메뉴 건너뛰기




Volumn 232, Issue 13, 2015, Pages 2343-2352

Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: Electrophysiological studies in the rat brain

Author keywords

5 HT1A< inf> receptor; 5 HT1B< inf> receptor; Electrophysiology; Escitalopram; Hippocampus; Serotonin; Vortioxetine

Indexed keywords

5 PROPOXY 3 (1,2,5,6 TETRAHYDRO 4 PYRIDYL)PYRROLO[3,2 B]PYRIDINE; ESCITALOPRAM; SEROTONIN 1A RECEPTOR; SEROTONIN 1B RECEPTOR; VORTIOXETINE; PIPERAZINE DERIVATIVE; SEROTONIN 1 AGONIST; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SULFIDE;

EID: 84930864010     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-015-3870-9     Document Type: Article
Times cited : (24)

References (37)
  • 1
    • 84904425500 scopus 로고    scopus 로고
    • Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder
    • 1:CAS:528:DC%2BC2cXhslKit7zM 4106971 25075188
    • Alvarez E, Perez V, Artigas F (2014) Pharmacology and clinical potential of vortioxetine in the treatment of major depressive disorder. Neuropsychiatr Dis Treat 10:1297-1307
    • (2014) Neuropsychiatr Dis Treat , vol.10 , pp. 1297-1307
    • Alvarez, E.1    Perez, V.2    Artigas, F.3
  • 2
    • 84858618643 scopus 로고    scopus 로고
    • Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects
    • 1:CAS:528:DC%2BC38XltFSmtLY%3D 21985522
    • Areberg J, Luntang-Jensen M, Søgaard B, Nilausen DØ (2012) Occupancy of the serotonin transporter after administration of Lu AA21004 and its relation to plasma concentration in healthy subjects. Basic Clin Pharmacol Toxicol 110:401-404
    • (2012) Basic Clin Pharmacol Toxicol , vol.110 , pp. 401-404
    • Areberg, J.1    Luntang-Jensen, M.2    Søgaard, B.3    Nilausen DØ.4
  • 4
    • 84877994064 scopus 로고    scopus 로고
    • The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptors antagonism
    • 23089374
    • Bétry C, Pehrson AL, Etiévant A, Ebert B, Sánchez C, Haddjeri (2013) The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT3 receptors antagonism. Int J Neuropsychopharmacol 16:1115-1127
    • (2013) Int. J. Neuropsychopharmacol , vol.16 , pp. 1115-1127
    • Bétry, C.1    Pehrson, A.L.2    Etiévant, A.3    Ebert, B.4    Sánchez, C.5    Haddjeri6
  • 5
    • 0028018846 scopus 로고
    • Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs
    • 1:CAS:528:DyaK2cXmt1Wrsbc%3D 1510133 7834200
    • Blier P, Bouchard C (1994) Modulation of 5-HT release in the guinea-pig brain following long-term administration of antidepressant drugs. Br J Pharmacol 113:485-495
    • (1994) Br J Pharmacol , vol.113 , pp. 485-495
    • Blier, P.1    Bouchard, C.2
  • 6
    • 0020521916 scopus 로고
    • Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat
    • 1:CAS:528:DyaL3sXkvVagtbo%3D 6304261
    • Blier P, De Montigny C (1983) Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat. J Neurosci 3:1270-1278
    • (1983) J Neurosci , vol.3 , pp. 1270-1278
    • Blier, P.1    De Montigny, C.2
  • 7
    • 0028287265 scopus 로고
    • Current advances and trends in the treatment of depression
    • 1:CAS:528:DyaK2cXlvFClurw%3D 7940983
    • Blier P, de Montigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220-226
    • (1994) Trends Pharmacol Sci , vol.15 , pp. 220-226
    • Blier, P.1    De Montigny, C.2
  • 8
    • 84883885115 scopus 로고    scopus 로고
    • Serotonin and beyond: Therapeutics for major depression
    • 3638389 23440470
    • Blier P, El Mansari M (2013) Serotonin and beyond: therapeutics for major depression. Philos Trans R Soc Lond B Biol Sci 368:20120536
    • (2013) Philos Trans R Soc Lond B Biol Sci , vol.368 , pp. 20120536
    • Blier, P.1    El Mansari, M.2
  • 9
    • 0022503904 scopus 로고
    • Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: Electrophysiological studies in the rat central nervous system
    • 1:CAS:528:DyaL28Xkslanu7s%3D 2423685
    • Blier P, De Montigny C, Azzaro AJ (1986) Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: electrophysiological studies in the rat central nervous system. J Pharmacol Exp Ther 237:987-994
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 987-994
    • Blier, P.1    De Montigny, C.2    Azzaro, A.J.3
  • 11
    • 0023818805 scopus 로고
    • Validation of the I.T50 method for assessing neuronal responsiveness to microiontophoretic applications: A single-cell recording study
    • 1:STN:280:DyaL1c3hsFGmsw%3D%3D 3367646
    • Brunel S, de Montigny C (1988) Validation of the I.T50 method for assessing neuronal responsiveness to microiontophoretic applications: a single-cell recording study. J Pharmacol Methods 19:23-30
    • (1988) J Pharmacol Methods , vol.19 , pp. 23-30
    • Brunel, S.1    De Montigny, C.2
  • 12
    • 0022454164 scopus 로고
    • Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain
    • 1:CAS:528:DyaL28XmtFykt70%3D 3022157
    • Chaput Y, de Montigny C, Blier P (1986) Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn Schmiedebergs Arch Pharmacol 333:342-348
    • (1986) Naunyn Schmiedebergs Arch Pharmacol , vol.333 , pp. 342-348
    • Chaput, Y.1    De Montigny, C.2    Blier, P.3
  • 13
    • 0026348807 scopus 로고
    • Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat
    • 1:CAS:528:DyaK38Xht1Srsr4%3D 1839498
    • Chaput Y, de Montigny C, Blier P (1991) Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. Neuropsychopharmacology 5:219-229
    • (1991) Neuropsychopharmacology , vol.5 , pp. 219-229
    • Chaput, Y.1    De Montigny, C.2    Blier, P.3
  • 14
    • 84890570648 scopus 로고    scopus 로고
    • Vortioxetine for major depressive disorder: A systematic review of the efficacy and safety profile for this newly approved antidepressant - What is the number needed to treat, number needed to harm and likelihood to be helped or harmed?
    • 1:CAS:528:DC%2BC3sXhvFOnurjK 24165478
    • Citrome L (2014) Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?. Int J Clin Pract 68:60-82
    • (2014) Int J Clin Pract , vol.68 , pp. 60-82
    • Citrome, L.1
  • 15
    • 0033864136 scopus 로고    scopus 로고
    • Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat
    • 1:CAS:528:DC%2BD3cXnt1Wjurk%3D 10997729
    • Czachura JF, Rasmussen K (2000) Effects of acute and chronic administration of fluoxetine on the activity of serotonergic neurons in the dorsal raphe nucleus of the rat. Naunyn Schmiedebergs Arch Pharmacol 362:266-275
    • (2000) Naunyn Schmiedebergs Arch Pharmacol , vol.362 , pp. 266-275
    • Czachura, J.F.1    Rasmussen, K.2
  • 16
    • 0038693666 scopus 로고    scopus 로고
    • The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism
    • de Groote L, Klompmakers AA, Olivier B, Westenberg HG (2003) The rapid recovery of 5-HT cell firing induced by the antidepressant vortioxetine involves 5-HT(3) receptor antagonism. Psychopharmacology (Berl) 167:153-158
    • (2003) Psychopharmacology (Berl) , vol.167 , pp. 153-158
    • De Groote, L.1    Klompmakers, A.A.2    Olivier, B.3    Westenberg, H.G.4
  • 17
    • 0036774363 scopus 로고    scopus 로고
    • Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hypothalamus
    • 1:CAS:528:DC%2BD38XntVWqurk%3D 12452522
    • Dremencov E, Gur E, Lerer B, Newman ME (2002) Effects of chronic antidepressants and electroconvulsive shock on serotonergic neurotransmission in the rat hypothalamus. Prog Neuropsychopharmacol Biol Psychiatry 26:1029-1034
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry , vol.26 , pp. 1029-1034
    • Dremencov, E.1    Gur, E.2    Lerer, B.3    Newman, M.E.4
  • 18
    • 20544472658 scopus 로고    scopus 로고
    • Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: An in vivo electrophysiological study in rat brain
    • 15702136
    • El Mansari M, Sánchez C, Chouvet G, Renaud B, Haddjeri N (2005) Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission: an in vivo electrophysiological study in rat brain. Neuropsychopharmacology 30:1269-1277
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1269-1277
    • El Mansari, M.1    Sánchez, C.2    Chouvet, G.3    Renaud, B.4    Haddjeri, N.5
  • 19
    • 0031016880 scopus 로고    scopus 로고
    • Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY 100,635 and GR 127,935
    • 1:CAS:528:DyaK2sXhsVaqurk%3D 9048762
    • Gobert A, Rivet JM, Cistarelli L, Millan MJ (1997) Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY 100,635 and GR 127,935. J Neurochem 68:1159-1163
    • (1997) J Neurochem , vol.68 , pp. 1159-1163
    • Gobert, A.1    Rivet, J.M.2    Cistarelli, L.3    Millan, M.J.4
  • 21
    • 0032400788 scopus 로고    scopus 로고
    • Antidepressant treatments tonically activate forebrain 5-HT1A receptors
    • 1:CAS:528:DyaK1cXnslyqsLc%3D 9822768
    • Haddjeri N, Blier P, de Montigny C (1998) Antidepressant treatments tonically activate forebrain 5-HT1A receptors. J Neurosci 18:10150-10156
    • (1998) J Neurosci , vol.18 , pp. 10150-10156
    • Haddjeri, N.1    Blier, P.2    De Montigny, C.3
  • 22
    • 0001192938 scopus 로고
    • Electrophysiology of hippocampal neurons. II. After-potentials and repetitive firing
    • 1:STN:280:DyaF3c%2FntVyktA%3D%3D 13751138
    • Kandel ER, Spencer WA (1961) Electrophysiology of hippocampal neurons. II. After-potentials and repetitive firing. J Neurophysiol 24:243-259
    • (1961) J. Neurophysiol , vol.24 , pp. 243-259
    • Kandel, E.R.1    Spencer, W.A.2
  • 23
    • 84862132965 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder
    • 22572889
    • Katona C, Hansen T, Olsen CK (2012) A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int Clin Psychopharmacol 27:215-223
    • (2012) Int Clin Psychopharmacol , vol.27 , pp. 215-223
    • Katona, C.1    Hansen, T.2    Olsen, C.K.3
  • 24
    • 84973259389 scopus 로고    scopus 로고
    • Efficacy of vortioxetine on cognitive function in adult patients with major depressive disorder: Results of a randomized, double-blind, active-referenced, placebo-controlled trial
    • Mahableshwarkar A, Zajecka J, Jacobson W, Chen Y, Keefe RSE (2014) Efficacy of vortioxetine on cognitive function in adult patients with major depressive disorder: Results of a randomized, double-blind, active-referenced, placebo-controlled trial. Int J Psychopharmacol 17(suppl1):016
    • (2014) Int J Psychopharmacol , vol.17 , pp. 016
    • Mahableshwarkar, A.1    Zajecka, J.2    Jacobson, W.3    Chen, Y.4    Keefe, R.S.E.5
  • 25
    • 84938074907 scopus 로고    scopus 로고
    • A randomized, Double-blind, Placebo-controlled Study of Vortioxetine on Cognitive function in depressed adults
    • McIntyre RS, Lophaven S, Olsen CK (2013) A randomized, Double-blind, Placebo-controlled Study of Vortioxetine on Cognitive function in depressed adults. Int J Neuropsychopharmacol 17:1557-1567
    • (2013) Int J Neuropsychopharmacol , vol.17 , pp. 1557-1567
    • McIntyre, R.S.1    Lophaven, S.2    Olsen, C.K.3
  • 26
  • 28
    • 0025213879 scopus 로고
    • Modulation by drugs of the release of total tritium and 3H-5-HT from rat hypothalamic slices
    • Moret C, Briley M (1990) Modulation by drugs of the release of total tritium and 3H-5-HT from rat hypothalamic slices. Naunyn Schmiedebergs Arch Pharmacol 34:398-403
    • (1990) Naunyn Schmiedebergs Arch Pharmacol , vol.34 , pp. 398-403
    • Moret, C.1    Briley, M.2
  • 31
    • 84901720404 scopus 로고    scopus 로고
    • Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction
    • 3968911 23903233
    • Pehrson AL, Sanchez C (2014) Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. CNS Spectr 19:121-33
    • (2014) CNS Spectr , vol.19 , pp. 121-133
    • Pehrson, A.L.1    Sanchez, C.2
  • 32
    • 84873523331 scopus 로고    scopus 로고
    • Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters-A rat microdialysis and electrophysiology study
    • 1:CAS:528:DC%2BC38XntlWjs7w%3D 22612991
    • Pehrson AL, Cremers T, Bétry C, van der Hart MG, Jørgensen L, Madsen M, Haddjeri N, Ebert B, Sanchez C (2013) Lu AA21004, a novel multimodal antidepressant, produces regionally selective increases of multiple neurotransmitters-a rat microdialysis and electrophysiology study. Eur Neuropsychopharmacol 23:133-145
    • (2013) Eur Neuropsychopharmacol , vol.23 , pp. 133-145
    • Pehrson, A.L.1    Cremers, T.2    Bétry, C.3    Van Der Hart, M.G.4    Jørgensen, L.5    Madsen, M.6    Haddjeri, N.7    Ebert, B.8    Sanchez, C.9
  • 33
    • 0028220927 scopus 로고
    • Desensitization of the neuronal 5-HT carrier following its long-term blockade
    • 1:CAS:528:DyaK2cXktVWltL0%3D 8182457
    • Pineyro G, Blier P, Dennis T, de Montigny C (1994) Desensitization of the neuronal 5-HT carrier following its long-term blockade. J Neurosci 14:3036-3047
    • (1994) J Neurosci , vol.14 , pp. 3036-3047
    • Pineyro, G.1    Blier, P.2    Dennis, T.3    De Montigny, C.4
  • 34
    • 0001797297 scopus 로고
    • Behavioral correlates and firing repertoires of neurons in the dorsal hippocampal formation and septum of unrestrained rats
    • Isaacson LR (ed) Plenum Press, New York
    • Ranck JB (1973) Behavioral correlates and firing repertoires of neurons in the dorsal hippocampal formation and septum of unrestrained rats. In: Isaacson LR (ed) The hippocampus. Plenum Press, New York, pp 207-244
    • (1973) The Hippocampus , pp. 207-244
    • Ranck, J.B.1
  • 35
    • 0030947546 scopus 로고    scopus 로고
    • Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo
    • 1:CAS:528:DyaK2sXksF2is74%3D 1564780 9222551
    • Sharp T, Umbers V, Gartside SE (1997) Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. Br J Pharmacol 121:941-946
    • (1997) Br J Pharmacol , vol.121 , pp. 941-946
    • Sharp, T.1    Umbers, V.2    Gartside, S.E.3
  • 36
    • 84884281105 scopus 로고    scopus 로고
    • 5-HTT and 5-HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects
    • 1:CAS:528:DC%2BC3sXislyrtLk%3D 23428337
    • Stenkrona P, Halldin C, Lundberg J (2013) 5-HTT and 5-HT1A receptor occupancy of the novel substance vortioxetine (Lu AA21004). A PET study in control subjects. Eur Neuropsychopharmacol 23:1190-1198
    • (2013) Eur Neuropsychopharmacol , vol.23 , pp. 1190-1198
    • Stenkrona, P.1    Halldin, C.2    Lundberg, J.3
  • 37
    • 33751175401 scopus 로고    scopus 로고
    • Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats
    • 17097082
    • Wesołowska A, Nikiforuk A, Stachowicz K (2006) Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats. Eur J Pharmacol 553:185-190
    • (2006) Eur J Pharmacol , vol.553 , pp. 185-190
    • Wesołowska, A.1    Nikiforuk, A.2    Stachowicz, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.