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Volumn 28, Issue 9, 2018, Pages 879-896

Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; GENETICS; INBRED MOUSE STRAIN; MALE; MOUSE; SEQUENCE ANALYSIS; SINGLE CELL ANALYSIS; SPERMATOGENESIS;

EID: 85052605372     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/s41422-018-0074-y     Document Type: Article
Times cited : (259)

References (77)
  • 1
    • 84946601188 scopus 로고    scopus 로고
    • Spermatogenesis: the commitment to meiosis
    • PID: 26537427
    • Griswold, M. D. Spermatogenesis: the commitment to meiosis. Physiol. Rev. 96, 1–17 (2016)
    • (2016) Physiol. Rev. , vol.96 , pp. 1-17
    • Griswold, M.D.1
  • 2
    • 0015255225 scopus 로고
    • Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal
    • PID: 4621362
    • Clermont, Y. Kinetics of spermatogenesis in mammals: seminiferous epithelium cycle and spermatogonial renewal. Physiol. Rev. 52, 198–236 (1972)
    • (1972) Physiol. Rev. , vol.52 , pp. 198-236
    • Clermont, Y.1
  • 3
    • 0035084511 scopus 로고    scopus 로고
    • Proliferation and differentiation of spermatogonial stem cells
    • PID: 11226060
    • de Rooij, D. G. Proliferation and differentiation of spermatogonial stem cells. Reproduction 121, 347–354 (2001)
    • (2001) Reproduction , vol.121 , pp. 347-354
    • de Rooij, D.G.1
  • 4
    • 84863881262 scopus 로고    scopus 로고
    • Unique aspects of transcription regulation in male germ cells
    • White-Cooper, H. & Davidson, I. Unique aspects of transcription regulation in male germ cells. Cold Spring Harb. Perspect. Biol. 3, a002626 (2011)
    • (2011) Cold Spring Harb. Perspect. Biol. , vol.3 , pp. a002626
    • White-Cooper, H.1    Davidson, I.2
  • 5
    • 84880533183 scopus 로고    scopus 로고
    • Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells
    • PID: 23579190
    • Kleene, K. C. Connecting cis-elements and trans-factors with mechanisms of developmental regulation of mRNA translation in meiotic and haploid mammalian spermatogenic cells. Reproduction 146, R1–R19 (2013)
    • (2013) Reproduction , vol.146 , pp. R1-R19
    • Kleene, K.C.1
  • 6
    • 84879795456 scopus 로고    scopus 로고
    • Cellular source and mechanisms of high transcriptome complexity in the mammalian testis
    • PID: 23791531
    • Soumillon, M. et al. Cellular source and mechanisms of high transcriptome complexity in the mammalian testis. Cell Rep. 3, 2179–2190 (2013)
    • (2013) Cell Rep. , vol.3 , pp. 2179-2190
    • Soumillon, M.1
  • 7
    • 84988349920 scopus 로고    scopus 로고
    • Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes
    • Ball, R. L. et al. Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes. BMC Genom. 17, 628 (2016)
    • (2016) BMC Genom. , vol.17
    • Ball, R.L.1
  • 8
    • 85007593464 scopus 로고    scopus 로고
    • Transcriptome analysis of highly purified mouse spermatogenic cell populations: gene expression signatures switch from meiotic-to postmeiotic-related processes at pachytene stage
    • da Cruz, I. et al. Transcriptome analysis of highly purified mouse spermatogenic cell populations: gene expression signatures switch from meiotic-to postmeiotic-related processes at pachytene stage. BMC Genom. 17, 294 (2016)
    • (2016) BMC Genom. , vol.17
    • da Cruz, I.1
  • 10
    • 34347242489 scopus 로고    scopus 로고
    • The conserved transcriptome in human and rodent male gametogenesis
    • PID: 17483452
    • Chalmel, F. et al. The conserved transcriptome in human and rodent male gametogenesis. Proc. Natl Acad. Sci. USA 104, 8346–8351 (2007)
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 8346-8351
    • Chalmel, F.1
  • 11
    • 0142091380 scopus 로고    scopus 로고
    • A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets
    • PID: 14526100
    • Schultz, N., Hamra, F. K. & Garbers, D. L. A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets. Proc. Natl Acad. Sci. USA 100, 12201–12206 (2003)
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 12201-12206
    • Schultz, N.1    Hamra, F.K.2    Garbers, D.L.3
  • 12
    • 2642578283 scopus 로고    scopus 로고
    • Analysis of cell-type-specific gene expression during mouse spermatogenesis
    • PID: 14960480
    • Almstrup, K. et al. Analysis of cell-type-specific gene expression during mouse spermatogenesis. Biol. Reprod. 70, 1751–1761 (2004)
    • (2004) Biol. Reprod. , vol.70 , pp. 1751-1761
    • Almstrup, K.1
  • 13
    • 46149123689 scopus 로고    scopus 로고
    • Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells
    • PID: 18544648
    • Johnston, D. S. et al. Stage-specific gene expression is a fundamental characteristic of rat spermatogenic cells and Sertoli cells. Proc. Natl Acad. Sci. USA 105, 8315–8320 (2008)
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 8315-8320
    • Johnston, D.S.1
  • 14
    • 84904440021 scopus 로고    scopus 로고
    • High-resolution profiling of novel transcribed regions during rat spermatogenesis
    • PID: 24740603
    • Chalmel, F. et al. High-resolution profiling of novel transcribed regions during rat spermatogenesis. Biol. Reprod. 91, 5 (2014)
    • (2014) Biol. Reprod. , vol.91 , pp. 5
    • Chalmel, F.1
  • 15
    • 0017691821 scopus 로고
    • Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization
    • PID: 874003
    • Bellve, A. R. et al. Spermatogenic cells of the prepuberal mouse. Isolation and morphological characterization. J. Cell. Biol. 74, 68–85 (1977)
    • (1977) J. Cell. Biol. , vol.74 , pp. 68-85
    • Bellve, A.R.1
  • 16
    • 85016487030 scopus 로고    scopus 로고
    • An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation
    • PID: 28366282
    • Naro, C. et al. An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation. Dev. Cell. 41, 82–93 (2017)
    • (2017) Dev. Cell. , vol.41 , pp. 82-93
    • Naro, C.1
  • 17
    • 84890322979 scopus 로고    scopus 로고
    • The splicing landscape is globally reprogrammed during male meiosis
    • PID: 24038356
    • Schmid, R. et al. The splicing landscape is globally reprogrammed during male meiosis. Nucleic Acids Res. 41, 10170–10184 (2013)
    • (2013) Nucleic Acids Res. , vol.41 , pp. 10170-10184
    • Schmid, R.1
  • 18
    • 84930613577 scopus 로고    scopus 로고
    • The transcriptome and DNA methylome landscapes of human primordial germ cells
    • PID: 26046443
    • Guo, F. et al. The transcriptome and DNA methylome landscapes of human primordial germ cells. Cell 161, 1437–1452 (2015)
    • (2015) Cell , vol.161 , pp. 1437-1452
    • Guo, F.1
  • 19
    • 84930618214 scopus 로고    scopus 로고
    • A unique gene regulatory network resets the human germline epigenome for development
    • PID: 26046444
    • Tang, W. W. et al. A unique gene regulatory network resets the human germline epigenome for development. Cell 161, 1453–1467 (2015)
    • (2015) Cell , vol.161 , pp. 1453-1467
    • Tang, W.W.1
  • 20
    • 84930476912 scopus 로고    scopus 로고
    • DNA demethylation dynamics in the human prenatal germline
    • PID: 26004067
    • Gkountela, S. et al. DNA demethylation dynamics in the human prenatal germline. Cell 161, 1425–1436 (2015)
    • (2015) Cell , vol.161 , pp. 1425-1436
    • Gkountela, S.1
  • 21
    • 84877076416 scopus 로고    scopus 로고
    • Turning a spermatogenic wave into a tsunami: synchronizing murine spermatogenesis using WIN 18,446
    • PID: 23284139
    • Hogarth, C. A. et al. Turning a spermatogenic wave into a tsunami: synchronizing murine spermatogenesis using WIN 18,446. Biol. Reprod. 88, 40 (2013)
    • (2013) Biol. Reprod. , vol.88 , pp. 40
    • Hogarth, C.A.1
  • 22
    • 0028978524 scopus 로고
    • Early G1 in the male rat meiotic cell cycle is hypersensitive to N-methyl-N-nitrosourea-induced micronucleus formation
    • PID: 7476262
    • Kallio, M. & Lahdetie, J. Early G1 in the male rat meiotic cell cycle is hypersensitive to N-methyl-N-nitrosourea-induced micronucleus formation. Mutagenesis 10, 279–285 (1995)
    • (1995) Mutagenesis , vol.10 , pp. 279-285
    • Kallio, M.1    Lahdetie, J.2
  • 23
    • 0001547544 scopus 로고
    • Ribonucleic acid synthesis during mitosis and meiosis in the mouse testis
    • PID: 14206420
    • Monesi, V. Ribonucleic acid synthesis during mitosis and meiosis in the mouse testis. J. Cell. Biol. 22, 521–532 (1964)
    • (1964) J. Cell. Biol. , vol.22 , pp. 521-532
    • Monesi, V.1
  • 24
    • 0033638183 scopus 로고    scopus 로고
    • Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11
    • PID: 11106739
    • Baudat, F., Manova, K., Yuen, J. P., Jasin, M. & Keeney, S. Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11. Mol. Cell 6, 989–998 (2000)
    • (2000) Mol. Cell , vol.6 , pp. 989-998
    • Baudat, F.1    Manova, K.2    Yuen, J.P.3    Jasin, M.4    Keeney, S.5
  • 25
    • 0033634652 scopus 로고    scopus 로고
    • The mouse Spo11 gene is required for meiotic chromosome synapsis
    • PID: 11106738
    • Romanienko, P. J. & Camerini-Otero, R. D. The mouse Spo11 gene is required for meiotic chromosome synapsis. Mol. Cell 6, 975–987 (2000)
    • (2000) Mol. Cell , vol.6 , pp. 975-987
    • Romanienko, P.J.1    Camerini-Otero, R.D.2
  • 26
    • 84964829892 scopus 로고    scopus 로고
    • Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes
    • PID: 26965368
    • Chen, Y. et al. Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes. Development 143, 1502–1511 (2016)
    • (2016) Development , vol.143 , pp. 1502-1511
    • Chen, Y.1
  • 27
    • 84922517270 scopus 로고    scopus 로고
    • Recombination, pairing, and synapsis of homologs during meiosis
    • Zickler, D. & Kleckner, N. Recombination, pairing, and synapsis of homologs during meiosis. Cold Spring Harb. Perspect. Biol. 7, a016626 (2015)
    • (2015) Cold Spring Harb. Perspect. Biol. , vol.7
    • Zickler, D.1    Kleckner, N.2
  • 28
    • 84888594733 scopus 로고    scopus 로고
    • Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes
    • PID: 24050176
    • de Massy, B. Initiation of meiotic recombination: how and where? Conservation and specificities among eukaryotes. Annu. Rev. Genet. 47, 563–599 (2013)
    • (2013) Annu. Rev. Genet. , vol.47 , pp. 563-599
    • de Massy, B.1
  • 29
    • 84959450253 scopus 로고    scopus 로고
    • A DNA topoisomerase VI-like complex initiates meiotic recombination
    • PID: 26917763
    • Vrielynck, N. et al. A DNA topoisomerase VI-like complex initiates meiotic recombination. Science 351, 939–943 (2016)
    • (2016) Science , vol.351 , pp. 939-943
    • Vrielynck, N.1
  • 30
    • 84959432836 scopus 로고    scopus 로고
    • The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation
    • PID: 26917764
    • Robert, T. et al. The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science 351, 943–949 (2016)
    • (2016) Science , vol.351 , pp. 943-949
    • Robert, T.1
  • 31
    • 16844370525 scopus 로고    scopus 로고
    • Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma
    • PID: 15723337
    • Simon-Kayser, B. et al. Molecular cloning and characterization of FBXO47, a novel gene containing an F-box domain, located in the 17q12 band deleted in papillary renal cell carcinoma. Genes Chromosomes Cancer 43, 83–94 (2005)
    • (2005) Genes Chromosomes Cancer , vol.43 , pp. 83-94
    • Simon-Kayser, B.1
  • 32
    • 85030687382 scopus 로고    scopus 로고
    • Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
    • PID: 28914256
    • Lin, Z. et al. Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis. Cell Res. 27, 1216–1230 (2017)
    • (2017) Cell Res. , vol.27 , pp. 1216-1230
    • Lin, Z.1
  • 33
    • 0032897595 scopus 로고    scopus 로고
    • Acquisition of competence to condense metaphase I chromosomes during spermatogenesis
    • PID: 9882497
    • Cobb, J., Cargile, B. & Handel, M. A. Acquisition of competence to condense metaphase I chromosomes during spermatogenesis. Dev. Biol. 205, 49–64 (1999)
    • (1999) Dev. Biol. , vol.205 , pp. 49-64
    • Cobb, J.1    Cargile, B.2    Handel, M.A.3
  • 34
    • 77950953915 scopus 로고    scopus 로고
    • Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa
    • PID: 19941292
    • Hermo, L., Pelletier, R. M., Cyr, D. G. & Smith, C. E. Surfing the wave, cycle, life history, and genes/proteins expressed by testicular germ cells. Part 2: changes in spermatid organelles associated with development of spermatozoa. Microsc. Res. Tech. 73, 279–319 (2010)
    • (2010) Microsc. Res. Tech. , vol.73 , pp. 279-319
    • Hermo, L.1    Pelletier, R.M.2    Cyr, D.G.3    Smith, C.E.4
  • 35
    • 84948393655 scopus 로고    scopus 로고
    • Fourteen babies born after round spermatid injection into human oocytes
    • PID: 26575628
    • Tanaka, A. et al. Fourteen babies born after round spermatid injection into human oocytes. Proc. Natl Acad. Sci. USA 112, 14629–14634 (2015)
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 14629-14634
    • Tanaka, A.1
  • 36
    • 0034888935 scopus 로고    scopus 로고
    • Gamete manipulation for development: new methods for conception
    • PID: 11545162
    • Yanagimachi, R. Gamete manipulation for development: new methods for conception. Reprod. Fertil. Dev. 13, 3–14 (2001)
    • (2001) Reprod. Fertil. Dev. , vol.13 , pp. 3-14
    • Yanagimachi, R.1
  • 37
    • 0034020067 scopus 로고    scopus 로고
    • Transcriptional regulation of meiosis in yeast
    • PID: 10801467
    • Vershon, A. K. & Pierce, M. Transcriptional regulation of meiosis in yeast. Curr. Opin. Cell Biol. 12, 334–339 (2000)
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 334-339
    • Vershon, A.K.1    Pierce, M.2
  • 38
    • 84938812668 scopus 로고    scopus 로고
    • RFX2 is a major transcriptional regulator of spermiogenesis
    • PID: 26162102
    • Kistler, W. S. et al. RFX2 is a major transcriptional regulator of spermiogenesis. PLoS Genet. 11, e1005368 (2015)
    • (2015) PLoS Genet. , vol.11
    • Kistler, W.S.1
  • 39
    • 85038242250 scopus 로고    scopus 로고
    • SOX30 is required for male fertility in mice
    • PID: 29247201
    • Feng, C. A. et al. SOX30 is required for male fertility in mice. Sci. Rep. 7, 17619 (2017)
    • (2017) Sci. Rep. , vol.7
    • Feng, C.A.1
  • 40
    • 79951845521 scopus 로고    scopus 로고
    • Distinct properties of the XY pseudoautosomal region crucial for male meiosis
    • PID: 21330546
    • Kauppi, L. et al. Distinct properties of the XY pseudoautosomal region crucial for male meiosis. Science 331, 916–920 (2011)
    • (2011) Science , vol.331 , pp. 916-920
    • Kauppi, L.1
  • 41
    • 84919624822 scopus 로고    scopus 로고
    • RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility
    • PID: 25474150
    • Bao, J. et al. RAN-binding protein 9 is involved in alternative splicing and is critical for male germ cell development and male fertility. PLoS Genet. 10, e1004825 (2014)
    • (2014) PLoS Genet. , vol.10
    • Bao, J.1
  • 42
    • 84987624973 scopus 로고    scopus 로고
    • MRG15 is required for pre-mRNA splicing and spermatogenesis
    • PID: 27573846
    • Iwamori, N. et al. MRG15 is required for pre-mRNA splicing and spermatogenesis. Proc. Natl Acad. Sci. USA 113, E5408–E5415 (2016)
    • (2016) Proc. Natl Acad. Sci. USA , vol.113 , pp. E5408-E5415
    • Iwamori, N.1
  • 43
    • 84862784195 scopus 로고    scopus 로고
    • HnRNPL as a key factor in spermatogenesis: lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome
    • Li, J. et al. HnRNPL as a key factor in spermatogenesis: lesson from functional proteomic studies of azoospermia patients with sertoli cell only syndrome. J. Proteom. 75, 2879–2891 (2012)
    • (2012) J. Proteom. , vol.75 , pp. 2879-2891
    • Li, J.1
  • 44
    • 26444490659 scopus 로고    scopus 로고
    • Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse
    • PID: 16118233
    • Wang, P. J., Page, D. C. & McCarrey, J. R. Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse. Hum. Mol. Genet. 14, 2911–2918 (2005)
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2911-2918
    • Wang, P.J.1    Page, D.C.2    McCarrey, J.R.3
  • 45
    • 0035071815 scopus 로고    scopus 로고
    • An abundance of X-linked genes expressed in spermatogonia
    • PID: 11279525
    • Wang, P. J., McCarrey, J. R., Yang, F. & Page, D. C. An abundance of X-linked genes expressed in spermatogonia. Nat. Genet. 27, 422–426 (2001)
    • (2001) Nat. Genet. , vol.27 , pp. 422-426
    • Wang, P.J.1    McCarrey, J.R.2    Yang, F.3    Page, D.C.4
  • 46
    • 34250626425 scopus 로고    scopus 로고
    • Meiotic sex chromosome inactivation
    • PID: 17329371
    • Turner, J. M. Meiotic sex chromosome inactivation. Development 134, 1823–1831 (2007)
    • (2007) Development , vol.134 , pp. 1823-1831
    • Turner, J.M.1
  • 47
    • 33645511177 scopus 로고    scopus 로고
    • Postmeiotic sex chromatin in the male germline of mice
    • PID: 16581510
    • Namekawa, S. H. et al. Postmeiotic sex chromatin in the male germline of mice. Curr. Biol. 16, 660–667 (2006)
    • (2006) Curr. Biol. , vol.16 , pp. 660-667
    • Namekawa, S.H.1
  • 48
    • 44349137392 scopus 로고    scopus 로고
    • The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
    • PID: 18454149
    • Mueller, J. L. et al. The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression. Nat. Genet. 40, 794–799 (2008)
    • (2008) Nat. Genet. , vol.40 , pp. 794-799
    • Mueller, J.L.1
  • 49
    • 84885692672 scopus 로고    scopus 로고
    • Taf7l cooperates with Trf2 to regulate spermiogenesis
    • PID: 24082143
    • Zhou, H. et al. Taf7l cooperates with Trf2 to regulate spermiogenesis. Proc. Natl Acad. Sci. USA 110, 16886–16891 (2013)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 16886-16891
    • Zhou, H.1
  • 51
    • 0026099141 scopus 로고
    • Protamine transcript sharing among postmeiotic spermatids
    • PID: 2006178
    • Caldwell, K. A. & Handel, M. A. Protamine transcript sharing among postmeiotic spermatids. Proc. Natl Acad. Sci. USA 88, 2407–2411 (1991)
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 2407-2411
    • Caldwell, K.A.1    Handel, M.A.2
  • 52
    • 0345676496 scopus 로고    scopus 로고
    • The DNA/RNA-binding protein, TB-RBP, moves from the nucleus to the cytoplasm and through intercellular bridges in male germ cells
    • PID: 9733578
    • Morales, C. R., Wu, X. Q. & Hecht, N. B. The DNA/RNA-binding protein, TB-RBP, moves from the nucleus to the cytoplasm and through intercellular bridges in male germ cells. Dev. Biol. 201, 113–123 (1998)
    • (1998) Dev. Biol. , vol.201 , pp. 113-123
    • Morales, C.R.1    Wu, X.Q.2    Hecht, N.B.3
  • 53
    • 84872188348 scopus 로고    scopus 로고
    • Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males
    • PID: 23267101
    • Tong, M. H., Yang, Q. E., Davis, J. C. & Griswold, M. D. Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males. Proc. Natl Acad. Sci. USA 110, 543–548 (2013)
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 543-548
    • Tong, M.H.1    Yang, Q.E.2    Davis, J.C.3    Griswold, M.D.4
  • 54
    • 0033636363 scopus 로고    scopus 로고
    • Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores
    • PID: 11102517
    • Scherthan, H. et al. Mammalian meiotic telomeres: protein composition and redistribution in relation to nuclear pores. Mol. Biol. Cell 11, 4189–4203 (2000)
    • (2000) Mol. Biol. Cell , vol.11 , pp. 4189-4203
    • Scherthan, H.1
  • 55
    • 0030937928 scopus 로고    scopus 로고
    • A drying-down technique for the spreading of mammalian meiocytes from the male and female germline
    • PID: 9088645
    • Peters, A. H., Plug, A. W., van Vugt, M. J. & de Boer, P. A drying-down technique for the spreading of mammalian meiocytes from the male and female germline. Chromosome Res. 5, 66–68 (1997)
    • (1997) Chromosome Res. , vol.5 , pp. 66-68
    • Peters, A.H.1    Plug, A.W.2    van Vugt, M.J.3    de Boer, P.4
  • 56
    • 0026263949 scopus 로고
    • Visualization of DNA sequences in meiotic chromosomes
    • PID: 1779855
    • Moens, P. B. & Pearlman, R. E. Visualization of DNA sequences in meiotic chromosomes. Methods Cell Biol. 35, 101–108 (1991)
    • (1991) Methods Cell Biol. , vol.35 , pp. 101-108
    • Moens, P.B.1    Pearlman, R.E.2
  • 57
    • 0029038113 scopus 로고
    • Mouse oocytes injected with testicular spermatozoa or round spermatids can develop into normal offspring
    • PID: 7671805
    • Kimura, Y. & Yanagimachi, R. Mouse oocytes injected with testicular spermatozoa or round spermatids can develop into normal offspring. Development 121, 2397–2405 (1995)
    • (1995) Development , vol.121 , pp. 2397-2405
    • Kimura, Y.1    Yanagimachi, R.2
  • 58
    • 84887101406 scopus 로고    scopus 로고
    • Smart-seq2 for sensitive full-length transcriptome profiling in single cells
    • PID: 24056875
    • Picelli, S. et al. Smart-seq2 for sensitive full-length transcriptome profiling in single cells. Nat. Methods 10, 1096–1098 (2013)
    • (2013) Nat. Methods , vol.10 , pp. 1096-1098
    • Picelli, S.1
  • 59
    • 84891677425 scopus 로고    scopus 로고
    • Full-length RNA-seq from single cells using Smart-seq2
    • PID: 24385147
    • Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171–181 (2014)
    • (2014) Nat. Protoc. , vol.9 , pp. 171-181
    • Picelli, S.1
  • 60
    • 85028722043 scopus 로고    scopus 로고
    • Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions
    • PID: 28575695
    • Li, L. et al. Single-cell RNA-seq analysis maps development of human germline cells and gonadal niche interactions. Cell. Stem. Cell. 20, 891–892 (2017)
    • (2017) Cell. Stem. Cell. , vol.20 , pp. 891-892
    • Li, L.1
  • 61
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: discovering splice junctions with RNA-Seq
    • PID: 19289445
    • Trapnell, C., Pachter, L. & Salzberg, S. L. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105–1111 (2009)
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 62
    • 84928987900 scopus 로고    scopus 로고
    • HTSeq—a Python framework to work with high-throughput sequencing data
    • PID: 25260700
    • Anders, S., Pyl, P. T. & Huber, W. HTSeq—a Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166–169 (2015)
    • (2015) Bioinformatics , vol.31 , pp. 166-169
    • Anders, S.1    Pyl, P.T.2    Huber, W.3
  • 63
    • 84859885816 scopus 로고    scopus 로고
    • Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
    • PID: 22383036
    • Trapnell, C. et al. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat. Protoc. 7, 562–578 (2012)
    • (2012) Nat. Protoc. , vol.7 , pp. 562-578
    • Trapnell, C.1
  • 64
  • 66
    • 67849130563 scopus 로고    scopus 로고
    • ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    • PID: 19465376
    • Chen, J., Bardes, E. E., Aronow, B. J. & Jegga, A. G. ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res. 37, W305–W311 (2009)
    • (2009) Nucleic Acids Res. , vol.37 , pp. W305-W311
    • Chen, J.1    Bardes, E.E.2    Aronow, B.J.3    Jegga, A.G.4
  • 67
    • 84865760395 scopus 로고    scopus 로고
    • GENCODE: the reference human genome annotation for The ENCODE Project
    • PID: 22955987
    • Harrow, J. et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res. 22, 1760–1774 (2012)
    • (2012) Genome Res. , vol.22 , pp. 1760-1774
    • Harrow, J.1
  • 68
    • 85016041593 scopus 로고    scopus 로고
    • Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse
    • PID: 27899570
    • Blake, J. A. et al. Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse. Nucleic Acids Res. 45, D723–D729 (2017)
    • (2017) Nucleic Acids Res. , vol.45 , pp. D723-D729
    • Blake, J.A.1
  • 69
    • 45349086252 scopus 로고
    • The igraph software package for complex network research
    • Csardi, G. & Nepusz, T. The igraph software package for complex network research. Inter. Complex Syst. 1-9, 2006 (1695)
    • (1695) Inter. Complex Syst. , vol.1-9 , pp. 2006
    • Csardi, G.1    Nepusz, T.2
  • 70
    • 84941121620 scopus 로고    scopus 로고
    • AnimalTFDB 2.0: a resource for expression, prediction and functional study of animal transcription factors
    • PID: 25262351
    • Zhang, H.-M. et al. AnimalTFDB 2.0: a resource for expression, prediction and functional study of animal transcription factors. Nucleic Acids Res. 43, D76–D81 (2015)
    • (2015) Nucleic Acids Res. , vol.43 , pp. D76-D81
    • Zhang, H.M.1
  • 71
    • 84905049901 scopus 로고    scopus 로고
    • Trimmomatic: a flexible trimmer for Illumina sequence data
    • PID: 24695404
    • Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114–2120 (2014)
    • (2014) Bioinformatics , vol.30 , pp. 2114-2120
    • Bolger, A.M.1    Lohse, M.2    Usadel, B.3
  • 72
    • 84859210032 scopus 로고    scopus 로고
    • Fast gapped-read alignment with Bowtie 2
    • PID: 22388286
    • Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9, 357–359 (2012)
    • (2012) Nat. Methods , vol.9 , pp. 357-359
    • Langmead, B.1    Salzberg, S.L.2
  • 73
    • 53849146020 scopus 로고    scopus 로고
    • Model-based analysis of ChIP-Seq (MACS)
    • PID: 18798982
    • Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008)
    • (2008) Genome Biol. , vol.9
    • Zhang, Y.1
  • 74
    • 84875634162 scopus 로고    scopus 로고
    • Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
    • PID: 22517427
    • Thorvaldsdóttir, H., Robinson, J. T. & Mesirov, J. P. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief. Bioinform. 14, 178–192 (2013)
    • (2013) Brief. Bioinform. , vol.14 , pp. 178-192
    • Thorvaldsdóttir, H.1    Robinson, J.T.2    Mesirov, J.P.3
  • 75
    • 84939181353 scopus 로고    scopus 로고
    • ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
    • PID: 25765347
    • Yu, G., Wang, L.-G. & He, Q.-Y. ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization. Bioinformatics 31, 2382–2383 (2015)
    • (2015) Bioinformatics , vol.31 , pp. 2382-2383
    • Yu, G.1    Wang, L.G.2    He, Q.Y.3
  • 77
    • 84919928214 scopus 로고    scopus 로고
    • A highly conserved program of neuronal microexons is misregulated in autistic brains
    • PID: 25525873
    • Irimia, M. et al. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell 159, 1511–1523 (2014)
    • (2014) Cell , vol.159 , pp. 1511-1523
    • Irimia, M.1


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