Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection

Science Advances

Volumn 4, Issue 8, 2018, Pages

  Raj, V Stalin ^a,h   Okba, Nisreen M A ^a   Gutierrez Alvarez, Javier ^b   Drabek, Dubravka ^a   van Dieren, Brenda ^c   Widagdo, W ^a   Lamers, Mart M ^a   Widjaja, Ivy ^c   Fernandez Delgado, Raul ^b   Sola, Isabel ^b   Bensaid, Albert ^d   Koopmans, Marion P ^a   Segalés, Joaquim ^e   Osterhaus, Albert D M E ^f,g   Bosch, Berend Jan ^c   Enjuanes, Luis ^b   Haagmans, Bart L ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UTRECHT UNIVERSITY   (Netherlands)

^d CENTRE DE RECERCA EN SANITAT ANIMAL CRESA   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^f Artemis One Health   (Netherlands)

^g UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^h INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CHAINS; EPITOPES; VIRUSES;

AFFINITY MATURATION; ANTIBODY RESPONSE; BINDING PROPERTIES; COMPLEMENTARITY-DETERMINING REGIONS; DIRECT CLONING; HEAVY-CHAIN ANTIBODIES; NEUTRALIZING ANTIBODIES; RECEPTOR-BINDING DOMAINS;

ANTIBODIES;

NANOBODY; NEUTRALIZING ANTIBODY; PROTEIN BINDING; VIRUS ANTIBODY;

ANIMAL; BIOSYNTHESIS; CAMEL; CORONAVIRUS INFECTION; DRUG EFFECT; FEMALE; HUMAN; IMMUNOLOGY; MALE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MOUSE; SERODIAGNOSIS; VIROLOGY; VIRUS ENTRY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CAMELUS; CORONAVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MICE; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NEUTRALIZATION TESTS; PROTEIN BINDING; SINGLE-DOMAIN ANTIBODIES; VIRUS INTERNALIZATION;

EID: 85051389156     PISSN: None     EISSN: 23752548     Source Type: Journal    
DOI: 10.1126/sciadv.aas9667     Document Type: Article

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