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Volumn 75, Issue 8, 2018, Pages 989-998

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

(194)  Hohman, Timothy J a   Dumitrescu, Logan a   Barnes, Lisa L b,ab   Thambisetty, Madhav c   Beecham, Gary d,af   Kunkle, Brian d,af   Gifford, Katherine A a   Bush, William S e   Chibnik, Lori B f,g   Mukherjee, Shubhabrata h   De Jager, Philip L i,j,as   Kukull, Walter h   Crane, Paul h   Resnick, Susan M c   Keene, C Dirk h   Montine, Thomas J k   Schellenberg, Gerard D l   Haines, Jonathan L e,f   Zetterberg, Henrik m,n,p   Blennow, Kaj m,n   more..


Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E; APOLIPOPROTEIN E4; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); APOE PROTEIN, HUMAN; MAPT PROTEIN, HUMAN; PEPTIDE FRAGMENT; PHOSPHOPROTEIN;

EID: 85052691775     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2018.0821     Document Type: Article
Times cited : (225)

References (50)
  • 1
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein e type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, StrittmatterWJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science. 1993;261(5123):921-923.
    • (1993) Science , vol.261 , Issue.5123 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 2
    • 84962300984 scopus 로고    scopus 로고
    • Alzheimer's Disease Genetics Consortium (ADGC). Assessment of the genetic variance of late-onset Alzheimer's disease
    • Ridge PG, Hoyt KB, Boehme K, et al; Alzheimer's Disease Genetics Consortium (ADGC). Assessment of the genetic variance of late-onset Alzheimer's disease. Neurobiol Aging. 2016;41:200.e13-200.e20.
    • (2016) Neurobiol Aging , vol.41 , Issue.200 , pp. e13-e18
    • Ridge, P.G.1    Hoyt, K.B.2    Boehme, K.3
  • 3
    • 0030823158 scopus 로고    scopus 로고
    • APOE and Alzheimer Disease Meta Analysis Consortium. Effects of age sex and ethnicity on the association between apolipoprotein e genotype and Alzheimer disease. Ameta-analysis
    • Farrer LA, Cupples LA, Haines JL, et al; APOE and Alzheimer Disease Meta Analysis Consortium. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. Ameta-analysis. JAMA. 1997;278(16):1349-1356.
    • (1997) JAMA , vol.278 , Issue.16 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3
  • 4
    • 85031731151 scopus 로고    scopus 로고
    • Apolipoprotein e genotype and sex risk factors for Alzheimer disease: Ameta-analysis
    • Neu SC, Pa J, KukullW, et al. Apolipoprotein E genotype and sex risk factors for Alzheimer disease: ameta-analysis. JAMA Neurol. 2017;74(10):1178-1189.
    • (2017) JAMA Neurol , vol.74 , Issue.10 , pp. 1178-1189
    • Neu, S.C.1    Pa, J.2    Kukull, W.3
  • 5
    • 84871001204 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. Apolipoprotein e not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging
    • JagustWJ, Landau SM; Alzheimer's Disease Neuroimaging Initiative. Apolipoprotein E, not fibrillar β-amyloid, reduces cerebral glucose metabolism in normal aging. J Neurosci. 2012;32 (50):18227-18233.
    • (2012) J Neurosci , vol.32 , Issue.50 , pp. 18227-18233
    • Landau, S.M.1
  • 6
    • 84873672546 scopus 로고    scopus 로고
    • Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    • Ossenkoppele R, van der Flier WM, Zwan MD, et al. Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia. Neurology. 2013;80(4):359-365.
    • (2013) Neurology , vol.80 , Issue.4 , pp. 359-365
    • Ossenkoppele, R.1    Van Der Flier, W.M.2    Zwan, M.D.3
  • 7
    • 84881297582 scopus 로고    scopus 로고
    • APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis
    • Schilling S, DeStefano AL, Sachdev PS, et al. APOE genotype and MRI markers of cerebrovascular disease: systematic review and meta-analysis. Neurology. 2013;81(3):292-300.
    • (2013) Neurology , vol.81 , Issue.3 , pp. 292-300
    • Schilling, S.1    DeStefano, A.L.2    Sachdev, P.S.3
  • 8
    • 84982994428 scopus 로고    scopus 로고
    • The ARIC-PET amyloid imaging study: Brain amyloid differences by age, race, sex, and APOE
    • Gottesman RF, Schneider AL, Zhou Y, et al. The ARIC-PET amyloid imaging study: brain amyloid differences by age, race, sex, and APOE. Neurology. 2016;87(5):473-480.
    • (2016) Neurology , vol.87 , Issue.5 , pp. 473-480
    • Gottesman, R.F.1    Schneider, A.L.2    Zhou, Y.3
  • 9
    • 66149084048 scopus 로고    scopus 로고
    • Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
    • Reiman EM, Chen K, Liu X, et al. Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease. Proc Natl Acad Sci U S A. 2009;106(16):6820-6825.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.16 , pp. 6820-6825
    • Reiman, E.M.1    Chen, K.2    Liu, X.3
  • 10
    • 85035794747 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
    • Shi Y, Yamada K, Liddelow SA, et al; Alzheimer's Disease Neuroimaging Initiative. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017;549 (7673):523-527.
    • (2017) Nature , vol.549 , Issue.7673 , pp. 523-527
    • Shi, Y.1    Yamada, K.2    Liddelow, S.A.3
  • 12
    • 77649314191 scopus 로고    scopus 로고
    • APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    • Morris JC, Roe CM, Xiong C, et al. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol. 2010;67(1): 122-131.
    • (2010) Ann Neurol , vol.67 , Issue.1 , pp. 122-131
    • Morris, J.C.1    Roe, C.M.2    Xiong, C.3
  • 13
    • 84877326649 scopus 로고    scopus 로고
    • ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions
    • Verghese PB, Castellano JM, Garai K, et al. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions. Proc Natl Acad Sci U S A. 2013;110(19): E1807-E1816.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.19 , pp. E1807-E1816
    • Verghese, P.B.1    Castellano, J.M.2    Garai, K.3
  • 14
    • 84862267382 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. Gender modulates the APOE e4 effect in healthy older adults: Convergent evidence from functional brain connectivity and spinal fluid tau levels
    • Damoiseaux JS, SeeleyWW, Zhou J, et al; Alzheimer's Disease Neuroimaging Initiative. Gender modulates the APOE e4 effect in healthy older adults: convergent evidence from functional brain connectivity and spinal fluid tau levels. J Neurosci. 2012;32(24):8254-8262.
    • (2012) J Neurosci , vol.32 , Issue.24 , pp. 8254-8262
    • Damoiseaux, J.S.1    Zhou, J.2
  • 15
    • 84981225490 scopus 로고    scopus 로고
    • Age, sex, and APOE e4 effects on memory, brain structure, and β-amyloid across the adult life span
    • Jack CR Jr, Wiste HJ, Weigand SD, et al. Age, sex, and APOE e4 effects on memory, brain structure, and β-amyloid across the adult life span. JAMA Neurol. 2015;72(5):511-519.
    • (2015) JAMA Neurol , vol.72 , Issue.5 , pp. 511-519
    • Jack, C.R.1    Wiste, H.J.2    Weigand, S.D.3
  • 16
    • 85018161943 scopus 로고    scopus 로고
    • Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: A cross-sectional study
    • Jack CR Jr, Wiste HJ, Weigand SD, et al. Age-specific and sex-specific prevalence of cerebral β-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study. Lancet Neurol. 2017; 16(6):435-444.
    • (2017) Lancet Neurol , Issue.6 , pp. 435-444
    • Jack, C.R.1    Wiste, H.J.2    Weigand, S.D.3
  • 17
    • 85021628789 scopus 로고    scopus 로고
    • Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults
    • Li G, Shofer JB, Petrie EC, et al. Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. Alzheimers Res Ther. 2017;9(1):48.
    • (2017) Alzheimers Res Ther , vol.9 , Issue.1 , pp. 48
    • Li, G.1    Shofer, J.B.2    Petrie, E.C.3
  • 18
    • 3242682466 scopus 로고    scopus 로고
    • The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: Modification by age, sex, and APOE polymorphism
    • Corder EH, Ghebremedhin E, Taylor MG, Thal DR, Ohm TG, Braak H. The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann N Y Acad Sci. 2004;1019(1):24-28.
    • (2004) Ann N y Acad Sci , vol.1019 , Issue.1 , pp. 24-28
    • Corder, E.H.1    Ghebremedhin, E.2    Taylor, M.G.3    Thal, D.R.4    Ohm, T.G.5    Braak, H.6
  • 19
    • 84940769248 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects
    • Toledo JB, Zetterberg H, van Harten AC, et al; Alzheimer's Disease Neuroimaging Initiative. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain. 2015;138(pt 9):2701-2715.
    • (2015) Brain , vol.138 , pp. 2701-2715
    • Toledo, J.B.1    Zetterberg, H.2    Van Harten, A.C.3
  • 20
    • 84899917388 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative Investigators. Sex modifies the APOE-related risk of developing Alzheimer disease
    • Altmann A, Tian L, Henderson VW, Greicius MD; Alzheimer's Disease Neuroimaging Initiative Investigators. Sex modifies the APOE-related risk of developing Alzheimer disease. Ann Neurol. 2014;75 (4):563-573.
    • (2014) Ann Neurol , vol.75 , Issue.4 , pp. 563-573
    • Altmann, A.1    Tian, L.2    Henderson, V.W.3    Greicius, M.D.4
  • 21
    • 84944463618 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
    • Sampedro F, Vilaplana E, de Leon MJ, et al; Alzheimer's Disease Neuroimaging Initiative. APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls. Oncotarget. 2015;6(29):26663-26674.
    • (2015) Oncotarget , vol.6 , Issue.29 , pp. 26663-26674
    • Sampedro, F.1    Vilaplana, E.2    De Leon, M.J.3
  • 22
    • 84971350745 scopus 로고    scopus 로고
    • The Vanderbilt Memory & Aging Project: Study design and baseline cohort overview
    • Jefferson AL, Gifford KA, Acosta LMY, et al. The Vanderbilt Memory & Aging Project: study design and baseline cohort overview. J Alzheimers Dis. 2016;52(2):539-559.
    • (2016) J Alzheimers Dis , vol.52 , Issue.2 , pp. 539-559
    • Jefferson, A.L.1    Gifford, K.A.2    Acosta, L.M.Y.3
  • 23
    • 85039984735 scopus 로고    scopus 로고
    • The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions
    • Johnson SC, Koscik RL, Jonaitis EM, et al. The Wisconsin Registry for Alzheimer's Prevention: a review of findings and current directions. Alzheimers Dement (Amst). 2017;10:130-142.
    • (2017) Alzheimers Dement (Amst , Issue.10 , pp. 130-142
    • Johnson, S.C.1    Koscik, R.L.2    Jonaitis, E.M.3
  • 24
    • 84926167473 scopus 로고    scopus 로고
    • Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype
    • AlbertM, Soldan A, Gottesman R, et al. Cognitive changes preceding clinical symptom onset of mild cognitive impairment and relationship to ApoE genotype. Curr Alzheimer Res. 2014;11(8): 773-784.
    • (2014) Curr Alzheimer Res , vol.11 , Issue.8 , pp. 773-784
    • Soldan, A.1    Gottesman, R.2
  • 25
    • 84907576425 scopus 로고    scopus 로고
    • Alzheimer's Disease Genetics Consortium (ADGC). Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
    • Beecham GW, Hamilton K, Naj AC, et al; Alzheimer's Disease Genetics Consortium (ADGC). Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet. 2014;10(9): e1004606.
    • (2014) PLoS Genet , vol.10 , Issue.9 , pp. e1004606
    • Beecham, G.W.1    Hamilton, K.2    Naj, A.C.3
  • 28
    • 0036845531 scopus 로고    scopus 로고
    • Dementia and Alzheimer disease incidence: A prospective cohort study
    • KukullWA, Higdon R, Bowen JD, et al. Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol. 2002;59 (11):1737-1746.
    • (2002) Arch Neurol , vol.59 , Issue.11 , pp. 1737-1746
    • Higdon, R.1    Bowen, J.D.2
  • 29
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43(5):436-441.
    • (2011) Nat Genet , vol.43 , Issue.5 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3
  • 30
    • 70350152831 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. Relationships between biomarkers in aging and dementia
    • JagustWJ, Landau SM, Shaw LM, et al; Alzheimer's Disease Neuroimaging Initiative. Relationships between biomarkers in aging and dementia. Neurology. 2009;73(15):1193-1199.
    • (2009) Neurology , vol.73 , Issue.15 , pp. 1193-1199
    • Landau, S.M.1    Shaw, L.M.2
  • 31
    • 84888233398 scopus 로고    scopus 로고
    • BIOCARD Research Team. CSF biomarker changes precede symptom onset of mild cognitive impairment
    • Moghekar A, Li S, Lu Y, et al; BIOCARD Research Team. CSF biomarker changes precede symptom onset of mild cognitive impairment. Neurology. 2013;81(20):1753-1758.
    • (2013) Neurology , vol.81 , Issue.20 , pp. 1753-1758
    • Moghekar, A.1    Li, S.2    Lu, Y.3
  • 32
    • 84862027790 scopus 로고    scopus 로고
    • CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease
    • Bendlin BB, Carlsson CM, Johnson SC, et al. CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. PLoS One. 2012;7(6):e37720.
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e37720
    • Bendlin, B.B.1    Carlsson, C.M.2    Johnson, S.C.3
  • 33
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239-259.
    • (1991) Acta Neuropathol , vol.82 , Issue.4 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 34
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II: Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): part II: standardization of the neuropathologic assessment of Alzheimer's disease. Neurology. 1991;41(4):479-486.
    • (1991) Neurology , vol.41 , Issue.4 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 35
    • 0031946864 scopus 로고    scopus 로고
    • Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
    • Xu H, Gouras GK, Greenfield JP, et al. Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides. Nat Med. 1998;4(4):447-451.
    • (1998) Nat Med , vol.4 , Issue.4 , pp. 447-451
    • Xu, H.1    Gouras, G.K.2    Greenfield, J.P.3
  • 36
    • 0030575880 scopus 로고    scopus 로고
    • Estradiol protects against beta-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells
    • Green PS, Gridley KE, Simpkins JW. Estradiol protects against beta-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci Lett. 1996;218(3):165-168.
    • (1996) Neurosci Lett , vol.218 , Issue.3 , pp. 165-168
    • Green, P.S.1    Gridley, K.E.2    Simpkins, J.W.3
  • 37
    • 80052640194 scopus 로고    scopus 로고
    • 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: Relevance to Alzheimer's prevention
    • Zhao L, Yao J, Mao Z, Chen S, Wang Y, Brinton RD. 17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's prevention. Neurobiol Aging. 2011;32(11):1949-1963.
    • (2011) Neurobiol Aging , Issue.32 , pp. 11
    • Zhao, L.1    Yao, J.2    Mao, Z.3    Chen, S.4    Wang, Y.5    Brinton, R.D.6
  • 38
    • 0037012777 scopus 로고    scopus 로고
    • Equine estrogens induce apolipoprotein e and glial fibrillary acidic protein in mixed glial cultures
    • Rozovsky I, Hoving S, Anderson CP, O'Callaghan J, Finch CE. Equine estrogens induce apolipoprotein E and glial fibrillary acidic protein in mixed glial cultures. Neurosci Lett. 2002;323(3):191-194.
    • (2002) Neurosci Lett , vol.323 , Issue.3 , pp. 191-194
    • Rozovsky, I.1    Hoving, S.2    Anderson, C.P.3    O'Callaghan, J.4    Finch, C.E.5
  • 39
    • 25144456905 scopus 로고    scopus 로고
    • Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease
    • Alvarez-de-la-Rosa M, Silva I, Nilsen J, et al. Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease. Ann N Y Acad Sci. 2005;1052(1):210-224.
    • (2005) Ann N y Acad Sci , vol.1052 , Issue.1 , pp. 210-224
    • Alvarez-de-La-Rosa, M.1    Silva, I.2    Nilsen, J.3
  • 40
    • 84957827761 scopus 로고    scopus 로고
    • Estrogen receptor-a is localized to neurofibrillary tangles in Alzheimer's disease
    • Wang C, Zhang F, Jiang S, et al. Estrogen receptor-a is localized to neurofibrillary tangles in Alzheimer's disease. Sci Rep. 2016;6:20352.
    • (2016) Sci Rep , Issue.6 , pp. 20352
    • Wang, C.1    Zhang, F.2    Jiang, S.3
  • 41
    • 0031454921 scopus 로고    scopus 로고
    • Estrogen up-regulates apolipoprotein e (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway
    • Srivastava RA, Srivastava N, Averna M, et al. Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway. J Biol Chem. 1997;272 (52):33360-33366.
    • (1997) J Biol Chem , vol.272 , Issue.52 , pp. 33360-33366
    • Srivastava, R.A.1    Srivastava, N.2    Averna, M.3
  • 42
    • 84892924069 scopus 로고    scopus 로고
    • Sex and gonadal hormones in mouse models of Alzheimer's disease: What is relevant to the human condition?
    • Dubal DB, Broestl L, Worden K. Sex and gonadal hormones in mouse models of Alzheimer's disease: what is relevant to the human condition? Biol Sex Differ. 2012;3(1):24-24.
    • (2012) Biol Sex Differ , vol.3 , Issue.1 , pp. 24-24
    • Dubal, D.B.1    Broestl, L.2    Worden, K.3
  • 43
    • 0141738373 scopus 로고    scopus 로고
    • CSF markers for incipient Alzheimer's disease
    • Blennow K, Hampel H. CSF markers for incipient Alzheimer's disease. Lancet Neurol. 2003; 2(10):605-613.
    • (2003) Lancet Neurol , vol.2 , Issue.10 , pp. 605-613
    • Blennow, K.1    Hampel, H.2
  • 44
    • 84957545781 scopus 로고    scopus 로고
    • Alzheimer's Neuroimaging Initiative. Sex differences in the association between AD biomarkers and cognitive decline
    • Koran MEI, Wagener M, Hohman TJ; Alzheimer's Neuroimaging Initiative. Sex differences in the association between AD biomarkers and cognitive decline. Brain Imaging Behav. 2017;11(1):205-213.
    • (2017) Brain Imaging Behav , vol.11 , Issue.1 , pp. 205-213
    • Koran, M.E.I.1    Wagener, M.2    Hohman, T.J.3
  • 45
    • 20844434785 scopus 로고    scopus 로고
    • Alzheimer's Disease Cooperative Study. Sex apolipoprotein e e 4 status and hippocampal volume in mild cognitive impairment
    • Fleisher A, Grundman M, Jack CR Jr, et al; Alzheimer's Disease Cooperative Study. Sex, apolipoprotein E e 4 status, and hippocampal volume in mild cognitive impairment. Arch Neurol. 2005;62(6):953-957.
    • (2005) Arch Neurol , vol.62 , Issue.6 , pp. 953-957
    • Fleisher, A.1    Grundman, M.2    Jack, C.R.3
  • 46
    • 85082233806 scopus 로고    scopus 로고
    • Apolipoprotein e and Alzheimer disease: Risk, mechanisms and therapy [published correction appears
    • Liu C-C, Liu CC, Kanekiyo T, Xu H, Bu G. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy [published correction appears in Nat Rev Neurol. 2013. Doi: 10.1038/nmeurol.2013.32]. Nat Rev Neurol. 2013;9 (2):106-118.
    • (2013) Nat Rev Neurol. 2013. Nat Rev Neurol , vol.9 , Issue.2 , pp. 106-118
    • Liu, C.-C.1    Liu, C.C.2    Kanekiyo, T.3    Xu, H.4    Bu, G.5
  • 47
    • 0035954324 scopus 로고    scopus 로고
    • Gender and age modify the association between APOE and AD-related neuropathology
    • Ghebremedhin E, Schultz C, Thal DR, et al. Gender and age modify the association between APOE and AD-related neuropathology. Neurology. 2001;56(12):1696-1701.
    • (2001) Neurology , vol.56 , Issue.12 , pp. 1696-1701
    • Ghebremedhin, E.1    Schultz, C.2    Thal, D.R.3
  • 48
    • 0030823158 scopus 로고    scopus 로고
    • APOE and Alzheimer Disease Meta Analysis Consortium. Effects of age sex and ethnicity on the association between apolipoprotein e genotype and Alzheimer disease: Ameta-analysis
    • Farrer LA, Cupples LA, Haines JL, et al; APOE and Alzheimer Disease Meta Analysis Consortium. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: ameta-analysis. JAMA. 1997;278(16): 1349-1356.
    • (1997) JAMA , vol.278 , Issue.16 , pp. 1349-1356
    • Farrer, L.A.1    Cupples, L.A.2    Haines, J.L.3
  • 49
    • 84925933234 scopus 로고    scopus 로고
    • Gender and incidence of dementia in the Framingham Heart Study from mid-adult life
    • Chene G, Beiser A, Au R, et al. Gender and incidence of dementia in the Framingham Heart Study from mid-adult life. Alzheimers Dement. 2015;11(3):310-320.
    • (2015) Alzheimers Dement , vol.11 , Issue.3 , pp. 310-320
    • Chene, G.1    Beiser, A.2    Au, R.3
  • 50
    • 85009754974 scopus 로고    scopus 로고
    • Alzheimer's Disease Neuroimaging Initiative. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice
    • Cacciottolo M, Christensen A, Moser A, et al; Alzheimer's Disease Neuroimaging Initiative. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging. 2016;37:47-57.
    • (2016) Neurobiol Aging , Issue.37 , pp. 47-57
    • Cacciottolo, M.1    Christensen, A.2    Moser, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.