Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

Nature Genetics

Volumn 49, Issue 3, 2017, Pages 416-425

  Wain, Louise V ^a,b   Shrine, Nick ^a   Artigas, María Soler ^a   Erzurumluoglu, A Mesut ^a   Noyvert, Boris ^a   Bossini Castillo, Lara ^c   Obeidat, Ma'En ^d   Henry, Amanda P ^e   Portelli, Michael A ^e   Hall, Robert J ^e   Billington, Charlotte K ^e   Rimington, Tracy L ^e   Fenech, Anthony G ^f   John, Catherine ^a   Blake, Tineka ^a   Jackson, Victoria E ^a   Allen, Richard J ^a   Prins, Bram P ^c,g   Campbell, Archie ^h   Porteous, David J ^h   Jarvelin, Marjo Riitta ^i,j,k,l   Wielscher, Matthias ⁱ   James, Alan L ^m,n   Hui, Jennie ^m,o   Wareham, Nicholas J ^p   Zhao, Jing Hua ^p   Wilson, James F ^q,r   Joshi, Peter K ^q   Stubbe, Beate ^s   Rawal, Rajesh ^t   Schulz, Holger ^t,u   Imboden, Medea ^v,w   Probst Hensch, Nicole M ^v,w   Karrasch, Stefan ^t,x   Gieger, Christian ^t   Deary, Ian J ^h   Harris, Sarah E ^h   Marten, Jonathan ^r   Rudan, Igor ^q   Enroth, Stefan ^y   Gyllensten, Ulf ^y   Kerr, Shona M ^r   Polasek, Ozren ^q,z   Kähönen, Mika ^aa   Surakka, Ida ^ab,ac   Vitart, Veronique ^r   Hayward, Caroline ^r   Lehtimäki, Terho ^aa   Raitakari, Olli T ^ad,ae   Evans, David M ^af,ag   Henderson, A John ^ag   Pennell, Craig E ^ah   Wang, Carol A ^ah   Sly, Peter D ^af   Wan, Emily S ^ai   Busch, Robert ^ai   Hobbs, Brian D ^ai   Litonjua, Augusto A ^ai   Sparrow, David W ^aj,ak   Gulsvik, Amund ^al   Bakke, Per S ^al   Crapo, James D ^am   Beaty, Terri H ^an   Hansel, Nadia N ^ao   Mathias, Rasika A ^ao   Ruczinski, Ingo ^an   Barnes, Kathleen C ^ap   Bossé, Yohan ^aq,ar   Joubert, Philippe ^aq,ar   Van Den Berge, Maarten ^as   Brandsma, Corry Anke ^as   Paré, Peter D ^d,at   Sin, Don D ^d,at   Nickle, David C ^au   Hao, Ke ^av   Gottesman, Omri ^aw   Dewey, Frederick E ^aw   Bruse, Shannon E ^aw   Carey, David J ^ax   Kirchner, H Lester ^ax   Jonsson, Stefan ^ay   Thorleifsson, Gudmar ^ay   Jonsdottir, Ingileif ^ay,az   Gislason, Thorarinn ^az,ba   Stefansson, Kari ^ay,az   Schurmann, Claudia ^av   Nadkarni, Girish ^av   Bottinger, Erwin P ^av   Loos, Ruth J F ^av   Walters, Robin G ^bb   Chen, Zhengming ^bb   Millwood, Iona Y ^bb,bc   Vaucher, Julien ^bb   Kurmi, Om P ^bb   Li, Liming ^bd,be   Hansell, Anna L ^i,bf   Brightling, Chris ^a,b   Zeggini, Eleftheria ^c   Cho, Michael H ^ai   Silverman, Edwin K ^ai   Sayers, Ian ^e   Trynka, Gosia ^c   Morris, Andrew P ^bg   Strachan, David P ^bh   Hall, Ian P ^e   Tobin, Martin D ^a,b   more..

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b GLENFIELD HOSPITAL   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research   (Canada)

^e UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^f UNIVERSITY OF MALTA   (Malta)

^g UK BIOBANK   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ IMPERIAL COLLEGE LONDON   (United Kingdom)

^j UNIVERSITY OF OULU   (Finland)

^k UNIVERSITY OF OULU   (Finland)

^l OULU UNIVERSITY HOSPITAL   (Finland)

^m SIR CHARLES GAIRDNER HOSPITAL   (Australia)

ⁿ UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^o UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^p UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^q UNIVERSITY OF EDINBURGH   (United Kingdom)

^r UNIVERSITY OF EDINBURGH   (United Kingdom)

^s UNIVERSITY MEDICINE GREIFSWALD   (Germany)

^t INSTITUTE OF EPIDEMIOLOGY   (Germany)

^u Member of the German Center for Lung Research   (Germany)

^v SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^w UNIVERSITY OF BASEL   (Switzerland)

^x LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^y UPPSALA UNIVERSITY   (Sweden)

^z UNIVERSITY OF SPLIT   (Croatia)

^aa TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^ab UNIVERSITY OF HELSINKI   (Finland)

^ac NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^ad TURKU UNIVERSITY HOSPITAL   (Finland)

^ae UNIVERSITY OF TURKU   (Finland)

^af UNIVERSITY OF QUEENSLAND   (Australia)

^ag UNIVERSITY OF BRISTOL   (United Kingdom)

^ah UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ai BRIGHAM AND WOMEN S HOSPITAL   (United States)

^aj VA BOSTON HEALTHCARE SYSTEM   (United States)

^ak BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^al UNIVERSITY OF BERGEN   (Norway)

^am DEPARTMENT OF MEDICINE   (United States)

^an JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^ao JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ap UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^aq UNIVERSITÉ LAVAL   (Canada)

^ar LAVAL UNIVERSITY   (Canada)

^as UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^at UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^au MERCK RESEARCH LABORATORIES   (United States)

^av MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^aw AB)   (United States)

^ax GEISINGER HEALTH SYSTEM   (United States)

^ay DECODE GENETICS   (Iceland)

^az UNIVERSITY OF ICELAND   (Iceland)

^ba LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^bb UNIVERSITY OF OXFORD   (United Kingdom)

^bc UNIVERSITY OF OXFORD   (United Kingdom)

^bd PEKING UNION MEDICAL COLLEGE   (China)

^be PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^bf ST MARY S HOSPITAL   (United Kingdom)

^bg UNIVERSITY OF LIVERPOOL   (United Kingdom)

^bh ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; DOXYCYCLINE; HLA DQB1 ANTIGEN; INOSITOL PHOSPHATE; MUSCARINIC M3 RECEPTOR;

ARTICLE; ASTHMA; BIOBANK; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG REPOSITIONING; ELASTIC FIBER; FOLLOW UP; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE FREQUENCY; GENE LOCUS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; LONGITUDINAL STUDY; LUNG FUNCTION; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; ADULT; AGED; ALLELE; FEMALE; GENETIC EPIGENESIS; GENETIC PREDISPOSITION; GENETICS; LUNG; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PROCEDURES; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ASTHMA; EPIGENESIS, GENETIC; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LUNG; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RISK FACTORS;

EID: 85011684926     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3787     Document Type: Article

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