Sex differences in the association between AD biomarkers and cognitive decline

Brain Imaging and Behavior

Volumn 11, Issue 1, 2017, Pages 205-213

  Koran, Mary Ellen I ^a   Wagener, Madison ^a   Hohman, Timothy J ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer s disease; Biomarkers; Cognition; Hippocampus; Sex differences

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; APOLIPOPROTEIN E4; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BIOLOGICAL MARKER; MAPT PROTEIN, HUMAN; PEPTIDE FRAGMENT;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; CEREBROSPINAL FLUID; CLINICAL FEATURE; CLOCK DRAWING TEST; COGNITION; CONTROLLED STUDY; DISEASE ASSOCIATION; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; HIPPOCAMPUS; HUMAN; LEFT HIPPOCAMPUS; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROPATHOLOGY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REY AUDITORY VERBAL LEARNING TEST; RIGHT HIPPOCAMPUS; SEX DIFFERENCE; TRAIL MAKING TEST; AGING; ATROPHY; BRAIN; COGNITIVE DEFECT; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; GENETICS; LONGITUDINAL STUDY; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; REGRESSION ANALYSIS; SEXUAL CHARACTERISTICS; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; APOLIPOPROTEIN E4; ATROPHY; BIOMARKERS; BRAIN; COGNITIVE DYSFUNCTION; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; REGRESSION ANALYSIS; SEX CHARACTERISTICS; TAU PROTEINS;

EID: 84957545781     PISSN: 19317557     EISSN: 19317565     Source Type: Journal    
DOI: 10.1007/s11682-016-9523-8     Document Type: Article

References (26)

1. Alvarez-de-la-Roza, M., Silva, I., Nilsen, J., Perez, M., Garcia-Segura, L. M., Ávila, J., & Naftolin, F. (2005). Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer’s disease. Annals of the New York Academy of Sciences, 1052(1), 210–224.
2. Anastasio, T. J. (2013). Exploring the contribution of estrogen to amyloid-beta regulation: a novel multifactorial computational modeling approach. Frontiers in Pharmacology, 4. doi:10.3389/fphar.2013.00016.
3. Apostolova, L. G., Dinov, I. D., Dutton, R. A., Hayashi, K. M., Toga, A. W., Cummings, J. L., & Thompson, P. M. (2006). 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer’s disease. Brain, 129(11), 2867–2873.
4. Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A., & Bennett, D. A. (2005). Sex differences in the clinical manifestations of Alzheimer disease pathology. Archives of General Psychiatry, 62(6), 685–691.
5. Crane, P. K., Carle, A., Gibbons, L. E., Insel, P., Mackin, R. S., Gross, A., et al. (2012). Development and assessment of a composite score for memory in the Alzheimer’s disease neuroimaging initiative (ADNI). Brain Imaging and Behavior, 6(4), 502–516.
6. Dale, A. M., Fischl, B., & Sereno, M. I. (1999). Cortical surface-based analysis: I. Segmentation and surface reconstruction. NeuroImage, 9(2), 179–194.
7. Desikan, R. S., Segonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., et al. (2006). An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage, 31(3), 968–980.
8. Farrer, L. A., Cupples, L. A., Haines, J. L., Hyman, B., Kukull, W. A., Mayeux, R., et al. (1997). Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. Jama, 278(16), 1349–1356.
9. Fischl, B., Sereno, M. I., Tootell, R. B. H., & Dale, A. M. (1999a). High-resolution intersubject averaging and a coordinate system for the cortical surface. Human Brain Mapping, 8(4), 272–284.
10. Fischl, B., Sereno, M. I., & Dale, A. M. (1999b). Cortical surface-based analysis: II: inflation, flattening, and a surface-based coordinate system. NeuroImage, 9(2), 195–207.
11. Gibbons, L. E., Carle, A. C., Mackin, R. S., Harvey, D., Mukherjee, S., Insel, P., et al. (2012). A composite score for executive functioning, validated in Alzheimer’s disease neuroimaging initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging and Behavior, 6(4), 517–527.
12. Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013). Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology, 80(19), 1778–1783.
13. Henderson, V. W., & Buckwalter, J. G. (1994). Cognitive deficits of men and women with Alzheimer’s disease. Neurology, 44(1), 90–90.
14. Hua, X., Hibar, D. P., Lee, S., Toga, A. W., Jack, C. R., Weiner, M. W., et al. (2010). Sex and age differences in atrophic rates: an ADNI study with n = 1368 MRI scans. Neurobiology of Aging, 31(8), 1463–1480.
15. Jack, C. R., Bernstein, M. A., Fox, N. C., Thompson, P., Alexander, G., Harvey, D., et al. (2008). The Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods. Journal of Magnetic Resonance Imaging, 27(4), 685–691.
16. Jagust, W. J., Landau, S. M., Shaw, L. M., Trojanowski, J. Q., Koeppe, R. A., Reiman, E. M., et al. (2009). Relationships between biomarkers in aging and dementia. Neurology, 73(15), 1193–1199.
17. Launer, L., Andersen, K., Dewey, M., Letenneur, L., Ott, A., Amaducci, L., et al. (1999). Rates and risk factors for dementia and Alzheimer’s disease results from EURODEM pooled analyses. Neurology, 52(1), 78–78.
18. Lin, K. A., Choudhury, K. R., Rathakrishnan, B. G., Marks, D. M., Petrella, J. R., Doraiswamy, P. M., & Initiative, A. S. D. N. (2015). Marked gender differences in progression of mild cognitive impairment over 8 years. Alzheimer’s & Dementia: translational Research & Clinical Interventions, 1(2), 103–110.
19. Luine, V. N. (2014). Estradiol and cognitive function: past, present and future. Hormones and Behavior, 66(4), 602–618. doi:10.1016/j.yhbeh.2014.08.011.
20. Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., et al. (2009). Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects. Brain, 132(5), 1310–1323.
21. Nilsen, J., Chen, S., Irwin, R. W., Iwamoto, S., & Brinton, R. D. (2006). Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. BMC Neuroscience, 7(1), 74.
22. Pfeffer, R., Kurosaki, T., Harrah, C., Chance, J., & Filos, S. (1982). Measurement of functional activities in older adults in the community. Journal of Gerontology, 37(3), 323–329.
23. Reuter, M., Schmansky, N. J., Rosas, H. D., & Fischl, B. (2012). Within-subject template estimation for unbiased longitudinal image analysis. NeuroImage, 61(4), 1402–1418.
24. Sampedro, F., Vilaplana, E., de Leon, M. J., Alcolea, D., Pegueroles, J., Montal, V., et al. (2015). APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls. Oncotarget, 6(29), 26663–26674. doi:10.18632/oncotarget.5185.
25. Shaw, L. M., Vanderstichele, H., Knapik-Czajka, M., Figurski, M., Coart, E., Blennow, K., et al. (2011). Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathologica, 121(5), 597–609.
26. Tschanz, J. T., Corcoran, C. D., Schwartz, S., Treiber, K., Green, R. C., Norton, M. C., et al. (2011). Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the cache county dementia progression study. The American Journal of Geriatric Psychiatry, 19(6), 532–542.