Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats

Brain Research Bulletin

Volumn 142, Issue , 2018, Pages 1-7

  Lu, Yanxia ^a   Ho, Cyrus S ^b,c   McIntyre, Roger S ^e,f,g   Wang, Wei ^a   Ho, Roger C ^c,d  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY HEALTH NETWORK   (Canada)

^g UNIVERSITY OF TORONTO   (Canada)

Author keywords

Brain derived neurotrophic factors; Chronic unpredictable mild stress; Depression; Fluoxetine; Vortioxetine

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; EOSIN; FLUOXETINE; HEMATOXYLIN; VORTIOXETINE; ANTIDEPRESSANT AGENT; BDNF PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CHRONIC STRESS; CHRONIC UNPREDICTABLE MILD STRESS; CONTROLLED STUDY; DEPRESSION; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; NEUROMODULATION; NONHUMAN; OPTICAL DENSITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; ANHEDONIA; ANIMAL; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; MAJOR DEPRESSION; MENTAL STRESS; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANHEDONIA; ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER, MAJOR; DISEASE MODELS, ANIMAL; FLUOXETINE; HIPPOCAMPUS; MALE; NEURONS; RANDOM ALLOCATION; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL; VORTIOXETINE;

EID: 85048741286     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2018.06.007     Document Type: Article

References (44)

1. Amidfar, M., Reus, G.Z., Quevedo, J., Kim, Y.K., Arbabi, M., Effect of co-administration of memantine and sertraline on the antidepressant-like activity and brain-derived neurotrophic factor (BDNF) levels in the rat brain. Brain Res. Bull. 128 (2017), 29–33.
2. Betry, C., Etievant, A., Pehrson, A., Sanchez, C., Haddjeri, N., Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory. Prog. Neuropsychopharmacol. Biol. Psychiatry 58 (2015), 38–46.
3. Chen, F., du Jardin, K.G., Waller, J.A., Sanchez, C., Nyengaard, J.R., Wegener, G., Vortioxetine promotes early changes in dendritic morphology compared to fluoxetine in rat hippocampus. Eur. Neuropsychopharmacol. 26 (2016), 234–245.
4. Denenberg, V.H., Open-field behavior in the rat: what does it mean?. Ann. N. Y. Acad. Sci. 159 (1969), 852–859.
5. du Jardin, K.G., Liebenberg, N., Muller, H.K., Elfving, B., Sanchez, C., Wegener, G., Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression. Psychopharmacology (Berl). 233 (2016), 2813–2825.
6. du Jardin, K.G., Muller, H.K., Sanchez, C., Wegener, G., Elfving, B., A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex. Eur. J. Pharmacol. 786 (2016), 29–35.
7. El Mansari, M., Lecours, M., Blier, P., Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology (Berl). 232 (2015), 2343–2352.
8. Garcia, L.S., Comim, C.M., Valvassori, S.S., Reus, G.Z., Barbosa, L.M., Andreazza, A.C., Stertz, L., Fries, G.R., Gavioli, E.C., Kapczinski, F., Quevedo, J., Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (2008), 140–144.
9. Henningsen, K., Andreasen, J.T., Bouzinova, E.V., Jayatissa, M.N., Jensen, M.S., Redrobe, J.P., Wiborg, O., Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. Behav. Brain. Res. 198 (2009), 136–141.
10. Ho, R.C., Mak, K.K., Chua, A.N., Ho, C.S., Mak, A., The effect of severity of depressive disorder on economic burden in a university hospital in Singapore. Expert Rev. Pharmacoecon. Outcomes Res. 13 (2013), 549–559.
11. Ho, R.C., Zhang, M.W., Ketamine as a rapid antidepressant: the debate and implications. BJPsych. Adv. 22 (2016), 222–233.
12. Jensen, E.C., Quantitative analysis of histological staining and fluorescence using ImageJ. Anat. Rec. (Hoboken) 296 (2013), 378–381.
13. Jensen, J.B., du Jardin, K.G., Song, D., Budac, D., Smagin, G., Sanchez, C., Pehrson, A.L., Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation. Eur. Neuropsychopharmacol. 24 (2014), 148–159.
14. Kaler, S., Dhar, P., Bhattacharya, A., Mehra, R.D., Preliminary morphological and immunohistochemical changes in rat hippocampus following postnatal exposure to sodium arsenite. Toxicol. Int. 20 (2013), 160–169.
15. Katz, R.J., Animal model of depression: pharmacological sensitivity of a hedonic deficit. Pharmacol. Biochem. Behav. 16 (1982), 965–968.
16. Khundakar, A.A., Zetterstrom, T.S., Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Brain Res. 1106 (2006), 12–20.
17. Kong, Q., Qin, C., Analysis of current laboratory animal science policies and administration in China. ILAR J. 51 (2009), e1–e11.
18. Li, N., Liu, R.J., Dwyer, J.M., Banasr, M., Lee, B., Son, H., Li, X.Y., Aghajanian, G., Duman, R.S., Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol. Psychiatry 69 (2011), 754–761.
19. Lu, J., Wu, X.Y., Zhu, Q.B., Li, J., Shi, L.G., Wu, J.L., Zhang, Q.J., Huang, M.L., Bao, A.M., Sex differences in the stress response in SD rats. Behav. Brain Res. 284 (2015), 231–237.
20. Lu, C.Y., Liu, X., Jiang, H., Pan, F., Ho, C.S., Ho, R.C., Effects of traumatic stress induced in the juvenile period on the expression of gamma-aminobutyric acid receptor type a subunits in adult rat brain. Neural Plast., 2017, 2017 5715816.
21. Martinez-Turrillas, R., Del Rio, J., Frechilla, D., Sequential changes in BDNF mRNA expression and synaptic levels of AMPA receptor subunits in rat hippocampus after chronic antidepressant treatment. Neuropharmacology 49 (2005), 1178–1188.
22. McIntyre, R.S., Cha, D.S., Soczynska, J.K., Woldeyohannes, H.O., Gallaugher, L.A., Kudlow, P., Alsuwaidan, M., Baskaran, A., Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depress. Anxiety 30 (2013), 515–527.
23. McIntyre, R.S., Harrison, J., Loft, H., Jacobson, W., Olsen, C.K., The effects of vortioxetine on cognitive function in patients with major depressive disorder: a meta-analysis of three randomized controlled trials. Int. J. Neuropsychopharmacol., 2016 pii: pyw055.
24. McIntyre, R.S., Florea, I., Tonnoir, B., Loft, H., Lam, R.W., Christensen, M.C., Efficacy of vortioxetine on cognitive functioning in working patients with major depressive disorder. J. Clin. Psychiatry 78 (2017), 115–121.
25. Model, M.A., Burkhardt, J.K., A standard for calibration and shading correction of a fluorescence microscope. Cytometry 44 (2001), 309–316.
26. Moghadami, S., Jahanshahi, M., Sepehri, H., Amini, H., Gonadectomy reduces the density of androgen receptor-immunoreactive neurons in male rat's hippocampus: testosterone replacement compensates it. Behav. Brain Funct., 12, 2016, 5.
27. Molteni, R., Calabrese, F., Cattaneo, A., Mancini, M., Gennarelli, M., Racagni, G., Riva, M.A., Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine. Neuropsychopharmacology 34 (2009), 1523–1532.
28. Nibuya, M., Morinobu, S., Duman, R.S., Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15 (1995), 7539–7547.
29. Nielsen, C.K., Arnt, J., Sanchez, C., Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress: interstrain and interindividual differences. Behav. Brain Res. 107 (2000), 21–33.
30. Paxinos, G., Watson, C.R., Emson, P.C., AChE-stained horizontal sections of the rat brain in stereotaxic coordinates. J. Neurosci. Methods 3 (1980), 129–149.
31. Puri, B.H.A., Ho, R.C., Revision Notes in Psychiatry. 2014, CRC Press, New York.
32. Reus, G.Z., Stringari, R.B., Ribeiro, K.F., Ferraro, A.K., Vitto, M.F., Cesconetto, P., Souza, C.T., Quevedo, J., Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain. Behav. Brain Res. 221 (2011), 166–171.
33. Riga, M.S., Sanchez, C., Celada, P., Artigas, F., Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: focus on glutamatergic and GABAergic neurotransmission. Neuropharmacology 108 (2016), 73–81.
34. Riga, M.S., Teruel-Marti, V., Sanchez, C., Celada, P., Artigas, F., Subchronic vortioxetine treatment -but not escitalopram- enhances pyramidal neuron activity in the rat prefrontal cortex. Neuropharmacology 113 (2017), 148–155.
35. Russo-Neustadt, A.A., Alejandre, H., Garcia, C., Ivy, A.S., Chen, M.J., Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise. Neuropsychopharmacology 29 (2004), 2189–2199.
36. Sagud, M., Nikolac Perkovic, M., Vuksan-Cusa, B., Maravic, A., Svob Strac, D., Mihaljevic Peles, A., Zivkovic, M., Kusevic, Z., Pivac, N., A prospective, longitudinal study of platelet serotonin and plasma brain-derived neurotrophic factor concentrations in major depression: effects of vortioxetine treatment. Psychopharmacology (Berl). 233 (2016), 3259–3267.
37. Sanchez, C., Asin, K.E., Artigas, F., Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol. Ther. 145 (2015), 43–57.
38. Stanford, S.C., The open field test: reinventing the wheel. J Psychopharmacol. 21 (2007), 134–135.
39. Vahdati Hassani, F., Naseri, V., Razavi, B.M., Mehri, S., Abnous, K., Hosseinzadeh, H., Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru, 22, 2014, 16.
40. Willner, P., The chronic mild stress (CMS) model of depression: history, evaluation and usage. Neurobiol. Stress 6 (2017), 78–93.
41. Willner, P., Towell, A., Sampson, D., Sophokleous, S., Muscat, R., Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl). 93 (1987), 358–364.
42. Yang, J.L., Liu, X., Jiang, H., Pan, F., Ho, C.S., Ho, R.C., The effects of high-fat-diet combined with chronic unpredictable mild stress on depression-like behavior and Leptin/LepRb in male rats. Sci. Rep., 6, 2016, 35239.
43. Yu, H., Chen, J.J., Zeng, B.Q., Zhong, Q.P., Xu, J.P., Liu, Y.G., Role of cAMP/CREB/BDNF signaling pathway in anti-depressive effect of vortioxetine in mice. Nan Fang Yi Ke Da Xue Xue Bao 37 (2017), 107–112.
44. Zhou, W., Wang, N., Yang, C., Li, X.M., Zhou, Z.Q., Yang, J.J., Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex. Eur. Psychiatry 29 (2014), 419–423.