메뉴 건너뛰기




Volumn 8, Issue 1, 2018, Pages

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; XENOBIOTIC AGENT;

EID: 85051086282     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-018-29763-2     Document Type: Article
Times cited : (19)

References (57)
  • 1
    • 84885657687 scopus 로고    scopus 로고
    • Each Organ Has a Unique Metabolic Profile
    • Section 30.2, W.H, Freeman, MacMillan Learning, New York
    • Berg, J. M., Tymoczko, J. L. & Stryer, L. Section 30.2, Each Organ Has a Unique Metabolic Profile., in Biochemistry. (ed. W.H. Freeman) (MacMillan Learning, New York; 2002)
    • (2002) Biochemistry
    • Berg, J.M.1    Tymoczko, J.L.2    Stryer, L.3
  • 2
    • 0025768055 scopus 로고
    • The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism
    • Van den Berghe, G. The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism. Journal of Inherited Metabolic Diseases 14, 407–420 (1991)
    • (1991) Journal of Inherited Metabolic Diseases , vol.14 , pp. 407-420
    • Van den Berghe, G.1
  • 3
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029–1033 (2009)
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 4
    • 85051070764 scopus 로고    scopus 로고
    • Human serum leads to differentiation of human hepatoma cells, restoration of VLDL secretion and a 1000-fold increase in HCV JFH-1 titers
    • Steenbergen, R. H. et al. Human serum leads to differentiation of human hepatoma cells, restoration of VLDL secretion and a 1000-fold increase in HCV JFH-1 titers. Hepatology (2013)
    • (2013) Hepatology
    • Steenbergen, R.H.1
  • 6
    • 84864921682 scopus 로고    scopus 로고
    • DREM 2.0: Improved reconstruction of dynamic regulatory networks from time-series expression data
    • PID: 22897824
    • Schulz, M. H. et al. DREM 2.0: Improved reconstruction of dynamic regulatory networks from time-series expression data. BMC Systems Biology 6, 104–104 (2012)
    • (2012) BMC Systems Biology , vol.6 , pp. 104
    • Schulz, M.H.1
  • 7
    • 33745248450 scopus 로고    scopus 로고
    • Sustained aryl hydrocarbon receptor activity attenuates liver regeneration
    • PID: 16636136
    • Mitchell, K. A., Lockhart, C. A., Huang, G. & Elferink, C. J. Sustained aryl hydrocarbon receptor activity attenuates liver regeneration. Mol Pharmacol 70, 163–170 (2006)
    • (2006) Mol Pharmacol , vol.70 , pp. 163-170
    • Mitchell, K.A.1    Lockhart, C.A.2    Huang, G.3    Elferink, C.J.4
  • 8
    • 75149115740 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis
    • PID: 19996281
    • Fan, Y. et al. The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis. Cancer research 70, 212–220 (2010)
    • (2010) Cancer research , vol.70 , pp. 212-220
    • Fan, Y.1
  • 9
    • 59149101810 scopus 로고    scopus 로고
    • Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology
    • PID: 18713746
    • Nebert, D. W. & Karp, C. L. Endogenous Functions of the Aryl Hydrocarbon Receptor (AHR): Intersection of Cytochrome P450 1 (CYP1)-metabolized Eicosanoids and AHR Biology. The Journal of Biological Chemistry 283, 36061–36065 (2008)
    • (2008) The Journal of Biological Chemistry , vol.283 , pp. 36061-36065
    • Nebert, D.W.1    Karp, C.L.2
  • 10
    • 30944446390 scopus 로고    scopus 로고
    • The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin
    • PID: 16138117
    • Baron, V., Adamson, E. D., Calogero, A., Ragona, G. & Mercola, D. The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther 13, 115–124 (2006)
    • (2006) Cancer Gene Ther , vol.13 , pp. 115-124
    • Baron, V.1    Adamson, E.D.2    Calogero, A.3    Ragona, G.4    Mercola, D.5
  • 11
    • 80052868490 scopus 로고    scopus 로고
    • Early growth response 1–a transcription factor in the crossfire of signal transduction cascades
    • PID: 22053691
    • Pagel, J. I. & Deindl, E. Early growth response 1–a transcription factor in the crossfire of signal transduction cascades. Indian J Biochem Biophys 48, 226–235 (2011)
    • (2011) Indian J Biochem Biophys , vol.48 , pp. 226-235
    • Pagel, J.I.1    Deindl, E.2
  • 12
    • 80051931336 scopus 로고    scopus 로고
    • Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression
    • PID: 21712389
    • Gokey, N. G., Lopez-Anido, C., Gillian-Daniel, A. L. & Svaren, J. Early growth response 1 (Egr1) regulates cholesterol biosynthetic gene expression. J Biol Chem 286, 29501–29510 (2011)
    • (2011) J Biol Chem , vol.286 , pp. 29501-29510
    • Gokey, N.G.1    Lopez-Anido, C.2    Gillian-Daniel, A.L.3    Svaren, J.4
  • 13
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • PID: 14685163
    • Oyadomari, S. & Mori, M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11, 381–389 (2004)
    • (2004) Cell Death Differ , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 14
    • 84964833362 scopus 로고    scopus 로고
    • Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver
    • PID: 26960794
    • Fusakio, M. E. et al. Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver. Mol Biol Cell 27, 1536–1551 (2016)
    • (2016) Mol Biol Cell , vol.27 , pp. 1536-1551
    • Fusakio, M.E.1
  • 15
    • 1642464760 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation
    • PID: 14684614
    • Pereira, R. C., Delany, A. M. & Canalis, E. CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. Endocrinology 145, 1952–1960 (2004)
    • (2004) Endocrinology , vol.145 , pp. 1952-1960
    • Pereira, R.C.1    Delany, A.M.2    Canalis, E.3
  • 16
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • PID: 21258394
    • Cairns, R. A., Harris, I. S. & Mak, T. W. Regulation of cancer cell metabolism. Nat Rev Cancer 11, 85–95 (2011)
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 17
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • PID: 21985671
    • Lunt, S. Y. & Vander Heiden, M. G. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27, 441–464 (2011)
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 18
    • 84955326448 scopus 로고    scopus 로고
    • The Emerging Hallmarks of Cancer Metabolism
    • PID: 26771115
    • Pavlova, N. N. & Thompson, C. B. The Emerging Hallmarks of Cancer Metabolism. Cell Metab 23, 27–47 (2016)
    • (2016) Cell Metab , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 19
    • 84887996231 scopus 로고    scopus 로고
    • Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells
    • PID: 24161736
    • Singaravelu, R. et al. Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells. Biochem Biophys Res Commun 441, 447–452 (2013)
    • (2013) Biochem Biophys Res Commun , vol.441 , pp. 447-452
    • Singaravelu, R.1
  • 20
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes
    • PID: 10634967
    • Laffel, L. Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab Res Rev 15, 412–426 (1999)
    • (1999) Diabetes Metab Res Rev , vol.15 , pp. 412-426
    • Laffel, L.1
  • 22
    • 0001371293 scopus 로고
    • Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium
    • Gey, G. O., Coffman, W. D. & Kubicek, M. T. Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer research 12, 264–265 (1952)
    • (1952) Cancer research , vol.12 , pp. 264-265
    • Gey, G.O.1    Coffman, W.D.2    Kubicek, M.T.3
  • 23
    • 85029667660 scopus 로고    scopus 로고
    • Use of a neonatal rat system as a bioincubator to generate adult-like mature cardiomyocytes from human and mouse pluripotent stem cells
    • PID: 28880277
    • Cho, G.-S., Tampakakis, E., Andersen, P. & Kwon, C. Use of a neonatal rat system as a bioincubator to generate adult-like mature cardiomyocytes from human and mouse pluripotent stem cells. Nature protocols 12, 2097 (2017)
    • (2017) Nature protocols , vol.12 , pp. 2097
    • Cho, G.-S.1    Tampakakis, E.2    Andersen, P.3    Kwon, C.4
  • 24
    • 84891672185 scopus 로고    scopus 로고
    • Differentiation of hepatocytes from pluripotent stem cells
    • Mallanna, S. K. & Duncan, S. A. Differentiation of hepatocytes from pluripotent stem cells. Current protocols in stem cell biology 26, 1G.4.1–1G.4.13 (2013)
    • (2013) Current protocols in stem cell biology , vol.26 , pp. 1G.4.1-1G.4.13
    • Mallanna, S.K.1    Duncan, S.A.2
  • 25
    • 60249085118 scopus 로고    scopus 로고
    • Mitochondria in cancer: not just innocent bystanders
    • PID: 19101633
    • Frezza, C. & Gottlieb, E. Mitochondria in cancer: not just innocent bystanders. Semin Cancer Biol 19, 4–11 (2009)
    • (2009) Semin Cancer Biol , vol.19 , pp. 4-11
    • Frezza, C.1    Gottlieb, E.2
  • 26
    • 33745149291 scopus 로고    scopus 로고
    • p53 regulates mitochondrial respiration
    • PID: 16728594
    • Matoba, S. et al. p53 regulates mitochondrial respiration. Science 312, 1650–1653 (2006)
    • (2006) Science , vol.312 , pp. 1650-1653
    • Matoba, S.1
  • 27
    • 0025262417 scopus 로고
    • Abnormal structure and expression of p53 gene in human hepatocellular carcinoma
    • PID: 2155427
    • Bressac, B. et al. Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc Natl Acad Sci USA 87, 1973–1977 (1990)
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1973-1977
    • Bressac, B.1
  • 28
    • 0027517726 scopus 로고
    • Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines
    • PID: 8224613
    • Puisieux, A. et al. Retinoblastoma and p53 tumor suppressor genes in human hepatoma cell lines. FASEB J 7, 1407–1413 (1993)
    • (1993) FASEB J , vol.7 , pp. 1407-1413
    • Puisieux, A.1
  • 29
    • 85031690181 scopus 로고    scopus 로고
    • Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
    • PID: 29030545
    • Peeters, K. et al. Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras. Nat Commun 8, 922 (2017)
    • (2017) Nat Commun , vol.8
    • Peeters, K.1
  • 30
    • 84856571459 scopus 로고    scopus 로고
    • Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach
    • PID: 22190182
    • Traves, P. G. et al. Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach. J Immunol 188, 1402–1410 (2012)
    • (2012) J Immunol , vol.188 , pp. 1402-1410
    • Traves, P.G.1
  • 31
    • 33847618703 scopus 로고    scopus 로고
    • MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly
    • PID: 17038630
    • Tsai, J., Qiu, W., Kohen-Avramoglu, R. & Adeli, K. MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly. Arterioscler Thromb Vasc Biol 27, 211–218 (2007)
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 211-218
    • Tsai, J.1    Qiu, W.2    Kohen-Avramoglu, R.3    Adeli, K.4
  • 32
    • 85007275975 scopus 로고    scopus 로고
    • The use of human umbilical cord blood serum is beneficial for the continuous production of hepatitis C virus
    • PID: 27902355
    • Jiao, X.-J., Steenbergen, R. H. G. & Tyrrell, D. L. The use of human umbilical cord blood serum is beneficial for the continuous production of hepatitis C virus. Journal of General Virology 97, 3248–3252 (2016)
    • (2016) Journal of General Virology , vol.97 , pp. 3248-3252
    • Jiao, X.-J.1    Steenbergen, R.H.G.2    Tyrrell, D.L.3
  • 33
    • 80051524749 scopus 로고    scopus 로고
    • Ex vivo expansion of conjunctival and limbal epithelial cells using cord blood serum-supplemented culture medium
    • PID: 21474776
    • Ang, L. P. et al. Ex vivo expansion of conjunctival and limbal epithelial cells using cord blood serum-supplemented culture medium. Invest Ophthalmol Vis Sci 52, 6138–6147 (2011)
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 6138-6147
    • Ang, L.P.1
  • 34
    • 80055019744 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-I) improves hepatic differentiation of human bone marrow-derived mesenchymal stem cells
    • PID: 21910691
    • Ayatollahi, M., Soleimani, M., Geramizadeh, B. & Imanieh, M. H. Insulin-like growth factor 1 (IGF-I) improves hepatic differentiation of human bone marrow-derived mesenchymal stem cells. Cell biology international 35, 1169–1176 (2011)
    • (2011) Cell biology international , vol.35 , pp. 1169-1176
    • Ayatollahi, M.1    Soleimani, M.2    Geramizadeh, B.3    Imanieh, M.H.4
  • 35
    • 84887929544 scopus 로고    scopus 로고
    • Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway
    • PID: 23836547
    • Magner, N. L. et al. Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway. Stem Cells 31, 2095–2103 (2013)
    • (2013) Stem Cells , vol.31 , pp. 2095-2103
    • Magner, N.L.1
  • 36
    • 84857952904 scopus 로고    scopus 로고
    • IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors
    • PID: 22401581
    • Regel, I. et al. IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors. Mol Cancer 11, 9 (2012)
    • (2012) Mol Cancer , vol.11
    • Regel, I.1
  • 37
    • 0016411153 scopus 로고
    • Lipid composition of bovine serum lipoproteins
    • PID: 163266
    • Stead, D. & Welch, V. A. Lipid composition of bovine serum lipoproteins. J Dairy Sci 58, 122–127 (1975)
    • (1975) J Dairy Sci , vol.58 , pp. 122-127
    • Stead, D.1    Welch, V.A.2
  • 38
    • 0025022294 scopus 로고
    • Increased production of apolipoprotein B and its lipoproteins by oleic acid in Caco-2 cells
    • PID: 2313196
    • Dashti, N., Smith, E. A. & Alaupovic, P. Increased production of apolipoprotein B and its lipoproteins by oleic acid in Caco-2 cells. Journal of lipid research 31, 113–123 (1990)
    • (1990) Journal of lipid research , vol.31 , pp. 113-123
    • Dashti, N.1    Smith, E.A.2    Alaupovic, P.3
  • 39
    • 0035985704 scopus 로고    scopus 로고
    • Cytochrome P450 pathways of arachidonic acid metabolism
    • PID: 12045397
    • Kroetz, D. L. & Zeldin, D. C. Cytochrome P450 pathways of arachidonic acid metabolism. Curr Opin Lipidol 13, 273–283 (2002)
    • (2002) Curr Opin Lipidol , vol.13 , pp. 273-283
    • Kroetz, D.L.1    Zeldin, D.C.2
  • 40
    • 0030305457 scopus 로고    scopus 로고
    • & Gentleman, R. R: A language for data analysis and graphics
    • Ihaka, R. & Gentleman, R. R: A language for data analysis and graphics. Journal of Computational and Graphical Statistics 5, 299–314 (1996)
    • (1996) Journal of Computational and Graphical Statistics , vol.5 , pp. 299-314
    • Ihaka, R.1
  • 41
    • 80052428676 scopus 로고    scopus 로고
    • Bioconductor: open software development for computational biology and bioinformatics
    • Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome biology 5, 1–16 (2004)
    • (2004) Genome biology , vol.5 , pp. 1-16
    • Gentleman, R.C.1
  • 42
    • 0142121516 scopus 로고    scopus 로고
    • Exploration, normalization, and summaries of high density oligonucleotide array probe level data
    • PID: 12925520
    • Irizarry, R. A. et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4, 249–264 (2003)
    • (2003) Biostatistics , vol.4 , pp. 249-264
    • Irizarry, R.A.1
  • 43
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • PID: 25605792
    • Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Research 43, e47 (2015)
    • (2015) Nucleic Acids Research , vol.43
    • Ritchie, M.E.1
  • 44
    • 77953212372 scopus 로고    scopus 로고
    • Gene ontology analysis for RNA-seq: accounting for selection bias
    • Young, M. D., Wakefield, M. J., Smyth, G. K. & Oshlack, A. Gene ontology analysis for RNA-seq: accounting for selection bias. Genome biology 11, 1–12 (2010)
    • (2010) Genome biology , vol.11 , pp. 1-12
    • Young, M.D.1    Wakefield, M.J.2    Smyth, G.K.3    Oshlack, A.4
  • 45
    • 84877315835 scopus 로고    scopus 로고
    • A community-driven global reconstruction of human metabolism
    • PID: 23455439
    • Thiele, I. et al. A community-driven global reconstruction of human metabolism. Nature biotechnology 31, 419–425 (2013)
    • (2013) Nature biotechnology , vol.31 , pp. 419-425
    • Thiele, I.1
  • 46
    • 79951536020 scopus 로고    scopus 로고
    • Functional integration of a metabolic network model and expression data without arbitrary thresholding
    • PID: 21172910
    • Jensen, P. A. & Papin, J. A. Functional integration of a metabolic network model and expression data without arbitrary thresholding. Bioinformatics 27, 541–547 (2011)
    • (2011) Bioinformatics , vol.27 , pp. 541-547
    • Jensen, P.A.1    Papin, J.A.2
  • 47
    • 14844326483 scopus 로고    scopus 로고
    • Computational prediction of human metabolic pathways from the complete human genome
    • PID: 15642094
    • Romero, P. et al. Computational prediction of human metabolic pathways from the complete human genome. Genome biology 6, R2 (2005)
    • (2005) Genome biology , vol.6
    • Romero, P.1
  • 48
    • 84897503768 scopus 로고    scopus 로고
    • Initial characterization of Vaccinia Virus B4 suggests a role in virus spread
    • PID: 24889230
    • Burles, K. et al. Initial characterization of Vaccinia Virus B4 suggests a role in virus spread. Virology 456–457, 108–120 (2014)
    • (2014) Virology , vol.456-457 , pp. 108-120
    • Burles, K.1
  • 49
    • 85019968827 scopus 로고    scopus 로고
    • Quantitative NMR analysis of intra- and extracellular metabolism of mammalian cells: A tutorial
    • PID: 28622799
    • Kostidis, S., Addie, R. D., Morreau, H., Mayboroda, O. A. & Giera, M. Quantitative NMR analysis of intra- and extracellular metabolism of mammalian cells: A tutorial. Anal Chim Acta 980, 1–24 (2017)
    • (2017) Anal Chim Acta , vol.980 , pp. 1-24
    • Kostidis, S.1    Addie, R.D.2    Morreau, H.3    Mayboroda, O.A.4    Giera, M.5
  • 50
    • 85051086254 scopus 로고    scopus 로고
    • A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice
    • Ryan, D. P. et al. A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice. Molecular Psychiatry (2017)
    • (2017) Molecular Psychiatry
    • Ryan, D.P.1
  • 51
    • 84878449546 scopus 로고    scopus 로고
    • Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice
    • PID: 23409951
    • Anwar-Mohamed, A. et al. Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice. Xenobiotica 43, 719–729 (2013)
    • (2013) Xenobiotica , vol.43 , pp. 719-729
    • Anwar-Mohamed, A.1
  • 52
    • 0027169767 scopus 로고
    • Reagent for the Single-Step Simultaneous Isolation of Rna, DNA and Proteins from Cell and Tissue Samples
    • Chomczynski, P. A Reagent for the Single-Step Simultaneous Isolation of Rna, DNA and Proteins from Cell and Tissue Samples. Biotechniques 15, 53–& (1993)
    • (1993) Biotechniques , vol.15 , pp. 53
    • Chomczynski, P.A.1
  • 54
    • 0023461268 scopus 로고
    • Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction
    • PID: 3431465
    • Mullis, K. B. & Faloona, F. A. Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol 155, 335–350 (1987)
    • (1987) Methods Enzymol , vol.155 , pp. 335-350
    • Mullis, K.B.1    Faloona, F.A.2
  • 55
    • 0036561247 scopus 로고    scopus 로고
    • Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR
    • PID: 12040753
    • Nishimura, M., Yoshitsugu, H., Naito, S. & Hiraoka, I. Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 122, 339–361 (2002)
    • (2002) Yakugaku Zasshi , vol.122 , pp. 339-361
    • Nishimura, M.1    Yoshitsugu, H.2    Naito, S.3    Hiraoka, I.4
  • 56
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method. Methods (San Diego, Calif 25, 402–408 (2001)
    • (2001) Methods (San Diego, Calif , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 57
    • 84871856516 scopus 로고    scopus 로고
    • A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS
    • PID: 23245243
    • Pillai, V. C., Strom, S. C., Caritis, S. N. & Venkataramanan, R. A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS. J Pharm Biomed Anal 74, 126–132 (2013)
    • (2013) J Pharm Biomed Anal , vol.74 , pp. 126-132
    • Pillai, V.C.1    Strom, S.C.2    Caritis, S.N.3    Venkataramanan, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.