Expression of the transcriptional regulator Egr-1 in experimental glomerulonephritis: Requirement for mesangial cell proliferation

Kidney International

Volumn 51, Issue 3, 1997, Pages 694-702

  Rupprecht, Harald D ^a   Hofer, Gerhard ^b   De Heer, Emile ^b   Sterzel, R Bernd ^b   Faller, Gerhard ^b   Schoecklmann, Harald O ^b  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE PROTEIN; PLATELET DERIVED GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; MALE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

EID: 0030888592     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1038/ki.1997.100     Document Type: Article

References (37)

1. ENG E, FLOEGE J, YOUNG BA, COUSER WG, JOHNSON RJ: Does extracellular matrix expansion in glomerular disease require mesangial cell proliferation? Kidney Int 45(Suppl 45):S45-S47, 1994
2. FLOEGE J, JOHNSON RJ, GORDON K, IIDA H, PRITZL P, YOSHIMURA A, CAMPBELL C, ALPERS CE, COUSER WG: Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Kidney Int 40:477-488, 1991
3. RUPPRECHT HD, DANN P, SUKHATME VP, STERZEL RB, COLEMAN DL: Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: Correlation with mitogenicity. Am J Physiol 263:F623-F636, 1992
4. RUPPRECHT HD, SUKHATME VP, LACY J, STERZEL RB, COLEMAN DL: PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am J Physiol 265:F351-F360, 1993
5. SUKHATME VP, KARTHA S, TOBACK FG, TAUB R, HOOVER RG, TSAI MORRIS CH: A novel early growth response gene rapidly induced by fibroblast, epithelial cell and lymphocyte mitogens. Oncogene Res 1:343-355, 1987
6. MCMAHON AP, CHAMPION JE, MCMAHON JA, SUKHATME VP: Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues. Development 108:281-287, 1990
7. SUKHATME VP, CAO XM, CHANG LC, TSAI MORRIS CH, STAMEN-KOVICH D, FERREIRA PC, COHEN DR, EDWARDS SA, SHOWS TB, CURRAN T, LEBEAU MM, ADAMSON ED: A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53:37-43, 1988
8. NGUYEN HQ, HOFFMAN LIEBERMANN B, LIEBERMANN DA: The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 72:197-209, 1993
9. HALLAHAN DE, SUKHATME VP, SHERMAN ML, VIRUDACHALAM S, KUFE D, WEICHSELBAUM RR: Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN. Proc Natl Acad Sci USA 88:2156-2160, 1991
10. AKAI Y, HOMMA T, BURNS KD, YASUDA T, BADR KF, HARRIS RC: Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol 267:C482-C490, 1994
11. RUPPRECHT HD, SUKHATME VP, RUPPRECHT AP, STERZEL RB, COLEMAN DL: Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene-1 by arginine vasopressin in rat mesangial cells. J Cell Physiol 159:311-323, 1994
12. LAU LF, NATHANS D: Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 84:1182-1186, 1987
13. CAO XM, KOSKI RA, GASHLER A, MCKIERNAN M, MORRIS CF, GAFFNEY R, HAY RV, SUKHATME VP: Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol 10:1931-1939, 1990
14. LEMAIRE P, VESQUE C, SCHMITT J, STUNNENBERG H, FRANK R, CHARNAY P: The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol Cell Biol 10:3456-3467, 1990
15. CHRISTY B, NATHANS D: DNA binding site of the growth factor-inducible protein Zif268. Proc Natl Acad Sci USA 86:8737-8741, 1989
16. PAVLETICH NP, PABO CO: Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A. Science 252:809-817, 1991
17. GUPTA MP, GUPTA M, ZAK R, SUKHATME VP: Egr-1, a serum-inducible zinc finger protein, regulates transcription of the rat cardiac alpha-myosin heavy chain gene. J Biol Chem 266:12813-12816, 1991
18. KINANE TB, FINDER JD, KAWASHIMA A, BROWN D, ABBATE M, SHANG C, FREDERICKS WJ, RAUSCHER FJ, SUKHATME VP, ERCOLANI L: Growth of LLC-PK1 renal cells is mediated by EGR-1 up-regulation of G protein alpha i-2 protooncogene transcription. J Biol Chem 269:27503-27509, 1994
19. MOLNAR G, CROZAT A. PARDEE AB: The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the GO-to-G1 transition of the cell cycle. Mol Cell Biol 14:5242-5248, 1994
20. BAGCHUS-WM, HOEDEMAEKER PJ, ROZING J, BAKKER WW: Glomerulonephritis induced by monoclonal anti-Thy 1.1 antibodies. A sequential histological and ultrastructural study in the rat. Lab Invest 55:680-687, 1986
21. DIJKSTRA CD, DÖPP EA, JOLING P, KRAAL G: The heterogeneity of mononuclcar phagocytes in lymphoid organs: Distinct macrophage subpopulations in rat recognized by monoclonal antibodies ED1, ED2 and ED3. Immunolgy 54:589-599, 1985
22. CHOMCZYNSKI P, SACCHI N: Single-step method of RNA isolation by acid guanidinium thioeyanate-phenol-chloroform extraction. Anal Bioehem 162:156-159, 1987
23. BAGCHUS WM, JEUNINK MF, ELEMA JD: The mesangium in anti-Thy-1 nephritis. Influx of macrophages, mesangial cell hypercellularity, and macromolecular accumulation. Am J Pathol 137:215-223, 1990
24. JOHNSON RJ, IIDA H, ALPERS CE, MAJESKY MW, SCHWARTZ SM, PRITZI P, GORDON K, GOWN AM: Expression of smooth muscle cell phenotype by rat mesangial cells in immune complex nephritis. Alpha-smooth muscle actin is a marker of mesangial cell proliferation. J Clin Invest 87:847-858, 1991
25. FLOEGE J, ENG E, LINDNER V, ALPERS CE, YOUNG, BA, REIDY MA, JOHNSON RJ: Rat glomerular mesangial cells synthesize basic fibroblast growth factor: Release, upregulated synthesis, and mitogenicity in mesangial proliferative glomerulonephritis. J Clin Invest 90:2362-2369, 1992
26. FLOEGE J, ENG E, YOUNG BA, COUSER WG, JOHNSON RJ: Heparin suppresses mesangial cell proliferation and matrix expansion in experimental mesangioproliferative glomerulonephritis. Kidney Int 43: 369-380, 1993
27. SHIMIZU A, KITAMURA H, MASUDA Y, ISHIZAKI M, SUGISAKI Y, YAMANAKA N: Apoptosis in the repair process of experimental proliferative glomerulonephritis. Kidney Int 47:114-121, 1995
28. COLEMAN DL, BARTISS AH, SUKHATME VP, LIU J, RUPPRECHT HD: Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. J Immunol 149:3045-3051, 1992
29. JOHNSON RJ, RAINES EW, FLOEGE J, YOSHIMURA A, PRITZI P, ALPERS C, ROSS R: Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 175:1413-1416, 1992
30. DAY ML, FAHRNER TJ, AYKENT S, MILBRANDT J: The zinc finger protein NGFI-A exists in both nuclear and cytoplasmic forms in nerve growth factor stimulated PC12 cells. J Biol Chem 265:15253-15260, 1990
31. BURGESS TL, FISHER EF, ROSS SL, BREADY JV, QIAN YX, BAYEWITCH LA, COHEN AM, HERRERA CJ, HU SS, KRAMER TB, ET AL: The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc Natl Acad Sci USA 92:4051-4055, 1995
32. CHENG T, WANG Y, DAI W: Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocytic differentiation of K562 cells. J Biol Chem 269:30848-30853, 1994
33. SELLS SF, MUTHUKUMAR S, SUKHATME VP, CRIST SA, RANGNEKAR VM: The zinc finger transcription factor EGR-1 impedes interleukin-1-inducible tumor growth arrest. Mol Cell Biol 15:682-692, 1995
34. MCMAHON SB, MONROE JG: Activation of the p21ras pathway couples antigen receptor stimulation to induction of the primary response gene egr-1 in B lymphocytes. J Exp Med 181:417-422, 1995
35. HIPSKIND RA, BÜSCHER D, NORDHEIM A, BACCARINI M: Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors. Genes Dev 8:1803-1816, 1994
36. CHRISTY B, NATHANS D: Functional serum response elements upstream of the growth factor-inducible gene zif268. Mol Cell Biol 9:4889-4895, 1989
37. QURESHI SA, CAO XM, SUKHATME VP, FOSTER DA: v-Src activates mitogen-responsive transcription factor Egr-1 via serum response elements. J Biol Chem 266:10802-10806, 1991