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Volumn 6, Issue 3, 2015, Pages P162-P178

A review on biomedical applications of chitosan-based biomaterials

Author keywords

Cross linked chitosan hydrogel; Drug delivery carriers; Hematostats; Polyelectrolyte complexes; Tissue adhesive; Wound dressing

Indexed keywords

ALGINIC ACID; BIOLOGIC GLUE; BIOMATERIAL; CHITOSAN; CHONDROITIN SULFATE; CYANOACRYLATE; FIBRIN GLUE; FUCOIDIN; GELATIN; GLYCEROL 2 PHOSPHATE; HEPARIN; HYALURONIC ACID; MACROGOL; NANOCARRIER; NANOPARTICLE; POLYELECTROLYTE; POLYGLACTIN; POLYGLYCOLIC ACID; POLYLACTIDE; PROTAMINE;

EID: 85051685281     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (14)

References (67)
  • 1
    • 0034821282 scopus 로고    scopus 로고
    • Relation between the degree of acetylation and the electrostatic properties of chitin and chitosan
    • Sorlier P., denuziere A., Viton C., Domand A. Relation between the degree of acetylation and the electrostatic properties of chitin and chitosan. Biomacromol, 2: 765-772, (2001).
    • (2001) Biomacromol , vol.2 , pp. 765-772
    • Sorlier, P.1    denuziere, A.2    Viton, C.3    Domand, A.4
  • 2
    • 1642578765 scopus 로고    scopus 로고
    • Chitin and Chitosan: Chemistry, properties and applications
    • Dutta P.K., Dutta J., Tripathi V.S., Chitin and Chitosan: Chemistry, properties and applications. J Sci Ind Res, 63: 20-31, (2004).
    • (2004) J Sci Ind Res , vol.63 , pp. 20-31
    • Dutta, P.K.1    Dutta, J.2    Tripathi, V.S.3
  • 3
    • 33646886609 scopus 로고    scopus 로고
    • Therapeutic potential of chitosan and its derivatives in regenerative medicine
    • Shi C., Zhu Y., Ran X., Wang M., Yongping S., Cheng T. Therapeutic potential of chitosan and its derivatives in regenerative medicine. J Surg Res, 133: 185-192, (2006).
    • (2006) J Surg Res , vol.133 , pp. 185-192
    • Shi, C.1    Zhu, Y.2    Ran, X.3    Wang, M.4    Yongping, S.5    Cheng, T.6
  • 4
    • 0036027616 scopus 로고    scopus 로고
    • In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant
    • Mi F-L., Tan Y-C., Liang H-F., Sung H-W. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials, 23: 181-191, (2002).
    • (2002) Biomaterials , vol.23 , pp. 181-191
    • Mi, F.-L.1    Tan, Y.-C.2    Liang, H.-F.3    Sung, H.-W.4
  • 5
    • 78049472974 scopus 로고    scopus 로고
    • Chitosan Nanoparticles: A promising system in novel drug delivery
    • Nagpal K., Singh S.K., Mishra D.N. Chitosan Nanoparticles: A promising system in novel drug delivery. Chem Pharm Bull, 58: 1423-1430, (2010).
    • (2010) Chem Pharm Bull , vol.58 , pp. 1423-1430
    • Nagpal, K.1    Singh, S.K.2    Mishra, D.N.3
  • 6
    • 0037413407 scopus 로고    scopus 로고
    • Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles
    • Xu Y.M., Du Y.M. Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles. Int J Pharm, 250: 215-226, (2003).
    • (2003) Int J Pharm , vol.250 , pp. 215-226
    • Xu, Y.M.1    Du, Y.M.2
  • 7
    • 77953602560 scopus 로고    scopus 로고
    • Chitosan and its antimicrobial potential-a critical literature survey
    • Raafat D., Sahl H.G. Chitosan and its antimicrobial potential-a critical literature survey. Microb Biotech, 2: 186-201, (2009).
    • (2009) Microb Biotech , vol.2 , pp. 186-201
    • Raafat, D.1    Sahl, H.G.2
  • 8
    • 0034186372 scopus 로고    scopus 로고
    • Effect of dietary chitosans with different viscosity on plasma lipids and lipid peroxidation in rats fed on a diet enriched with cholesterol
    • Chiang M.T., Yao H.T., Chen H.C. Effect of dietary chitosans with different viscosity on plasma lipids and lipid peroxidation in rats fed on a diet enriched with cholesterol, Biosci Biotechnol Biochem, 64: 965-971, (2000).
    • (2000) Biosci Biotechnol Biochem , vol.64 , pp. 965-971
    • Chiang, M.T.1    Yao, H.T.2    Chen, H.C.3
  • 10
    • 82055170510 scopus 로고    scopus 로고
    • Chitosan derivatives with antimicrobial, antitumour and antioxidant activities-a review
    • Jamila V., Varrikova E. Chitosan derivatives with antimicrobial, antitumour and antioxidant activities-a review, Curr Pharm Des, 17: 3596-3607, (2011).
    • (2011) Curr Pharm Des , vol.17 , pp. 3596-3607
    • Jamila, V.1    Varrikova, E.2
  • 12
    • 85051686626 scopus 로고    scopus 로고
    • Development and evaluation of chitosan honey hydrogel sheets as wound dressing
    • Sasikara L., Durai B. Development and evaluation of chitosan honey hydrogel sheets as wound dressing. Int J Pharm Bio Sci. 6 (1):26-37, 2015.
    • (2015) Int J Pharm Bio Sci , vol.6 , Issue.1 , pp. 26-37
    • Sasikara, L.1    Durai, B.2
  • 13
    • 0346094228 scopus 로고    scopus 로고
    • Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications
    • Berger J., Reist M., Mayer J.M., Felt O., Peppas N.A., Gurny R. Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications, Eur J Pharm Biopharm, 57: 19-34, (2004).
    • (2004) Eur J Pharm Biopharm , vol.57 , pp. 19-34
    • Berger, J.1    Reist, M.2    Mayer, J.M.3    Felt, O.4    Peppas, N.A.5    Gurny, R.6
  • 16
    • 0036870804 scopus 로고    scopus 로고
    • Photocrosslinkable chitosan hydrogel as a wound dressing and biological adhesive
    • Ishihara M. Photocrosslinkable chitosan hydrogel as a wound dressing and biological adhesive. Trends in Glycoscience and Glycotechnology, 14: 331-341, (2002).
    • (2002) Trends in Glycoscience and Glycotechnology , vol.14 , pp. 331-341
    • Ishihara, M.1
  • 18
    • 8744252260 scopus 로고    scopus 로고
    • Preparation and biodegradation of thermosensitive chitosan hydrogel as a function of pH and temperature
    • Han H.D., Nam D.E., Seo D.H., Kim T.W., Shin B.C. Preparation and biodegradation of thermosensitive chitosan hydrogel as a function of pH and temperature, Macromol Res, 12: 507-511, (2004).
    • (2004) Macromol Res , vol.12 , pp. 507-511
    • Han, H.D.1    Nam, D.E.2    Seo, D.H.3    Kim, T.W.4    Shin, B.C.5
  • 19
    • 84874372988 scopus 로고    scopus 로고
    • In vivo gene transfer using pDNA/chitosan/chondroitin sulfate ternary complexs: Inflence of chondroitin sulfate on the stability of freeze-dried complexes and transgene expression in vivo
    • Hagiwara K., Kishimoto S., Ishihara M., Koyama Y., Mazda O., Sato T. In vivo gene transfer using pDNA/chitosan/chondroitin sulfate ternary complexs: Inflence of chondroitin sulfate on the stability of freeze-dried complexes and transgene expression in vivo, J Gene Med, 15: 83-92 (2013).
    • (2013) J Gene Med , vol.15 , pp. 83-92
    • Hagiwara, K.1    Kishimoto, S.2    Ishihara, M.3    Koyama, Y.4    Mazda, O.5    Sato, T.6
  • 20
    • 77951202079 scopus 로고    scopus 로고
    • Preparation and characterization of low-molecular-weight heparin/protamine nanoparticles (LMW-H/P NPs) as FGF-2 carrier
    • Mori Y., Nakamura S., Kishimoto S., Kawakami M., Suzuki S., Matsui T., Ishihara M. Preparation and characterization of low-molecular-weight heparin/protamine nanoparticles (LMW-H/P NPs) as FGF-2 carrier. Int J Nanomed, 5: 147-155, (2010).
    • (2010) Int J Nanomed , vol.5 , pp. 147-155
    • Mori, Y.1    Nakamura, S.2    Kishimoto, S.3    Kawakami, M.4    Suzuki, S.5    Matsui, T.6    Ishihara, M.7
  • 23
    • 84888405143 scopus 로고    scopus 로고
    • Injectable, biodegradable hydrogels for tissue engineering application
    • Tan H., Marra K.G. Injectable, biodegradable hydrogels for tissue engineering application, Materials, 3:1746-1767, (2010).
    • (2010) Materials , vol.3 , pp. 1746-1767
    • Tan, H.1    Marra, K.G.2
  • 24
    • 84908159718 scopus 로고    scopus 로고
    • Natural polymers for microencapsulation of cell
    • Gasperini L., Mano J.F., Reis R.L. Natural polymers for microencapsulation of cells, J R Soc Interface, 11: 20140817, rsif.royalsocietypublishing.org., (2014).
    • (2014) J R Soc Interface , vol.11
    • Gasperini, L.1    Mano, J.F.2    Reis, R.L.3
  • 25
    • 85082356298 scopus 로고    scopus 로고
    • A review on applications and toxicity of nanoparticles
    • Kalirawana T.C., Sharma P., Joshi S.C. A review on applications and toxicity of nanoparticles, Int J Pharm Bio Sci. 6 (1): (P) 772-874, 2015.
    • (2015) Int J Pharm Bio Sci , vol.6 , Issue.1 , pp. 772-874
    • Kalirawana, T.C.1    Sharma, P.2    Joshi, S.C.3
  • 26
    • 77949888510 scopus 로고    scopus 로고
    • Biocompatibility evaluation of chitosan-based injectable hydrogels for culturing mice mesenchymal stem cell in vitro
    • Yan J., Yang L., Wang G., Xiao Y., Zhang B., Qi N. Biocompatibility evaluation of chitosan-based injectable hydrogels for culturing mice mesenchymal stem cell in vitro, J Biomater Appl, 24: 625-637, (2010).
    • (2010) J Biomater Appl , vol.24 , pp. 625-637
    • Yan, J.1    Yang, L.2    Wang, G.3    Xiao, Y.4    Zhang, B.5    Qi, N.6
  • 27
    • 0027113235 scopus 로고
    • Effect of protein charge heterogeneity in protein-polyelectrolyte complexation
    • Park J.M., Muhoberac B.B., Dubin P.L., Xia J. Effect of protein charge heterogeneity in protein-polyelectrolyte complexation, Macromolecules, 25: 290-295, (1992).
    • (1992) Macromolecules , vol.25 , pp. 290-295
    • Park, J.M.1    Muhoberac, B.B.2    Dubin, P.L.3    Xia, J.4
  • 28
    • 42049114322 scopus 로고    scopus 로고
    • In vitro gene delivery by pDNA/chitosan complexes coated with anionic PEG derivatives that have a sugar side chain
    • Hashimoto M., Koyama Y., Sato T. In vitro gene delivery by pDNA/chitosan complexes coated with anionic PEG derivatives that have a sugar side chain, Chem Lett, 37: 266-267 (2008).
    • (2008) Chem Lett , vol.37 , pp. 266-267
    • Hashimoto, M.1    Koyama, Y.2    Sato, T.3
  • 29
  • 30
    • 0030176094 scopus 로고    scopus 로고
    • A new biological glue from gelatin and poly (L-glutamic acid)
    • Otani Y., Tabata Y., Ikada Y. A new biological glue from gelatin and poly (L-glutamic acid). J Biomed Mater Res, 31: 157-166, (1996).
    • (1996) J Biomed Mater Res , vol.31 , pp. 157-166
    • Otani, Y.1    Tabata, Y.2    Ikada, Y.3
  • 31
    • 0025341818 scopus 로고
    • Modification of synthesis and investigation of properties for 2-cyanoacrylates
    • Tseng Y.C., Hyon S.H., Ikada Y. Modification of synthesis and investigation of properties for 2-cyanoacrylates. Biomaterials, 11: 73-79, (1990).
    • (1990) Biomaterials , vol.11 , pp. 73-79
    • Tseng, Y.C.1    Hyon, S.H.2    Ikada, Y.3
  • 32
    • 0027642424 scopus 로고
    • Cyanoacrylate tissue adhesive for closing skin wounds: a double blind randomaized comparison with suture
    • Vanholder R., Misotten A., Roels H., Matton G. Cyanoacrylate tissue adhesive for closing skin wounds: a double blind randomaized comparison with suture. Biomaterials, 14: 737-742, (1993).
    • (1993) Biomaterials , vol.14 , pp. 737-742
    • Vanholder, R.1    Misotten, A.2    Roels, H.3    Matton, G.4
  • 35
    • 84864399974 scopus 로고    scopus 로고
    • Rapid curable chitosan-PEG hydrogels as tissue adhesive for hematostasis and wound healing
    • Lih E., Lee J.S., Park K.M., Park K.D. Rapid curable chitosan-PEG hydrogels as tissue adhesive for hematostasis and wound healing, Acta Biomater, 8: 3261-3269, (2012).
    • (2012) Acta Biomater , vol.8 , pp. 3261-3269
    • Lih, E.1    Lee, J.S.2    Park, K.M.3    Park, K.D.4
  • 36
    • 79960235683 scopus 로고    scopus 로고
    • Catechol-functionalized chitosan/puronic hydrogels for tissue adhesives and hemostatic materials
    • Ryu J.H., Lee Y., Kong W.H., Kim T.G., Park T.G., Lee H. Catechol-functionalized chitosan/puronic hydrogels for tissue adhesives and hemostatic materials, Biomacromolecules, 11: 2653-2659, (2011).
    • (2011) Biomacromolecules , vol.11 , pp. 2653-2659
    • Ryu, J.H.1    Lee, Y.2    Kong, W.H.3    Kim, T.G.4    Park, T.G.5    Lee, H.6
  • 38
    • 33846501551 scopus 로고    scopus 로고
    • A simple application technique of fibrin-coated collagen fleece (TachoComb) in Laparoscopic surgery
    • Nakajima K., Yasumasa K., Endo S., Takahashi T., Kai Y., Nezu R., Nishida T. A simple application technique of fibrin-coated collagen fleece (TachoComb) in Laparoscopic surgery. Surg Today, 37, 176-179, (2007).
    • (2007) Surg Today , vol.37 , pp. 176-179
    • Nakajima, K.1    Yasumasa, K.2    Endo, S.3    Takahashi, T.4    Kai, Y.5    Nezu, R.6    Nishida, T.7
  • 44
    • 34047159301 scopus 로고    scopus 로고
    • Selective fluid cusion in the submucosal layer by water jet: advantage for endoscopic mucosal resection
    • Kaehler G.F., Sold M.G., Fischer K., Post S., Enderle M. Selective fluid cusion in the submucosal layer by water jet: advantage for endoscopic mucosal resection, Eur Surg Res, 39: 93-97, (2007).
    • (2007) Eur Surg Res , vol.39 , pp. 93-97
    • Kaehler, G.F.1    Sold, M.G.2    Fischer, K.3    Post, S.4    Enderle, M.5
  • 46
    • 0037409924 scopus 로고    scopus 로고
    • Implantable applications of chitin and chitosan
    • Khor E., Lim L.Y. Implantable applications of chitin and chitosan, Biomaterials, 24: 2339-2349 (2003).
    • (2003) Biomaterials , vol.24 , pp. 2339-2349
    • Khor, E.1    Lim, L.Y.2
  • 47
    • 0344642607 scopus 로고    scopus 로고
    • Collagen based dressings-a review
    • Purna S.K., Babu M. Collagen based dressings-a review, Burns 26: 54-62, 2000.
    • (2000) Burns , vol.26 , pp. 54-62
    • Purna, S.K.1    Babu, M.2
  • 48
    • 27744499355 scopus 로고    scopus 로고
    • Application of stem cells for vascular tissue engineering
    • Riha G.M., Lin P.H., Lumsden A.B., Yao Q., Chen C., Application of stem cells for vascular tissue engineering, Tissue Eng, 11: 1535-1552, (2005).
    • (2005) Tissue Eng , vol.11 , pp. 1535-1552
    • Riha, G.M.1    Lin, P.H.2    Lumsden, A.B.3    Yao, Q.4    Chen, C.5
  • 49
    • 26844489855 scopus 로고    scopus 로고
    • Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells
    • Dang J.M., Sun D.D., Shin-Ya Y., Sieber A.N., Kostuik J.P., Leong K.W. Temperature-responsive hydroxybutyl chitosan for the culture of mesenchymal stem cells and intervertebral disk cells, Biomaterials, 27: 406-418, (2006).
    • (2006) Biomaterials , vol.27 , pp. 406-418
    • Dang, J.M.1    Sun, D.D.2    Shin-Ya, Y.3    Sieber, A.N.4    Kostuik, J.P.5    Leong, K.W.6
  • 50
    • 84888440221 scopus 로고    scopus 로고
    • Effective expansion of human adipose-derived stromal cells and bone marrow-derived mesenchymal stem cells cultured on a fragmin/protamine nanoparticles-coated substratum with human platelet-rich plasma
    • Kishimoto S., Ishihara M., Mori Y., Takikawa M., Hattori H., Nakamura S., Sato T. Effective expansion of human adipose-derived stromal cells and bone marrow-derived mesenchymal stem cells cultured on a fragmin/protamine nanoparticles-coated substratum with human platelet-rich plasma, J Tissue Engineer Reg Med, 7: 955-964, (2012).
    • (2012) J Tissue Engineer Reg Med , vol.7 , pp. 955-964
    • Kishimoto, S.1    Ishihara, M.2    Mori, Y.3    Takikawa, M.4    Hattori, H.5    Nakamura, S.6    Sato, T.7
  • 51
    • 14944380686 scopus 로고    scopus 로고
    • Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle
    • Hoemann C.D., Sun J., Legare A., McKee M.D., Buschmann M.D. Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle, Osteoartheritis Cartilage, 13: 318-329, (2005).
    • (2005) Osteoartheritis Cartilage , vol.13 , pp. 318-329
    • Hoemann, C.D.1    Sun, J.2    Legare, A.3    McKee, M.D.4    Buschmann, M.D.5
  • 52
    • 84891510062 scopus 로고    scopus 로고
    • Comparison of uncultured marrow mononuclear cells and culture-expanded mesenchymal stem cells in 3D collagen-chitosan microbeads for orthopedic tissue engineering
    • Wise J.K., Alford A.I., Goldstein S.A., Stegemann J.P. Comparison of uncultured marrow mononuclear cells and culture-expanded mesenchymal stem cells in 3D collagen-chitosan microbeads for orthopedic tissue engineering, Tissue Eng Part A, 20: 210-224, (2014).
    • (2014) Tissue Eng Part A , vol.20 , pp. 210-224
    • Wise, J.K.1    Alford, A.I.2    Goldstein, S.A.3    Stegemann, J.P.4
  • 53
    • 77956635355 scopus 로고    scopus 로고
    • Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed of chitin/chitosan, fucoidan, and alginate as wound dressing
    • Murakami K, Ishihara M., Aoki H., Nakamura S., Yanagibayashi S., Takikawa M., Kishimoto S., Yokoe H., Kiyosawa T., Sato Y. Enhanced healing of mitomycin C-treated healing-impaired wounds in rats with hydrosheets composed of chitin/chitosan, fucoidan, and alginate as wound dressing, Wound Rep Regen, 18: 478-485, (2010).
    • (2010) Wound Rep Regen , vol.18 , pp. 478-485
    • Murakami, K.1    Ishihara, M.2    Aoki, H.3    Nakamura, S.4    Yanagibayashi, S.5    Takikawa, M.6    Kishimoto, S.7    Yokoe, H.8    Kiyosawa, T.9    Sato, Y.10
  • 55
    • 77951950071 scopus 로고    scopus 로고
    • Evaluation of the chitosan/glycerol-beta-phosphate disodium salt hydrogel application in peripheral nerve regeneration
    • Zheng L., Ao Q., Han H., Zhang X., Gong Y. Evaluation of the chitosan/glycerol-beta-phosphate disodium salt hydrogel application in peripheral nerve regeneration, Biomed Mater, 5: 35003, (2010).
    • (2010) Biomed Mater , vol.5 , pp. 35003
    • Zheng, L.1    Ao, Q.2    Han, H.3    Zhang, X.4    Gong, Y.5
  • 57
    • 0032856344 scopus 로고    scopus 로고
    • Water-soluble chitin as a wound healing accelerator
    • Cho Y.W., Cho Y.N., Chung S.H., Yoo G., Ko S.W. Water-soluble chitin as a wound healing accelerator. Biomaterials, 20: 2139-2145, (1999).
    • (1999) Biomaterials , vol.20 , pp. 2139-2145
    • Cho, Y.W.1    Cho, Y.N.2    Chung, S.H.3    Yoo, G.4    Ko, S.W.5
  • 60
    • 7444268954 scopus 로고    scopus 로고
    • Recent advances on chitosan based micro-and nanoparticles in drug delivery
    • Agnihotri S.A., Mallikarjuna N.N., Aminabhavi T.M. Recent advances on chitosan based micro-and nanoparticles in drug delivery. J Control Rel, 100: 5-28, (2004).
    • (2004) J Control Rel , vol.100 , pp. 5-28
    • Agnihotri, S.A.1    Mallikarjuna, N.N.2    Aminabhavi, T.M.3
  • 62
    • 33646555163 scopus 로고    scopus 로고
    • A self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin
    • Kissei T., Mao S., Jintapattanakit U. A self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin, J Pharm Sci, 95: 1035-1048, (2006).
    • (2006) J Pharm Sci , vol.95 , pp. 1035-1048
    • Kissei, T.1    Mao, S.2    Jintapattanakit, U.3
  • 63
    • 39749108700 scopus 로고    scopus 로고
    • Towards biocompatible vaccine delivery systems: Interactions of colloidal PECs based on polysaccharides with HIV-1 p24 antigen
    • Drogoz A., Munier S., Verrier B., David I., Dornard A., Delair T. Towards biocompatible vaccine delivery systems: Interactions of colloidal PECs based on polysaccharides with HIV-1 p24 antigen, Biomacromolecules, 9: 583-591 (2008).
    • (2008) Biomacromolecules , vol.9 , pp. 583-591
    • Drogoz, A.1    Munier, S.2    Verrier, B.3    David, I.4    Dornard, A.5    Delair, T.6
  • 65
    • 1942470953 scopus 로고    scopus 로고
    • The effect of the degree of chitosan deacetylation on the efficiency of gene transfection
    • Kiang T., Wen J., Lim H.W., Leong K.W., Kam K.W. The effect of the degree of chitosan deacetylation on the efficiency of gene transfection, Biomaterials, 25: 5293-5301, (2004).
    • (2004) Biomaterials , vol.25 , pp. 5293-5301
    • Kiang, T.1    Wen, J.2    Lim, H.W.3    Leong, K.W.4    Kam, K.W.5
  • 66
    • 33745077164 scopus 로고    scopus 로고
    • High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation
    • Lavertu M., Methot S., Tran-Khanh N., Buschmann M.D. High efficiency gene transfer using chitosan/DNA nanoparticles with specific combinations of molecular weight and degree of deacetylation, Biomaterials, 27: 4815-4825, (2006).
    • (2006) Biomaterials , vol.27 , pp. 4815-4825
    • Lavertu, M.1    Methot, S.2    Tran-Khanh, N.3    Buschmann, M.D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.