HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation

Cell

Volumn 174, Issue 3, 2018, Pages 659-671.e14

  Morris, Kyle L ^a   Buffalo, Cosmo Z ^a   Stürzel, Christina M ^b   Heusinger, Elena ^b   Kirchhoff, Frank ^b   Ren, Xuefeng ^a   Hurley, James H ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY HOSPITAL ULM   (Germany)

^c LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

adaptor protein; clathrin; cryo EM; HIV; HIV Nef; trafficking

Indexed keywords

BONE MARROW STROMAL ANTIGEN 2; GLUTATHIONE TRANSFERASE; NEF PROTEIN; TRANSCRIPTION FACTOR AP 1; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; CLATHRIN; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VESICULAR TRANSPORT ADAPTOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYOELECTRON MICROSCOPY; DIMERIZATION; DOWN REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY; GOLGI COMPLEX; HEK293 CELL LINE; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; ULTRASTRUCTURE;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADP-RIBOSYLATION FACTOR 1; BONE MARROW STROMAL ANTIGEN 2; CLATHRIN; GOLGI APPARATUS; HEK293 CELLS; HIV-1; HUMANS; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PROTEIN TRANSPORT; TRANSCRIPTION FACTOR AP-1;

EID: 85050095137     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2018.07.004     Document Type: Article

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