The confounded effects of age and exposure history in response to influenza vaccination

Vaccine

Volumn 34, Issue 4, 2016, Pages 540-546

  Mosterín Höpping, Ana ^a,b   McElhaney, Janet ^d   Fonville, Judith M ^a,b   Powers, Douglas C ^a,b,c,d   Beyer, Walter E P ^c   Smith, Derek J ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d Advanced Medical Research Institute of Canada   (Canada)

Author keywords

Elderly; Immunosenescence; Influenza vaccine; Repeated vaccination; Vaccine efficacy

Indexed keywords

INFLUENZA VACCINE; INACTIVATED VACCINE; VIRUS ANTIBODY;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; GROUPS BY AGE; HUMAN; IMMUNE SYSTEM; IMMUNOSENESCENCE; INFLUENZA A VIRUS (H1N1); INFLUENZA VACCINATION; PRIORITY JOURNAL; AGE; BLOOD; EPIDEMIOLOGY; HUMORAL IMMUNITY; INFLUENZA, HUMAN; LONGITUDINAL STUDY; MIDDLE AGED; STATISTICAL MODEL; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; CONFOUNDING FACTORS (EPIDEMIOLOGY); HUMANS; IMMUNITY, HUMORAL; INFLUENZA VACCINES; INFLUENZA, HUMAN; LINEAR MODELS; LONGITUDINAL STUDIES; MIDDLE AGED; VACCINES, INACTIVATED; YOUNG ADULT;

EID: 84952975495     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2015.11.058     Document Type: Article

References (25)

1. de Bruijn I.A., Remarque E.J., Beyer W.E., le Cessie S., Masurel N., Ligthart G.J. Annually repeated influenza vaccination improves humoral responses to several influenza virus strains in healthy elderly. Vaccine 1997, 15(12-13):1323-1329. Epub 1997/08/01.
2. Glathe H., Bigl S., Grosche A. Comparison of humoral immune responses to trivalent influenza split vaccine in young, middle-aged and elderly people. Vaccine 1993, 11(7):702-705. Epub 1993/01/01.
3. Sasaki S., Sullivan M., Narvaez C.F., Holmes T.H., Furman D., Zheng N.Y., et al. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest 2011, 121(8):3109-3119. Epub 2011/07/26.
4. Iorio A.M., Camilloni B., Basileo M., Neri M., Lepri E., Spighi M. Effects of repeated annual influenza vaccination on antibody responses against unchanged vaccine antigens in elderly frail institutionalized volunteers. Gerontology 2007, 53(6):411-418. Epub 2007/11/03.
5. Beyer W.E., Palache A.M., Baljet M., Masurel N. Antibody induction by influenza vaccines in the elderly: a review of the literature. Vaccine 1989, 7(5):385-394. Epub 1989/10/01.
6. Goodwin K., Viboud C., Simonsen L. Antibody response to influenza vaccination in the elderly: a quantitative review. Vaccine 2006, 24(8):1159-1169. Epub 2005/10/11.
7. Voordouw A.C., Beyer W.E., Smith D.J., Sturkenboom M.C., Stricker B.H. Evaluation of serological trials submitted for annual re-licensure of influenza vaccines to regulatory authorities between 1992 and 2002. Vaccine 2009, 28(2):392-397. Epub 2009/11/03.
8. Gruver A.L., Hudson L.L., Sempowski G.D. Immunosenescence of ageing. J Pathol 2007, 211(2):144-156. Epub 2007/01/04.
9. Appay V., Sauce D., Prelog M. The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals. Aging 2010, 2(2):78-81. Epub 2010/04/01.
10. Fülöp Ts. Handbook on immunosenescence: basic understanding and clinical applications 2009, Springer, New York, NY; Dordrecht.
11. Aspinall R., Andrew D. Thymic involution in aging. J Clin Immunol 2000, 20(4):250-256. Epub 2000/08/12.
12. Carroll T.D., Matzinger S.R., Barry P.A., McChesney M.B., Fairman J., Miller C.J. Efficacy of influenza vaccination of elderly rhesus macaques is dramatically improved by addition of a cationic lipid/DNA adjuvant. J Infect Dis 2014, 209(1):24-33.
13. Coe C.L., Lubach G.R., Kinnard J. Immune senescence in old and very old rhesus monkeys: reduced antibody response to influenza vaccination. Age 2012, 34(5):1169-1177.
14. den Elzen W.P., Vossen A.C., Cools H.J., Westendorp R.G., Kroes A.C., Gussekloo J. Cytomegalovirus infection and responsiveness to influenza vaccination in elderly residents of long-term care facilities. Vaccine 2011, 29(29-30):4869-4874.
15. Wald A., Selke S., Magaret A., Boeckh M. Impact of human cytomegalovirus (CMV) infection on immune response to pandemic 2009 H1N1 influenza vaccine in healthy adults. J Med Virol 2013, 85(9):1557-1560.
16. Trzonkowski P., Mysliwska J., Szmit E., Wieckiewicz J., Lukaszuk K., Brydak L.B., et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence. Vaccine 2003, 21(25-26):3826-3836.
17. Reber A.J., Chirkova T., Kim J.H., Cao W., Biber R., Shay D.K., et al. Immunosenescence and challenges of vaccination against influenza in the aging population. Aging Dis 2012, 3(1):68-90. Epub 2012/04/14.
18. Targonski P.V., Jacobson R.M., Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 2007, 25(16):3066-3069. Epub 2007/02/06.
19. WHO Collaborating Center for Influenza BPD. The hemagglutination inhibition test for influenza viruses. vol. version 31. Atlanta, GA: DHEW, PHS, CDC, Center for Infectious Disease, revised, 1981: 1-21.
20. Beyer W.E., de Bruijn I.A., Palache A.M., Westendorp R.G., Osterhaus A.D. Protection against influenza after annually repeated vaccination: a meta-analysis of serologic and field studies. Arch Intern Med 1999, 159(2):182-188. Epub 1999/02/02.
21. Beyer W.E., McElhaney J., Smith D.J., Monto A.S., Nguyen-Van-Tam J.S., Osterhaus A.D. Cochrane re-arranged: support for policies to vaccinate elderly people against influenza. Vaccine 2013, 31(50):6030-6033.
22. van Essen G.A., Palache A.M., Forleo E., Fedson D.S. Influenza vaccination in 2000: recommendations and vaccine use in 50 developed and rapidly developing countries. Vaccine 2003, 21(16):1780-1785. Epub 2003/04/11.
23. Coudeville L., Bailleux F., Riche B., Megas F., Andre P., Ecochard R. Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model. BMC Med Res Methodol 2010, 10:18.
24. McLean H.Q., Thompson M.G., Sundaram M.E., Meece J.K., McClure D.L., Friedrich T.C., et al. Impact of repeated vaccination on vaccine effectiveness against influenza A(H3N2) and B during 8 seasons. Clin Infect Dis 2014, 59(10):1375-1385. an official publication of the Infectious Diseases Society of America.
25. Smith D.J., Forrest S., Ackley D.H., Perelson A.S. Variable efficacy of repeated annual influenza vaccination. Proc Natl Acad Sci U S A 1999, 96(24):14001-14006. Epub 1999/11/26.