메뉴 건너뛰기




Volumn 27, Issue 4, 2011, Pages 328-334

Defective innate immunity in inflammatory bowel disease: A Crohn's disease exclusivity?

Author keywords

autophagy; Crohn's disease; immunodeficiency; neutrophil; ulcerative colitis

Indexed keywords

ANTIINFECTIVE AGENT; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; DEFENSIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

EID: 79958774972     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e3283463b45     Document Type: Review
Times cited : (45)

References (55)
  • 1
    • 70349756909 scopus 로고    scopus 로고
    • The immunopathogenesis of Crohn's disease: A three-stage model
    • Sewell GW, Marks DJ, Segal AW. The immunopathogenesis of Crohn's disease: a three-stage model. Curr Opin Immunol 2009; 21:506-513.
    • (2009) Curr Opin Immunol , vol.21 , pp. 506-513
    • Sewell, G.W.1    Marks, D.J.2    Segal, A.W.3
  • 3
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • This report demonstrates impaired bacterial clearance in vivo in Crohn's patients and localizes the defect in macrophage cytokine secretion to premature trafficking of proteins to the lysosomal compartment
    • Smith AM, Rahman FZ, Hayee B, et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med 2009; 206:1883-1897. This report demonstrates impaired bacterial clearance in vivo in Crohn's patients and localizes the defect in macrophage cytokine secretion to premature trafficking of proteins to the lysosomal compartment.
    • (2009) J Exp Med , vol.206 , pp. 1883-1897
    • Smith, A.M.1    Rahman, F.Z.2    Hayee, B.3
  • 4
    • 69549121823 scopus 로고    scopus 로고
    • Revisiting Crohn's disease as a primary immunodeficiency of macrophages
    • Casanova JL, Abel L. Revisiting Crohn's disease as a primary immunodeficiency of macrophages. J Exp Med 2009; 206:1839-1843.
    • (2009) J Exp Med , vol.206 , pp. 1839-1843
    • Casanova, J.L.1    Abel, L.2
  • 5
    • 70449479010 scopus 로고    scopus 로고
    • Mechanisms and functional implications of intestinal barrier defects
    • Shen L, Su L, Turner JR. Mechanisms and functional implications of intestinal barrier defects. Dig Dis 2009; 27:443-449.
    • (2009) Dig Dis , vol.27 , pp. 443-449
    • Shen, L.1    Su, L.2    Turner, J.R.3
  • 6
    • 84857768770 scopus 로고    scopus 로고
    • Antimicrobial peptides in gastrointestinal inflammation
    • Jager S, Stange EF, Wehkamp J. Antimicrobial peptides in gastrointestinal inflammation. Int J Inflamm 2010; 2010:910283.
    • (2010) Int J Inflamm , vol.2010 , pp. 910283
    • Jager, S.1    Stange, E.F.2    Wehkamp, J.3
  • 7
    • 79953900371 scopus 로고    scopus 로고
    • Crohn's disease of the colon: Ultrastructural changes in submuscular interstitial cells of Cajal
    • Rumessen JJ, Vanderwinden JM, Horn T. Crohn's disease of the colon: ultrastructural changes in submuscular interstitial cells of Cajal. Cell Tissue Res 2011; 343:421-428.
    • (2011) Cell Tissue Res , vol.343 , pp. 421-428
    • Rumessen, J.J.1    Vanderwinden, J.M.2    Horn, T.3
  • 8
    • 34247189575 scopus 로고    scopus 로고
    • Relationships between the autonomic nervous system, humoral factors and immune functions in the intestine
    • DOI 10.1159/000100512
    • Kiba T. Relationships between the autonomic nervous system, humoral factors and immune functions in the intestine. Digestion 2006; 74:215-227. (Pubitemid 46622793)
    • (2006) Digestion , vol.74 , Issue.3-4 , pp. 215-227
    • Kiba, T.1
  • 9
    • 77950641148 scopus 로고    scopus 로고
    • MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function
    • Yamamoto-Furusho JK, Barnich N, Hisamatsu T, et al. MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function. Inflamm Bowel Dis 2010; 16:736-742.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 736-742
    • Yamamoto-Furusho, J.K.1    Barnich, N.2    Hisamatsu, T.3
  • 10
    • 77953633456 scopus 로고    scopus 로고
    • Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2
    • Rohrl J, Yang D, Oppenheim JJ, Hehlgans T. Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2. J Immunol 2010; 184:6688-6694.
    • (2010) J Immunol , vol.184 , pp. 6688-6694
    • Rohrl, J.1    Yang, D.2    Oppenheim, J.J.3    Hehlgans, T.4
  • 11
    • 77949471940 scopus 로고    scopus 로고
    • Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients
    • Kosovac K, Brenmoehl J, Holler E, et al. Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis 2010; 16:1311-1321.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1311-1321
    • Kosovac, K.1    Brenmoehl, J.2    Holler, E.3
  • 12
    • 79958839083 scopus 로고    scopus 로고
    • Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype
    • Epub ahead of print
    • Gutierrez A, Holler E, Zapater P, et al. Antimicrobial peptide response to blood translocation of bacterial DNA in Crohn's disease is affected by NOD2/CARD15 genotype. Inflamm Bowel Dis 2010. [Epub ahead of print]
    • (2010) Inflamm Bowel Dis
    • Gutierrez, A.1    Holler, E.2    Zapater, P.3
  • 14
    • 75749113277 scopus 로고    scopus 로고
    • Long-term antibiotic treatment for Crohn's disease: Systematic review and meta-analysis of placebo-controlled trials
    • A meta-analysis of 16 trials suggesting the benefit of antimycobacterial chemotherapy in Crohn's disease
    • Feller M, Huwiler K, Schoepfer A, et al. Long-term antibiotic treatment for Crohn's disease: systematic review and meta-analysis of placebo-controlled trials. Clin Infect Dis 2010; 50:473-480. A meta-analysis of 16 trials suggesting the benefit of antimycobacterial chemotherapy in Crohn's disease.
    • (2010) Clin Infect Dis , vol.50 , pp. 473-480
    • Feller, M.1    Huwiler, K.2    Schoepfer, A.3
  • 15
    • 74049127960 scopus 로고    scopus 로고
    • Genomewide association study of leprosy
    • Zhang FR, Huang W, Chen SM, et al. Genomewide association study of leprosy. N Engl J Med 2009; 361:2609-2618.
    • (2009) N Engl J Med , vol.361 , pp. 2609-2618
    • Zhang, F.R.1    Huang, W.2    Chen, S.M.3
  • 16
    • 77950954449 scopus 로고    scopus 로고
    • Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states
    • Berrington WR, Macdonald M, Khadge S, et al. Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J Infect Dis 2010; 201:1422-1435.
    • (2010) J Infect Dis , vol.201 , pp. 1422-1435
    • Berrington, W.R.1    Macdonald, M.2    Khadge, S.3
  • 17
    • 70349970943 scopus 로고    scopus 로고
    • Nontuberculous mycobacteria infections and antitumor necrosis factor-alpha therapy
    • Postmarketing surveillance data showing that antitumour necrosis factor therapy increases the risk of nontuberculous mycobacterial infection, particularly Mycobacterium avium species
    • Winthrop KL, Chang E, Yamashita S, et al. Nontuberculous mycobacteria infections and antitumor necrosis factor-alpha therapy. Emerg Infect Dis 2009; 15:1556-1561. Postmarketing surveillance data showing that antitumour necrosis factor therapy increases the risk of nontuberculous mycobacterial infection, particularly Mycobacterium avium species.
    • (2009) Emerg Infect Dis , vol.15 , pp. 1556-1561
    • Winthrop, K.L.1    Chang, E.2    Yamashita, S.3
  • 18
    • 77956542379 scopus 로고    scopus 로고
    • Atypical mycobacteria: Showerheads, anti-TNF therapy and Crohn's disease
    • Desai AA, Marks DJ. Atypical mycobacteria: showerheads, anti-TNF therapy and Crohn's disease. Expert Rev Clin Immunol 2010; 6:695-699.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 695-699
    • Desai, A.A.1    Marks, D.J.2
  • 19
    • 77954418713 scopus 로고    scopus 로고
    • Mycobacteria in Crohn's disease: How innate immune deficiency may result in chronic inflammation
    • A review article that synthesizes the data on mycobacteria in Crohn's disease, and discusses how these might relate to impaired innate immunity
    • Lalande JD, Behr MA. Mycobacteria in Crohn's disease: how innate immune deficiency may result in chronic inflammation. Expert Rev Clin Immunol 2010; 6:633-641. A review article that synthesizes the data on mycobacteria in Crohn's disease, and discusses how these might relate to impaired innate immunity.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 633-641
    • Lalande, J.D.1    Behr, M.A.2
  • 20
    • 77956056603 scopus 로고    scopus 로고
    • Abnormalities in the handling of intracellular bacteria in Crohn's disease
    • Lapaquette P, Darfeuille-Michaud A. Abnormalities in the handling of intracellular bacteria in Crohn's disease. J Clin Gastroenterol 2010; 44 (Suppl 1):S26-S29.
    • (2010) J Clin Gastroenterol , vol.44 , Issue.SUPPL. 1
    • Lapaquette, P.1    Darfeuille-Michaud, A.2
  • 21
    • 79958864017 scopus 로고    scopus 로고
    • Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease
    • Epub ahead of print
    • Sepehri S, Khafipour E, Bernstein CN, et al. Characterization of Escherichia coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease. Inflamm Bowel Dis 2010. [Epub ahead of print]
    • (2010) Inflamm Bowel Dis
    • Sepehri, S.1    Khafipour, E.2    Bernstein, C.N.3
  • 22
    • 78649335559 scopus 로고    scopus 로고
    • Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes
    • One of two studies publishing the genome sequence of adherent-invasive E. coli, an organism that evades innate immune defences and may be of pathogenic relevance in Crohn's disease
    • Nash JH, Villegas A, Kropinski AM, et al. Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes. BMC Genomics 2010; 11:667. One of two studies publishing the genome sequence of adherent-invasive E. coli, an organism that evades innate immune defences and may be of pathogenic relevance in Crohn's disease.
    • (2010) BMC Genomics , vol.11 , pp. 667
    • Nash, J.H.1    Villegas, A.2    Kropinski, A.M.3
  • 23
    • 77958603351 scopus 로고    scopus 로고
    • Complete genome sequence of Crohn's disease associated adherent-invasive E. coli strain LF82
    • The second study reporting the genome sequence of adherent-invasive E. coli
    • Miquel S, Peyretaillade E, Claret L, et al. Complete genome sequence of Crohn's disease associated adherent-invasive E. coli strain LF82. PLoS One 2010; 5. The second study reporting the genome sequence of adherent-invasive E. coli.
    • (2010) PLoS One , pp. 5
    • Miquel, S.1    Peyretaillade, E.2    Claret, L.3
  • 27
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-962.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 28
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • A study revealing a direct interaction between the proteins encoded by the two principal susceptibility genes for Crohn's disease and demonstrating that the polymorphisms result in loss-of-function culminating in impaired bacterial killing
    • Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010; 11:55-62. A study revealing a direct interaction between the proteins encoded by the two principal susceptibility genes for Crohn's disease and demonstrating that the polymorphisms result in loss-of-function culminating in impaired bacterial killing.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 29
    • 77957682295 scopus 로고    scopus 로고
    • ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    • Homer CR, Richmond AL, Rebert NA, et al. ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 2010; 139:1630-1641.
    • (2010) Gastroenterology , vol.139 , pp. 1630-1641
    • Homer, C.R.1    Richmond, A.L.2    Rebert, N.A.3
  • 30
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • A study demonstrating that the Crohn's disease-associated mutations in CARD15 and ATG16L1 impair bacterial processing and antigen presentation
    • Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010; 16:90-97. A study demonstrating that the Crohn's disease-associated mutations in CARD15 and ATG16L1 impair bacterial processing and antigen presentation.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 31
    • 70349459620 scopus 로고    scopus 로고
    • Activation of innate immune antiviral responses by Nod2
    • A study that identifies an extended spectrum of innate immune activity of Nod2 to include responsiveness to viral infection
    • Sabbah A, Chang TH, Harnack R, et al. Activation of innate immune antiviral responses by Nod2. Nat Immunol 2009; 10:1073-1080. A study that identifies an extended spectrum of innate immune activity of Nod2 to include responsiveness to viral infection.
    • (2009) Nat Immunol , vol.10 , pp. 1073-1080
    • Sabbah, A.1    Chang, T.H.2    Harnack, R.3
  • 32
    • 70449722759 scopus 로고    scopus 로고
    • T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii
    • ShawMH, Reimer T, Sanchez-Valdepenas C, et al. T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. Nat Immunol 2009; 10:1267-1274.
    • (2009) Nat Immunol , vol.10 , pp. 1267-1274
    • Shaw, M.H.1    Reimer, T.2    Sanchez-Valdepenas, C.3
  • 33
    • 76249120134 scopus 로고    scopus 로고
    • Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
    • Clarke TB, Davis KM, Lysenko ES, et al. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 2010; 16:228-231.
    • (2010) Nat Med , vol.16 , pp. 228-231
    • Clarke, T.B.1    Davis, K.M.2    Lysenko, E.S.3
  • 34
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • Villani AC, Lemire M, Fortin G, et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009; 41:71-76.
    • (2009) Nat Genet , vol.41 , pp. 71-76
    • Villani, A.C.1    Lemire, M.2    Fortin, G.3
  • 35
    • 78650887065 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
    • Epub ahead of print
    • Hirota SA, Ng J, Lueng A, et al. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis 2010. [Epub ahead of print]
    • (2010) Inflamm Bowel Dis
    • Hirota, S.A.1    Ng, J.2    Lueng, A.3
  • 36
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • The most recent update of genome-wide association studies in Crohn's disease. The 39 novel susceptibility loci identified elevate the total number to 71
    • Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010; 42:1118-1125. The most recent update of genome-wide association studies in Crohn's disease. The 39 novel susceptibility loci identified elevate the total number to 71.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 37
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher B. Personal genomes: the case of the missing heritability. Nature 2008; 456:18-21.
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 38
    • 60749102218 scopus 로고    scopus 로고
    • Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease
    • A case series demonstrating that Crohn's-like inflammatory bowel disease arises in approximately 50% of patients with chronic granulomatous disease
    • Marks DJ, Miyagi K, Rahman FZ, et al. Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease. Am J Gastroenterol 2009; 104:117-124. A case series demonstrating that Crohn's-like inflammatory bowel disease arises in approximately 50% of patients with chronic granulomatous disease.
    • (2009) Am J Gastroenterol , vol.104 , pp. 117-124
    • Marks, D.J.1    Miyagi, K.2    Rahman, F.Z.3
  • 39
    • 59749090982 scopus 로고    scopus 로고
    • Phagocyte dysfunction and inflammatory bowel disease
    • Rahman FZ, Marks DJ, Hayee BH, et al. Phagocyte dysfunction and inflammatory bowel disease. Inflamm Bowel Dis 2008; 14:1443-1452.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1443-1452
    • Rahman, F.Z.1    Marks, D.J.2    Hayee, B.H.3
  • 40
    • 77952745033 scopus 로고    scopus 로고
    • Gastrointestinal manifestations in patients with primary immunodeficiencies causing antibody deficiency
    • Diez R, Garcia MJ, Vivas S, et al. Gastrointestinal manifestations in patients with primary immunodeficiencies causing antibody deficiency. Gastroenterol Hepatol 2010; 33:347-351.
    • (2010) Gastroenterol Hepatol , vol.33 , pp. 347-351
    • Diez, R.1    Garcia, M.J.2    Vivas, S.3
  • 41
    • 78249259690 scopus 로고    scopus 로고
    • Inflammatory bowel diseases in patients with adaptive and complement immunodeficiency disorders
    • Marks DJ, Seymour CR, Sewell GW, et al. Inflammatory bowel diseases in patients with adaptive and complement immunodeficiency disorders. Inflamm Bowel Dis 2010; 16:1984-1992.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1984-1992
    • Marks, D.J.1    Seymour, C.R.2    Sewell, G.W.3
  • 42
    • 77950359402 scopus 로고    scopus 로고
    • Therapeutic strategy in p47-phox deficient chronic granulomatous disease presenting as inflammatory bowel disease
    • Freudenberg F, Wintergerst U, Roesen-Wolff A, et al. Therapeutic strategy in p47-phox deficient chronic granulomatous disease presenting as inflammatory bowel disease. J Allergy Clin Immunol 2010; 125:943-946.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 943-946
    • Freudenberg, F.1    Wintergerst, U.2    Roesen-Wolff, A.3
  • 43
    • 78649890475 scopus 로고    scopus 로고
    • Complications of tumor necrosis factoralpha blockade in chronic granulomatous disease-related colitis
    • Uzel G, Orange JS, Poliak N, et al. Complications of tumor necrosis factoralpha blockade in chronic granulomatous disease-related colitis. Clin Infect Dis 2010; 51:1429-1434.
    • (2010) Clin Infect Dis , vol.51 , pp. 1429-1434
    • Uzel, G.1    Orange, J.S.2    Poliak, N.3
  • 44
    • 79958858963 scopus 로고    scopus 로고
    • The neutrophil respiratory burst and bacterial digestion in Crohn's disease
    • Epub ahead of print
    • Hayee B, Rahman FZ, Tempero J, et al. The neutrophil respiratory burst and bacterial digestion in Crohn's disease. Dig Dis Sci 2010. [Epub ahead of print]
    • (2010) Dig Dis Sci
    • Hayee, B.1    Rahman, F.Z.2    Tempero, J.3
  • 46
    • 77953718243 scopus 로고    scopus 로고
    • Phase I trial of sargramostim in pediatric Crohn's disease
    • Kelsen JR, Rosh J, Heyman M, et al. Phase I trial of sargramostim in pediatric Crohn's disease. Inflamm Bowel Dis 2010; 16:1203-1208.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1203-1208
    • Kelsen, J.R.1    Rosh, J.2    Heyman, M.3
  • 49
    • 78649895490 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase I study
    • Duijvestein M, Vos AC, Roelofs H, et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: results of a phase I study. Gut 2010; 59:1662-1669.
    • (2010) Gut , vol.59 , pp. 1662-1669
    • Duijvestein, M.1    Vos, A.C.2    Roelofs, H.3
  • 50
    • 77149152570 scopus 로고    scopus 로고
    • Course of inflammatory bowel disease in patients infected with human immunodeficiency virus
    • Viazis N, Vlachogiannakos J, Georgiou O, et al. Course of inflammatory bowel disease in patients infected with human immunodeficiency virus. Inflamm Bowel Dis 2010; 16:507-511.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 507-511
    • Viazis, N.1    Vlachogiannakos, J.2    Georgiou, O.3
  • 51
    • 77955894773 scopus 로고    scopus 로고
    • An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
    • Berry MP, Graham CM, McNab FW, et al. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 2010; 466:973-977.
    • (2010) Nature , vol.466 , pp. 973-977
    • Berry, M.P.1    Graham, C.M.2    McNab, F.W.3
  • 53
    • 33750380800 scopus 로고    scopus 로고
    • An exuberant inflammatory response to e coli: Implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum [3]
    • DOI 10.1136/gut.2006.104943
    • Marks DJ, Rahman FZ, Novelli M, et al. An exuberant inflammatory response to E. coli: implications for the pathogenesis of ulcerative colitis and pyoderma gangrenosum. Gut 2006; 55:1662-1663. (Pubitemid 44629220)
    • (2006) Gut , vol.55 , Issue.11 , pp. 1662-1663
    • Marks, D.J.B.1    Rahman, F.Z.2    Novelli, M.3    Yu, R.C.4    McCartney, S.5    Bloom, S.6    Segal, A.W.7
  • 54
    • 79952115519 scopus 로고    scopus 로고
    • Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4
    • A study examining the innate immune response in ulcerative colitis provides no evidence of immunodeficiency but reveals that inflammation resolution is defective
    • Rahman FZ, Smith AM, Hayee B, et al. Delayed resolution of acute inflammation in ulcerative colitis is associated with elevated cytokine release downstream of TLR4. PLoS One 2010; 5:e9891. A study examining the innate immune response in ulcerative colitis provides no evidence of immunodeficiency but reveals that inflammation resolution is defective.
    • (2010) PLoS One , vol.5
    • Rahman, F.Z.1    Smith, A.M.2    Hayee, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.