Turning a spermatogenic wave into a tsunami: Synchronizing murine spermatogenesis using WIN 18,446

Biology of Reproduction

Volumn 88, Issue 2, 2013, Pages

  Hogarth, Cathryn A ^a   Evanoff, Ryan ^a   Mitchell, Debra ^a   Kent, Travis ^a   Small, Christopher ^a   Amory, John K ^b   Griswold, Michael D ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Contraception; Retinoids; Spermatogenesis; Testis; WIN 18,446

Indexed keywords

DIAMINE DERIVATIVE; FERTILYSIN; MALE CONTRACEPTIVE AGENT; RETINOIC ACID; RETINOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; EJACULATION; GERM CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEWBORN; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE EPITHELIUM; SHORT COURSE THERAPY; SPERMATOGENESIS; TESTIS; VITAMIN METABOLISM;

ANIMALS; CELL DIFFERENTIATION; DIAMINES; MALE; MICE; MODELS, ANIMAL; SPERMATOGENESIS; TESTIS; TRETINOIN;

MAMMALIA; MURINAE; MUS;

EID: 84877076416     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.112.105346     Document Type: Article

References (29)

1. Oakberg EF. A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal. Am J Anat 1956; 99:391-413.
2. Russell LD, Ettlin RA, Sinha Hikim AP, Clegg EP. Histological and Histopathological Evaluation of the Testis. St. Louis, MO: Cache River Press; 1990.
3. Hogarth CA, Griswold MD. The key role of vitamin A in spermatogenesis. J Clin Investig 2010; 120:956-962.
4. Morales CG, Griswold MD. Retinol-induced stage synchronization in seminiferous tubules of the rat. Endocrinology 1987; 121(1):432-434.
5. Snyder EM, Davis JC, Zhou Q, Evanoff R, Griswold MD. Exposure to retinoic acid in the neonatal but not adult mouse results in synchronous spermatogenesis. Biol Reprod 2011; 84:886-893.
6. Van Beek ME, Meistrich ML. A method for quantifying synchrony in testes of rats treated with vitamin A deprivation and readministration. Biol Reprod 1990; 42:424-431.
7. Griswold MD, Hogarth CA, Bowles J, Koopman P. Initiating meiosis: the case for retinoic acid. Biol Reprod 2012; 86:35.
8. Li H, Palczewski K, Baehr W, Clagett-Dame M. Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod 2011; 84:336-341.
9. Amory JK, Muller CH, Shimshoni JA, Isoherranen N, Paik J, Moreb JS, Amory DW Sr, Evanoff R, Goldstein AS, Griswold MD. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl 2011; 32:111-119.
10. Hogarth CA, Evanoff R, Snyder E, Kent T, Mitchell D, Small C, Amory JK, Griswold MD. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod 2011; 84:957-965.
11. Heller CG, Moore DJ, Paulsen CA. Suppression of spermatogenesis and chronic toxicity in men by a new series of bis(dichloroacetyl) diamines. Toxicol Appl Pharmacol 1961; 3:1-11.
12. Brooks NL, van der Horst G. Short-term effects of N0N-bis(dichloroacetyl)-1,8-octamethylenediamine (WIN 18446) on the testes, selected sperm parameters and fertility of male CBA mice. Lab Anim 2003; 37:363-373.
13. McLean DJ, Russell LD, Griswold MD. Biological activity and enrichment of spermatogonial stem cells in vitamin A-deficient and hyperthermia-exposed testes from mice based on colonization following germ cell transplantation. Biol Reprod 2002; 66:1374-1379.
14. Loveland KL, Hogarth C, Szczepny A, Prabhu SM, Jans DA. Expression of nuclear transport importins beta 1 and beta 3 is regulated during rodent spermatogenesis. Biol Reprod 2006; 74:67-74.
15. Zhou Q, Shima JE, Nie R, Friel PJ, Griswold MD. Androgen-regulated transcripts in the neonatal mouse testis as determined through microarray analysis. Biol Reprod 2005; 72:1010-1019.
16. van Pelt AM, de Rooij DG. Synchronization of the seminiferous epithelium after vitamin A replacement in vitamin A-deficient mice. Biol Reprod 1990; 43:363-367.
17. Griswold MD, Bishop PD, Kim KH, Ping R, Siiteri JE, Morales C. Function of vitamin A in normal and synchronized seminiferous tubules. Ann N Y Acad Sci 1989; 564:154-172.
18. Zhou Q, Li Y, Nie R, Friel P, Mitchell D, Evanoff RM, Pouchnik D, Banasik B, McCarrey JR, Small C, Griswold MD. Expression of stimulated by retinoic acid gene 8 (Stra8) and maturation of murine gonocytes and spermatogonia induced by retinoic acid in vitro. Biol Reprod 2008; 78:537-545.
19. Pellegrini M, Filipponi D, Gori M, Barrios F, Lolicato F, Grimaldi P, Rossi P, Jannini EA, Geremia R, Dolci S. ATRA and KL promote differentiation toward the meiotic program of male germ cells. Cell Cycle 2008; 7:3878-3888.
20. Zhou Q, Nie R, Li Y, Friel P, Mitchell D, Hess RA, Small C, Griswold MD. Expression of stimulated by retinoic acid gene 8 (Stra8) in spermatogenic cells induced by retinoic acid: an in vivo study in vitamin A-sufficient postnatal murine testes. Biol Reprod 2008; 79:35-42.
21. Buaas FW, Kirsh AL, Sharma M, McLean DJ, Morris JL, Griswold MD, de Rooij DG, Braun RE. Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet 2004; 36:647-652.
22. Costoya JA, Hobbs RM, Barna M, Cattoretti G, Manova K, Sukhwani M, Orwig KE, Wolgemuth DJ, Pandolfi PP. Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet 2004; 36:653-659.
23. Rossant J, Zirngibl R, Cado D, Shago M, Giguere V. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 1991; 5:1333-1344.
24. Snyder EM, Small C, Griswold MD. Retinoic acid availability drives the asynchronous initiation of spermatogonial differentiation in the mouse. Biol Reprod 2010; 83:783-790.
25. Snyder EM, Davis JC, Zhou Q, Evanoff R, Griswold MD. Exposure to retinoic acid in the neonatal but not adult mouse results in synchronous spermatogenesis. Biol Reprod 2011; 84:886-893.
26. Arnold SL, Amory JK, Walsh TJ, Isoherranen N. A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS. J Lipid Res 2012; 53:587-598.
27. Vernet N, Dennefeld C, Rochette-Egly C, Oulad-Abdelghani M, Chambon P, Ghyselinck NB, Mark M. Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis. Endocrinology 2006; 147:96-110.
28. Sugimoto R, Nabeshima Y, Yoshida S. Retinoic acid metabolism links the periodical differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium. Mech Dev 2012; 128:610-624.
29. Luk JM, Mok BW, Shum CK, Yeung WS, Tam PC, Tse JY, Chow JF, Woo J, Kam K, Lee KF. Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display. Biochem Biophys Res Comm 2003; 307:782-790.