Pro-inflammatory effects of e-cigarette vapour condensate on human alveolar macrophages

Thorax

Volumn 73, Issue 12, 2018, Pages 1161-1169

  Scott, Aaron ^a   Lugg, Sebastian T ^a   Aldridge, Kerrie ^a   Lewis, Keir E ^b   Bowden, Allen ^a   Mahida, Rahul Y ^a   Grudzinska, Frances Susanna ^a   Dosanjh, Davinder ^a   Parekh, Dhruv ^a   Foronjy, Robert ^c   Sapey, Elizabeth ^a   Naidu, Babu ^a   Thickett, David R ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b SWANSEA UNIVERSITY   (United Kingdom)

^c SUNY Downstate Medical Center   (United States)

Author keywords

macrophage biology; oxidative stress; respiratory infection

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CHEMOKINE; CIGARETTE SMOKE CONDENSATE; CYTOKINE; GELATINASE B; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEINASE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; CCL2 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PHAGOCYTOSIS; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; LETHAL DOSE; LUNG ALVEOLUS MACROPHAGE; LUNG VOLUME; MACROPHAGE CULTURE; MACROPHAGE FUNCTION; MALE; PRIORITY JOURNAL; THP-1 CELL LINE; VAPING; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DRUG EFFECT; DRUG MIXTURE; ELECTRONIC CIGARETTE; GAS; INFLAMMATION; METABOLISM; NECROSIS; PATHOLOGY; PHAGOCYTOSIS; PHYSIOLOGY;

ACETYLCYSTEINE; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; CHEMOKINE CCL2; COMPLEX MIXTURES; ELECTRONIC NICOTINE DELIVERY SYSTEMS; GASES; HUMANS; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; MACROPHAGES, ALVEOLAR; MATRIX METALLOPROTEINASE 9; NECROSIS; NICOTINE; PHAGOCYTOSIS; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; THP-1 CELLS; TUMOR NECROSIS FACTOR-ALPHA; VAPING;

EID: 85052400144     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2018-211663     Document Type: Article

References (43)

1. Rom O, Pecorelli A, Valacchi G, et al. Are e-cigarettes a safe and good alternative to cigarette smoking? Ann N Y Acad Sci 2015;1340:65-74.
2. Higham A, Rattray NJ, Dewhurst JA, et al. Electronic cigarette exposure triggers neutrophil infammatory responses. Respir Res 2016;17:56.
3. Chun L F, Moazed F, Calfee CS, et al. Pulmonary toxicity of e-cigarettes. Am J Physiol Lung Cell Mol Physiol 2017;313:l193-l206.
4. Lerner CA, Sundar IK, Watson RM, et al. Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols. Environ Pollut 2015;198:100-7.
5. Williams M, Villarreal A, Bozhilov K, et al. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fuid and aerosol. PLoS One 2013;8:e57987.
6. Mikheev VB, Brinkman MC, Granville CA, et al. Real-time Measurement of electronic cigarette aerosol Size Distribution and Metals content analysis. Nicotine Tob Res 2016;18:1895-902.
7. Geiss O, Bianchi I, Barrero-Moreno J. Correlation of volatile carbonyl yields emitted by e-cigarettes with the temperature of the heating coil and the perceived sensorial quality of the generated vapours. Int J Hyg Environ Health 2016;219:268-77.
8. Kosmider L, Sobczak A, Fik M, et al. Carbonyl compounds in electronic cigarette vapors: effects of nicotine solvent and battery output voltage. Nicotine Tob Res 2014;16:1319-26.
9. Kosmider L, Sobczak A, Prokopowicz A, et al. Cherry-favoured electronic cigarettes expose users to the inhalation irritant, benzaldehyde. Thorax 2016;71:376-7.
10. Leigh NJ, Lawton RI, Hershberger PA, et al. Flavourings signifcantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (enDS). Tob Control 2016;25(Suppl 2):ii81-ii87.
11. Margham J, Mcadam K, Forster M, et al. Chemical composition of aerosol from an e-cigarette: a Quantitative comparison with cigarette Smoke. Chem Res Toxicol 2016;29:1662-78.
12. Aug A, Altraja S, Kilk K, et al. E-cigarette affects the Metabolome of Primary normal Human Bronchial epithelial cells. PLoS One 2015;10:e0142053.
13. Garcia-Arcos I, Geraghty P, Baumlin N, et al. Chronic electronic cigarette exposure in mice induces features of cOPD in a nicotine-dependent manner. Thorax 2016;71:1119-29.
14. Lerner CA, Sundar IK, Yao H, et al. Vapors produced by electronic cigarettes and e-juices with favorings induce toxicity, oxidative stress, and infammatory response in lung epithelial cells and in mouse lung. PLoS One 2015;10:e0116732.
15. Vlahos R, Bozinovski S. Role of alveolar macrophages in chronic obstructive pulmonary disease. Front Immunol 2014;5:435.
16. Behar RZ, Hua M, Talbot P. Puffng topography and nicotine intake of electronic cigarette users. PLoS One 2015;10:e0117222.
17. Farsalinos KE, Spyrou A, Tsimopoulou K, et al. Nicotine absorption from electronic cigarette use: comparison between frst and new-generation devices. Sci Rep 2014;4:4133.
18. Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 2014;23:133-9.
19. Hua M, Yip H, Talbot P. Mining data on usage of electronic nicotine delivery systems (enDS) from Youtube videos. Tob Control 2013;22:103-6.
20. Robinson RJ, Hensel EC, Morabito PN, et al. Electronic cigarette topography in the natural environment. PLoS One 2015;10:e0129296.
21. Norton KJ, June KM, O'Connor RJ. Initial puffng behaviors and subjective responses differ between an electronic nicotine delivery system and traditional cigarettes. Tob Induc Dis 2014;12:17.
22. Tsuchiya S, Kobayashi Y, Goto Y, et al. Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester. Cancer Res 1982;42:1530-6.
23. Anderson C, Majeste A, Hanus J, et al. E-cigarette aerosol exposure induces reactive Oxygen Species, Dna Damage, and cell Death in Vascular endothelial cells. Toxicol Sci 2016;154:332-40.
24. Baker JR, Vuppusetty C, Colley T, et al. Oxidative stress dependent microrna-34a activation via Pi3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells. Sci Rep 2016;6:35871.
25. Wetscher GJ, Bagchi D, Perdikis G, et al. In vitro free radical production in rat esophageal mucosa induced by nicotine. Dig Dis Sci 1995;40:853-8.
26. Mahapatra SK, Das S, Bhattacharjee S, et al. In vitro nicotine-induced oxidative stress in mice peritoneal macrophages: a dose-dependent approach. Toxicol Mech Methods 2009;19:100-8.
27. Reidel B, Radicioni G, Clapp PW, et al. E-cigarette Use causes a Unique innate immune response in the lung, involving increased neutrophilic activation and altered Mucin Secretion. Am J Respir Crit Care Med 2018;197:492-501.
28. Gerloff J, Sundar IK, Freter R, et al. Infammatory response and Barrier Dysfunction by Different e-cigarette Flavoring chemicals identifed by gas chromatography-Mass Spectrometry in e-liquids and e-Vapors on Human lung epithelial cells and Fibroblasts. Appl In Vitro Toxicol 2017;3:28-40.
29. Sussan TE, Gajghate S, Thimmulappa RK, et al. Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One 2015;10:e0116861.
30. Miyashita L, Suri R, Dearing E, et al. E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. Eur Respir J 2018;51:1701592.
31. Mcconnell R, Barrington-Trimis JL, Wang K, et al. Electronic cigarette Use and respiratory Symptoms in adolescents. Am J Respir Crit Care Med 2017;195:1043-9.
32. Van Der Zanden E P, Snoek SA, Heinsbroek SE, et al. Vagus nerve activity augments intestinal macrophage phagocytosis via nicotinic acetylcholine receptor alpha4beta2. Gastroenterology 2009;137:1029-39.
33. Ogunwale MA, Li M, Ramakrishnam Raju M V, et al. Aldehyde Detection in electronic cigarette aerosols. ACS Omega 2017;2:1207-14.
34. Dalleau S, Baradat M, Guéraud F, et al. Cell death and diseases related to oxidative stress: 4-hydroxynonenal (Hne) in the balance. Cell Death Differ 2013;20:1615-30.
35. Poli G, Schaur RJ, Siems WG, et al. 4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest. Med Res Rev 2008;28:569-631.
36. Austin V, Crack PJ, Bozinovski S, et al. COPD and stroke: are systemic infammation and oxidative stress the missing links? Clin Sci 2016;130:1039-50.
37. Thorley AJ, Tetley TD. Pulmonary epithelium, cigarette smoke, and chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2007;2:409-28.
38. Galvis G, Lips KS, Kummer W. Expression of nicotinic acetylcholine receptors on murine alveolar macrophages. J Mol Neurosci 2006;30:107-8.
39. Kihara T, Shimohama S, Sawada H, et al. Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block a beta-amyloid-induced neurotoxicity. J Biol Chem 2001;276:13541-6.
40. Kozlowski LT, Mehta N Y, Sweeney CT, et al. Filter ventilation and nicotine content of tobacco in cigarettes from canada, the United Kingdom, and the United States. Tob Control 1998;7:369-75.
41. Benowitz NL, Jacob P. Daily intake of nicotine during cigarette smoking. Clin Pharmacol Ther 1984;35:499-504.
42. Benowitz NL, Hukkanen J, Jacob P. 3rd. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol 2009;192:29-60.
43. Clapp PW, Pawlak EA, Lackey JT, et al. Flavored e-cigarette liquids and cinnamaldehyde impair respiratory innate immune cell function. Am J Physiol Lung Cell Mol Physiol 2017;313:l278-l292.