메뉴 건너뛰기




Volumn 315, Issue 4, 2018, Pages L467-L475

Inhalation of electronic cigarette aerosol induces reflex bronchoconstriction by activation of vagal bronchopulmonary C-fibers

Author keywords

Airway; Bronchoconstriction; C fiber; Electronic cigarette; Nicotine

Indexed keywords

ATROPINE; LIDOCAINE; NICOTINE;

EID: 85053382195     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00137.2018     Document Type: Article
Times cited : (6)

References (47)
  • 2
    • 0026668155 scopus 로고
    • Substance P-immunoreactive sensory axons in the rat respiratory tract: A quantitative study of their distribution and role in neurogenic inflammation
    • Baluk P, Nadel JA, McDonald DM. Substance P-immunoreactive sensory axons in the rat respiratory tract: a quantitative study of their distribution and role in neurogenic inflammation. J Comp Neurol 319: 586–598, 1992. doi:10.1002/cne.903190408.
    • (1992) J Comp Neurol , vol.319 , pp. 586-598
    • Baluk, P.1    Nadel, J.A.2    McDonald, D.M.3
  • 3
    • 0035126782 scopus 로고    scopus 로고
    • Neurogenic inflammation in the airways
    • Barnes PJ. Neurogenic inflammation in the airways. Respir Physiol 125: 145–154, 2001. doi:10.1016/S0034-5687(00)00210-3.
    • (2001) Respir Physiol , vol.125 , pp. 145-154
    • Barnes, P.J.1
  • 4
    • 84922647841 scopus 로고    scopus 로고
    • Puffing topography and nicotine intake of electronic cigarette users
    • Behar RZ, Hua M, Talbot P. Puffing topography and nicotine intake of electronic cigarette users. PLoS One 10: e0117222, 2015. doi:10.1371/journal.pone.0117222.
    • (2015) Plos One , vol.10
    • Behar, R.Z.1    Hua, M.2    Talbot, P.3
  • 5
    • 77957894138 scopus 로고    scopus 로고
    • Sensory detection and responses to toxic gases: Mechanisms, health effects, and countermeasures
    • Bessac BF, Jordt SE. Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc Am Thorac Soc 7: 269–277, 2010. doi:10.1513/pats.201001-004SM.
    • (2010) Proc am Thorac Soc , vol.7 , pp. 269-277
    • Bessac, B.F.1    Jordt, S.E.2
  • 7
    • 0026512140 scopus 로고
    • Capsaicin-induced bronchoconstriction in the guinea-pig: Contribution of vagal cholinergic reflexes, local axon reflexes and their modulation by BW443C81
    • Buchan P, Adcock JJ. Capsaicin-induced bronchoconstriction in the guinea-pig: contribution of vagal cholinergic reflexes, local axon reflexes and their modulation by BW443C81. Br J Pharmacol 105: 448–452, 1992. doi:10.1111/j.1476-5381.1992.tb14273.x.
    • (1992) Br J Pharmacol , vol.105 , pp. 448-452
    • Buchan, P.1    Adcock, J.J.2
  • 8
    • 84856680087 scopus 로고    scopus 로고
    • Muscarinic receptor antagonists: Effects on pulmonary function
    • Buels KS, Fryer AD. Muscarinic receptor antagonists: effects on pulmonary function. Handb Exp Pharmacol 208: 317–341, 2012. doi:10.1007/978-3-642-23274-9_14.
    • (2012) Handb Exp Pharmacol , vol.208 , pp. 317-341
    • Buels, K.S.1    Fryer, A.D.2
  • 10
    • 0021299663 scopus 로고
    • Afferent vagal C fibre innervation of the lungs and airways and its functional significance
    • Coleridge JC, Coleridge HM. Afferent vagal C fibre innervation of the lungs and airways and its functional significance. Rev Physiol Biochem Pharmacol 99: 1–110, 1984. doi:10.1007/BFb0027715.
    • (1984) Rev Physiol Biochem Pharmacol , vol.99 , pp. 1-110
    • Coleridge, J.C.1    Coleridge, H.M.2
  • 11
    • 84983489118 scopus 로고    scopus 로고
    • Acute cardiopulmonary toxicity of inhaled aldehydes: Role of TRPA1
    • Conklin DJ. Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1. Ann N Y Acad Sci 1374: 59–67, 2016. doi:10.1111/nyas.13055.
    • (2016) Ann N Y Acad Sci , vol.1374 , pp. 59-67
    • Conklin, D.J.1
  • 12
    • 84990898340 scopus 로고    scopus 로고
    • Development, validation and application of a device to measure e-cigarette users’ puffing topography
    • Cunningham A, Slayford S, Vas C, Gee J, Costigan S, Prasad K. Development, validation and application of a device to measure e-cigarette users’ puffing topography. Sci Rep 6: 35071, 2016. doi:10.1038/srep35071.
    • (2016) Sci Rep , vol.6
    • Cunningham, A.1    Slayford, S.2    Vas, C.3    Gee, J.4    Costigan, S.5    Prasad, K.6
  • 13
    • 33644800014 scopus 로고    scopus 로고
    • Extending the understanding of sensory neuropeptides
    • De Swert KO, Joos GF. Extending the understanding of sensory neuropeptides. Eur J Pharmacol 533: 171–181, 2006. doi:10.1016/j.ejphar. 2005.12.066.
    • (2006) Eur J Pharmacol , vol.533 , pp. 171-181
    • de Swert, K.O.1    Joos, G.F.2
  • 14
    • 77949270744 scopus 로고    scopus 로고
    • Cough: The emerging role of the TRPA1 channel
    • Suppl 1: S63–S68, doi:10. 1007/s00408-009-9201-3
    • Geppetti P, Patacchini R, Nassini R, Materazzi S. Cough: the emerging role of the TRPA1 channel. Lung 188, Suppl 1: S63–S68, 2010. doi:10. 1007/s00408-009-9201-3.
    • (2010) Lung , vol.188
    • Geppetti, P.1    Patacchini, R.2    Nassini, R.3    Materazzi, S.4
  • 16
    • 33745218112 scopus 로고    scopus 로고
    • Muscarinic receptor signaling in the pathophysiology of asthma and COPD
    • Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 7: 73, 2006. doi:10.1186/1465-9921-7-73.
    • (2006) Respir Res , vol.7 , pp. 73
    • Gosens, R.1    Zaagsma, J.2    Meurs, H.3    Halayko, A.J.4
  • 17
    • 40049094315 scopus 로고    scopus 로고
    • Expression of neuronal nicotinic acetylcholine receptors in rat vagal pulmonary sensory neurons
    • Gu Q, Ni D, Lee LY. Expression of neuronal nicotinic acetylcholine receptors in rat vagal pulmonary sensory neurons. Respir Physiol Neurobiol 161: 87–91, 2008. doi:10.1016/j.resp.2007.11.006.
    • (2008) Respir Physiol Neurobiol , vol.161 , pp. 87-91
    • Gu, Q.1    Ni, D.2    Lee, L.Y.3
  • 19
    • 0020067840 scopus 로고
    • Afferent and efferent components of the bronchial vagal branches in cats
    • Jammes Y, Fornaris E, Mei N, Barrat E. Afferent and efferent components of the bronchial vagal branches in cats. J Auton Nerv Syst 5: 165–176, 1982. doi:10.1016/0165-1838(82)90037-6.
    • (1982) J Auton Nerv Syst , vol.5 , pp. 165-176
    • Jammes, Y.1    Fornaris, E.2    Mei, N.3    Barrat, E.4
  • 20
    • 0033179555 scopus 로고    scopus 로고
    • Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle
    • Kesler BS, Canning BJ. Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle. J Physiol 518: 843–855, 1999. doi:10. 1111/j.1469-7793.1999.0843p.x.
    • (1999) J Physiol , vol.518 , pp. 843-855
    • Kesler, B.S.1    Canning, B.J.2
  • 21
    • 84922449397 scopus 로고    scopus 로고
    • Trends in awareness and use of electronic cigarettes among US adults, 2010–2013
    • King BA, Patel R, Nguyen KH, Dube SR. Trends in awareness and use of electronic cigarettes among US adults, 2010–2013. Nicotine Tob Res 17: 219–227, 2015. doi:10.1093/ntr/ntu191.
    • (2015) Nicotine Tob Res , vol.17 , pp. 219-227
    • King, B.A.1    Patel, R.2    Nguyen, K.H.3    Dube, S.R.4
  • 22
    • 0025743414 scopus 로고
    • Distribution of substance P-immunoreactive and calcitonin gene-related peptide-immuno-reactive nerves in normal human lungs
    • Komatsu T, Yamamoto M, Shimokata K, Nagura H. Distribution of substance P-immunoreactive and calcitonin gene-related peptide-immuno-reactive nerves in normal human lungs. Int Arch Allergy Appl Immunol 95: 23–28, 1991. doi:10.1159/000235449.
    • (1991) Int Arch Allergy Appl Immunol , vol.95 , pp. 23-28
    • Komatsu, T.1    Yamamoto, M.2    Shimokata, K.3    Nagura, H.4
  • 23
    • 0027454475 scopus 로고
    • Nicotine is responsible for airway irritation evoked by cigarette smoke inhalation in men
    • Lee LY, Gerhardstein DC, Wang AL, Burki NK. Nicotine is responsible for airway irritation evoked by cigarette smoke inhalation in men. J Appl Pysiol (1985) 75: 1955–1961, 1993. doi:10.1152/jappl.1993.75.5. 1955.
    • (1993) J Appl Pysiol (1985) , vol.75 , pp. 1955-1961
    • Lee, L.Y.1    Gerhardstein, D.C.2    Wang, A.L.3    Burki, N.K.4
  • 24
    • 56049109544 scopus 로고    scopus 로고
    • Cough sensors. IV. Nicotinic membrane receptors on cough sensors
    • Lee LY, Gu Q. Cough sensors. IV. Nicotinic membrane receptors on cough sensors. Handb Exp Pharmacol 187: 77–98, 2009. doi:10.1007/978-3-540-79842-2_5.
    • (2009) Handb Exp Pharmacol , vol.187 , pp. 77-98
    • Lee, L.Y.1    Gu, Q.2
  • 26
    • 85051086805 scopus 로고    scopus 로고
    • Reflex bronchoconstriction evoked by inhaled nicotine aerosol in guinea pigs: Role of the nicotinic acetylcholine receptor
    • Lee LY, Lin RL, Khosravi M, Xu F. Reflex bronchoconstriction evoked by inhaled nicotine aerosol in guinea pigs: role of the nicotinic acetylcholine receptor. J Appl Physiol (1985) 125: 117–123, 2018. doi:10.1152/japplphysiol.01039.2017.
    • (2018) J Appl Physiol (1985) , vol.125 , pp. 117-123
    • Lee, L.Y.1    Lin, R.L.2    Khosravi, M.3    Xu, F.4
  • 27
    • 0035116372 scopus 로고    scopus 로고
    • Afferent properties and reflex functions of bronchopulmonary C-fibers
    • Lee LY, Pisarri TE. Afferent properties and reflex functions of bronchopulmonary C-fibers. Respir Physiol 125: 47–65, 2001. doi:10.1016/S0034-5687(00)00204-8.
    • (2001) Respir Physiol , vol.125 , pp. 47-65
    • Lee, L.Y.1    Pisarri, T.E.2
  • 28
    • 84899860722 scopus 로고    scopus 로고
    • Sensory nerves in lung and airways
    • Lee LY, Yu J. Sensory nerves in lung and airways. Compr Physiol 4: 287–324, 2014. doi:10.1002/cphy.c130020.
    • (2014) Compr Physiol , vol.4 , pp. 287-324
    • Lee, L.Y.1    Yu, J.2
  • 30
    • 84922717584 scopus 로고    scopus 로고
    • Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung
    • Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One 10: e0116732, 2015. doi:10.1371/journal.pone.0116732.
    • (2015) Plos One , vol.10
    • Lerner, C.A.1    Sundar, I.K.2    Yao, H.3    Gerloff, J.4    Ossip, D.J.5    McIntosh, S.6    Robinson, R.7    Rahman, I.8
  • 31
    • 84983744646 scopus 로고    scopus 로고
    • Vagal afferent innervation of the airways in health and disease
    • Mazzone SB, Undem BJ. Vagal afferent innervation of the airways in health and disease. Physiol Rev 96: 975–1024, 2016. doi:10.1152/physrev. 00039.2015.
    • (2016) Physiol Rev , vol.96 , pp. 975-1024
    • Mazzone, S.B.1    Undem, B.J.2
  • 32
    • 84937641377 scopus 로고    scopus 로고
    • Trends in electronic cigarette use among U.S. adults: Use is increasing in both smokers and nonsmokers
    • McMillen RC, Gottlieb MA, Shaefer RM, Winickoff JP, Klein JD. Trends in electronic cigarette use among U.S. adults: use is increasing in both smokers and nonsmokers. Nicotine Tob Res 17: 1195–1202, 2015. doi:10.1093/ntr/ntu213.
    • (2015) Nicotine Tob Res , vol.17 , pp. 1195-1202
    • McMillen, R.C.1    Gottlieb, M.A.2    Shaefer, R.M.3    Winickoff, J.P.4    Klein, J.D.5
  • 33
    • 0001609734 scopus 로고
    • Relation of volume history of lungs to respiratory mechanics in anesthetized dogs
    • Mead J, Collier C. Relation of volume history of lungs to respiratory mechanics in anesthetized dogs. J Appl Physiol 14: 669–678, 1959. doi:10.1152/jappl.1959.14.5.669.
    • (1959) J Appl Physiol , vol.14 , pp. 669-678
    • Mead, J.1    Collier, C.2
  • 34
    • 85040450580 scopus 로고    scopus 로고
    • Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine
    • Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I. Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Front Physiol 8: 1130, 2018. doi:10.3389/fphys.2017. 01130.
    • (2018) Front Physiol , vol.8 , pp. 1130
    • Muthumalage, T.1    Prinz, M.2    Ansah, K.O.3    Gerloff, J.4    Sundar, I.K.5    Rahman, I.6
  • 35
    • 40949085115 scopus 로고    scopus 로고
    • Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs
    • Nassenstein C, Kwong K, Taylor-Clark T, Kollarik M, Macglashan DM, Braun A, Undem BJ. Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs. J Physiol 586: 1595–1604, 2008. doi:10.1113/jphysiol.2007.148379.
    • (2008) J Physiol , vol.586 , pp. 1595-1604
    • Nassenstein, C.1    Kwong, K.2    Taylor-Clark, T.3    Kollarik, M.4    Macglashan, D.M.5    Braun, A.6    Undem, B.J.7
  • 36
    • 84927606962 scopus 로고    scopus 로고
    • Atlanta, GA: CDC
    • National Center for Health Statistics. National Health Interview Survey. Atlanta, GA: CDC, 2014.
    • (2014) National Health Interview Survey
  • 37
    • 84995639417 scopus 로고    scopus 로고
    • The potential that electronic nicotine delivery systems can be a disruptive technology: Results from a national survey
    • Pechacek TF, Nayak P, Gregory KR, Weaver SR, Eriksen MP. the potential that electronic nicotine delivery systems can be a disruptive technology: results from a national survey. Nicotine Tob Res 18: 1989– 1997, 2016. doi:10.1093/ntr/ntw102.
    • (2016) Nicotine Tob Res , vol.18 , pp. 1989-1997
    • Pechacek, T.F.1    Nayak, P.2    Gregory, K.R.3    Weaver, S.R.4    Eriksen, M.P.5
  • 38
    • 84957804112 scopus 로고    scopus 로고
    • Counseling patients with asthma and allergy about electronic cigarettes: An evidence-based approach
    • Polosa R, Campagna D, Sands MF. Counseling patients with asthma and allergy about electronic cigarettes: an evidence-based approach. Ann Allergy Asthma Imunol mmunology 116: 106–111, 2016. doi:10.1016/j. anai.2015.10.012.
    • (2016) Ann Allergy Asthma Imunol Mmunology , vol.116 , pp. 106-111
    • Polosa, R.1    Campagna, D.2    Sands, M.F.3
  • 39
    • 84936803097 scopus 로고    scopus 로고
    • Electronic cigarette topography in the natural environment
    • Robinson RJ, Hensel EC, Morabito PN, Roundtree KA. Electronic cigarette topography in the natural environment. PLoS One 10: e0129296, 2015. doi:10.1371/journal.pone.0129296.
    • (2015) Plos One , vol.10
    • Robinson, R.J.1    Hensel, E.C.2    Morabito, P.N.3    Roundtree, K.A.4
  • 40
    • 0026316163 scopus 로고
    • Sensory neuropeptides and airway function
    • Solway J, Leff AR. Sensory neuropeptides and airway function. J Appl Physiol (1985) 71: 2077–2087, 1991. doi:10.1152/jappl.1991.71.6.2077.
    • (1991) J Appl Physiol (1985) , vol.71 , pp. 2077-2087
    • Solway, J.1    Leff, A.R.2
  • 41
    • 85043763900 scopus 로고    scopus 로고
    • Quantifying population-level health benefits and harms of e-cigarette use in the United States
    • Soneji SS, Sung HY, Primack BA, Pierce JP, Sargent JD. Quantifying population-level health benefits and harms of e-cigarette use in the United States. PLoS One 13: e0193328, 2018. doi:10.1371/journal.pone.0193328.
    • (2018) Plos One , vol.13
    • Soneji, S.S.1    Sung, H.Y.2    Primack, B.A.3    Pierce, J.P.4    Sargent, J.D.5
  • 42
    • 84922465390 scopus 로고    scopus 로고
    • Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: Measurements and model predictions
    • Talih S, Balhas Z, Eissenberg T, Salman R, Karaoghlanian N, El Hellani A, Baalbaki R, Saliba N, Shihadeh A. Effects of user puff topography, device voltage, and liquid nicotine concentration on electronic cigarette nicotine yield: measurements and model predictions. Nicotine Tob Res 17: 150–157, 2015. doi:10.1093/ntr/ntu174.
    • (2015) Nicotine Tob Res , vol.17 , pp. 150-157
    • Talih, S.1    Balhas, Z.2    Eissenberg, T.3    Salman, R.4    Karaoghlanian, N.5    El Hellani, A.6    Baalbaki, R.7    Saliba, N.8    Shihadeh, A.9
  • 43
    • 63849217721 scopus 로고    scopus 로고
    • Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation
    • Taylor-Clark TE, Kiros F, Carr MJ, McAlexander MA. Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol 40: 756–762, 2009. doi:10. 1165/rcmb.2008-0292OC.
    • (2009) Am J Respir Cell Mol Biol , vol.40 , pp. 756-762
    • Taylor-Clark, T.E.1    Kiros, F.2    Carr, M.J.3    McAlexander, M.A.4
  • 44
    • 80052450196 scopus 로고    scopus 로고
    • Sensing pulmonary oxidative stress by lung vagal afferents
    • Taylor-Clark TE, Undem BJ. Sensing pulmonary oxidative stress by lung vagal afferents. Respir Physiol Neurobiol 178: 406–413, 2011. doi:10.1016/j.resp.2011.05.003.
    • (2011) Respir Physiol Neurobiol , vol.178 , pp. 406-413
    • Taylor-Clark, T.E.1    Undem, B.J.2
  • 45
    • 84862006677 scopus 로고    scopus 로고
    • Short-term pulmonary effects of using an electronic cigarette: Impact on respiratory flow resistance, impedance, and exhaled nitric oxide
    • Vardavas CI, Anagnostopoulos N, Kougias M, Evangelopoulou V, Connolly GN, Behrakis PK. Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide. Chest 141: 1400–1406, 2012. doi:10.1378/chest.11-2443.
    • (2012) Chest , vol.141 , pp. 1400-1406
    • Vardavas, C.I.1    Anagnostopoulos, N.2    Kougias, M.3    Evangelopoulou, V.4    Connolly, G.N.5    Behrakis, P.K.6
  • 46
    • 33746471163 scopus 로고    scopus 로고
    • Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system
    • Watanabe N, Horie S, Michael GJ, Keir S, Spina D, Page CP, Priestley JV. Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system. Neuroscience 141: 1533–1543, 2006. doi:10.1016/j.neuroscience. 2006.04.073.
    • (2006) Neuroscience , vol.141 , pp. 1533-1543
    • Watanabe, N.1    Horie, S.2    Michael, G.J.3    Keir, S.4    Spina, D.5    Page, C.P.6    Priestley, J.V.7
  • 47
    • 33846213650 scopus 로고    scopus 로고
    • Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons
    • Xu J, Yang W, Zhang G, Gu Q, Lee LY. Calcium transient evoked by nicotine in isolated rat vagal pulmonary sensory neurons. Am J Physiol Lung Cell Mol Physiol 292: L54–L61, 2007. doi:10.1152/ajplung.00182. 2006.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L54-L61
    • Xu, J.1    Yang, W.2    Zhang, G.3    Gu, Q.4    Lee, L.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.