Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Baker, J R ^a   Vuppusetty, C ^a   Colley, T ^a   Papaioannou, Andriana I ^b   Fenwick, P ^a   Donnelly, Louise ^a   Ito, K ^a   Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b SISMANOGLIO HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGOMIR; DNA BINDING PROTEIN; HYDROGEN PEROXIDE; MESSENGER RNA; MICRORNA; MIRN34 MICRORNA, HUMAN; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PPP1R10 PROTEIN, HUMAN; RNA BINDING PROTEIN; SIRT6 PROTEIN, HUMAN; SIRTUIN; SIRTUIN 1;

3' UNTRANSLATED REGION; ANTAGONISTS AND INHIBITORS; CELL AGING; CELL LINE; CHEMISTRY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; EPITHELIUM CELL; GENETICS; HUMAN; LUNG; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; SPUTUM; UPREGULATION;

3' UNTRANSLATED REGIONS; ANTAGOMIRS; CELL LINE; CELLULAR SENESCENCE; DNA-BINDING PROTEINS; DOWN-REGULATION; EPITHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; LUNG; MICRORNAS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; RNA-BINDING PROTEINS; SIRTUIN 1; SIRTUINS; SPUTUM; UP-REGULATION;

EID: 84992313449     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep35871     Document Type: Article

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