-
1
-
-
84873956600
-
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
-
Vestbo J, Hurd SS, Agustí AG, Jones PW, Vogelmeier C, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187:347–365.
-
(2013)
Am J Respir Crit Care Med
, vol.187
, pp. 347-365
-
-
Vestbo, J.1
Hurd, S.S.2
Agustí, A.G.3
Jones, P.W.4
Vogelmeier, C.5
Anzueto, A.6
-
2
-
-
78650029099
-
Genetic influences on chronic obstructive pulmonary disease – A twin study
-
Ingebrigtsen T, Thomsen SF, Vestbo J, van der Sluis S, Kyvik KO, Silverman EK, et al. Genetic influences on chronic obstructive pulmonary disease – a twin study. Respir Med 2010;104: 1890–1895.
-
(2010)
Respir Med
, vol.104
, pp. 1890-1895
-
-
Ingebrigtsen, T.1
Thomsen, S.F.2
Vestbo, J.3
Van Der Sluis, S.4
Kyvik, K.O.5
Silverman, E.K.6
-
3
-
-
0031807729
-
Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease: Risk to relatives for airflow obstruction and chronic bronchitis
-
Silverman EK, Chapman HA, Drazen JM, Weiss ST, Rosner B, Campbell EJ, et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease: risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med 1998;157: 1770–1778.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 1770-1778
-
-
Silverman, E.K.1
Chapman, H.A.2
Drazen, J.M.3
Weiss, S.T.4
Rosner, B.5
Campbell, E.J.6
-
4
-
-
84895799527
-
Risk loci for chronic obstructive pulmonary disease: A genome-wide association study and meta-analysis
-
Cho MH, McDonald MLN, Zhou X, Mattheisen M, Castaldi PJ, Hersh CP, et al.; NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med 2014;2: 214–225.
-
(2014)
Lancet Respir Med
, vol.2
, pp. 214-225
-
-
Cho, M.H.1
McDonald, M.L.N.2
Zhou, X.3
Mattheisen, M.4
Castaldi, P.J.5
Hersh, C.P.6
-
5
-
-
77649189442
-
Variants in FAM13A are associated with chronic obstructive pulmonary disease
-
Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010;42:200–202.
-
(2010)
Nat Genet
, vol.42
, pp. 200-202
-
-
Cho, M.H.1
Boutaoui, N.2
Klanderman, B.J.3
Sylvia, J.S.4
Ziniti, J.P.5
Hersh, C.P.6
-
6
-
-
84856337050
-
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
-
Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, et al.; ICGN Investigators; ECLIPSE Investigators; COPDGene Investigators. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet 2012;21:947–957.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 947-957
-
-
Cho, M.H.1
Castaldi, P.J.2
Wan, E.S.3
Siedlinski, M.4
Hersh, C.P.5
Demeo, D.L.6
-
7
-
-
84944882763
-
Candidate genes for COPD: Current evidence and research
-
Kim WJ, Lee SD. Candidate genes for COPD: current evidence and research. Int J Chron Obstruct Pulmon Dis 2015;10:2249–2255.
-
(2015)
Int J Chron Obstruct Pulmon Dis
, vol.10
, pp. 2249-2255
-
-
Kim, W.J.1
Lee, S.D.2
-
8
-
-
85011684926
-
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
-
Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, et al.; Understanding Society Scientific Group; Geisinger-Regeneron DiscovEHR Collaboration. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet 2017;49: 416–425.
-
(2017)
Nat Genet
, vol.49
, pp. 416-425
-
-
Wain, L.V.1
Shrine, N.2
Artigas, M.S.3
Erzurumluoglu, A.M.4
Noyvert, B.5
Bossini-Castillo, L.6
-
9
-
-
85021733485
-
Genetic association and risk scores in a chronic obstructive pulmonary disease meta-analysis of 16,707 subjects
-
Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points; International COPD Genetics Network
-
Busch R, Hobbs BD, Zhou J, Castaldi PJ, McGeachie MJ, Hardin ME, et al.; National Emphysema Treatment Trial Genetics; Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points; International COPD Genetics Network; COPDGene Investigators. Genetic association and risk scores in a chronic obstructive pulmonary disease meta-analysis of 16,707 subjects. Am J Respir Cell Mol Biol 2017;57:35–46.
-
(2017)
Am J Respir Cell Mol Biol
, vol.57
, pp. 35-46
-
-
Busch, R.1
Hobbs, B.D.2
Zhou, J.3
Castaldi, P.J.4
McGeachie, M.J.5
Hardin, M.E.6
-
10
-
-
85011649918
-
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
-
Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, et al.; COPDGene Investigators; ECLIPSE Investigators; LifeLines Investigators; SPIROMICS Research Group; International COPD Genetics Network Investigators; UK BiLEVE Investigators; International COPD Genetics Consortium. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet 2017;49:426–432.
-
(2017)
Nat Genet
, vol.49
, pp. 426-432
-
-
Hobbs, B.D.1
De Jong, K.2
Lamontagne, M.3
Bossé, Y.4
Shrine, N.5
Artigas, M.S.6
-
11
-
-
84886403801
-
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers
-
Zhou JJ, Cho MH, Castaldi PJ, Hersh CP, Silverman EK, Laird NM. Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med 2013;188: 941–947.
-
(2013)
Am J Respir Crit Care Med
, vol.188
, pp. 941-947
-
-
Zhou, J.J.1
Cho, M.H.2
Castaldi, P.J.3
Hersh, C.P.4
Silverman, E.K.5
Laird, N.M.6
-
12
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, et al. Finding the missing heritability of complex diseases. Nature 2009;461:747–753.
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.A.5
Hunter, D.J.6
-
14
-
-
26244453991
-
A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease
-
Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, et al. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2005;33:355–362.
-
(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 355-362
-
-
Kelleher, C.M.1
Silverman, E.K.2
Broekelmann, T.3
Litonjua, A.A.4
Hernandez, M.5
Sylvia, J.S.6
-
15
-
-
84919734488
-
A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD
-
Brandsma CA, van den Berge M, Postma DS, Jonker MR, Brouwer S, Paré PD, et al. A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD. Thorax 2015;70: 21–32.
-
(2015)
Thorax
, vol.70
, pp. 21-32
-
-
Brandsma, C.A.1
Van Den Berge, M.2
Postma, D.S.3
Jonker, M.R.4
Brouwer, S.5
Paré, P.D.6
-
16
-
-
84961291345
-
Telomerase mutations in smokers with severe emphysema
-
Stanley SE, Chen JJL, Podlevsky JD, Alder JK, Hansel NN, Mathias RA, et al. Telomerase mutations in smokers with severe emphysema. J Clin Invest 2015;125:563–570.
-
(2015)
J Clin Invest
, vol.125
, pp. 563-570
-
-
Stanley, S.E.1
Chen, J.J.L.2
Podlevsky, J.D.3
Alder, J.K.4
Hansel, N.N.5
Mathias, R.A.6
-
17
-
-
84928528797
-
Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants
-
Belkadi A, Bolze A, Itan Y, Cobat A, Vincent QB, Antipenko A, et al. Whole-genome sequencing is more powerful than whole-exome sequencing for detecting exome variants. Proc Natl Acad Sci USA 2015;112:5473–5478.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 5473-5478
-
-
Belkadi, A.1
Bolze, A.2
Itan, Y.3
Cobat, A.4
Vincent, Q.B.5
Antipenko, A.6
-
18
-
-
84943171338
-
A global reference for human genetic variation
-
The 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 2015;526:68–74.
-
(2015)
Nature
, vol.526
, pp. 68-74
-
-
-
19
-
-
84983479616
-
A reference panel of 64,976 haplotypes for genotype imputation
-
McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, et al.; Haplotype Reference Consortium. A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet 2016;48:1279–1283.
-
(2016)
Nat Genet
, vol.48
, pp. 1279-1283
-
-
McCarthy, S.1
Das, S.2
Kretzschmar, W.3
Delaneau, O.4
Wood, A.R.5
Teumer, A.6
-
20
-
-
77949363490
-
Genetic epidemiology of COPD (COPDGene) study design
-
Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, et al.; COPDGene Investigators. Genetic epidemiology of COPD (COPDGene) study design. COPD 2010;7:32–43.
-
(2010)
COPD
, vol.7
, pp. 32-43
-
-
Regan, E.A.1
Hokanson, J.E.2
Murphy, J.R.3
Make, B.4
Lynch, D.A.5
Beaty, T.H.6
-
21
-
-
84966320549
-
Utilizing the Jaccard index to reveal population stratification in sequencing data: A simulation study and an application to the 1000 Genomes Project
-
Prokopenko D, Hecker J, Silverman EK, Pagano M, Nöthen MM, Dina C, et al. Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project. Bioinformatics 2016;32: 1366–1372.
-
(2016)
Bioinformatics
, vol.32
, pp. 1366-1372
-
-
Prokopenko, D.1
Hecker, J.2
Silverman, E.K.3
Pagano, M.4
Nöthen, M.M.5
Dina, C.6
-
22
-
-
85056125473
-
-
EPACTS. Available from: https://genome.sph.umich.edu/wiki/EPACTS.
-
-
-
-
23
-
-
85016555036
-
On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows
-
Loehlein Fier H, Prokopenko D, Hecker J, Cho MH, Silverman EK, Weiss ST, et al. On the association analysis of genome-sequencing data: a spatial clustering approach for partitioning the entire genome into nonoverlapping windows. Genet Epidemiol 2017;41:332–340.
-
(2017)
Genet Epidemiol
, vol.41
, pp. 332-340
-
-
Loehlein Fier, H.1
Prokopenko, D.2
Hecker, J.3
Cho, M.H.4
Silverman, E.K.5
Weiss, S.T.6
-
24
-
-
84878878253
-
Sequence kernel association tests for the combined effect of rare and common variants
-
Ionita-Laza I, Lee S, Makarov V, Buxbaum JD, Lin X. Sequence kernel association tests for the combined effect of rare and common variants. Am J Hum Genet 2013;92:841–853.
-
(2013)
Am J Hum Genet
, vol.92
, pp. 841-853
-
-
Ionita-Laza, I.1
Lee, S.2
Makarov, V.3
Buxbaum, J.D.4
Lin, X.5
-
25
-
-
84864942403
-
Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies
-
Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, et al.; NHLBI GO Exome Sequencing Project—ESP Lung Project Team. Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet 2012;91:224–237.
-
(2012)
Am J Hum Genet
, vol.91
, pp. 224-237
-
-
Lee, S.1
Emond, M.J.2
Bamshad, M.J.3
Barnes, K.C.4
Rieder, M.J.5
Nickerson, D.A.6
-
26
-
-
85052936105
-
FastSKAT: Sequence kernel association tests for very large sets of markers
-
online ahead of print 22 Jun
-
Lumley T, Brody J, Peloso G, Morrison A, Rice K. FastSKAT: sequence kernel association tests for very large sets of markers. Genet Epidemiol [online ahead of print] 22 Jun 2018; DOI: 10.1002/ gepi.22136.
-
(2018)
Genet Epidemiol
-
-
Lumley, T.1
Brody, J.2
Peloso, G.3
Morrison, A.4
Rice, K.5
-
27
-
-
84884642095
-
Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels
-
Thun GA, Imboden M, Ferrarotti I, Kumar A, Obeidat M, Zorzetto M, et al. Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet 2013; 9:e1003585.
-
(2013)
PLoS Genet
, vol.9
, pp. e1003585
-
-
Thun, G.A.1
Imboden, M.2
Ferrarotti, I.3
Kumar, A.4
Obeidat, M.5
Zorzetto, M.6
-
28
-
-
0036840537
-
Multi-Ethnic Study of Atherosclerosis: Objectives and design
-
Bild DE, Bluemke DA, Burke GL, Detrano R, Diez Roux AV, Folsom AR, et al. Multi-Ethnic Study of Atherosclerosis: objectives and design. Am J Epidemiol 2002;156:871–881.
-
(2002)
Am J Epidemiol
, vol.156
, pp. 871-881
-
-
Bild, D.E.1
Bluemke, D.A.2
Burke, G.L.3
Detrano, R.4
Diez Roux, A.V.5
Folsom, A.R.6
-
29
-
-
77949528328
-
The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: A cross-sectional study
-
Rodriguez J, Jiang R, Johnson WC, MacKenzie BA, Smith LJ, Barr RG. The association of pipe and cigar use with cotinine levels, lung function, and airflow obstruction: a cross-sectional study. Ann Intern Med 2010;152:201–210.
-
(2010)
Ann Intern Med
, vol.152
, pp. 201-210
-
-
Rodriguez, J.1
Jiang, R.2
Johnson, W.C.3
MacKenzie, B.A.4
Smith, L.J.5
Barr, R.G.6
-
30
-
-
84863279822
-
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP
-
Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, et al. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet 2012;21: 1325–1335.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 1325-1335
-
-
Zhou, X.1
Baron, R.M.2
Hardin, M.3
Cho, M.H.4
Zielinski, J.5
Hawrylkiewicz, I.6
-
31
-
-
46149098096
-
Long-range LD can confound genome scans in admixed populations
-
author reply 135–139
-
Price AL, Weale ME, Patterson N, Myers SR, Need AC, Shianna KV, et al. Long-range LD can confound genome scans in admixed populations. Am J Hum Genet 2008;83:132–135; author reply 135–139.
-
(2008)
Am J Hum Genet
, vol.83
, pp. 132-135
-
-
Price, A.L.1
Weale, M.E.2
Patterson, N.3
Myers, S.R.4
Need, A.C.5
Shianna, K.V.6
-
32
-
-
85028882963
-
Rare coding variants pinpoint genes that control human hematological traits
-
Mousas A, Ntritsos G, Chen MH, Song C, Huffman JE, Tzoulaki I, et al. Rare coding variants pinpoint genes that control human hematological traits. PLoS Genet 2017;13:e1006925.
-
(2017)
PLoS Genet
, vol.13
, pp. e1006925
-
-
Mousas, A.1
Ntritsos, G.2
Chen, M.H.3
Song, C.4
Huffman, J.E.5
Tzoulaki, I.6
-
33
-
-
77956534324
-
ANNOVAR: Functional annotation of genetic variants from high-throughput sequencing data
-
Wang K, Li M, Hakonarson H. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 2010;38:e164.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. e164
-
-
Wang, K.1
Li, M.2
Hakonarson, H.3
-
34
-
-
85025176301
-
Extreme trait whole-genome sequencing identifies PTPRO as a novel candidate gene in emphysema with severe airflow obstruction
-
Radder JE, Zhang Y, Gregory AD, Yu S, Kelly NJ, Leader JK, et al. Extreme trait whole-genome sequencing identifies PTPRO as a novel candidate gene in emphysema with severe airflow obstruction. Am J Respir Crit Care Med 2017;196:159–171.
-
(2017)
Am J Respir Crit Care Med
, vol.196
, pp. 159-171
-
-
Radder, J.E.1
Zhang, Y.2
Gregory, A.D.3
Yu, S.4
Kelly, N.J.5
Leader, J.K.6
-
35
-
-
84901625706
-
Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction
-
Wain LV, Sayers I, Soler Artigas M, Portelli MA, Zeggini E, Obeidat M, et al. Whole exome re-sequencing implicates CCDC38 and cilia structure and function in resistance to smoking related airflow obstruction. PLoS Genet 2014;10: e1004314.
-
(2014)
PLoS Genet
, vol.10
, pp. e1004314
-
-
Wain, L.V.1
Sayers, I.2
Soler Artigas, M.3
Portelli, M.A.4
Zeggini, E.5
Obeidat, M.6
-
36
-
-
85010433812
-
Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls
-
UK BiLEVE
-
Artigas MS, Wain LV, Shrine N, McKeever TM, UK BiLEVE, Sayers I, Hall IP, et al. Targeted sequencing of lung function loci in chronic obstructive pulmonary disease cases and controls. PLoS One 2017; 12:e0170222.
-
(2017)
PLoS One
, vol.12
, pp. e0170222
-
-
Artigas, M.S.1
Wain, L.V.2
Shrine, N.3
McKeever, T.M.4
Sayers, I.5
Hall, I.P.6
-
37
-
-
84988909503
-
Exome sequencing analysis in severe, early-onset chronic obstructive pulmonary disease
-
Lung GO
-
Qiao D, Lange C, Beaty TH, Crapo JD, Barnes KC, Bamshad M, et al.; Lung GO; NHLBI Exome Sequencing Project; COPDGene Investigators. Exome sequencing analysis in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2016;193:1353–1363.
-
(2016)
Am J Respir Crit Care Med
, vol.193
, pp. 1353-1363
-
-
Qiao, D.1
Lange, C.2
Beaty, T.H.3
Crapo, J.D.4
Barnes, K.C.5
Bamshad, M.6
-
38
-
-
84976904305
-
ClinVar: Public archive of interpretations of clinically relevant variants
-
Landrum MJ, Lee JM, Benson M, Brown G, Chao C, Chitipiralla S, et al. ClinVar: public archive of interpretations of clinically relevant variants. Nucleic Acids Res 2016;44:D862–D868.
-
(2016)
Nucleic Acids Res
, vol.44
, pp. D862-D868
-
-
Landrum, M.J.1
Lee, J.M.2
Benson, M.3
Brown, G.4
Chao, C.5
Chitipiralla, S.6
-
39
-
-
80053414310
-
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
-
Soler Artigas M, Wain LV, Repapi E, Obeidat M, Sayers I, Burton PR, et al.; SpiroMeta Consortium. Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. Am J Respir Crit Care Med 2011;184:786–795.
-
(2011)
Am J Respir Crit Care Med
, vol.184
, pp. 786-795
-
-
Soler Artigas, M.1
Wain, L.V.2
Repapi, E.3
Obeidat, M.4
Sayers, I.5
Burton, P.R.6
-
40
-
-
84942248106
-
A genome-wide association study of emphysema and airway quantitative imaging phenotypes
-
Cho MH, Castaldi PJ, Hersh CP, Hobbs BD, Barr RG, Tal-Singer R, et al.; NETT Genetics, ECLIPSE, and COPDGene Investigators. A genome-wide association study of emphysema and airway quantitative imaging phenotypes. Am J Respir Crit Care Med 2015; 192:559–569.
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 559-569
-
-
Cho, M.H.1
Castaldi, P.J.2
Hersh, C.P.3
Hobbs, B.D.4
Barr, R.G.5
Tal-Singer, R.6
-
41
-
-
85026754123
-
Alpha-1 antitrypsin PiMZ genotype is associated with COPD in two racial groups
-
Foreman MG, Wilson C, DeMeo DL, Hersh CP, Beaty TH, Cho MH,, et al.; Genetic Epidemiology of COPD (COPDGene) Investigators. Alpha-1 antitrypsin PiMZ genotype is associated with COPD in two racial groups. Ann Am Thorac Soc 2017;14:1280–1287.
-
(2017)
Ann Am Thorac Soc
, vol.14
, pp. 1280-1287
-
-
Foreman, M.G.1
Wilson, C.2
DeMeo, D.L.3
Hersh, C.P.4
Beaty, T.H.5
Cho, M.H.6
-
42
-
-
85007000400
-
Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations
-
Pulit SL, de With SAJ, de Bakker PIW. Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations. Genet Epidemiol 2017;41: 145–151.
-
(2017)
Genet Epidemiol
, vol.41
, pp. 145-151
-
-
Pulit, S.L.1
De With, S.A.J.2
De Bakker, P.I.W.3
|