-based cohort study. Am J Epidemiol 183: 1149–1158
    • (2016) Am J Epidemiol , vol.183 , pp. 1149-1158
    • Martin, J.1    Tilling, K.2    Hubbard, L.3
  • 40
    • 84892609862 scopus 로고    scopus 로고
    • Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems
    • Meyer U, (2014) Prenatal poly(i:C) exposure and other developmental immune activation models in rodent systems. Biol Psychiatry 75: 307–315
    • (2014) Biol Psychiatry , vol.75 , pp. 307-315
    • Meyer, U.1
  • 41
    • 85027704866 scopus 로고    scopus 로고
    • Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: A systematic review
    • Misiak B, Stramecki F, Gaweda L. (2018) Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: A systematic review. Mol Neurobiol 55: 5075–5100
    • (2018) Mol Neurobiol , vol.55 , pp. 5075-5100
    • Misiak, B.1    Stramecki, F.2    Gaweda, L.3
  • 42
    • 54249162304 scopus 로고    scopus 로고
    • Gene-environment interaction and covariation in schizophrenia: The role of obstetric complications
    • Mittal VA, Ellman LM, Cannon TD, (2008) Gene-environment interaction and covariation in schizophrenia: The role of obstetric complications. Schizophr Bull 34: 1083–1094
    • (2008) Schizophr Bull , vol.34 , pp. 1083-1094
    • Mittal, V.A.1    Ellman, L.M.2    Cannon, T.D.3
  • 43
    • 34548772356 scopus 로고    scopus 로고
    • Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission
    • Müller N, Schwarz M, (2006) Schizophrenia as an inflammation-mediated dysbalance of glutamatergic neurotransmission. Neurotox Res 10: 131–148
    • (2006) Neurotox Res , vol.10 , pp. 131-148
    • Müller, N.1    Schwarz, M.2
  • 44
    • 85013676387 scopus 로고    scopus 로고
    • Restraint stress during pregnancy rapidly raises kynurenic acid levels in mouse placenta and fetal brain
    • Notarangelo FM, Schwarcz R, (2016) Restraint stress during pregnancy rapidly raises kynurenic acid levels in mouse placenta and fetal brain. Dev Neurosci 38: 458–468
    • (2016) Dev Neurosci , vol.38 , pp. 458-468
    • Notarangelo, F.M.1    Schwarcz, R.2
  • 45
    • 84996658044 scopus 로고    scopus 로고
    • Prenatal LPS exposure preferentially increases kynurenine pathway metabolism in the fetal brain
    • Notarangelo FM, Wons KS, Schwarcz R, (2015) Prenatal LPS exposure preferentially increases kynurenine pathway metabolism in the fetal brain. Soc Neurosci Abstr 40: 74.02
    • (2015) Soc Neurosci Abstr , vol.40
    • Notarangelo, F.M.1    Wons, K.S.2    Schwarcz, R.3
  • 46
    • 84862785742 scopus 로고    scopus 로고
    • Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain
    • Notarangelo FM, Wu HQ, Macherone A. (2012) Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain. Anal Biochem 421: 573–581
    • (2012) Anal Biochem , vol.421 , pp. 573-581
    • Notarangelo, F.M.1    Wu, H.Q.2    Macherone, A.3
  • 47
    • 84905390577 scopus 로고    scopus 로고
    • Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1
    • O’Leary C, Desbonnet L, Clarke N. (2014) Phenotypic effects of maternal immune activation and early postnatal milieu in mice mutant for the schizophrenia risk gene neuregulin-1. Neuroscience 277: 294–305
    • (2014) Neuroscience , vol.277 , pp. 294-305
    • O’Leary, C.1    Desbonnet, L.2    Clarke, N.3
  • 49
    • 84940498145 scopus 로고    scopus 로고
    • Kynurenine 3-monooxygenase: An influential mediator of neuropathology
    • Parrott JM, O’Connor JC, (2015) Kynurenine 3-monooxygenase: An influential mediator of neuropathology. Front Psychiatry 6: 116
    • (2015) Front Psychiatry , vol.6 , pp. 116
    • Parrott, J.M.1    O’Connor, J.C.2
  • 50
    • 84999947490 scopus 로고    scopus 로고
    • Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation
    • Parrott JM, Redus L, Santana-Coelho. (2016) Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Transl Psychiatry 6: e918
    • (2016) Transl Psychiatry , vol.6 , pp. e918
    • Parrott, J.M.1    Redus, L.2    Santana-Coelho3
  • 51
    • 84914163967 scopus 로고    scopus 로고
    • Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: Implications for schizophrenia
    • Pershing ML, Bortz DM, Pocivavsek A. (2015) Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: Implications for schizophrenia. Neuropharmacology 90: 33–41
    • (2015) Neuropharmacology , vol.90 , pp. 33-41
    • Pershing, M.L.1    Bortz, D.M.2    Pocivavsek, A.3
  • 52
    • 84982175060 scopus 로고    scopus 로고
    • Prenatal kynurenine exposure in rats: Age-dependent changes in NMDA receptor expression and conditioned fear responding
    • Pershing ML, Phenis D, Valentini V. (2016) Prenatal kynurenine exposure in rats: Age-dependent changes in NMDA receptor expression and conditioned fear responding. Psychopharmacology (Berl) 233: 3725–3735
    • (2016) Psychopharmacology (Berl) , vol.233 , pp. 3725-3735
    • Pershing, M.L.1    Phenis, D.2    Valentini, V.3
  • 53
    • 84926113824 scopus 로고    scopus 로고
    • Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway
    • Pisar M, Forrest CM, Khalil OS. (2014) Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway. Brain Res 1576: 1–17
    • (2014) Brain Res , vol.1576 , pp. 1-17
    • Pisar, M.1    Forrest, C.M.2    Khalil, O.S.3
  • 54
    • 84998694466 scopus 로고    scopus 로고
    • Astrocytes as pharmacological targets in the treatment of schizophrenia: Focus on kynurenic acid
    • Mikhail V.P., John L.W., (eds), San Diego, CA, Elsevier,. In:, (eds
    • Pocivavsek A, Notarangelo FM, Wu HQ. (2016) Astrocytes as pharmacological targets in the treatment of schizophrenia: Focus on kynurenic acid. In: Mikhail VP, John LW, (eds) Handbook of Behavioral Neuroscience. Vol. 23. San Diego, CA: Elsevier, pp. 423–443
    • (2016) Handbook of Behavioral Neuroscience , vol.23 , pp. 423-443
    • Pocivavsek, A.1    Notarangelo, F.M.2    Wu, H.Q.3
  • 55
    • 84903594073 scopus 로고    scopus 로고
    • Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats
    • Pocivavsek A, Thomas MA, Elmer GI. (2014) Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats. Psychopharmacology (Berl) 231: 2799–2809
    • (2014) Psychopharmacology (Berl) , vol.231 , pp. 2799-2809
    • Pocivavsek, A.1    Thomas, M.A.2    Elmer, G.I.3
  • 56
    • 84861234916 scopus 로고    scopus 로고
    • Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood
    • Pocivavsek A, Wu HQ, Elmer GI. (2012) Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood. Eur J Neurosci 35: 1605–1612
    • (2012) Eur J Neurosci , vol.35 , pp. 1605-1612
    • Pocivavsek, A.1    Wu, H.Q.2    Elmer, G.I.3
  • 57
    • 0031434549 scopus 로고    scopus 로고
    • Synthesis and biochemical evaluation of N- (4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase
    • Röver S, Cesura AM, Huguenin P. (1997) Synthesis and biochemical evaluation of N- (4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem 40: 4378–4385
    • (1997) J Med Chem , vol.40 , pp. 4378-4385
    • Röver, S.1    Cesura, A.M.2    Huguenin, P.3
  • 58
    • 80054853253 scopus 로고    scopus 로고
    • Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia
    • Sathyasaikumar KV, Stachowski EK, Wonodi I. (2011) Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophr Bull 37: 1147–1156
    • (2011) Schizophr Bull , vol.37 , pp. 1147-1156
    • Sathyasaikumar, K.V.1    Stachowski, E.K.2    Wonodi, I.3
  • 59
    • 0031834430 scopus 로고    scopus 로고
    • Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro
    • Scharfman HE, Goodman JH, (1998) Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro. Neuroscience 86: 751–764
    • (1998) Neuroscience , vol.86 , pp. 751-764
    • Scharfman, H.E.1    Goodman, J.H.2
  • 60
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) Biological insights from 108 schizophrenia-associated genetic loci. Nature 511: 421–427
    • (2014) Nature , vol.511 , pp. 421-427
  • 61
    • 0035477818 scopus 로고    scopus 로고
    • Increased cortical kynurenate content in schizophrenia
    • Schwarcz R, Rassoulpour A, Wu HQ. (2001) Increased cortical kynurenate content in schizophrenia. Biol Psychiatry 50: 521–530
    • (2001) Biol Psychiatry , vol.50 , pp. 521-530
    • Schwarcz, R.1    Rassoulpour, A.2    Wu, H.Q.3
  • 62
    • 0033918989 scopus 로고    scopus 로고
    • The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project
    • Seidman LJ, Buka SL, Goldstein JM. (2000) The relationship of prenatal and perinatal complications to cognitive functioning at age 7 in the New England Cohorts of the National Collaborative Perinatal Project. Schizophr Bull 26: 309–321
    • (2000) Schizophr Bull , vol.26 , pp. 309-321
    • Seidman, L.J.1    Buka, S.L.2    Goldstein, J.M.3
  • 63
    • 0042887022 scopus 로고    scopus 로고
    • Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat
    • Shepard PD, Joy B, Clerkin L. (2003) Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat. Neuropsychopharmacology 28: 1454–1462
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1454-1462
    • Shepard, P.D.1    Joy, B.2    Clerkin, L.3
  • 64
    • 84870175374 scopus 로고    scopus 로고
    • The long and the short of it: Gene and environment interactions during early cortical development and consequences for long-term neurological disease
    • Stolp H, Neuhaus A, Sundramoorthi R. (2012) The long and the short of it: Gene and environment interactions during early cortical development and consequences for long-term neurological disease. Front Psychiatry 3: 50
    • (2012) Front Psychiatry , vol.3 , pp. 50
    • Stolp, H.1    Neuhaus, A.2    Sundramoorthi, R.3
  • 65
    • 0025482465 scopus 로고
    • Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors
    • Swartz KJ, During MJ, Freese A. (1990) Cerebral synthesis and release of kynurenic acid: An endogenous antagonist of excitatory amino acid receptors. J Neurosci 10: 2965–2973
    • (1990) J Neurosci , vol.10 , pp. 2965-2973
    • Swartz, K.J.1    During, M.J.2    Freese, A.3
  • 66
    • 84991199215 scopus 로고    scopus 로고
    • Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions
    • Tashiro T, Murakami Y, Mouri A. (2017) Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions. Behav Brain Res 317: 279–285
    • (2017) Behav Brain Res , vol.317 , pp. 279-285
    • Tashiro, T.1    Murakami, Y.2    Mouri, A.3
  • 67
    • 0033008956 scopus 로고    scopus 로고
    • Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization
    • Walker DW, Curtis B, Lacey B.. (1999) Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization. Pediatr Res 45: 820–826
    • (1999) Pediatr Res , vol.45 , pp. 820-826
    • Walker, D.W.1    Curtis, B.2    Lacey, B.3
  • 68
    • 85029818347 scopus 로고    scopus 로고
    • Maternal inflammation results in altered tryptophan metabolism in rabbit placenta and fetal brain
    • Williams M, Zhang Z, Nance E. (2017) Maternal inflammation results in altered tryptophan metabolism in rabbit placenta and fetal brain. Dev Neurosci 39: 399–412
    • (2017) Dev Neurosci , vol.39 , pp. 399-412
    • Williams, M.1    Zhang, Z.2    Nance, E.3
  • 69
    • 79960312085 scopus 로고    scopus 로고
    • Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes
    • Wonodi I, Stine OC, Sathyasaikumar KV. (2011) Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Arch Gen Psychiatry 68: 665–674
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 665-674
    • Wonodi, I.1    Stine, O.C.2    Sathyasaikumar, K.V.3
  • 70
    • 51749086627 scopus 로고    scopus 로고
    • Wild-type male offspring of fmr-1+/− mothers exhibit characteristics of the fragile X phenotype
    • Zupan B, Toth M, (2008) Wild-type male offspring of fmr-1+/− mothers exhibit characteristics of the fragile X phenotype. Neuropsychopharmacology. 33: 2667–2675
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2667-2675
    • Zupan, B.1    Toth, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.