A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Science

Volumn 354, Issue 6308, 2016, Pages

  Wang, Yingfei ^a,b   An, Ran ^a,c   Umanah, George K ^a   Park, Hyejin ^a,d   Nambiar, Kalyani ^a   Eacker, Stephen M ^a,d   Kim, Bongwoo ^b   Bao, Lei ^b   Harraz, Maged M ^a   Chang, Calvin ^a   Chen, Rong ^a   Wang, Jennifer E ^b   Kam, Tae In ^a,d   Jeong, Jun Seop ^a   Xie, Zhi ^a,e   Neifert, Stewart ^a,d   Qian, Jiang ^a   Andrabi, Shaida A ^a,f   Blackshaw, Seth ^a   Zhu, Heng ^a   Song, Hongjun ^a   Ming, Guo Li ^a   Dawson, Valina L ^a,d   Dawson, Ted M ^a,d   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c FUDAN UNIVERSITY   (China)

^d ADRIENNE HELIS MALVIN MEDICAL RESEARCH FOUNDATION   (United States)

^e SUN YAT SEN UNIVERSITY   (China)

^f University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; DNA; GENOMIC DNA; GLUTAMIC ACID; MACROPHAGE MIGRATION INHIBITION FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; CHROMATIN; DEOXYRIBONUCLEASE; ISOMERASE; MIF PROTEIN, HUMAN; SINGLE STRANDED DNA;

APOPTOSIS; CELLS AND CELL COMPONENTS; DAMAGE; DISEASE TREATMENT; DNA; ENZYME ACTIVITY; GENE EXPRESSION; GENOMICS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION; CELL DEATH; CELL NUCLEUS; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; EXCITOTOXICITY; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; ACTIVE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; CHEMISTRY; CHROMATIN; CONFORMATION; DNA CLEAVAGE; DNA FRAGMENTATION; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HELA CELL LINE; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; MUTATION; NERVE CELL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BASE SEQUENCE; CATALYTIC DOMAIN; CELL NUCLEUS; CHROMATIN; DEOXYRIBONUCLEASES; DNA CLEAVAGE; DNA DAMAGE; DNA FRAGMENTATION; DNA, SINGLE-STRANDED; GLUTAMIC ACID; HELA CELLS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUTATION; NEURONS; NUCLEIC ACID CONFORMATION; OXIDATIVE STRESS; POLY (ADP-RIBOSE) POLYMERASE-1; STROKE;

EID: 84990189685     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad6872     Document Type: Article

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