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Volumn 2, Issue 19, 2017, Pages

Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation

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EID: 85054732521     PISSN: None     EISSN: 23793708     Source Type: Journal    
DOI: 10.1172/jci.insight.95302     Document Type: Article
Times cited : (83)

References (43)
  • 1
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston A, Coles A. Multiple sclerosis. Lancet. 2008;372(9648):1502–1517.
    • (2008) Lancet , vol.372 , Issue.9648 , pp. 1502-1517
    • Compston, A1    Coles, A.2
  • 2
    • 84887058596 scopus 로고    scopus 로고
    • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium (IMSGC), et al
    • International Multiple Sclerosis Genetics Consortium (IMSGC), et al. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013;45(11):1353–1360.
    • (2013) Nat Genet , vol.45 , Issue.11 , pp. 1353-1360
  • 3
    • 84962602520 scopus 로고    scopus 로고
    • Metabolomics in multiple sclerosis
    • Bhargava P, Calabresi PA. Metabolomics in multiple sclerosis. Mult Scler. 2016;22(4):451–460.
    • (2016) Mult Scler , vol.22 , Issue.4 , pp. 451-460
    • Bhargava, P1    Calabresi, PA.2
  • 4
    • 84922094929 scopus 로고    scopus 로고
    • Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach
    • Aw W, Fukuda S. Toward the comprehensive understanding of the gut ecosystem via metabolomics-based integrated omics approach. Semin Immunopathol. 2015;37(1):5–16.
    • (2015) Semin Immunopathol , vol.37 , Issue.1 , pp. 5-16
    • Aw, W1    Fukuda, S.2
  • 5
    • 84950341407 scopus 로고    scopus 로고
    • Metabolome analyses in exposome studies: Profiling methods for a vast chemical space
    • Athersuch T. Metabolome analyses in exposome studies: Profiling methods for a vast chemical space. Arch Biochem Biophys. 2016;589:177–186.
    • (2016) Arch Biochem Biophys , vol.589 , pp. 177-186
    • Athersuch, T.1
  • 6
    • 84925964860 scopus 로고    scopus 로고
    • A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis
    • Dickens AM, et al. A type 2 biomarker separates relapsing-remitting from secondary progressive multiple sclerosis. Neurology. 2014;83(17):1492–1499.
    • (2014) Neurology , vol.83 , Issue.17 , pp. 1492-1499
    • Dickens, AM1
  • 7
    • 77149179378 scopus 로고    scopus 로고
    • NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases — a diagnostic tool?
    • Sinclair AJ, et al. NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases — a diagnostic tool? NMR Biomed. 2010;23(2):123–132.
    • (2010) NMR Biomed , vol.23 , Issue.2 , pp. 123-132
    • Sinclair, AJ1
  • 8
    • 85019584324 scopus 로고    scopus 로고
    • Metabolomic signatures associated with disease severity in multiple sclerosis
    • Villoslada P, et al. Metabolomic signatures associated with disease severity in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2017;4(2):e321.
    • (2017) Neurol Neuroimmunol Neuroinflamm , vol.4 , Issue.2 , pp. e321
    • Villoslada, P1
  • 9
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296(23):2832–2838.
    • (2006) JAMA , vol.296 , Issue.23 , pp. 2832-2838
    • Munger, KL1    Levin, LI2    Hollis, BW3    Howard, NS4    Ascherio, A.5
  • 10
    • 77951713604 scopus 로고    scopus 로고
    • Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis
    • Mowry EM, et al. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol. 2010;67(5):618–624.
    • (2010) Ann Neurol , vol.67 , Issue.5 , pp. 618-624
    • Mowry, EM1
  • 11
    • 85016214983 scopus 로고    scopus 로고
    • Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls
    • Bhargava P, et al. Multiple sclerosis patients have a diminished serologic response to vitamin D supplementation compared to healthy controls. Mult Scler. 2016;22(6):753–760.
    • (2016) Mult Scler , vol.22 , Issue.6 , pp. 753-760
    • Bhargava, P1
  • 12
    • 84959295128 scopus 로고    scopus 로고
    • Vitamin D supplementation affects the beck depression inventory, insulin resistance, and biomarkers of oxidative stress in patients with major depressive disorder: A Randomized, Controlled Clinical Trial
    • Sepehrmanesh Z, et al. Vitamin D supplementation affects the beck depression inventory, insulin resistance, and biomarkers of oxidative stress in patients with major depressive disorder: A Randomized, Controlled Clinical Trial. J Nutr. 2016;146(2):243–248.
    • (2016) J Nutr , vol.146 , Issue.2 , pp. 243-248
    • Sepehrmanesh, Z1
  • 13
    • 84964000518 scopus 로고    scopus 로고
    • The effects of vitamin D-K-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
    • Razavi M, Jamilian M, Karamali M, Bahmani F, Aghadavod E, Asemi Z. The effects of vitamin D-K-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Horm Metab Res. 2016;48(7):446–451.
    • (2016) Horm Metab Res , vol.48 , Issue.7 , pp. 446-451
    • Razavi, M1    Jamilian, M2    Karamali, M3    Bahmani, F4    Aghadavod, E5    Asemi, Z.6
  • 14
    • 84921026413 scopus 로고    scopus 로고
    • Glutathione in multiple sclerosis: more than just an antioxidant?
    • Carvalho AN, Lim JL, Nijland PG, Witte ME, Van Horssen J. Glutathione in multiple sclerosis: more than just an antioxidant? Mult Scler. 2014;20(11):1425–1431.
    • (2014) Mult Scler , vol.20 , Issue.11 , pp. 1425-1431
    • Carvalho, AN1    Lim, JL2    Nijland, PG3    Witte, ME4    Van Horssen, J.5
  • 15
    • 84939878706 scopus 로고    scopus 로고
    • Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron
    • Haider L, et al. Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron. J Neurol Neurosurg Psychiatr. 2014;85(12):1386–1395.
    • (2014) J Neurol Neurosurg Psychiatr , vol.85 , Issue.12 , pp. 1386-1395
    • Haider, L1
  • 16
    • 84922485376 scopus 로고    scopus 로고
    • Pathological mechanisms in progressive multiple sclerosis
    • Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015;14(2):183–193.
    • (2015) Lancet Neurol , vol.14 , Issue.2 , pp. 183-193
    • Mahad, DH1    Trapp, BD2    Lassmann, H.3
  • 17
    • 84858444025 scopus 로고    scopus 로고
    • Peripheral oxidative stress in relapsing-remitting multiple sclerosis
    • Tasset I, et al. Peripheral oxidative stress in relapsing-remitting multiple sclerosis. Clin Biochem. 2012;45(6):440–444.
    • (2012) Clin Biochem , vol.45 , Issue.6 , pp. 440-444
    • Tasset, I1
  • 18
    • 84878828439 scopus 로고    scopus 로고
    • Disease-specific molecular events in cortical multiple sclerosis lesions
    • (pt 6)
    • Fischer MT, et al. Disease-specific molecular events in cortical multiple sclerosis lesions. Brain. 2013;136(pt 6):1799–1815.
    • (2013) Brain , vol.136 , pp. 1799-1815
    • Fischer, MT1
  • 19
    • 84907710954 scopus 로고    scopus 로고
    • S-Allylmercapto-N-acetylcysteine (ASSNAC) protects cultured nerve cells from oxidative stress and attenuates experimental autoimmune encephalomyelitis
    • Savion N, Izigov N, Morein M, Pri-Chen S, Kotev-Emeth S. S-Allylmercapto-N-acetylcysteine (ASSNAC) protects cultured nerve cells from oxidative stress and attenuates experimental autoimmune encephalomyelitis. Neurosci Lett. 2014;583:108–113.
    • (2014) Neurosci Lett , vol.583 , pp. 108-113
    • Savion, N1    Izigov, N2    Morein, M3    Pri-Chen, S4    Kotev-Emeth, S.5
  • 20
    • 84857786155 scopus 로고    scopus 로고
    • Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis
    • Noga MJ, et al. Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis. Metabolomics. 2012;8(2):253–263.
    • (2012) Metabolomics , vol.8 , Issue.2 , pp. 253-263
    • Noga, MJ1
  • 21
    • 84921325742 scopus 로고    scopus 로고
    • Profile of circulatory metabolites in a relapsing-remitting animal model of multiple sclerosis using global metabolomics
    • Mangalam A, et al. Profile of circulatory metabolites in a relapsing-remitting animal model of multiple sclerosis using global metabolomics. J Clin Cell Immunol. 2013;4.
    • (2013) J Clin Cell Immunol , vol.4
    • Mangalam, A1
  • 22
    • 84924043802 scopus 로고    scopus 로고
    • Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis
    • Reinke SN, et al. Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis. Mult Scler. 2014;20(10):1396–1400.
    • (2014) Mult Scler , vol.20 , Issue.10 , pp. 1396-1400
    • Reinke, SN1
  • 23
    • 84934874560 scopus 로고    scopus 로고
    • An integrated metabolomics approach for the research of new cerebrospinal fluid biomarkers of multiple sclerosis
    • Pieragostino D, et al. An integrated metabolomics approach for the research of new cerebrospinal fluid biomarkers of multiple sclerosis. Mol Biosyst. 2015;11(6):1563–1572.
    • (2015) Mol Biosyst , vol.11 , Issue.6 , pp. 1563-1572
    • Pieragostino, D1
  • 24
    • 85011557258 scopus 로고    scopus 로고
    • (1)H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis
    • Cocco E, et al. (1)H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2016;3(1):e185.
    • (2016) Neurol Neuroimmunol Neuroinflamm , vol.3 , Issue.1 , pp. e185
    • Cocco, E1
  • 25
    • 84976612100 scopus 로고    scopus 로고
    • Alterations of the human gut microbiome in multiple sclerosis
    • Jangi S, et al. Alterations of the human gut microbiome in multiple sclerosis. Nat Commun. 2016;7:12015.
    • (2016) Nat Commun , vol.7 , pp. 12015
    • Jangi, S1
  • 26
    • 84976536578 scopus 로고    scopus 로고
    • Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
    • Chen J, et al. Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Sci Rep. 2016;6:28484.
    • (2016) Sci Rep , vol.6 , pp. 28484
    • Chen, J1
  • 27
    • 84929378321 scopus 로고    scopus 로고
    • Vitamin D cell signalling in health and disease
    • Berridge MJ. Vitamin D cell signalling in health and disease. Biochem Biophys Res Commun. 2015;460(1):53–71.
    • (2015) Biochem Biophys Res Commun , vol.460 , Issue.1 , pp. 53-71
    • Berridge, MJ.1
  • 28
    • 84870624437 scopus 로고    scopus 로고
    • Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet
    • Lau WL, et al. Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet. Kidney Int. 2012;82(12):1261–1270.
    • (2012) Kidney Int , vol.82 , Issue.12 , pp. 1261-1270
    • Lau, WL1
  • 29
    • 84876926149 scopus 로고    scopus 로고
    • Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus
    • Gradinaru D, Borsa C, Ionescu C, Margina D, Prada GI, Jansen E. Vitamin D status and oxidative stress markers in the elderly with impaired fasting glucose and type 2 diabetes mellitus. Aging Clin Exp Res. 2012;24(6):595–602.
    • (2012) Aging Clin Exp Res , vol.24 , Issue.6 , pp. 595-602
    • Gradinaru, D1    Borsa, C2    Ionescu, C3    Margina, D4    Prada, GI5    Jansen, E.6
  • 30
    • 84903597076 scopus 로고    scopus 로고
    • Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection
    • Salamon H, et al. Cutting edge: Vitamin D regulates lipid metabolism in Mycobacterium tuberculosis infection. J Immunol. 2014;193(1):30–34.
    • (2014) J Immunol , vol.193 , Issue.1 , pp. 30-34
    • Salamon, H1
  • 31
    • 84925512134 scopus 로고    scopus 로고
    • Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs
    • Leyssens C, et al. Remodeling of phospholipid composition in colon cancer cells by 1α,25(OH)2D3 and its analogs. J Steroid Biochem Mol Biol. 2015;148:172–178.
    • (2015) J Steroid Biochem Mol Biol , vol.148 , pp. 172-178
    • Leyssens, C1
  • 32
    • 84922236755 scopus 로고    scopus 로고
    • The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial
    • Shab-Bidar S, Neyestani TR, Djazayery A. The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial. Eur J Clin Nutr. 2015;69(2):216–222.
    • (2015) Eur J Clin Nutr , vol.69 , Issue.2 , pp. 216-222
    • Shab-Bidar, S1    Neyestani, TR2    Djazayery, A.3
  • 33
    • 84926391265 scopus 로고    scopus 로고
    • Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers
    • de Medeiros Cavalcante IG, et al. Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers. Exp Gerontol. 2015;66:10–16.
    • (2015) Exp Gerontol , vol.66 , pp. 10-16
    • de Medeiros Cavalcante, IG1
  • 34
    • 84908377574 scopus 로고    scopus 로고
    • The vitamin D to ameliorate multiple sclerosis (VIDAMS) trial: study design for a multicenter, randomized, double-blind controlled trial of vitamin D in multiple sclerosis
    • Bhargava P, et al. The vitamin D to ameliorate multiple sclerosis (VIDAMS) trial: study design for a multicenter, randomized, double-blind controlled trial of vitamin D in multiple sclerosis. Contemp Clin Trials. 2014;39(2):288–293.
    • (2014) Contemp Clin Trials , vol.39 , Issue.2 , pp. 288-293
    • Bhargava, P1
  • 35
    • 81255152070 scopus 로고    scopus 로고
    • Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial
    • Smolders J, et al. Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial. J Neurol Sci. 2011;311(1–2):44–49.
    • (2011) J Neurol Sci , vol.311 , Issue.1–2 , pp. 44-49
    • Smolders, J1
  • 36
    • 77955807773 scopus 로고    scopus 로고
    • Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline
    • Sha W, et al. Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J. 2010;24(8):2962–2975.
    • (2010) FASEB J , vol.24 , Issue.8 , pp. 2962-2975
    • Sha, W1
  • 37
    • 68849083050 scopus 로고    scopus 로고
    • Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
    • Evans AM, DeHaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem. 2009;81(16):6656–6667.
    • (2009) Anal Chem , vol.81 , Issue.16 , pp. 6656-6667
    • Evans, AM1    DeHaven, CD2    Barrett, T3    Mitchell, M4    Milgram, E.5
  • 38
    • 60549111634 scopus 로고    scopus 로고
    • WGCNA: an R package for weighted correlation network analysis
    • Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9:559.
    • (2008) BMC Bioinformatics , vol.9 , pp. 559
    • Langfelder, P1    Horvath, S.2
  • 39
    • 84923384915 scopus 로고    scopus 로고
    • Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
    • Gupta S, et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism. Nat Commun. 2014;5:5748.
    • (2014) Nat Commun , vol.5 , pp. 5748
    • Gupta, S1
  • 40
    • 84884570719 scopus 로고    scopus 로고
    • Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer
    • Zhang G, et al. Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res. 2013;19(18):4983–4993.
    • (2013) Clin Cancer Res , vol.19 , Issue.18 , pp. 4983-4993
    • Zhang, G1
  • 41
    • 85012012724 scopus 로고    scopus 로고
    • Integrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism
    • Tisoncik-Go J, et al. Integrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: the crucial role of lipid metabolism. Cell Host Microbe. 2016;19(2):254–266.
    • (2016) Cell Host Microbe , vol.19 , Issue.2 , pp. 254-266
    • Tisoncik-Go, J1
  • 42
    • 85024398714 scopus 로고    scopus 로고
    • Adaptive testing of SNP-brain functional connectivity association via a modular network analysis
    • Gao C, Kim J, Pan W. Adaptive testing of SNP-brain functional connectivity association via a modular network analysis. Pac Symp Biocomput. 2016;22:58–69.
    • (2016) Pac Symp Biocomput , vol.22 , pp. 58-69
    • Gao, C1    Kim, J2    Pan, W.3
  • 43
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 2007;8(1):118–127.
    • (2007) Biostatistics , vol.8 , Issue.1 , pp. 118-127
    • Johnson, WE1    Li, C2    Rabinovic, A.3


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