Effect of resveratrol supplementation on cognitive performance and mood in adults: A systematic literature review and meta-analysis of randomized controlled trials

Nutrition Reviews

Volumn 76, Issue 6, 2018, Pages 432-443

  Marx, Wolfgang ^a   Kelly, Jaimon T ^b   Marshall, Skye ^b   Cutajar, Jennifer ^d   Annois, Brigitte ^a   Pipingas, Andrew ^c   Tierney, Audrey ^a   Itsiopoulos, Catherine ^a  

^a LA TROBE UNIVERSITY   (Australia)

^b BOND UNIVERSITY   (Australia)

^c SWINBURNE UNIVERSITY OF TECHNOLOGY   (Australia)

^d NONE

Author keywords

Cognitive performance; Dietary supplement; Polyphenol; Resveratrol; Systematic review

Indexed keywords

RESVERATROL; ANTIOXIDANT;

ADULT; ANXIETY; COGNITION; DIET SUPPLEMENTATION; HUMAN; LEARNING; MEMORY; MENTAL FUNCTION; META ANALYSIS; MOOD; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REACTION TIME; REVIEW; SYSTEMATIC REVIEW; AFFECT; DIETARY SUPPLEMENT; DRUG EFFECT; FEMALE; MALE;

ADULT; AFFECT; ANTIOXIDANTS; COGNITION; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESVERATROL;

EID: 85053846175     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1093/nutrit/nuy010     Document Type: Review

References (45)

1. Harada CN, Natelson Love MC, Triebel K. Normal cognitive aging. Clin Geriatr Med. 2013;29:737-752.
2. Millan-Calenti JC, Tubio J, Pita-Fernandez S, et al. Cognitive impairment as predictor of functional dependence in an elderly sample. Arch Gerontol Geriatrics. 2012;54:197-201.
3. Pan C-W, Wang X, Ma Q, et al. Cognitive dysfunction and health-related quality of life among older Chinese. Sci Rep. 2015;5:17301.
4. United Nations, Department of Economic and Social Affairs, Population Division. World Population Prospects: The 2017 Revision, Key Findings and Advance Tables. Geneva, Switzerland: United Nations; 2017.
5. Morris MC, Tangney CC, Wang Y, et al. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015;11:1015-1022.
6. Solfrizzi V, Panza F, Frisardi V, et al. Diet and Alzheimer's disease risk factors or prevention: the current evidence. Expert Rev Neurother. 2011;11:677-708.
7. National Centre for Social and Economic Modelling. Economic Cost of Dementia in Australia: 2016-2056. Canberra, Australia: National Centre for Social and Economic Modelling; 2016.
8. Ide K, Yamada H, Takuma N, et al. Green tea consumption affects cognitive dysfunction in the elderly: a pilot study. Nutrients. 2014;6:4032-4042.
9. Krikorian R, Shidler MD, Nash TA, et al. Blueberry supplementation improves memory in older adults. J Agric Food Chem. 2010;58:3996-4000.
10. Mastroiacovo D, Kwik-Uribe C, Grassi D, et al. Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study-a randomized controlled trial. Am J Clin Nutr. 2015;101:538-548.
11. Valls-Pedret C, Lamuela-Raventos RM, Medina-Remon A, et al. Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk. J Alzheimer's Dis. 2012;29: 773-782.
12. Kesse-Guyot E, Fezeu L, Andreeva VA, et al. Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later. J Nutr. 2012;142:76-83.
13. Bell L, Lamport DJ, Butler LT, et al. A review of the cognitive effects observed in humans following acute supplementation with flavonoids, and their associated mechanisms of action. Nutrients. 2015;7:10290-10306.
14. Burns J, Yokota T, Ashihara H, et al. Plant foods and herbal sources of resveratrol. J Agric Food Chem. 2002;50:3337-3340.
15. Albani D, Polito L, Signorini A, et al. Neuroprotective properties of resveratrol in different neurodegenerative disorders. BioFactors (Oxford, England). 2010;36:370-376.
16. Sharma M, Gupta YK. Chronic treatment with trans resveratrol prevents intracere-broventricular streptozotocin induced cognitive impairment and oxidative stress in rats. Life Sci. 2002;71:2489-2498.
17. Kim D, Nguyen MD, Dobbin MM, et al. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007;26:3169-3179.
18. Dal-Pan A, Pifferi F, Marchal J, et al. Cognitive performances are selectively enhanced during chronic caloric restriction or resveratrol supplementation in a primate. PLos One. 2011;6:e16581.
19. Oomen CA, Farkas E, Roman V, et al. Resveratrol preserves cerebrovascular density and cognitive function in aging mice. Front Ag Neurosci. 2009;1:4.
20. Singh N, Agrawal M, Dore S. Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models. ACS Chem Neurosci. 2013;4:1151-1162.
21. Li H, Xia N, Forstermann U. Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide. 2012;26:102-110.
22. Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
23. Brasnyo P, Molnar GA, Mohas M, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr. 2011;106:383-389.
24. Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabol. 2011;14:612-622.
25. Higgins JPT, Green S, eds. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. London, UK: Cochrane Collaboration; 2011.
26. National Health and Medical Research Council. NHMRC Additional Levels of Evidence and Grades for Recommendations for Developers of Guidelines. Canberra, Australia: National Health and Medical Research Council; 2009.
27. Guyatt GH, Oxman AD, Schünemann HJ, et al. GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2011;64: 380-382.
28. Schünemann H, Brozek _ J, Guyatt G, et al, eds. GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations. http://guidelinedevelopment.org/handbook. Updated October 2013. Accessed August 1, 2017.
29. Pase MP, Stough C. An evidence-based method for examining and reporting cognitive processes in nutrition research. Nutr Res Rev. 2014;27:232-241.
30. Higgins, JPT, Green, S, eds. 17.8.2 Study summaries using more than one patient-reported outcome. In: Cochrane Handbook for Systematic Reviews of Interventions. London, UK: Cochrane Collaboration; 2011. http://training.cochrane.org/handbook. Accessed June 15, 2017.
31. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177-188.
32. Scholey A, Benson S, Stough C, et al. Effects of resveratrol and alcohol on mood and cognitive function in older individuals. Nutr Aging 2014;2:133-138.
33. Wong RH, Raederstorff D, Howe PR. Acute resveratrol consumption improves neu-rovascular coupling capacity in adults with type 2 diabetes mellitus. Nutrients. 2016;8:piiE425.
34. Evans HM, Howe PRC, Wong RHX. Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women; a 14-week randomised placebo-controlled intervention trial. Nutrients. 2017;9:27.
35. Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr. 2010;91:1590-1597.
36. Kobe T, Witte AV, Schnelle A, et al. Impact of resveratrol on glucose control, hippocampal structure and connectivity, and memory performance in patients with mild cognitive impairment. Front Neurosci. 2017;11:105.
37. Wightman EL, Haskell-Ramsay CF, Reay JL, et al. The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans. Br J Nutr. 2015;114:1427-1437.
38. Wightman EL, Reay JL, Haskell CF, et al. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014;112:203-213.
39. Witte AV, Kerti L, Margulies DS, et al. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J Neurosci. 2014;34:7862-7870.
40. Wong RH, Berry NM, Coates AM, et al. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens. 2013;31:1819-1827.
41. Zortea K, Franco VC, Guimaraes P, et al. Resveratrol supplementation did not improve cognition in patients with schizophrenia: results from a randomized clinical trial. Front Psychiatry. 2016;7:159.
42. Byers AL, Yaffe K, Covinsky KE, et al. High occurrence of mood and anxiety disorders among older adults: the national comorbidity survey replication. Arch Gen Psychiatry. 2010;67:489-496.
43. Whiting WL, Smith AD. Differential age-related processing limitations in recall and recognition tasks. Psychol Aging. 1997;12:216-224.
44. Johnson JJ, Nihal M, Siddiqui IA, et al. Enhancing the bioavailability of resveratrol by combining it with piperine. Mol Nutr Food Res. 2011;55:1169-1176.
45. De Santi C, Pietrabissa A, Spisni R, et al. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica. 2000;30:857-866.