Poor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012-2013

Clinical Infectious Diseases

Volumn 67, Issue 3, 2018, Pages 327-333

  Cobey, Sarah ^a   Gouma, Sigrid ^b   Parkhouse, Kaela ^b   Chambers, Benjamin S ^b,k   Ertl, Hildegund C ^c,d   Schmader, Kenneth E ^c,d   Halpin, Rebecca A ^e   Lin, Xudong ^e   Stockwell, Timothy B ^e   Das, Suman R ^e,l   Landon, Emily ^a   Tesic, Vera ^a   Youngster, Ilan ^f,g   Pinsky, Benjamin A ^h   Wentworth, David E ^e,m   Hensley, Scott E ^b   Grad, Yonatan H ^i,j  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d DURHAM VA MEDICAL CENTER   (United States)

^e J CRAIG VENTER INSTITUTE   (United States)

^f TEL AVIV UNIVERSITY   (Israel)

^g BOSTON CHILDREN S HOSPITAL   (United States)

^h STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^j BRIGHAM AND WOMEN S HOSPITAL   (United States)

^k DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^m CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

more..

Author keywords

egg adaptation; genome sequencing; influenza; vaccine effectiveness; vaccine immunogenicity

Indexed keywords

INFLUENZA VACCINE; VIRUS ANTIGEN;

ADULT; AGED; ANTIBODY BLOOD LEVEL; ARTICLE; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG EFFICACY; FEMALE; GENETIC DIFFERENCE; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; INFLUENZA A (H3N2); INFLUENZA VACCINATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; UNITED STATES; VACCINE IMMUNOGENICITY; VIRUS STRAIN; ADAPTATION; ANIMAL; CROSS REACTION; EGG; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; INFLUENZA; INFLUENZA A VIRUS (H3N2); ISOLATION AND PURIFICATION; MUSTELA PUTORIUS FURO; MUTATION; PHYLOGENY; SEASON; VERY ELDERLY; VIROLOGY; VIRUS GENOME;

ADAPTATION, PHYSIOLOGICAL; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIGENS, VIRAL; COHORT STUDIES; CROSS REACTIONS; EGGS; FERRETS; GENOME, VIRAL; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOGENICITY, VACCINE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MUTATION; PHYLOGENY; SEASONS;

EID: 85049451355     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/ciy097     Document Type: Article

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