Genetic variants in RORA are associated with asthma and allergy markers in an admixed population

Cytokine

Volumn 113, Issue , 2019, Pages 177-184

  Lima, Louise Correia ^a   Queiroz, Gerson de Almeida ^b   Costa, Ryan dos Santos ^b   Alcantara Neves, Neuza Maria ^b   Marques, Cíntia Rodrigues ^b   Costa, Gustavo Nunes de Oliveira ^b   Barreto, Mauricio Lima ^b   Figueiredo, Camila Alexandrina Viana ^b   Carneiro, Valdirene Leão ^a  

^a UNIVERSIDADE DO ESTADO DA BAHIA   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Asthma; Atopic sensitization; Polymorphism; RORA

Indexed keywords

IMMUNOGLOBULIN E; RETINOID RELATED ORPHAN RECEPTOR ALPHA; BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 13; RORA PROTEIN, HUMAN;

ALLERGY; ARTICLE; ASTHMA; ATOPY; BRAZIL; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE; GENE EXPRESSION; GENE TARGETING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRICK TEST; PRIORITY JOURNAL; RETINOIC ACID DEPENDENT ORPHAN RECEPTOR ALPHA GENE; SINGLE NUCLEOTIDE POLYMORPHISM; UPREGULATION; BLOOD; COHORT ANALYSIS; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HYPERSENSITIVITY; INFLAMMATION; INNATE IMMUNITY; LUNG; METABOLISM; PRESCHOOL CHILD; TH2 CELL;

ASTHMA; BIOMARKERS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CYTOKINES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERSENSITIVITY; IMMUNITY, INNATE; IMMUNOGLOBULIN E; INFLAMMATION; INTERLEUKIN-13; LUNG; MALE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 1; POLYMORPHISM, SINGLE NUCLEOTIDE; TH2 CELLS;

EID: 85049483483     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2018.07.004     Document Type: Article

References (41)

1. S. Croisant, “Epidemiology of asthma: prevalence and burden of disease,” in Heterogeneity in Asthma, Springer, 2014, pp. 17–29.
2. Bara, I., Ozier, A., De Lara, J.T., Marthan, R., Berger, P., Pathophysiology of bronchial smooth muscle remodelling in asthma. Eur. Respir. J. 36:5 (2010), 1174–1184.
3. Wenzel, S.E., Asthma phenotypes: the evolution from clinical to molecular approaches. Nat. Med. 18:5 (2012), 716–725.
4. Doherty, S.P., Grabowski, J., Hoffman, C., Ng, S.P., Zelikoff, J.T., Early life insult from cigarette smoke may be predictive of chronic diseases later in life. Biomarkers 14:suppl. 1 (2009), 97–101.
5. Jaradat, M., et al. Modulatory role for retinoid-related orphan receptor α in allergen-induced lung inflammation. Am. J. Respir. Crit. Care Med. 174:12 (2006), 1299–1309.
6. Fahy, J.V., Type 2 inflammation in asthma [mdash] present in most, absent in many. Nat. Rev. Immunol. 15:1 (2015), 57–65.
7. Cosmi, L., Liotta, F., Maggi, E., Romagnani, S., Annunziato, F., Th17 cells: new players in asthma pathogenesis. Allergy 66:8 (2011), 989–998.
8. Halim, T.Y., et al. Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses. Nat. Immunol. 17:1 (2016), 57–64.
9. Jetten, A.M., Ueda, E., The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog. Nucleic Acid Res. Mol. Biol. 69 (2001), 205–247.
10. J. Mjösberg et al., “The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells,” immunity, vol. 37, no. 4, pp. 649–659, 2012.
11. Wong, S.H., et al. Transcription factor ROR [alpha] is critical for nuocyte development. Nat. Immunol. 13:3 (2012), 229–236.
12. Fitzsimmons, R.L., Lau, P., Muscat, G.E., Retinoid-related orphan receptor alpha and the regulation of lipid homeostasis. J. Steroid Biochem. Mol. Biol. 130:3 (2012), 159–168.
13. Solt, L.A., Burris, T.P., Action of RORs and their ligands in (patho) physiology. Trends Endocrinol. Metab. 23:12 (2012), 619–627.
14. Mangelsdorf, D.J., Evans, R.M., The RXR heterodimers and orphan receptors. Cell 83:6 (1995), 841–850.
15. D. N. Cook, H. S. Kang, and A. M. Jetten, “Retinoic acid-related orphan receptors (RORs): regulatory functions in immunity, development, circadian rhythm, and metabolism,” Nucl. Recept. Res., vol. 2, 2015.
16. Duez, H., Staels, B., Nuclear receptors linking circadian rhythms and cardiometabolic control. Arterioscler. Thromb. Vasc. Biol. 30:8 (2010), 1529–1534.
17. Halim, T.Y., Krauß R.H., Sun, A.C., Takei, F., Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36:3 (2012), 451–463.
18. Cookson, W., The alliance of genes and environment in asthma and allergy. Nature 402 (1999), 5–11.
19. Holgate, S.T., Genetic and environmental interaction in allergy and asthma. J. Allergy Clin. Immunol. 104:6 (1999), 1139–1146.
20. Costa, G.N., et al. A genome-wide association study of asthma symptoms in Latin American children. BMC Genet., 16(1), 2015, 141.
21. Imboden, M., et al. Genome-wide association study of lung function decline in adults with and without asthma. J. Allergy Clin. Immunol. 129:5 (2012), 1218–1228.
22. Moffatt, M.F., et al. A large-scale, consortium-based genomewide association study of asthma. N. Engl. J. Med. 363:13 (2010), 1211–1221.
23. Spycher, B.D., et al. Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort. J. Allergy Clin. Immunol. 130:2 (2012), 503–509.
24. Acevedo, N., et al. Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma. PloS One, 8(4), 2013, e60111.
25. Alcantara-Neves, N.M., et al. The effect of single and multiple infections on atopy and wheezing in children. J. Allergy Clin. Immunol. 129:2 (2012), 359–367.
26. Barreto, M.L., et al. Risk factors and immunological pathways for asthma and other allergic diseases in children: background and methodology of a longitudinal study in a large urban center in Northeastern Brazil (Salvador-SCAALA study). BMC Pulm. Med., 6(1), 2006, 15.
27. Figueiredo, C.A., et al. Chronic intestinal helminth infections are associated with immune hyporesponsiveness and induction of a regulatory network. Infect. Immun. 78:7 (2010), 3160–3167.
28. Kehdy, F.S., et al. Origin and dynamics of admixture in Brazilians and its effect on the pattern of deleterious mutations. Proc. Natl. Acad. Sci. 112:28 (2015), 8696–8701.
29. Purcell, S., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81:3 (2007), 559–575.
30. Queiroz, G.A., et al. IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. Int. J. Immunogenet. 44:2 (2017), 51–61.
31. Wang, Y., Zhao, L.P., Dudoit, S., A fine-scale linkage-disequilibrium measure based on length of haplotype sharing. Am. J. Hum. Genet. 78:4 (2006), 615–628.
32. Boyle, A.P., et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res. 22:9 (2012), 1790–1797.
33. Bunyavanich, S., Schadt, E.E., Systems biology of asthma and allergic diseases: a multiscale approach. J. Allergy Clin. Immunol. 135:1 (2015), 31–42.
34. Melén, E., et al. Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin. Exp. Allergy 43:4 (2013), 463–474.
35. Simpson, A., et al. Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study. Am. J. Respir. Crit. Care Med. 181:11 (2010), 1200–1206.
36. Halim, T.Y., et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40:3 (2014), 425–435.
37. Lambrecht, B.N., Hammad, H., The airway epithelium in asthma. Nat. Med. 18:5 (2012), 684–692.
38. Hubner, N., et al. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nat. Genet. 37:3 (2005), 243–253.
39. Ramasamy, A., et al. Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PloS One, 7(9), 2012, e44008.
40. Mathias, R.A., et al. A genome-wide association study on African-ancestry populations for asthma. J. Allergy Clin. Immunol. 125:2 (2010), 336–346.
41. Vergara, C., et al. African ancestry is a risk factor for asthma and high total IgE levels in African admixed populations. Genet. Epidemiol. 37:4 (2013), 393–401.