Vitamins C and E prevent endothelial VEGF and VEGFR-2 overexpression induced by porcine hypercholesterolemic LDL

Cardiovascular Research

Volumn 65, Issue 3, 2005, Pages 665-673

  Rodríguez, José A ^a   Nespereira, Beatriz ^a   Pérez Ilzarbe, Maitane ^a   Eguinoa, Ezequiel ^a   Páramo, José A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Atherosclerosis; Endothelial factors; Endothelial receptors; Growth factors; Lipoproteins

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA TOCOPHEROL; CHOLESTEROL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PROTEIN; SUPEROXIDE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CORONARY ARTERY; DRUG EFFECT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; HYPERCHOLESTEROLEMIA; INCUBATION TIME; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SWINE; UPREGULATION; VASCULAR ENDOTHELIUM; VITAMIN SUPPLEMENTATION;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELLS, CULTURED; CHOLESTEROL, LDL; ENDOTHELIUM, VASCULAR; HYPERCHOLESTEROLEMIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SWINE; SWINE, MINIATURE; TRANSCRIPTION FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VITAMIN E;

EID: 12344266849     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.08.006     Document Type: Article

References (30)

1. H.M. Kwon, G. Sangiorgi, E.L. Ritman, C. McKenna, D.R. Holmes, and R.S. Schwartz Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia J. Clin. Invest. 101 1998 1551 1556
2. M. Rodriguez Porcel, A. Lerman, P.J. Best, J.D. Krier, C. Napoli, and L.O. Lerman Hypercholesterolemia impairs myocardial perfusion and permeability: role of oxidative stress and endogenous scavenging activity J. Am. Coll. Cardiol. 37 2001 608 615
3. S. Wilson, J. Herrmann, L.O. Lerman, D.R. Holmes, C. Napoli, and E.L. Ritman Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering Circulation 105 2002 415 418
4. 2 in rat heart endothelial cells Free Radic. Biol. Med. 25 1998 891 897
5. E. Brogi, T. Wu, A. Namiki, and J.M. Isner Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only Circulation 90 1994 649 652
6. Y. Tsurumi, T. Murohara, K. Krasinski, D. Chen, B. Witzenbichler, and M. Kearney Reciprocal relation between VEGF and NO in the regulation of endothelial integrity Nat. Med. 3 1997 879 886
7. A. Jozkowicz, J.P. Cooke, I. Guevara, I. Huk, P. Funovics, and O. Pachinger Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF Cardiovasc. Res. 51 2001 773 783
8. F. Shalaby, J. Ho, W.L. Stanford, K.D. Fischer, A.C. Schuh, and L. Schwartz A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis Cell 89 1997 981 990
9. T.D. Henry, B.H. Annex, G.R. McKendall, M.A. Azrin, J.J. Lopez, and F.J. Giordano The VIVA trial: vascular endothelial growth factor in Ischemia for vascular angiogenesis Circulation 107 2003 1359 1365
10. F.L. Celletti, P.R. Hilfiker, P. Ghafouri, and M.D. Dake Effect of human recombinant vascular endothelial growth factor165 on progression of atherosclerotic plaque J. Am. Coll. Cardiol. 37 2001 2126 2130
11. A.D. Blann, F.M. Belgore, J. Constans, C. Conri, and G.Y. Lip Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate Am. J. Cardiol. 87 2001 1160 1163
12. B. Nespereira, M. Perez-Ilzarbe, P. Fernandez, A.M. Fuentes, J.A. Paramo, and J.A. Rodriguez Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice Atherosclerosis 171 2003 67 73
13. E. Lonn Do antioxidant vitamins protect against atherosclerosis? The proof is still lacking J. Am. Coll. Cardiol. 38 2001 1795 1798
14. R. Brigelius-Flohe, F.J. Kelly, J.T. Salonen, J. Neuzil, J.M. Zingg, and A. Azzi The European perspective on vitamin E: current knowledge and future research Am. J. Clin. Nutr. 76 2002 703 716
15. A.C. Carr, B.Z. Zhu, and B. Frei Potential antiatherogenic mechanisms of ascorbate (vitamin C) and alpha-tocopherol (vitamin E) Circ. Res. 87 2000 349 354
16. J.A. Rodriguez, A. Grau, E. Eguinoa, B. Nespereira, M. Perez-Ilzarbe, and R. Arias Dietary supplementation with vitamins C and E prevents downregulation of endothelial NOS expression in hypercholesterolemia in vivo and in vitro Atherosclerosis 165 2002 33 40
17. J. Orbe, J.A. Rodriguez, R. Arias, M. Belzunce, B. Nespereira, and M. Perez-Ilzarbe Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization Atherosclerosis 167 2003 45 53
18. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement by the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
19. L. Wang, V. Schmitz, A. Perez-Mediavilla, I. Izal, J. Prieto, and C. Qian Suppression of angiogenesis and tumor growth by adenoviral-mediated gene transfer of pigment epithelium-derived factor Molec. Ther. 8 2003 72 79
20. J.J. Khatri, C. Johnson, R. Magid, S.M. Lessner, K.M. Laude, and S.I. Dikalov Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma Circulation 109 2004 520 525 (Electronic publication 2004 Jan 26)
21. F.L. Celletti, J.M. Waugh, P.G. Amabile, A. Brendolan, P.R. Hilfiker, and M.D. Dake Vascular endothelial growth factor enhances atherosclerotic plaque progression Nat. Med. 7 2001 425 429
22. D. Pratico, R.K. Tangirala, D.J. Rader, J. Rokach, and G.A. FitzGerald Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice Nat. Med. 4 1998 1189 1192
23. J. Orbe, J. Rodríguez, A. Calvo, A. Grau, M. Belzunce, and D. Martinez Caro Antioxidants attenuate plasminogen activator inhibitor-1 (PAI-1) expression in a hypercholesterolemic porcine model of angioplasty Cardiovasc. Res. 49 2001 484 492
24. M. Inoue, H. Itoh, T. Tanaka, T.H. Chun, K. Doi, and Y. Fukunaga Oxidized LDL regulates vascular endothelial growth factor expression in human macrophages and endothelial cells through activation of peroxisome proliferator-activated receptor-gamma Arterioscler. Thromb. Vasc. Biol. 21 2001 560 566
25. I. Zachary, A. Mathur, S. Yla Herttuala, and J. Martin Vascular protection: a novel nonangiogenic cardiovascular role for vascular endothelial growth factor Arterioscler. Thromb. Vasc. Biol. 20 2000 1512 1520
26. Q. Zhao, K. Egashira, S. Inoue, M. Usui, S. Kitamoto, and W. Ni Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis Circulation 105 2002 1110 1115
27. K.S. Moulton, E. Heller, M.A. Konerding, E. Flynn, W. Palinski, and J. Folkman Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice Circulation 99 1999 1726 1732
28. B.Q. Shen, D.Y. Lee, H.P. Gerber, B.A. Keyt, N. Ferrara, and T.F. Zioncheck Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro J. Biol. Chem. 273 1998 29979 29985
29. J. Neuzil, S.R. Thomas, and R. Stocker Requirement for, promotion, or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation Free Radic. Biol. Med. 22 1997 57 71
30. A. Tasinato, D. Boscoboinik, G.M. Bartoli, P. Maroni, and A. Azzi d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties Proc. Natl. Acad. Sci. U. S. A. 92 1995 12190 12194