메뉴 건너뛰기




Volumn 25, Issue 3, 2016, Pages 113-119

Non-cell-autonomous Neurotoxicity of α-synuclein through microglial toll-like receptor 2

Author keywords

Microglia; Neurodegeneration; Parkinson's disease; Toll like receptor 2; synuclein

Indexed keywords


EID: 84995563875     PISSN: 12262560     EISSN: 20938144     Source Type: Journal    
DOI: 10.5607/en.2016.25.3.113     Document Type: Article
Times cited : (75)

References (31)
  • 2
    • 84871414210 scopus 로고    scopus 로고
    • The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
    • Lashuel HA, Overk CR, Oueslati A, Masliah E (2013) The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14:38-48.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 38-48
    • Lashuel, H.A.1    Overk, C.R.2    Oueslati, A.3    Masliah, E.4
  • 3
    • 61549111872 scopus 로고    scopus 로고
    • Alpha-synuclein and neuronal cell death
    • Cookson MR (2009) Alpha-synuclein and neuronal cell death. Mol Neurodegener 4:9.
    • (2009) Mol Neurodegener , vol.4 , pp. 9
    • Cookson, M.R.1
  • 4
    • 0242304111 scopus 로고    scopus 로고
    • Abstracts of the 25th Annual Meeting of the American Society for Bone and Mineral Research
    • Minneapolis, Minnesota, USA. September 19-23, 2003
    • Abstracts of the 25th Annual Meeting of the American Society for Bone and Mineral Research. Minneapolis, Minnesota, USA. September 19-23, 2003 (2003) J Bone Miner Res 18 Suppl 2:S2-S463.
    • (2003) J Bone Miner Res , vol.18 , pp. S2-S463
  • 5
    • 77958065285 scopus 로고    scopus 로고
    • Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies
    • Mollenhauer B, El-Agnaf OM, Marcus K, Trenkwalder C, Schlossmacher MG (2010) Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies. Biomarkers Med 4:683-699.
    • (2010) Biomarkers Med , vol.4 , pp. 683-699
    • Mollenhauer, B.1    El-Agnaf, O.M.2    Marcus, K.3    Trenkwalder, C.4    Schlossmacher, M.G.5
  • 7
    • 21344456506 scopus 로고    scopus 로고
    • Intravesicular localization and exocytosis of alpha-synuclein and its aggregates
    • Lee HJ, Patel S, Lee SJ (2005) Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 25:6016-6024.
    • (2005) J Neurosci , vol.25 , pp. 6016-6024
    • Lee, H.J.1    Patel, S.2    Lee, S.J.3
  • 8
    • 77951885732 scopus 로고    scopus 로고
    • Nonclassical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions
    • Jang A, Lee HJ, Suk JE, Jung JW, Kim KP, Lee SJ (2010) Nonclassical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions. J Neurochem 113:1263-1274.
    • (2010) J Neurochem , vol.113 , pp. 1263-1274
    • Jang, A.1    Lee, H.J.2    Suk, J.E.3    Jung, J.W.4    Kim, K.P.5    Lee, S.J.6
  • 10
    • 79251565507 scopus 로고    scopus 로고
    • Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity
    • Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ (2011) Heat-shock protein 70 modulates toxic extracellular alpha-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J 25:326-336.
    • (2011) FASEB J , vol.25 , pp. 326-336
    • Danzer, K.M.1    Ruf, W.P.2    Putcha, P.3    Joyner, D.4    Hashimoto, T.5    Glabe, C.6    Hyman, B.T.7    McLean, P.J.8
  • 11
    • 77950571596 scopus 로고    scopus 로고
    • Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies
    • Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ (2010) Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. J Biol Chem 285:9262-9272.
    • (2010) J Biol Chem , vol.285 , pp. 9262-9272
    • Lee, H.J.1    Suk, J.E.2    Patrick, C.3    Bae, E.J.4    Cho, J.H.5    Rho, S.6    Hwang, D.7    Masliah, E.8    Lee, S.J.9
  • 13
    • 84875870356 scopus 로고    scopus 로고
    • Microglia: actively surveying and shaping neuronal circuit structure and function
    • Wake H, Moorhouse AJ, Miyamoto A, Nabekura J (2013) Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci 36:209-217.
    • (2013) Trends Neurosci , vol.36 , pp. 209-217
    • Wake, H.1    Moorhouse, A.J.2    Miyamoto, A.3    Nabekura, J.4
  • 14
    • 0036847841 scopus 로고    scopus 로고
    • Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis
    • Carson MJ (2002) Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 40:218-231.
    • (2002) Glia , vol.40 , pp. 218-231
    • Carson, M.J.1
  • 15
    • 84883612112 scopus 로고    scopus 로고
    • Brain inflammation and microglia: facts and misconceptions
    • Jeong HK, Ji K, Min K, Joe EH (2013) Brain inflammation and microglia: facts and misconceptions. Exp Neurobiol 22:59-67.
    • (2013) Exp Neurobiol , vol.22 , pp. 59-67
    • Jeong, H.K.1    Ji, K.2    Min, K.3    Joe, E.H.4
  • 16
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10:1387-1394.
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 17
    • 70350346842 scopus 로고    scopus 로고
    • The influence of microglia on the pathogenesis of Parkinson's disease
    • Long-Smith CM, Sullivan AM, Nolan YM (2009) The influence of microglia on the pathogenesis of Parkinson's disease. Prog Neurobiol 89:277-287.
    • (2009) Prog Neurobiol , vol.89 , pp. 277-287
    • Long-Smith, C.M.1    Sullivan, A.M.2    Nolan, Y.M.3
  • 18
    • 84954517040 scopus 로고    scopus 로고
    • Control of inflammatory responses: a new paradigm for the treatment of chronic neuronal diseases
    • Woo JH, Lee JH, Kim H, Park SJ, Joe EH, Jou I (2015) Control of inflammatory responses: a new paradigm for the treatment of chronic neuronal diseases. Exp Neurobiol 24:95-102.
    • (2015) Exp Neurobiol , vol.24 , pp. 95-102
    • Woo, J.H.1    Lee, J.H.2    Kim, H.3    Park, S.J.4    Joe, E.H.5    Jou, I.6
  • 19
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 20
    • 84991219339 scopus 로고    scopus 로고
    • ATP13A2/PARK9 deficiency neither cause lysosomal impairment nor alter alpha-synuclein metabolism in SH-SY5Y cells
    • Bae EJ, Lee C, Lee HJ, Kim S, Lee SJ (2014) ATP13A2/PARK9 deficiency neither cause lysosomal impairment nor alter alpha-synuclein metabolism in SH-SY5Y cells. Exp Neurobiol 23:365-371.
    • (2014) Exp Neurobiol , vol.23 , pp. 365-371
    • Bae, E.J.1    Lee, C.2    Lee, H.J.3    Kim, S.4    Lee, S.J.5
  • 21
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammationmediated neurodegeneration: multiple triggers with a common mechanism
    • Block ML, Hong JS (2005) Microglia and inflammationmediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76:77-98.
    • (2005) Prog Neurobiol , vol.76 , pp. 77-98
    • Block, M.L.1    Hong, J.S.2
  • 22
    • 33748973074 scopus 로고    scopus 로고
    • Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra
    • Ferrari CC, Pott Godoy MC, Tarelli R, Chertoff M, Depino AM, Pitossi FJ (2006) Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol Dis 24:183-193.
    • (2006) Neurobiol Dis , vol.24 , pp. 183-193
    • Ferrari, C.C.1    Pott Godoy, M.C.2    Tarelli, R.3    Chertoff, M.4    Depino, A.M.5    Pitossi, F.J.6
  • 23
    • 33748702290 scopus 로고    scopus 로고
    • Blocking soluble tumor necrosis factor signaling with dominantnegative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    • McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, Tansey KE, Tansey MG (2006) Blocking soluble tumor necrosis factor signaling with dominantnegative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J Neurosci 26:9365-9375.
    • (2006) J Neurosci , vol.26 , pp. 9365-9375
    • McCoy, M.K.1    Martinez, T.N.2    Ruhn, K.A.3    Szymkowski, D.E.4    Smith, C.G.5    Botterman, B.R.6    Tansey, K.E.7    Tansey, M.G.8
  • 25
    • 79955745301 scopus 로고    scopus 로고
    • Toll-like receptor signaling in neural plasticity and disease
    • Okun E, Griffioen KJ, Mattson MP (2011) Toll-like receptor signaling in neural plasticity and disease. Trends Neurosci 34:269-281.
    • (2011) Trends Neurosci , vol.34 , pp. 269-281
    • Okun, E.1    Griffioen, K.J.2    Mattson, M.P.3
  • 27
    • 84907407571 scopus 로고    scopus 로고
    • Microglial phenotypes and tolllike receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients
    • Doorn KJ, Moors T, Drukarch B, van de Berg WD, Lucassen PJ, van Dam AM (2014) Microglial phenotypes and tolllike receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson's disease patients. Acta Neuropathol Commun 2:90.
    • (2014) Acta Neuropathol Commun , vol.2 , pp. 90
    • Doorn, K.J.1    Moors, T.2    Drukarch, B.3    van de Berg, W.D.4    Lucassen, P.J.5    van Dam, A.M.6
  • 30
    • 84858652204 scopus 로고    scopus 로고
    • Misfolded alphasynuclein and toll-like receptors: therapeutic targets for Parkinson's disease
    • Béraud D, Maguire-Zeiss KA (2012) Misfolded alphasynuclein and toll-like receptors: therapeutic targets for Parkinson's disease. Parkinsonism Relat Disord. 18 Suppl 1:S17-S20.
    • (2012) Parkinsonism Relat Disord , vol.18 , pp. S17-S20
    • Béraud, D.1    Maguire-Zeiss, K.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.