메뉴 건너뛰기




Volumn 9, Issue 4, 2018, Pages 1511-1532

A Randomized Controlled Trial of Dapagliflozin Plus Once-Weekly Exenatide Versus Placebo in Individuals with Obesity and Without Diabetes: Metabolic Effects and Markers Associated with Bodyweight Loss

Author keywords

Dapagliflozin; Exenatide; Lipid metabolism; Obesity; Single nucleotide polymorphism; Weight loss

Indexed keywords

DAPAGLIFLOZIN; EXENDIN 4; FATTY ACID; GLUCAGON; GLUCOSE; INSULIN;

EID: 85050729883     PISSN: 18696953     EISSN: 18696961     Source Type: Journal    
DOI: 10.1007/s13300-018-0449-6     Document Type: Article
Times cited : (26)

References (59)
  • 1
    • 67749129442 scopus 로고    scopus 로고
    • Accessed 5 Feb 2018
    • World Health Organization. Obesity and overweight fact sheet. 2017. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 5 Feb 2018
    • (2017) Obesity and overweight fact sheet
  • 3
    • 84958632559 scopus 로고    scopus 로고
    • Patients with obesity-related comorbidities have higher disability compared with those without obesity-related comorbidities: results from a cross-sectional study
    • PID: 26579698
    • Sirtori A, Brunani A, Capodaglio P, et al. Patients with obesity-related comorbidities have higher disability compared with those without obesity-related comorbidities: results from a cross-sectional study. Int J Rehabil Res. 2016;39:63–9
    • (2016) Int J Rehabil Res , vol.39 , pp. 63-69
    • Sirtori, A.1    Brunani, A.2    Capodaglio, P.3
  • 4
    • 84878340521 scopus 로고    scopus 로고
    • Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women
    • Beavers DP, Beavers KM, Lyles MF, Nicklas BJ. Cardiometabolic risk after weight loss and subsequent weight regain in overweight and obese postmenopausal women. J Gerontol Ser A, Biol Sci Med Sci. 2013;68:691–8
    • (2013) J Gerontol Ser A, Biol Sci Med Sci. , vol.68 , pp. 691-698
    • Beavers, D.P.1    Beavers, K.M.2    Lyles, M.F.3    Nicklas, B.J.4
  • 5
    • 84930867272 scopus 로고    scopus 로고
    • Effects of weight regain following intentional weight loss on glucoregulatory function in overweight and obese adults with pre-diabetes
    • Beavers KM, Case LD, Blackwell CS, Katula JA, Goff DC Jr, Vitolins MZ. Effects of weight regain following intentional weight loss on glucoregulatory function in overweight and obese adults with pre-diabetes. Obesity Res Clin Pract. 2015;9:266–73
    • (2015) Obesity Res Clin Pract , vol.9 , pp. 266-273
    • Beavers, K.M.1    Case, L.D.2    Blackwell, C.S.3    Katula, J.A.4    Goff, D.C.5    Vitolins, M.Z.6
  • 6
    • 84907397130 scopus 로고    scopus 로고
    • Impact of weight regain on metabolic disease risk: a review of human trials
    • PID: 25197563
    • Kroeger CM, Hoddy KK, Varady KA. Impact of weight regain on metabolic disease risk: a review of human trials. J Obes. 2014;2014:614519
    • (2014) J Obes , vol.2014 , pp. 614519
    • Kroeger, C.M.1    Hoddy, K.K.2    Varady, K.A.3
  • 7
    • 84938746787 scopus 로고    scopus 로고
    • Physiological adaptations to weight loss and factors favouring weight regain
    • Greenway FL. Physiological adaptations to weight loss and factors favouring weight regain. Int J Obes. 2015;39:1188–96
    • (2015) Int J Obes , vol.39 , pp. 1188-1196
    • Greenway, F.L.1
  • 8
    • 85035076386 scopus 로고    scopus 로고
    • Combination therapy for obesity
    • PID: 29132230
    • Wilding JP. Combination therapy for obesity. J Psychopharmacol. 2017;31:1503–8
    • (2017) J Psychopharmacol , vol.31 , pp. 1503-1508
    • Wilding, J.P.1
  • 9
    • 84997124377 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide once weekly over 6 years in patients with type 2 diabetes: an uncontrolled open-label extension of the DURATION-1 study
    • Henry RR, Klein EJ, Han J, Iqbal N. Efficacy and tolerability of exenatide once weekly over 6 years in patients with type 2 diabetes: an uncontrolled open-label extension of the DURATION-1 study. Diabetes Technol Therapeutics. 2016;18:677–86
    • (2016) Diabetes Technol Therapeutics. , vol.18 , pp. 677-686
    • Henry, R.R.1    Klein, E.J.2    Han, J.3    Iqbal, N.4
  • 10
    • 84892479365 scopus 로고    scopus 로고
    • Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin
    • PID: 23906445
    • Bolinder J, Ljunggren O, Johansson L, et al. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Diabetes Obes Metab. 2014;16:159–69
    • (2014) Diabetes Obes Metab , vol.16 , pp. 159-169
    • Bolinder, J.1    Ljunggren, O.2    Johansson, L.3
  • 11
    • 84928426587 scopus 로고    scopus 로고
    • Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data
    • PID: 25735400
    • Del Prato S, Nauck M, Duran-Garcia S, et al. Long-term glycaemic response and tolerability of dapagliflozin versus a sulphonylurea as add-on therapy to metformin in patients with type 2 diabetes: 4-year data. Diabetes Obes Metab. 2015;17:581–90
    • (2015) Diabetes Obes Metab , vol.17 , pp. 581-590
    • Del Prato, S.1    Nauck, M.2    Duran-Garcia, S.3
  • 12
    • 84923791994 scopus 로고    scopus 로고
    • Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus
    • PID: 25488697
    • Scheen AJ. Pharmacodynamics, efficacy and safety of sodium-glucose co-transporter type 2 (SGLT2) inhibitors for the treatment of type 2 diabetes mellitus. Drugs. 2015;75:33–59
    • (2015) Drugs. , vol.75 , pp. 33-59
    • Scheen, A.J.1
  • 14
    • 85021428641 scopus 로고    scopus 로고
    • Combination SGLT2 inhibitor and GLP-1 receptor agonist therapy: A complementary approach to the treatment of type 2 diabetes
    • Busch RS, Kane MP. Combination SGLT2 inhibitor and GLP-1 receptor agonist therapy: a complementary approach to the treatment of type 2 diabetes. Postgraduate medicine. 2017:1–12
    • (2017) Postgraduate Medicine , pp. 1-12
    • Busch, R.S.1    Kane, M.P.2
  • 15
    • 84994508611 scopus 로고    scopus 로고
    • Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial
    • PID: 27651331
    • Frias JP, Guja C, Hardy E, et al. Exenatide once weekly plus dapagliflozin once daily versus exenatide or dapagliflozin alone in patients with type 2 diabetes inadequately controlled with metformin monotherapy (DURATION-8): a 28 week, multicentre, double-blind, phase 3, randomised controlled trial. Lancet Diabetes Endocrinol. 2016;4:1004–16
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 1004-1016
    • Frias, J.P.1    Guja, C.2    Hardy, E.3
  • 16
    • 84989327940 scopus 로고    scopus 로고
    • Dapagliflozin once-daily and exenatide once-weekly dual therapy: a 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes
    • PID: 27550386
    • Lundkvist P, Sjostrom CD, Amini S, Pereira MJ, Johnsson E, Eriksson JW. Dapagliflozin once-daily and exenatide once-weekly dual therapy: a 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes. Diabetes Obes Metab. 2017;19:49–60
    • (2017) Diabetes Obes Metab , vol.19 , pp. 49-60
    • Lundkvist, P.1    Sjostrom, C.D.2    Amini, S.3    Pereira, M.J.4    Johnsson, E.5    Eriksson, J.W.6
  • 17
    • 85020067582 scopus 로고    scopus 로고
    • Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year
    • PID: 28345814
    • Lundkvist P, Pereira MJ, Katsogiannos P, Sjostrom CD, Johnsson E, Eriksson JW. Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year. Diabetes Obes Metab. 2017;19:1276–88
    • (2017) Diabetes Obes Metab , vol.19 , pp. 1276-1288
    • Lundkvist, P.1    Pereira, M.J.2    Katsogiannos, P.3    Sjostrom, C.D.4    Johnsson, E.5    Eriksson, J.W.6
  • 19
    • 84891865819 scopus 로고    scopus 로고
    • Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes
    • PID: 23735727
    • DeFronzo RA, Hompesch M, Kasichayanula S, et al. Characterization of renal glucose reabsorption in response to dapagliflozin in healthy subjects and subjects with type 2 diabetes. Diabetes Care. 2013;36:3169–76
    • (2013) Diabetes Care , vol.36 , pp. 3169-3176
    • DeFronzo, R.A.1    Hompesch, M.2    Kasichayanula, S.3
  • 20
    • 34047179603 scopus 로고    scopus 로고
    • SNPassoc: an R package to perform whole genome association studies
    • PID: 17267436
    • Gonzalez JR, Armengol L, Sole X, et al. SNPassoc: an R package to perform whole genome association studies. Bioinformatics. 2007;23:644–5
    • (2007) Bioinformatics , vol.23 , pp. 644-645
    • Gonzalez, J.R.1    Armengol, L.2    Sole, X.3
  • 21
    • 19544362938 scopus 로고    scopus 로고
    • Bayesian model averaging: development of an improved multi-class, gene selection and classification tool for microarray data
    • PID: 15713736
    • Yeung KY, Bumgarner RE, Raftery AE. Bayesian model averaging: development of an improved multi-class, gene selection and classification tool for microarray data. Bioinformatics. 2005;21:2394–402
    • (2005) Bioinformatics , vol.21 , pp. 2394-2402
    • Yeung, K.Y.1    Bumgarner, R.E.2    Raftery, A.E.3
  • 22
    • 77950537175 scopus 로고    scopus 로고
    • Regularization paths for generalized linear models via coordinate descent
    • PID: 20808728
    • Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33:1–22
    • (2010) J Stat Softw , vol.33 , pp. 1-22
    • Friedman, J.1    Hastie, T.2    Tibshirani, R.3
  • 23
    • 84938739087 scopus 로고    scopus 로고
    • Predicting adult weight change in the real world: a systematic review and meta-analysis accounting for compensatory changes in energy intake or expenditure
    • Dhurandhar EJ, Kaiser KA, Dawson JA, Alcorn AS, Keating KD, Allison DB. Predicting adult weight change in the real world: a systematic review and meta-analysis accounting for compensatory changes in energy intake or expenditure. Int J Obes. 2015;39:1181–7
    • (2015) Int J Obes. , vol.39 , pp. 1181-1187
    • Dhurandhar, E.J.1    Kaiser, K.A.2    Dawson, J.A.3    Alcorn, A.S.4    Keating, K.D.5    Allison, D.B.6
  • 24
    • 84955716283 scopus 로고    scopus 로고
    • Food cue reactivity and craving predict eating and weight gain: a meta-analytic review
    • PID: 26644270
    • Boswell RG, Kober H. Food cue reactivity and craving predict eating and weight gain: a meta-analytic review. Obes Rev. 2016;17:159–77
    • (2016) Obes Rev , vol.17 , pp. 159-177
    • Boswell, R.G.1    Kober, H.2
  • 26
    • 84993982735 scopus 로고    scopus 로고
    • How strongly does appetite counter weight loss? Quantification of the feedback control of human energy intake
    • PID: 27804272
    • Polidori D, Sanghvi A, Seeley RJ, Hall KD. How strongly does appetite counter weight loss? Quantification of the feedback control of human energy intake. Obesity. 2016;24:2289–95
    • (2016) Obesity. , vol.24 , pp. 2289-2295
    • Polidori, D.1    Sanghvi, A.2    Seeley, R.J.3    Hall, K.D.4
  • 27
    • 84955304504 scopus 로고    scopus 로고
    • Benefits and harms of once-weekly glucagon-like peptide-1 receptor agonist treatments: a systematic review and network meta-analysis
    • PID: 26642233
    • Zaccardi F, Htike ZZ, Webb DR, Khunti K, Davies MJ. Benefits and harms of once-weekly glucagon-like peptide-1 receptor agonist treatments: a systematic review and network meta-analysis. Ann Intern Med. 2016;164:102–13
    • (2016) Ann Intern Med , vol.164 , pp. 102-113
    • Zaccardi, F.1    Htike, Z.Z.2    Webb, D.R.3    Khunti, K.4    Davies, M.J.5
  • 28
    • 84938718347 scopus 로고    scopus 로고
    • The effect of glucagon-like peptide 1 receptor agonists on weight loss in type 2 diabetes: a systematic review and mixed treatment comparison meta-analysis
    • PID: 26121478
    • Potts JE, Gray LJ, Brady EM, Khunti K, Davies MJ, Bodicoat DH. The effect of glucagon-like peptide 1 receptor agonists on weight loss in type 2 diabetes: a systematic review and mixed treatment comparison meta-analysis. PLoS ONE. 2015;10:e0126769
    • (2015) PLoS ONE , vol.10
    • Potts, J.E.1    Gray, L.J.2    Brady, E.M.3    Khunti, K.4    Davies, M.J.5    Bodicoat, D.H.6
  • 29
    • 84922380651 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss in patients with type 2 diabetes: a systematic review and network meta-analysis
    • PID: 25688373
    • Sun F, Chai S, Li L, et al. Effects of glucagon-like peptide-1 receptor agonists on weight loss in patients with type 2 diabetes: a systematic review and network meta-analysis. J Diabetes Res. 2015;2015:157201
    • (2015) J Diabetes Res. , vol.2015 , pp. 157201
    • Sun, F.1    Chai, S.2    Li, L.3
  • 30
    • 84960433486 scopus 로고    scopus 로고
    • SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis
    • PID: 26911584
    • Shyangdan DS, Uthman OA, Waugh N. SGLT-2 receptor inhibitors for treating patients with type 2 diabetes mellitus: a systematic review and network meta-analysis. BMJ Open. 2016;6:e009417
    • (2016) BMJ Open , vol.6
    • Shyangdan, D.S.1    Uthman, O.A.2    Waugh, N.3
  • 31
    • 84928628823 scopus 로고    scopus 로고
    • Comparative efficacy and safety of antidiabetic drug regimens added to metformin monotherapy in patients with type 2 diabetes: a network meta-analysis
    • PID: 25919293
    • Mearns ES, Sobieraj DM, White CM, et al. Comparative efficacy and safety of antidiabetic drug regimens added to metformin monotherapy in patients with type 2 diabetes: a network meta-analysis. PLoS ONE. 2015;10:e0125879
    • (2015) PLoS ONE , vol.10
    • Mearns, E.S.1    Sobieraj, D.M.2    White, C.M.3
  • 32
    • 85019391775 scopus 로고    scopus 로고
    • Coadministration of canagliflozin and phentermine for weight management in overweight and obese individuals without diabetes: a randomized clinical trial
    • PID: 28289041
    • Hollander P, Bays HE, Rosenstock J, et al. Coadministration of canagliflozin and phentermine for weight management in overweight and obese individuals without diabetes: a randomized clinical trial. Diabetes Care. 2017;40:632–9
    • (2017) Diabetes Care , vol.40 , pp. 632-639
    • Hollander, P.1    Bays, H.E.2    Rosenstock, J.3
  • 33
    • 80052203917 scopus 로고    scopus 로고
    • Quantification of the effect of energy imbalance on bodyweight
    • PID: 21872751
    • Hall KD, Sacks G, Chandramohan D, et al. Quantification of the effect of energy imbalance on bodyweight. Lancet. 2011;378:826–37
    • (2011) Lancet , vol.378 , pp. 826-837
    • Hall, K.D.1    Sacks, G.2    Chandramohan, D.3
  • 34
    • 84964608804 scopus 로고    scopus 로고
    • Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes
    • PID: 26861783
    • Ferrannini E, Baldi S, Frascerra S, et al. Shift to fatty substrate utilization in response to sodium-glucose cotransporter 2 inhibition in subjects without diabetes and patients with type 2 diabetes. Diabetes. 2016;65:1190–5
    • (2016) Diabetes , vol.65 , pp. 1190-1195
    • Ferrannini, E.1    Baldi, S.2    Frascerra, S.3
  • 35
    • 84893872877 scopus 로고    scopus 로고
    • Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients
    • PID: 24463454
    • Ferrannini E, Muscelli E, Frascerra S, et al. Metabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients. J Clin Investig. 2014;124:499–508
    • (2014) J Clin Investig , vol.124 , pp. 499-508
    • Ferrannini, E.1    Muscelli, E.2    Frascerra, S.3
  • 36
    • 84887342376 scopus 로고    scopus 로고
    • Relation between serum free fatty acids and adiposity, insulin resistance, and cardiovascular risk factors from adolescence to adulthood
    • PID: 23670973
    • Frohnert BI, Jacobs DR Jr, Steinberger J, Moran A, Steffen LM, Sinaiko AR. Relation between serum free fatty acids and adiposity, insulin resistance, and cardiovascular risk factors from adolescence to adulthood. Diabetes. 2013;62:3163–9
    • (2013) Diabetes , vol.62 , pp. 3163-3169
    • Frohnert, B.I.1    Jacobs, D.R.2    Steinberger, J.3    Moran, A.4    Steffen, L.M.5    Sinaiko, A.R.6
  • 37
    • 84896816933 scopus 로고    scopus 로고
    • Changes in insulin sensitivity and insulin secretion with the sodium glucose cotransporter 2 inhibitor dapagliflozin
    • Mudaliar S, Henry RR, Boden G, et al. Changes in insulin sensitivity and insulin secretion with the sodium glucose cotransporter 2 inhibitor dapagliflozin. Diabetes Technol Therapeutics. 2014;16:137–44
    • (2014) Diabetes Technol Therapeutics. , vol.16 , pp. 137-144
    • Mudaliar, S.1    Henry, R.R.2    Boden, G.3
  • 38
    • 85013888705 scopus 로고    scopus 로고
    • Effect of exenatide on postprandial glucose fluxes, lipolysis, and β-cell function in non-diabetic, morbidly obese patients
    • PID: 27898183
    • Camastra S, Astiarraga B, Tura A, et al. Effect of exenatide on postprandial glucose fluxes, lipolysis, and β-cell function in non-diabetic, morbidly obese patients. Diabetes Obes Metab. 2017;19:412–20
    • (2017) Diabetes Obes Metab , vol.19 , pp. 412-420
    • Camastra, S.1    Astiarraga, B.2    Tura, A.3
  • 39
    • 84954384684 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis
    • PID: 26394161
    • Armstrong MJ, Hull D, Guo K, et al. Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis. J Hepatol. 2016;64:399–408
    • (2016) J Hepatol , vol.64 , pp. 399-408
    • Armstrong, M.J.1    Hull, D.2    Guo, K.3
  • 40
    • 84995804566 scopus 로고    scopus 로고
    • Exenatide improves both hepatic and adipose tissue insulin resistance: a dynamic positron emission tomography study
    • PID: 27639082
    • Gastaldelli A, Gaggini M, Daniele G, et al. Exenatide improves both hepatic and adipose tissue insulin resistance: a dynamic positron emission tomography study. Hepatology. 2016;64:2028–37
    • (2016) Hepatology , vol.64 , pp. 2028-2037
    • Gastaldelli, A.1    Gaggini, M.2    Daniele, G.3
  • 41
    • 84962339296 scopus 로고    scopus 로고
    • Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition
    • PID: 26078479
    • Peters AL, Buschur EO, Buse JB, Cohan P, Diner JC, Hirsch IB. Euglycemic diabetic ketoacidosis: a potential complication of treatment with sodium-glucose cotransporter 2 inhibition. Diabetes Care. 2015;38:1687–93
    • (2015) Diabetes Care , vol.38 , pp. 1687-1693
    • Peters, A.L.1    Buschur, E.O.2    Buse, J.B.3    Cohan, P.4    Diner, J.C.5    Hirsch, I.B.6
  • 42
    • 84975853831 scopus 로고    scopus 로고
    • CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis
    • PID: 27289126
    • Ferrannini E, Mark M, Mayoux E. CV protection in the EMPA-REG OUTCOME trial: a “thrifty substrate” hypothesis. Diabetes Care. 2016;39:1108–14
    • (2016) Diabetes Care , vol.39 , pp. 1108-1114
    • Ferrannini, E.1    Mark, M.2    Mayoux, E.3
  • 43
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
    • PID: 27289124
    • Mudaliar S, Alloju S, Henry RR. Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care. 2016;39:1115–22
    • (2016) Diabetes Care , vol.39 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 44
    • 84893827104 scopus 로고    scopus 로고
    • Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production
    • PID: 24463448
    • Merovci A, Solis-Herrera C, Daniele G, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Investig. 2014;124:509–14
    • (2014) J Clin Investig , vol.124 , pp. 509-514
    • Merovci, A.1    Solis-Herrera, C.2    Daniele, G.3
  • 45
    • 33749342602 scopus 로고    scopus 로고
    • WFS1 protein modulates the free Ca(2 +) concentration in the endoplasmic reticulum
    • PID: 16989814
    • Takei D, Ishihara H, Yamaguchi S, et al. WFS1 protein modulates the free Ca(2 +) concentration in the endoplasmic reticulum. FEBS Lett. 2006;580:5635–40
    • (2006) FEBS Lett , vol.580 , pp. 5635-5640
    • Takei, D.1    Ishihara, H.2    Yamaguchi, S.3
  • 47
    • 33745202552 scopus 로고    scopus 로고
    • WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells
    • PID: 16571599
    • Yamada T, Ishihara H, Tamura A, et al. WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells. Hum Mol Genet. 2006;15:1600–9
    • (2006) Hum Mol Genet , vol.15 , pp. 1600-1609
    • Yamada, T.1    Ishihara, H.2    Tamura, A.3
  • 48
    • 27744523525 scopus 로고    scopus 로고
    • Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis
    • PID: 16215705
    • Riggs AC, Bernal-Mizrachi E, Ohsugi M, et al. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Diabetologia. 2005;48:2313–21
    • (2005) Diabetologia , vol.48 , pp. 2313-2321
    • Riggs, A.C.1    Bernal-Mizrachi, E.2    Ohsugi, M.3
  • 49
    • 0024599929 scopus 로고
    • Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram’s syndrome
    • PID: 2649325
    • Karasik A, O’Hara C, Srikanta S, et al. Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram’s syndrome. Diabetes Care. 1989;12:135–8
    • (1989) Diabetes Care , vol.12 , pp. 135-138
    • Karasik, A.1    O’Hara, C.2    Srikanta, S.3
  • 50
    • 34547536393 scopus 로고    scopus 로고
    • Common variants in WFS1 confer risk of type 2 diabetes
    • PID: 17603484
    • Sandhu MS, Weedon MN, Fawcett KA, et al. Common variants in WFS1 confer risk of type 2 diabetes. Nat Genet. 2007;39:951–3
    • (2007) Nat Genet , vol.39 , pp. 951-953
    • Sandhu, M.S.1    Weedon, M.N.2    Fawcett, K.A.3
  • 51
    • 67349190497 scopus 로고    scopus 로고
    • A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
    • PID: 19330314
    • Schafer SA, Mussig K, Staiger H, et al. A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia. 2009;52:1075–82
    • (2009) Diabetologia , vol.52 , pp. 1075-1082
    • Schafer, S.A.1    Mussig, K.2    Staiger, H.3
  • 52
    • 76749093118 scopus 로고    scopus 로고
    • Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function
    • PID: 19833888
    • Simonis-Bik AM, Nijpels G, van Haeften TW, et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes. 2010;59:293–301
    • (2010) Diabetes , vol.59 , pp. 293-301
    • Simonis-Bik, A.M.1    Nijpels, G.2    van Haeften, T.W.3
  • 53
    • 84877005240 scopus 로고    scopus 로고
    • Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis
    • Cheng S, Wu Y, Wu W, Zhang D. Association of rs734312 and rs10010131 polymorphisms in WFS1 gene with type 2 diabetes mellitus: a meta-analysis. Endocrine J. 2013;60:441–7
    • (2013) Endocrine J , vol.60 , pp. 441-447
    • Cheng, S.1    Wu, Y.2    Wu, W.3    Zhang, D.4
  • 54
    • 77950344135 scopus 로고    scopus 로고
    • Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes
    • PID: 20028944
    • Haupt A, Thamer C, Heni M, et al. Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes. 2010;59:747–50
    • (2010) Diabetes , vol.59 , pp. 747-750
    • Haupt, A.1    Thamer, C.2    Heni, M.3
  • 55
    • 84956931423 scopus 로고    scopus 로고
    • Baseline characteristics associated with different BMI trajectories in weight loss trials: a case for better targeting of interventions
    • PID: 25828627
    • Batterham M, Tapsell LC, Charlton KE. Baseline characteristics associated with different BMI trajectories in weight loss trials: a case for better targeting of interventions. Eur J Clin Nutr. 2016;70:207–11
    • (2016) Eur J Clin Nutr , vol.70 , pp. 207-211
    • Batterham, M.1    Tapsell, L.C.2    Charlton, K.E.3
  • 56
    • 84857370827 scopus 로고    scopus 로고
    • Preoperative predictors of weight loss following bariatric surgery: systematic review
    • PID: 21833817
    • Livhits M, Mercado C, Yermilov I, et al. Preoperative predictors of weight loss following bariatric surgery: systematic review. Obes Surg. 2012;22:70–89
    • (2012) Obes Surg , vol.22 , pp. 70-89
    • Livhits, M.1    Mercado, C.2    Yermilov, I.3
  • 58
    • 85050577894 scopus 로고    scopus 로고
    • Hyperinsulinemia: a cause of obesity?
    • PID: 28466412
    • Erion KA, Corkey BE. Hyperinsulinemia: a cause of obesity? Curr Obes Rep. 2017;6:178–86
    • (2017) Curr Obes Rep , vol.6 , pp. 178-186
    • Erion, K.A.1    Corkey, B.E.2
  • 59
    • 80052083260 scopus 로고    scopus 로고
    • Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study
    • PID: 21617179
    • Rebelos E, Muscelli E, Natali A, et al. Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study. Diabetes. 2011;60:1938–45
    • (2011) Diabetes , vol.60 , pp. 1938-1945
    • Rebelos, E.1    Muscelli, E.2    Natali, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.