메뉴 건너뛰기




Volumn 24, Issue 7, 2018, Pages 931-938

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

(33)  Yun, Seung Pil a,b   Kam, Tae In a   Panicker, Nikhil a   Kim, Sangmin a   Oh, Yumin a,c   Park, Jong Sung a,c   Kwon, Seung Hwan a   Park, Yong Joo a,c   Karuppagounder, Senthilkumar S a,b   Park, Hyejin a   Kim, Sangjune a   Oh, Nayeon a   Kim, Nayoung Alice a   Lee, Saebom a   Brahmachari, Saurav a,b   Mao, Xiaobo a,b   Lee, Jun Hee d   Kumar, Manoj a   An, Daniel a   Kang, Sung Ung a   more..


Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; NEUROPROTECTIVE AGENT; NLY 01; UNCLASSIFIED DRUG; AMYLOID;

EID: 85048318201     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-018-0051-5     Document Type: Article
Times cited : (734)

References (44)
  • 1
    • 85029667865 scopus 로고    scopus 로고
    • Reactive astrocytes: Production, function, and therapeutic potential
    • Liddelow, S. A. &Barres, B. A. Reactive astrocytes: production, function, and therapeutic potential. Immunity 46, 957-967 (2017).
    • (2017) Immunity , vol.46 , pp. 957-967
    • Liddelow, S.A.1    Barres, B.A.2
  • 2
    • 85016155890 scopus 로고    scopus 로고
    • Neurotoxic reactive astrocytes are induced by activated microglia
    • Liddelow, S. A. et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541, 481-487 (2017).
    • (2017) Nature , vol.541 , pp. 481-487
    • Liddelow, S.A.1
  • 3
    • 84957388554 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: Mechanisms of action
    • Athauda, D. &Foltynie, T. The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action. Drug Discov. Today 21, 802-818 (2016).
    • (2016) Drug Discov. Today , vol.21 , pp. 802-818
    • Athauda, D.1    Foltynie, T.2
  • 4
    • 84878542289 scopus 로고    scopus 로고
    • Exenatide and the treatment of patients with Parkinson's disease
    • Aviles-Olmos, I. et al. Exenatide and the treatment of patients with Parkinson's disease. J. Clin. Invest. 123, 2730-2736 (2013).
    • (2013) J. Clin. Invest. , vol.123 , pp. 2730-2736
    • Aviles-Olmos, I.1
  • 5
    • 84888058168 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation
    • Chen, S. et al. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience 256, 137-146 (2014).
    • (2014) Neuroscience , vol.256 , pp. 137-146
    • Chen, S.1
  • 6
    • 76449115696 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection
    • Harkavyi, A. &Whitton, P. S. Glucagon-like peptide 1 receptor stimulation as a means of neuroprotection. Br. J. Pharmacol. 159, 495-501 (2010).
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 495-501
    • Harkavyi, A.1    Whitton, P.S.2
  • 7
    • 84955199683 scopus 로고    scopus 로고
    • Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice
    • Li, Y. et al. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in mice. J. Neurochem. 135, 1203-1217 (2015).
    • (2015) J. Neurochem. , vol.135 , pp. 1203-1217
    • Li, Y.1
  • 8
    • 59049087723 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
    • Li, Y. et al. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc. Natl Acad. Sci. USA 106, 1285-1290 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1285-1290
    • Li, Y.1
  • 9
    • 84870054636 scopus 로고    scopus 로고
    • GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
    • Meier, J. J. GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus. Nat. Rev. Endocrinol. 8, 728-742 (2012).
    • (2012) Nat. Rev. Endocrinol. , vol.8 , pp. 728-742
    • Meier, J.J.1
  • 10
    • 84892579498 scopus 로고    scopus 로고
    • Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice
    • Rachmany, L. et al. Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice. Age (Dordr.) 35, 1621-1636 (2013).
    • (2013) Age (Dordr.) , vol.35 , pp. 1621-1636
    • Rachmany, L.1
  • 11
    • 79960996273 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia
    • Teramoto, S. et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 31, 1696-1705 (2011).
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1696-1705
    • Teramoto, S.1
  • 12
    • 84954026166 scopus 로고    scopus 로고
    • Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4
    • Tweedie, D. et al. Blast traumatic brain injury-induced cognitive deficits are attenuated by preinjury or postinjury treatment with the glucagon-like peptide-1 receptor agonist, exendin-4. Alzheimers Dement. 12, 34-48 (2016).
    • (2016) Alzheimers Dement. , vol.12 , pp. 34-48
    • Tweedie, D.1
  • 13
    • 85028049108 scopus 로고    scopus 로고
    • Exenatide once weekly versus placebo in Parkinson's disease: A randomised, double-blind, placebo-controlled trial
    • Athauda, D. et al. Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial. Lancet 390, 1664-1675 (2017).
    • (2017) Lancet , vol.390 , pp. 1664-1675
    • Athauda, D.1
  • 14
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk, K. C. et al. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338, 949-953 (2012).
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1
  • 15
    • 84989172537 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
    • Mao, X. et al. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science 353, aah3374 (2016).
    • (2016) Science , vol.353 , pp. aah3374
    • Mao, X.1
  • 16
    • 0037173006 scopus 로고    scopus 로고
    • Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 - Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
    • Lee, M. K. et al. Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 - Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice. Proc. Natl Acad. Sci. USA 99, 8968-8973 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8968-8973
    • Lee, M.K.1
  • 17
    • 84905447142 scopus 로고    scopus 로고
    • Astrocytic modulation of blood brain barrier: Perspectives on Parkinson's disease
    • Cabezas, R. et al. Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Front. Cell. Neurosci. 8, 211 (2014).
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 211
    • Cabezas, R.1
  • 18
    • 84928825095 scopus 로고    scopus 로고
    • Striatal blood-brain barrier permeability in Parkinson's disease
    • Gray, M. T. &Woulfe, J. M. Striatal blood-brain barrier permeability in Parkinson's disease. J. Cereb. Blood Flow Metab. 35, 747-750 (2015).
    • (2015) J. Cereb. Blood Flow Metab. , vol.35 , pp. 747-750
    • Gray, M.T.1    Woulfe, J.M.2
  • 19
    • 85046343042 scopus 로고    scopus 로고
    • Best practices for generating and using alpha-synuclein pre-formed fibrils to model Parkinson's disease in rodents
    • Polinski, N. K. et al. Best practices for generating and using alpha-synuclein pre-formed fibrils to model parkinson's disease in rodents. J. Parkinsons Dis. https://doi.org/10.3233/JPD-171248 (2018).
    • (2018) J. Parkinsons Dis.
    • Polinski, N.K.1
  • 20
    • 84983745648 scopus 로고    scopus 로고
    • Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration
    • Brahmachari, S. et al. Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration. J. Clin. Invest. 126, 2970-2988 (2016).
    • (2016) J. Clin. Invest. , vol.126 , pp. 2970-2988
    • Brahmachari, S.1
  • 21
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang, Y. et al. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34, 11929-11947 (2014).
    • (2014) J. Neurosci. , vol.34 , pp. 11929-11947
    • Zhang, Y.1
  • 22
    • 84995563875 scopus 로고    scopus 로고
    • Non-cell-autonomous neurotoxicity of α-synuclein through microglial Toll-like receptor 2
    • Kim, C., Lee, H. J., Masliah, E. &Lee, S. J. Non-cell-autonomous neurotoxicity of α-synuclein through microglial Toll-like receptor 2. Exp. Neurobiol. 25, 113-119 (2016).
    • (2016) Exp. Neurobiol. , vol.25 , pp. 113-119
    • Kim, C.1    Lee, H.J.2    Masliah, E.3    Lee, S.J.4
  • 23
    • 84861162180 scopus 로고    scopus 로고
    • Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2
    • Daher, J. P. et al. Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Hum. Mol. Genet. 21, 2420-2431 (2012).
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 2420-2431
    • Daher, J.P.1
  • 24
    • 85034624068 scopus 로고    scopus 로고
    • Peripheral monocyte entry is required for alpha-synuclein induced inflammation and neurodegeneration in a model of Parkinson disease
    • Harms, A. S. et al. Peripheral monocyte entry is required for alpha-synuclein induced inflammation and neurodegeneration in a model of Parkinson disease. Exp. Neurol. 300, 179-187 (2018).
    • (2018) Exp. Neurol. , vol.300 , pp. 179-187
    • Harms, A.S.1
  • 25
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez, F. O. &Gordon, S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6, 13 (2014).
    • (2014) F1000Prime Rep. , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 26
    • 84923207477 scopus 로고    scopus 로고
    • Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease
    • Allen Reish, H. E. &Standaert, D. G. Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease. J. Parkinsons Dis. 5, 1-19 (2015).
    • (2015) J. Parkinsons Dis. , vol.5 , pp. 1-19
    • Allen Reish, H.E.1    Standaert, D.G.2
  • 27
    • 84966340290 scopus 로고    scopus 로고
    • Protective effect of a GLP-1 analog on ischemia-reperfusion induced blood-retinal barrier breakdown and inflammation
    • Goncalves, A. et al. Protective effect of a GLP-1 analog on ischemia-reperfusion induced blood-retinal barrier breakdown and inflammation. Invest. Ophthalmol. Vis. Sci. 57, 2584-2592 (2016).
    • (2016) Invest. Ophthalmol. Vis. Sci. , vol.57 , pp. 2584-2592
    • Goncalves, A.1
  • 28
    • 85028915787 scopus 로고    scopus 로고
    • Plant polyphenols and exendin-4 prevent hyperactivity and TNF-α release in LPS-treated in vitro neuron/astrocyte/microglial networks
    • Gullo, F. et al. Plant polyphenols and exendin-4 prevent hyperactivity and TNF-α release in LPS-treated in vitro neuron/astrocyte/microglial networks. Front. Neurosci. 11, 500 (2017).
    • (2017) Front. Neurosci. , vol.11 , pp. 500
    • Gullo, F.1
  • 29
    • 70349334516 scopus 로고    scopus 로고
    • Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
    • Kim, S., Moon, M. &Park, S. Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease. J. Endocrinol. 202, 431-439 (2009).
    • (2009) J. Endocrinol. , vol.202 , pp. 431-439
    • Kim, S.1    Moon, M.2    Park, S.3
  • 30
    • 85018256212 scopus 로고    scopus 로고
    • Activation of glucagon-like peptide-1 receptor promotes neuroprotection in experimental autoimmune encephalomyelitis by reducing neuroinflammatory responses
    • Lee, C.-H. et al. Activation of glucagon-like peptide-1 receptor promotes neuroprotection in experimental autoimmune encephalomyelitis by reducing neuroinflammatory responses. Mol. Neurobiol. 55, 3007-3020 (2018).
    • (2018) Mol. Neurobiol. , vol.55 , pp. 3007-3020
    • Lee, C.-H.1
  • 31
    • 84863115597 scopus 로고    scopus 로고
    • Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
    • Li, Y. et al. Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis. PLoS ONE 7, e32008 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e32008
    • Li, Y.1
  • 32
    • 85039057827 scopus 로고    scopus 로고
    • Both classic Gs-cAMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β /CREB signal pathways mediate exenatide-stimulated expression of M2 microglial markers
    • Wu, H.-Y., Tang, X.-Q., Liu, H., Mao, X.-F. &Wang, Y.-X. Both classic Gs-cAMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β /CREB signal pathways mediate exenatide-stimulated expression of M2 microglial markers. J. Neuroimmunol. 316, 17-22 (2018).
    • (2018) J. Neuroimmunol. , vol.316 , pp. 17-22
    • Wu, H.-Y.1    Tang, X.-Q.2    Liu, H.3    Mao, X.-F.4    Wang, Y.-X.5
  • 33
    • 85019346078 scopus 로고    scopus 로고
    • Exendin-4 treatment improves LPS-induced depressive-like behavior without affecting pro-inflammatorycytokines
    • Ventorp, F. et al. Exendin-4 treatment improves LPS-induced depressive-like behavior without affecting pro-inflammatorycytokines. J. Parkinsons Dis. 7, 263-273 (2017).
    • (2017) J. Parkinsons Dis. , vol.7 , pp. 263-273
    • Ventorp, F.1
  • 34
    • 84962236691 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF
    • Ji, C. et al. A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF. Brain Res. 1634, 1-11 (2016).
    • (2016) Brain Res. , vol.1634 , pp. 1-11
    • Ji, C.1
  • 35
    • 84862748768 scopus 로고    scopus 로고
    • Neuroprotective and neurotrophic actions of glucagon-like peptide-1: An emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    • Salcedo, I., Tweedie, D., Li, Y. &Greig, N. H. Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders. Br. J. Pharmacol. 166, 1586-1599 (2012).
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 1586-1599
    • Salcedo, I.1    Tweedie, D.2    Li, Y.3    Greig, N.H.4
  • 36
    • 84907033533 scopus 로고    scopus 로고
    • Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates
    • Volpicelli-Daley, L. A., Luk, K. C. &Lee, V. M. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nat. Protoc. 9, 2135-2146 (2014).
    • (2014) Nat. Protoc. , vol.9 , pp. 2135-2146
    • Volpicelli-Daley, L.A.1    Luk, K.C.2    Lee, V.M.3
  • 37
    • 79955014687 scopus 로고    scopus 로고
    • Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics
    • Kim, T. H. et al. Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics. Bioconjug. Chem. 22, 625-632 (2011).
    • (2011) Bioconjug. Chem. , vol.22 , pp. 625-632
    • Kim, T.H.1
  • 38
    • 84869748023 scopus 로고    scopus 로고
    • Site-specific PEGylated exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects
    • Kim, T. H. et al. Site-specific PEGylated exendin-4 modified with a high molecular weight trimeric PEG reduces steric hindrance and increases type 2 antidiabetic therapeutic effects. Bioconjug. Chem. 23, 2214-2220 (2012).
    • (2012) Bioconjug. Chem. , vol.23 , pp. 2214-2220
    • Kim, T.H.1
  • 39
    • 84899892500 scopus 로고    scopus 로고
    • The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
    • Karuppagounder, S. S. et al. The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease. Sci. Rep. 4, 4874 (2014).
    • (2014) Sci. Rep. , vol.4 , pp. 4874
    • Karuppagounder, S.S.1
  • 40
    • 84884902975 scopus 로고    scopus 로고
    • Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss
    • Lee, Y. et al. Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss. Nat. Neurosci. 16, 1392-1400 (2013).
    • (2013) Nat. Neurosci. , vol.16 , pp. 1392-1400
    • Lee, Y.1
  • 41
    • 85040865717 scopus 로고    scopus 로고
    • GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers
    • Kim, S. et al. GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers. Proc. Natl Acad. Sci. USA 115, 798-803 (2018).
    • (2018) Proc. Natl Acad. Sci. USA , vol.115 , pp. 798-803
    • Kim, S.1
  • 42
    • 84936881452 scopus 로고    scopus 로고
    • Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson's disease
    • Panicker, N. et al. Fyn kinase regulates microglial neuroinflammatory responses in cell culture and animal models of Parkinson's disease. J. Neurosci. 35, 10058-10077 (2015).
    • (2015) J. Neurosci. , vol.35 , pp. 10058-10077
    • Panicker, N.1
  • 43
    • 79958079994 scopus 로고    scopus 로고
    • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
    • Andrabi, S. A. et al. Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. Nat. Med. 17, 692-699 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 692-699
    • Andrabi, S.A.1
  • 44
    • 84990189685 scopus 로고    scopus 로고
    • A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
    • Wang, Y. et al. A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science 354, aad6872 (2016).
    • (2016) Science , vol.354 , pp. aad6872
    • Wang, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.