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Volumn 58, Issue 2, 2019, Pages 197-205

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis

Author keywords

Bone; Cytokines and inflammatory mediators; DMARDs; Gastrointestinal; Ligaments and tendons; Skin; Spondyloarthropathies (including psoriatic arthritis); Synovium

Indexed keywords

BARICITINIB; CYTOKINE; FILGOTINIB; JANUS KINASE; JANUS KINASE INHIBITOR; PEFICITINIB; TOFACITINIB; UPADACITINIB; ANTIRHEUMATIC AGENT; STAT PROTEIN;

EID: 85055105305     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/key070     Document Type: Review
Times cited : (73)

References (72)
  • 1
    • 84878374844 scopus 로고    scopus 로고
    • Management and evaluation of extra-articular manifestations in spondyloarthritis
    • van der Horst-Bruinsma IE, Nurmohamed MT. Management and evaluation of extra-articular manifestations in spondyloarthritis. Ther Adv Musculoskelet Dis 2012;4:413-22.
    • (2012) Ther Adv Musculoskelet Dis , vol.4 , pp. 413-422
    • Van Der Horst-Bruinsma, I.E.1    Nurmohamed, M.T.2
  • 2
    • 84959912573 scopus 로고    scopus 로고
    • Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 treatment recommendations for psoriatic arthritis
    • Coates LC, Kavanaugh A, Mease PJ et al. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis 2015 treatment recommendations for psoriatic arthritis. Arthritis Rheumatol 2016;68:1060-71.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 1060-1071
    • Coates, L.C.1    Kavanaugh, A.2    Mease, P.J.3
  • 3
    • 84899878750 scopus 로고    scopus 로고
    • Is there a need for new agents with novel mechanisms of action in psoriatic arthritis?
    • Orr C, Veale DJ. Is there a need for new agents with novel mechanisms of action in psoriatic arthritis? Ann Rheum Dis 2014;73:951-3.
    • (2014) Ann Rheum Dis , vol.73 , pp. 951-953
    • Orr, C.1    Veale, D.J.2
  • 4
    • 84954556278 scopus 로고    scopus 로고
    • Therapeutic targeting of IL-17 and IL-23 cytokines in immune-mediated diseases
    • Fragoulis GE, Siebert S, McInnes IB. Therapeutic targeting of IL-17 and IL-23 cytokines in immune-mediated diseases. Annu Rev Med 2016;67:337-53.
    • (2016) Annu Rev Med , vol.67 , pp. 337-353
    • Fragoulis, G.E.1    Siebert, S.2    McInnes, I.B.3
  • 6
    • 84891365474 scopus 로고    scopus 로고
    • Jakpot! New small molecules in autoimmune and inflammatory diseases
    • Ghoreschi K, Gadina M. Jakpot! New small molecules in autoimmune and inflammatory diseases. Exp Dermatol 2014;23:7-11.
    • (2014) Exp Dermatol , vol.23 , pp. 7-11
    • Ghoreschi, K.1    Gadina, M.2
  • 7
    • 85016307327 scopus 로고    scopus 로고
    • Mechanisms and consequences of Jak-STAT signaling in the immune system
    • Villarino AV, Kanno Y, O'Shea JJ. Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat Immunol 2017;18:374-84.
    • (2017) Nat Immunol , vol.18 , pp. 374-384
    • Villarino, A.V.1    Kanno, Y.2    O'Shea, J.J.3
  • 9
    • 36048964195 scopus 로고    scopus 로고
    • Histopathologic changes at "synovio-entheseal complexes" suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritis
    • Benjamin M, McGonagle D. Histopathologic changes at "synovio-entheseal complexes" suggesting a novel mechanism for synovitis in osteoarthritis and spondylarthritis. Arthritis Rheum 2007;56:3601-9.
    • (2007) Arthritis Rheum , vol.56 , pp. 3601-3609
    • Benjamin, M.1    McGonagle, D.2
  • 10
    • 84871797995 scopus 로고    scopus 로고
    • Are spondylarthritides related but distinct conditions or a single disease with a heterogeneous phenotype?
    • Baeten D, Breban M, Lories R, Schett G, Sieper J. Are spondylarthritides related but distinct conditions or a single disease with a heterogeneous phenotype? Arthritis Rheum 2013;65:12-20.
    • (2013) Arthritis Rheum , vol.65 , pp. 12-20
    • Baeten, D.1    Breban, M.2    Lories, R.3    Schett, G.4    Sieper, J.5
  • 11
    • 84964772502 scopus 로고    scopus 로고
    • Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
    • Ellinghaus D, Jostins L, Spain SL et al. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nat Genet 2016;48:510-8.
    • (2016) Nat Genet , vol.48 , pp. 510-518
    • Ellinghaus, D.1    Jostins, L.2    Spain, S.L.3
  • 12
    • 84961202842 scopus 로고    scopus 로고
    • Melanocyte antigen triggers autoimmunity in human psoriasis
    • Arakawa A, Siewert K, Stöhr J et al. Melanocyte antigen triggers autoimmunity in human psoriasis. J Exp Med 2015;212:2203-12.
    • (2015) J Exp Med , vol.212 , pp. 2203-2212
    • Arakawa, A.1    Siewert, K.2    Stöhr, J.3
  • 13
    • 84899717815 scopus 로고    scopus 로고
    • Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
    • Menon B, Gullick NJ, Walter GJ et al. Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheumatol 2014;66:1272-81.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1272-1281
    • Menon, B.1    Gullick, N.J.2    Walter, G.J.3
  • 14
    • 84863697312 scopus 로고    scopus 로고
    • IL-23 induces spondyloarthropathy by acting on ROR-gt+ CD3+CD4-CD8- entheseal resident T cells
    • Sherlock JP, Joyce-Shaikh B, Turner SP et al. IL-23 induces spondyloarthropathy by acting on ROR-gt+ CD3+CD4-CD8- entheseal resident T cells. Nat Med 2012;18:1069-76.
    • (2012) Nat Med , vol.18 , pp. 1069-1076
    • Sherlock, J.P.1    Joyce-Shaikh, B.2    Turner, S.P.3
  • 15
    • 84891747499 scopus 로고    scopus 로고
    • Proof of concept: Enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells
    • Jacques P, Lambrecht S, Verheugen E et al. Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Ann Rheum Dis 2014;73:437-45.
    • (2014) Ann Rheum Dis , vol.73 , pp. 437-445
    • Jacques, P.1    Lambrecht, S.2    Verheugen, E.3
  • 18
    • 85003546086 scopus 로고    scopus 로고
    • Brief report: Dialister as a microbial marker of disease activity in spondyloarthritis
    • Tito RY, Cypers H, Joossens M et al. Brief report: dialister as a microbial marker of disease activity in spondyloarthritis. Arthritis Rheumatol 2017;69:114-21.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 114-121
    • Tito, R.Y.1    Cypers, H.2    Joossens, M.3
  • 20
    • 84952020166 scopus 로고    scopus 로고
    • Microbiome in inflammatory arthritis and human rheumatic diseases
    • Scher JU, Littman DR, Abramson SB. Microbiome in inflammatory arthritis and human rheumatic diseases. Arthritis Rheumatol 2016;68:35-45.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 35-45
    • Scher, J.U.1    Littman, D.R.2    Abramson, S.B.3
  • 22
    • 84976272630 scopus 로고    scopus 로고
    • NK cells and type 1 innate lymphoid cells: Partners in host defense
    • Spits H, Bernink JH, Lanier L. NK cells and type 1 innate lymphoid cells: partners in host defense. Nat Immunol 2016;17:758-64.
    • (2016) Nat Immunol , vol.17 , pp. 758-764
    • Spits, H.1    Bernink, J.H.2    Lanier, L.3
  • 23
    • 9644291539 scopus 로고    scopus 로고
    • IL-12 and IL-23: Master regulators of innate and adaptive immunity
    • Langrish CL, McKenzie BS, Wilson NJ et al. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 2004;202:96-105.
    • (2004) Immunol Rev , vol.202 , pp. 96-105
    • Langrish, C.L.1    McKenzie, B.S.2    Wilson, N.J.3
  • 24
    • 84896285523 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in spondyloarthritis pathogenesis: Th17 and beyond
    • Smith JA, Colbert RA. The IL-23/IL-17 axis in spondyloarthritis pathogenesis: Th17 and beyond. Arthritis Rheumatol 2014;66:231-41.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 231-241
    • Smith, J.A.1    Colbert, R.A.2
  • 25
    • 84934900296 scopus 로고    scopus 로고
    • Sarilumab for the treatment of ankylosing spondylitis: Results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)
    • Sieper J, Braun J, Kay J et al. Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN). Ann Rheum Dis 2015;74:1051-7.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1051-1057
    • Sieper, J.1    Braun, J.2    Kay, J.3
  • 26
    • 84963967684 scopus 로고    scopus 로고
    • Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: A randomized phase 2 study
    • Krueger J, Clark JD, Suárez-Farinãs M et al. Tofacitinib attenuates pathologic immune pathways in patients with psoriasis: a randomized phase 2 study. J Allergy Clin Immunol 2016;137:1079-90.
    • (2016) J Allergy Clin Immunol , vol.137 , pp. 1079-1090
    • Krueger, J.1    Clark, J.D.2    Suárez-Farinãs, M.3
  • 27
    • 84954402415 scopus 로고    scopus 로고
    • Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors
    • Gao W, McGarry T, Orr C et al. Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors. Ann Rheum Dis 2016;75:311-5.
    • (2016) Ann Rheum Dis , vol.75 , pp. 311-315
    • Gao, W.1    McGarry, T.2    Orr, C.3
  • 28
    • 84948720053 scopus 로고    scopus 로고
    • Bone remodeling in psoriasis and psoriatic arthritis: An update
    • Paine A, Ritchlin C. Bone remodeling in psoriasis and psoriatic arthritis: an update. Curr Opin Rheumatol 2016;28:66-75.
    • (2016) Curr Opin Rheumatol , vol.28 , pp. 66-75
    • Paine, A.1    Ritchlin, C.2
  • 29
    • 84860583631 scopus 로고    scopus 로고
    • Insights into the pathophysiology of ankylosing spondylitis: Contributions from animal models
    • Braem K, Lories RJ. Insights into the pathophysiology of ankylosing spondylitis: contributions from animal models. Joint Bone Spine 2012;79:243-8.
    • (2012) Joint Bone Spine , vol.79 , pp. 243-248
    • Braem, K.1    Lories, R.J.2
  • 30
    • 0025633436 scopus 로고
    • Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: An animal model of HLA-B27-associated human disorders
    • Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 1990;63:1099-112.
    • (1990) Cell , vol.63 , pp. 1099-1112
    • Hammer, R.E.1    Maika, S.D.2    Richardson, J.A.3    Tang, J.P.4    Taurog, J.D.5
  • 31
    • 79951900615 scopus 로고    scopus 로고
    • Evidence for the prevention of enthesitis in HLA-B27/hβ(2)m transgenic rats treated with a monoclonal antibody against TNF-α
    • Milia AF, Ibba-Manneschi L, Manetti M et al. Evidence for the prevention of enthesitis in HLA-B27/hβ(2)m transgenic rats treated with a monoclonal antibody against TNF-α. J Cell Mol Med 2011;15:270-9.
    • (2011) J Cell Mol Med , vol.15 , pp. 270-279
    • Milia, A.F.1    Ibba-Manneschi, L.2    Manetti, M.3
  • 32
    • 84962819587 scopus 로고    scopus 로고
    • Anti-IL- 17A treatment blocks inflammation, destruction and new bone formation in experimental spondyloarthritis in HLA-B27 transgenic rats
    • 20 March 2018, date last accessed
    • van Tok M, van Duivenvoorde LM, Kramer I et al. Anti-IL- 17A treatment blocks inflammation, destruction and new bone formation in experimental spondyloarthritis in HLA-B27 transgenic rats. Arthritis Rheumatol 2015;67 (suppl 10). http://acrabstracts.org/abstract/anti-il-17atreatment- blocks-inflammation-destruction-and-newbone- formation-in-experimental-spondyloarthritis-in-hlab27- transgenic-rats/ (20 March 2018, date last accessed).
    • (2015) Arthritis Rheumatol , pp. 67
    • Van Tok, M.1    Van Duivenvoorde, L.M.2    Kramer, I.3
  • 33
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999;10:387-98.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 34
    • 84858664948 scopus 로고    scopus 로고
    • β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice
    • Ruutu M, Thomas G, Steck R et al. β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis Rheum 2012;64:2211-22.
    • (2012) Arthritis Rheum , vol.64 , pp. 2211-2222
    • Ruutu, M.1    Thomas, G.2    Steck, R.3
  • 35
    • 84988844036 scopus 로고    scopus 로고
    • Interleukin- 23-dependent g/d T cells produce interleukin-17 and accumulate in the enthesis, aortic valve, and ciliary body in mice
    • Reinhardt A, Yevsa T, Worbs T et al. Interleukin- 23-dependent g/d T cells produce interleukin-17 and accumulate in the enthesis, aortic valve, and ciliary body in mice. Arthritis Rheumatol 2016;68:2476-86.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 2476-2486
    • Reinhardt, A.1    Yevsa, T.2    Worbs, T.3
  • 36
    • 84983535347 scopus 로고    scopus 로고
    • A20 inhibition of STAT1 expression in myeloid cells: A novel endogenous regulatory mechanism preventing development of enthesitis
    • De Wilde K, Martens A, Lambrecht S et al. A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis. Ann Rheum Dis 2017;76:585-92.
    • (2017) Ann Rheum Dis , vol.76 , pp. 585-592
    • De Wilde, K.1    Martens, A.2    Lambrecht, S.3
  • 37
    • 84897019848 scopus 로고    scopus 로고
    • Combination of tumor necrosis factor a and interleukin-6 induces mouse osteoclast- Like cells with bone resorption activity both in vitro and in vivo
    • Yokota K, Sato K, Miyazaki T et al. Combination of tumor necrosis factor a and interleukin-6 induces mouse osteoclast- like cells with bone resorption activity both in vitro and in vivo. Arthritis Rheumatol 2014;66:121-9.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 121-129
    • Yokota, K.1    Sato, K.2    Miyazaki, T.3
  • 38
    • 75749101014 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 and dexamethasone synergistically increase alkaline phosphatase levels through JAK/STAT signaling in C3H10T1/2 cells
    • Mikami Y, Asano M, Honda MJ, Takagi M. Bone morphogenetic protein 2 and dexamethasone synergistically increase alkaline phosphatase levels through JAK/STAT signaling in C3H10T1/2 cells. J Cell Physiol 2010;223:123-33.
    • (2010) J Cell Physiol , vol.223 , pp. 123-133
    • Mikami, Y.1    Asano, M.2    Honda, M.J.3    Takagi, M.4
  • 39
    • 77955375143 scopus 로고    scopus 로고
    • Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
    • Meyer DM, Jesson MI, Li X et al. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond) 2010;7:41.
    • (2010) J Inflamm (Lond) , vol.7 , pp. 41
    • Meyer, D.M.1    Jesson, M.I.2    Li, X.3
  • 40
    • 84896110513 scopus 로고    scopus 로고
    • The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a Janus kinase inhibitor, in humans
    • Dowty ME, Lin J, Ryder TF et al. The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a Janus kinase inhibitor, in humans. Drug Metab Dispos 2014;42:759-73.
    • (2014) Drug Metab Dispos , vol.42 , pp. 759-773
    • Dowty, M.E.1    Lin, J.2    Ryder, T.F.3
  • 41
    • 84963905058 scopus 로고    scopus 로고
    • The mechanism of action of tofacitinib - An oral Janus kinase inhibitor for the treatment of rheumatoid arthritis
    • Hodge JA, Kawabata TT, Krishnaswami S et al. The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. Clin Exp Rheumatol 2016;34:318-28.
    • (2016) Clin Exp Rheumatol , vol.34 , pp. 318-328
    • Hodge, J.A.1    Kawabata, T.T.2    Krishnaswami, S.3
  • 42
    • 85031767309 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo for psoriatic arthritis
    • Mease P, Hall S, Fitzgerald O et al. Tofacitinib or adalimumab versus placebo for psoriatic arthritis. N Engl J Med 2017;377:1537-50.
    • (2017) N Engl J Med , vol.377 , pp. 1537-1550
    • Mease, P.1    Hall, S.2    Fitzgerald, O.3
  • 43
    • 85031800565 scopus 로고    scopus 로고
    • Tofacitinib for psoriatic arthritis in patients with an inadequate response to TNF inhibitors
    • Gladman D, Rigby W, Azevedo VF et al. Tofacitinib for psoriatic arthritis in patients with an inadequate response to TNF inhibitors. N Engl J Med 2017;377:1525-36.
    • (2017) N Engl J Med , vol.377 , pp. 1525-1536
    • Gladman, D.1    Rigby, W.2    Azevedo, V.F.3
  • 44
    • 85011343425 scopus 로고    scopus 로고
    • Tofacitinib in patients with ankylosing spondylitis: A phase II, 16-week, randomised, placebo-controlled, dose-ranging study
    • van der Heijde D, Deodhar A, Wei JC et al. Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study. Ann Rheum Dis 2017;76:1340-7.
    • (2017) Ann Rheum Dis , vol.76 , pp. 1340-1347
    • Van Der Heijde, D.1    Deodhar, A.2    Wei, J.C.3
  • 46
    • 84956881232 scopus 로고    scopus 로고
    • JAK inhibition using tofacitinib for inflammatory bowel disease treatment: A hub for multiple inflammatory cytokines
    • Danese S, Grisham MB, Hodge J, Telliez JB. JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines. Am J Physiol Gastrointest Liver Physiol 2016;310:G155-62.
    • (2016) Am J Physiol Gastrointest Liver Physiol , vol.310 , pp. G155-G162
    • Danese, S.1    Grisham, M.B.2    Hodge, J.3    Telliez, J.B.4
  • 47
    • 85019133160 scopus 로고    scopus 로고
    • Tofacitinib as induction and maintenance therapy for ulcerative colitis
    • Sandborn WJ, Su C, Sands BE et al. Tofacitinib as induction and maintenance therapy for ulcerative colitis. N Engl J Med 2017;376:1723-36.
    • (2017) N Engl J Med , vol.376 , pp. 1723-1736
    • Sandborn, W.J.1    Su, C.2    Sands, B.E.3
  • 48
    • 85019469954 scopus 로고    scopus 로고
    • Tofacitinib for induction and maintenance therapy of Crohn's disease: Results of two phase IIb randomised placebo-controlled trials
    • Panés J, Sandborn WJ, Schreiber S et al. Tofacitinib for induction and maintenance therapy of Crohn's disease: results of two phase IIb randomised placebo-controlled trials. Gut 2017;66:1049-59.
    • (2017) Gut , vol.66 , pp. 1049-1059
    • Panés, J.1    Sandborn, W.J.2    Schreiber, S.3
  • 49
    • 85011698236 scopus 로고    scopus 로고
    • Filgotinib, a selective JAK1 inhibitor, induces clinical remission in patients with moderate-to-severe Crohn's disease: Interim analysis from the Phase 2 FITZROY study
    • Vermeire S, Schreiber S, Petryka R et al. Filgotinib, a selective JAK1 inhibitor, induces clinical remission in patients with moderate-to-severe Crohn's disease: interim analysis from the Phase 2 FITZROY study. J Crohns Colitis 2016;10:S15.
    • (2016) J Crohns Colitis , vol.10 , pp. S15
    • Vermeire, S.1    Schreiber, S.2    Petryka, R.3
  • 50
    • 79958774972 scopus 로고    scopus 로고
    • Defective innate immunity in inflammatory bowel disease: A Crohn's disease exclusivity?
    • Marks DJ. Defective innate immunity in inflammatory bowel disease: a Crohn's disease exclusivity? Curr Opin Gastroenterol 2011;27:328-34.
    • (2011) Curr Opin Gastroenterol , vol.27 , pp. 328-334
    • Marks, D.J.1
  • 51
    • 84938975662 scopus 로고    scopus 로고
    • Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: A phase 3 randomised noninferiority trial
    • Bachelez H, van de Kerkof PC, Strohal R et al. Tofacitinib versus etanercept or placebo in moderate-to-severe chronic plaque psoriasis: a phase 3 randomised noninferiority trial. Lancet 2015;386:552-61.
    • (2015) Lancet , vol.386 , pp. 552-561
    • Bachelez, H.1    Van De Kerkof, P.C.2    Strohal, R.3
  • 52
    • 84929133732 scopus 로고    scopus 로고
    • Tofacitinib withdrawal and retreatment in moderate-to-severe chronic plaque psoriasis: A randomized controlled trial
    • Bissonnette R, Iversen L, Sofen H et al. Tofacitinib withdrawal and retreatment in moderate-to-severe chronic plaque psoriasis: a randomized controlled trial. Br J Dermatol 2015;172:1395-406.
    • (2015) Br J Dermatol , vol.172 , pp. 1395-1406
    • Bissonnette, R.1    Iversen, L.2    Sofen, H.3
  • 53
    • 84963992731 scopus 로고    scopus 로고
    • Two Phase 3 studies of oral tofacitinib in patients with moderate to severe plaque psoriasis: 16-week efficacy and safety results
    • Papp KA, Menter A, Abe M et al. Two Phase 3 studies of oral tofacitinib in patients with moderate to severe plaque psoriasis: 16-week efficacy and safety results. J Am Acad Dermatol 2015;72 (Suppl 1):AB66.
    • (2015) J Am Acad Dermatol , vol.72 , pp. AB66
    • Papp, K.A.1    Menter, A.2    Abe, M.3
  • 54
    • 84879988459 scopus 로고    scopus 로고
    • A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis
    • Ports WC, Khan S, Lan S et al. A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis. Br J Dermatol 2013;169:137-45.
    • (2013) Br J Dermatol , vol.169 , pp. 137-145
    • Ports, W.C.1    Khan, S.2    Lan, S.3
  • 55
    • 84989344281 scopus 로고    scopus 로고
    • Topical tofacitinib for atopic dermatitis: A phase IIa randomized trial
    • Bissonnette R, Papp KA, Poulin Y et al. Topical tofacitinib for atopic dermatitis: a phase IIa randomized trial. Br J Dermatol 2016;175:902-11.
    • (2016) Br J Dermatol , vol.175 , pp. 902-911
    • Bissonnette, R.1    Papp, K.A.2    Poulin, Y.3
  • 56
    • 84975106324 scopus 로고    scopus 로고
    • A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis
    • Papp KA, Menter MA, Raman M et al. A randomized phase 2b trial of baricitinib, an oral Janus kinase (JAK) 1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis. Br J Dermatol 2016;174:1266-76.
    • (2016) Br J Dermatol , vol.174 , pp. 1266-1276
    • Papp, K.A.1    Menter, M.A.2    Raman, M.3
  • 57
    • 84863304245 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550), a Janus kinase inhibitor for dry eye disease: Results from a Phase 1/2 trial
    • Liew SH, Nichols KK, Klamerus KJ et al. Tofacitinib (CP-690, 550), a Janus kinase inhibitor for dry eye disease: results from a Phase 1/2 trial. Ophthalmology 2012;119:1328-35.
    • (2012) Ophthalmology , vol.119 , pp. 1328-1335
    • Liew, S.H.1    Nichols, K.K.2    Klamerus, K.J.3
  • 59
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
    • Burmester GR, Blanco R, Charles-Schoeman C et al. Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet 2013;381:451-60.
    • (2013) Lancet , vol.381 , pp. 451-460
    • Burmester, G.R.1    Blanco, R.2    Charles-Schoeman, C.3
  • 60
    • 84864716411 scopus 로고    scopus 로고
    • Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis
    • Fleischmann R, Kremer J, Cush J et al. Placebo-controlled trial of tofacitinib monotherapy in rheumatoid arthritis. N Engl J Med 2012;367:495-507.
    • (2012) N Engl J Med , vol.367 , pp. 495-507
    • Fleischmann, R.1    Kremer, J.2    Cush, J.3
  • 61
    • 84882266430 scopus 로고    scopus 로고
    • Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial
    • Kremer J, Li Z-G, Hall S et al. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial. Ann Intern Med 2013;159:253-61.
    • (2013) Ann Intern Med , vol.159 , pp. 253-261
    • Kremer, J.1    Li, Z.-G.2    Hall, S.3
  • 62
    • 84902593564 scopus 로고    scopus 로고
    • Tofacitinib versus methotrexate in rheumatoid arthritis
    • Lee EB, Fleischmann R, Hall S et al. Tofacitinib versus methotrexate in rheumatoid arthritis. N Engl J Med 2014;370:2377-86.
    • (2014) N Engl J Med , vol.370 , pp. 2377-2386
    • Lee, E.B.1    Fleischmann, R.2    Hall, S.3
  • 63
    • 84874402383 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study
    • van der Heijde D, Tanaka Y, Fleischmann R et al. Tofacitinib (CP-690, 550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum 2013;65:559-70.
    • (2013) Arthritis Rheum , vol.65 , pp. 559-570
    • Van Der Heijde, D.1    Tanaka, Y.2    Fleischmann, R.3
  • 64
    • 84864703156 scopus 로고    scopus 로고
    • Tofacitinib or adalimumab versus placebo in rheumatoid arthritis
    • van Vollenhoven RF, Fleischmann R, Cohen S et al. Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. N Engl J Med 2012;367:508-19.
    • (2012) N Engl J Med , vol.367 , pp. 508-519
    • Van Vollenhoven, R.F.1    Fleischmann, R.2    Cohen, S.3
  • 65
    • 84899705410 scopus 로고    scopus 로고
    • Safety and efficacy of tofacitinib, an oral Janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies
    • Wollenhaupt J, Silverfield J, Lee EB et al. Safety and efficacy of tofacitinib, an oral Janus kinase inhibitor, for the treatment of rheumatoid arthritis in open-label, longterm extension studies. J Rheumatol 2014;41:837-52.
    • (2014) J Rheumatol , vol.41 , pp. 837-852
    • Wollenhaupt, J.1    Silverfield, J.2    Lee, E.B.3
  • 66
    • 84962375370 scopus 로고    scopus 로고
    • Baricitinib in patients with refractory rheumatoid arthritis
    • Genovese MC, Kremer J, Zamani O et al. Baricitinib in patients with refractory rheumatoid arthritis. N Engl J Med 2016;374:1243-52.
    • (2016) N Engl J Med , vol.374 , pp. 1243-1252
    • Genovese, M.C.1    Kremer, J.2    Zamani, O.3
  • 67
    • 84997824455 scopus 로고    scopus 로고
    • A Phase IIb study of ABT-494, a selective JAK-1 inhibitor, in patients with rheumatoid arthritis and an inadequate response to antitumor necrosis factor therapy
    • Kremer JM, Emery P, Camp HS et al. A Phase IIb study of ABT-494, a selective JAK-1 inhibitor, in patients with rheumatoid arthritis and an inadequate response to antitumor necrosis factor therapy. Arthritis Rheumatol 2016;68:2867-77.
    • (2016) Arthritis Rheumatol , vol.68 , pp. 2867-2877
    • Kremer, J.M.1    Emery, P.2    Camp, H.S.3
  • 68
    • 84937967474 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacokinetic/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of Phase IIb dose selection
    • Namour F, Diderichsen PM, Cox E et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic modeling of filgotinib (GLPG0634), a selective JAK1 inhibitor, in support of Phase IIb dose selection. Clin Pharmacokinet 2015;54:859-74.
    • (2015) Clin Pharmacokinet , vol.54 , pp. 859-874
    • Namour, F.1    Diderichsen, P.M.2    Cox, E.3
  • 69
    • 85016429607 scopus 로고    scopus 로고
    • Peficitinib, a JAK inhibitor, in the treatment of moderate-to-severe rheumatoid arthritis in patients with an inadequate response to methotrexate
    • Kivitz AJ, Gutierrez-Urenã SR, Poiley J et al. Peficitinib, a JAK inhibitor, in the treatment of moderate-to-severe rheumatoid arthritis in patients with an inadequate response to methotrexate. Arthritis Rheumatol 2017;69:709-19.
    • (2017) Arthritis Rheumatol , vol.69 , pp. 709-719
    • Kivitz, A.J.1    Gutierrez-Urenã, S.R.2    Poiley, J.3
  • 70
    • 79955027327 scopus 로고    scopus 로고
    • Modulation of innate and adaptive immune responses by tofacitinib (CP-690, 550)
    • Ghoreschi K, Jesson MI, Li X et al. Modulation of innate and adaptive immune responses by tofacitinib (CP-690, 550). J Immunol 2011;186:4234-43.
    • (2011) J Immunol , vol.186 , pp. 4234-4243
    • Ghoreschi, K.1    Jesson, M.I.2    Li, X.3
  • 71
    • 84963972425 scopus 로고    scopus 로고
    • Lack of differentiation of Janus kinase inhibitors in rheumatoid arthritis based on Janus kinase pharmacology and clinically meaningful concentrations
    • Dowty M, Lin T, Wang L et al. Lack of differentiation of Janus kinase inhibitors in rheumatoid arthritis based on Janus kinase pharmacology and clinically meaningful concentrations. Ann Rheum Dis 2014;73 (Suppl 2):116.
    • (2014) Ann Rheum Dis , vol.73 , pp. 116
    • Dowty, M.1    Lin, T.2    Wang, L.3
  • 72
    • 84946232656 scopus 로고    scopus 로고
    • Tofacitinib, an oral Janus kinase inhibitor, in the treatment of rheumatoid arthritis: Safety and clinical and radiographic efficacy in open-label, long-term extension studies over 7 years
    • abstract
    • Wollenhaupt J, Silverfield J, Lee EB et al. Tofacitinib, an oral Janus kinase inhibitor, in the treatment of rheumatoid arthritis: safety and clinical and radiographic efficacy in open-label, long-term extension studies over 7 years. Arthritis Rheumatol 2015;67:1645 (abstract).
    • (2015) Arthritis Rheumatol , vol.67 , pp. 1645
    • Wollenhaupt, J.1    Silverfield, J.2    Lee, E.B.3


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