High-throughput screening of TRPC channel ligands using cell-based assays

TRP Channels

Volumn , Issue , 2016, Pages 1-20

  Miller, Melissa ^a   Wu, Meng ^a   Xu, Jia ^a   Weaver, David ^b   Li, Min ^a   Zhu, Michael X ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85052200285     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (32)

1. Clapham, D.E. 2003. TRP channels as cellular sensors. Nature 426: 517.
2. Hofmann, T., A.G. Obukhov, M. Schaefer, C. Harteneck, T. Gudermann, and G. Schultz. 1999. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397: 259.
3. McKemy, D.D., W.M. Neuhausser, and D. Julius. 2002. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416: 52.
4. Hu, H.Z., Q. Gu, C. Wang et al. 2004. 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. Journal of Biological Chemistry 279: 35,741.
5. Jordt, S.E., D.M. Bautista, H. Chuang et al. 2004. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427: 260.
6. Putney, J.W. 2005. Physiological mechanisms of TRPC activation. Pflügers Arch 451: 29.
7. Möller, C.C., J. Flesche, and J. Reiser. 2009. Sensitizing the slit diaphragm with TRPC6 ion channels. Journal of American Society of Nephrology 20: 950.
8. Guinamard, R., and P. Bois. 2007. Involvement of transient receptor potential proteins in cardiac hypertrophy. Biochimica et Biophysica Acta 1772: 885.
9. Tsvilovskyy, V.V., A.V. Zholos, T. Aberle et al. 2009. Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo. Gastroenterology 137: 1415.
10. Hartmann, J., E. Dragicevic, H. Adelsberger et al. 2008. TRPC3 channels are required for synaptic transmission and motor coordination. Neuron 59: 392.
11. 2+ influx and the severity of acute pancreatitis. Gastroenterology 137: 1509.
12. Greka, A., B. Navarro, E. Oancea, A. Duggan, and D.E. Clapham. 2003. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nature Neuroscience 6: 837.
13. Riccio, A., Y. Li, J. Moon et al. 2009. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137: 761.
14. -/- mice. Molecular Cell Biology 25: 6980.
15. 2+-permeable cation channel. Circulation Research 88: 325.
16. Jung, S., R. Strotmann, G. Schultz, and T.D. Plant. 2002. TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells. American Journal of Physiology -Cell Physiology 282: C347.
17. Schultheiss, G., M. Frings, G. Hollingshaus, and M. Diener. 2000. Multiple action sites of flufenamate on ion transport across the rat distal colon. British Journal of Pharmacology 130: 875.
18. 2+ entry. Journal of Biology and Chemistry 273: 133.
19. Xu, S.Z., F. Zeng, G. Boulay, C. Grimm, C. Harteneck, and D.J. Beech. 2005. Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect. British Journal of Pharmacology 145: 405.
20. 2+ channels. Science 287: 1647.
21. 2+ signal generation by 2-aminoethoxydiphenyl borate. Biochemical Journal 376: 667.
22. Lievremont, J.P., G.S. Bird, and J.W. Putney, Jr. 2005. Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. Molecular Pharmacology 68: 758.
23. Kiyonaka, S., K. Kato, M. Nishida et al. 2009. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proceedings of the National Academy Sciences of the United States of America 106: 5400.
24. Pelletier, J., and N. Sonenberg. 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334: 320.
25. Leclere, P.G., A. Panjwani, R. Docherty, M. Berry, J. Pizzey, and D.A. Tonge. 2005. Effective gene delivery to adult neurons by a modified form of electroporation. Journal of Neuroscience Methods 142: 137.
26. Liao, Y., C. Erxleben, J. Abramowitz et al. 2008. Functional interactions among Orai1, TRPCs, and STIM1 suggest a STIM-regulated heteromeric Orai/TRPC model for SOCE/Icrac channels. Proceedings of the National Academy Sciences of the United States of America 105: 2895.
27. Vazquez, G., B.J. Wedel, M. Trebak, G. St John Bird, and J.W. Putney, Jr. 2003. Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. Journal Biological Chemistry 278: 21649.
28. Schaefer, M., T.D. Plant, A.G. Obukhov, T. Hofmann, T. Gudermann, and G. Schultz. 2000. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. Journal of Biological Chemistry 275: 17517.
29. Zheng, W., R.H. Spencer, and L. Kiss. 2004. High throughput assay technologies for ion channel drug discovery. Assay Drug Development Technology 2: 543.
30. Zhang, J.H., T.D. Chung, and K.R. Oldenburg. 1999. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. Journal of Biomolecular Screening 4: 67.
31. Brideau, C., B. Gunter, B. Pikounis, and A. Liaw. 2003. Improved statistical methods for hit selection in high-throughput screening. Journal of Biomolecular Screening 8: 634.
32. Malo, N., J.A. Hanley, S. Cerquozzi, J. Pelletier, and R. Nadon. 2006. Statistical practice in high-throughput screening data analysis. Nature Biotechnology 24: 167.