Lung defense through IL-8 carries a cost of chronic lung remodeling and impaired function

American Journal of Respiratory Cell and Molecular Biology

Volumn 59, Issue 5, 2018, Pages 557-571

  Reynolds, Catherine J ^a,b   Quigley, Kathryn ^a,b   Cheng, Xiaoming ^a   Suresh, Apurva ^a   Tahir, Sundas ^a   Ahmed Jushuf, Fiyyaz ^a   Nawab, Khizr ^a   Choy, Katherine ^b   Walker, Simone Alexandra ^b   Mathie, Sara A ^b   Sim, Malcolm ^a   Stowell, Janet ^a   Manji, Jiten ^a   Pollard, Tracey ^a   Altmann, Daniel M ^a   Boyton, Rosemary J ^a,b,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Bacterial infection; Host immunity; IL 8; Lung remodeling; Tight junction

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL PROTEIN; CD4 ANTIGEN; CD40 ANTIGEN; CD8ALPHA ANTIGEN; CLARA CELL 10 KD PROTEIN; CLARA CELL PROTEIN; CLAUDIN 18; FAS LIGAND; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 8; JUNCTIONAL ADHESION MOLECULE A; JUNCTIONAL ADHESION MOLECULE B; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MEMBRANE PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; OCCLUDIN; OUTER MEMBRANE PORIN F PROTEIN; RANTES; STAT1 PROTEIN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL IMMUNITY; BODY PLETHYSMOGRAPHY; BRONCHUS EPITHELIUM; BRONCHUS HYPERREACTIVITY; CELL MATURATION; CHRONIC LUNG DISEASE; CONTROLLED STUDY; GENE OVEREXPRESSION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNOPHENOTYPING; INFECTION PREVENTION; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LUNG COMPLIANCE; LUNG DISEASE; LUNG FIBROSIS; LUNG FUNCTION; LUNG INFECTION; LUNG INJURY; LUNG REMODELING; LUNG RESISTANCE; MOUSE; MUCUS SECRETION; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NEUTROPHILIA; NONHUMAN; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; REGULATORY T LYMPHOCYTE; TIGHT JUNCTION; ANIMAL; C57BL MOUSE; CHRONIC DISEASE; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; MICROBIOLOGY; PATHOLOGY; PNEUMONIA; TRANSGENIC MOUSE;

ANIMALS; CHRONIC DISEASE; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-8; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PNEUMONIA; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; PULMONARY FIBROSIS;

EID: 85051286608     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: 10.1165/rcmb.2018-0007OC     Document Type: Article

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